1,2-Dimethylhydrazine
A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
Colonic Neoplasms
Tumors or cancer of the COLON.
Carcinogens
Hydrazines
Colon
Aberrant Crypt Foci
Precancerous Conditions
Chlorophyllides
Methylazoxymethanol Acetate
Neoplasms, Experimental
Rats, Inbred F344
Intestinal Mucosa
Anticarcinogenic Agents
Amorphophallus
Adenosarcoma
Azo Compounds
Cecal Neoplasms
Tumors or cancer of the CECUM.
Intestine, Large
Dietary Fiber
Rats, Inbred Strains
Colonic Diseases
Alkylation
Pectins
High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.
Guanine
Cellulose
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
Rats, Wistar
Rectum
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
Injections, Subcutaneous
Azoxymethane
A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.
Cecum
Intestine, Small
Cell Division
Ginger
Rhizome
Plant Extracts
Fatty Alcohols
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Gastrointestinal Diseases
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.