A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.
Coumarins
Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.
Oxygenases
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.