Noradrenergic and specific serotonergic antidepressants (NaSSAs), often referred to as "nortropanes," are a class of drugs that function by selectively binding to and partially blocking the α2-adrenergic receptors and 5-HT2 receptors, thereby increasing the concentration of norepinephrine and serotonin in the synaptic cleft, which helps alleviate symptoms of depression.