Serum alkalineIntestinalTNAPEnzymeColi alkaline phosphatasePlacental alkaline phosphataseAssay KitAntibodyIntestineDephosphorylationOsteoblastic activitySubstrateColorimetricPhysiological functionEmbryonicTissueProteinGeneElectrophoresisMarkerPhosphateIsoenzymesPreparationsAlanineProteinsHepatitisDegradationLaboratoriesAbnormalConcentrationsActivityDiagnosisLiver functionDetectionDiseaseAcidProneHighResultsHealth care provider maySymptomsBonesTest measures the amountHuman
Serum alkaline7
- A case is reported in which the serum alkaline phosphatase reached high levels, and in which the differential diagnosis between hepatic secondary deposits and osteomalacia proved difficult by the usual means. (bmj.com)
- They may also contribute to the circulating pool of serum alkaline phosphatase under specific situations when there is increased stimulation of their production. (statpearls.com)
- Serum alkaline phosphatase levels will vary with age in normal individuals. (statpearls.com)
- [8] In individuals with blood groups O and B, serum alkaline phosphatase levels increase after consuming a fatty meal, due to contribution from the intestinal tract. (statpearls.com)
- Measurement of serum alkaline phosphatase-in some cases, bone-specific alkaline phosphatase (BSAP)-can be useful in the diagnosis of Paget disease. (medscape.com)
- We retrospectively examined the correlation of serum alkaline phosphatase (ALP) levels with several clinicopathological characteristics of 207 cases of oesophageal carcinoma. (who.int)
- Regarding hepatic effects, PFHpS significantly increased liver weight, serum alkaline phosphatase, and serum alanine aminotransferase. (cdc.gov)
Intestinal5
- Psilocybin is dephosphorylated to Psilocin and inorganic phosphate by purified calf intestinal alkaline phosphatase. (erowid.org)
- The aim of this study was to determine the influence of age on intestinal brush-border disaccharidases (lactase, sucrase, and maltase), and alkaline phosphatase activity in CD26 deficient mice. (srce.hr)
- Measurement of alkaline phosphatase of intestinal origin in plasma by p-bromotetramisole inhibition. (bmj.com)
- Intestinal alkaline phosphatase is coded by a separate gene, which is different from the gene that codes for placental alkaline phosphatase and the Regan isoenzyme (produced in excess amounts in Hodgkin lymphoma). (statpearls.com)
- Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). (apoptosises.com)
TNAP4
- Tissue-nonspecific alkaline phosphatase (TNAP) recently emerged as a promising therapeutic target to block cardiovascular calcification. (nih.gov)
- Calcifications were amorphous areas surrounded by a fibrocartilaginous metaplasia containing hypertrophic chondrocyte-like cells that expressed tissue non-specific alkaline phosphatase (TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which are two key enzymes of the mineralization process. (iasp-pain.org)
- A growing body of data suggests that the loss of tissue nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels may be associated with changes in endothelial cell barrier integrity. (biorxiv.org)
- Mutations of the tissue non-specific alkaline phosphatase gene (TNAP) causing a non-lethal case of perinatal hypophosphatasia. (ox.ac.uk)
Enzyme9
- The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) has the physiological role of dephosphorylating compounds. (wikipedia.org)
- Alkaline phosphatase is a zinc-containing dimeric enzyme with the MW: 86,000 Da, each subunit containing 429 amino acids with four cysteine residues linking the two subunits. (wikipedia.org)
- Alkaline phosphatase contains four Zn ions and two Mg ions, with Zn occupying active sites A and B, and Mg occupying site C, so the fully active native alkaline phosphatase is referred to as (ZnAZnBMgC)2 enzyme. (wikipedia.org)
- Alkaline phosphatase (ALP) is an enzyme that is found throughout the body but mostly found in liver, bones, kidneys, and digestive system. (anylabtestnow.com)
- FastAP is a novel alkaline phosphatase, which is active in all Thermo Scientific restriction enzyme buffers as well as in PCR buffers. (biogen.cz)
- FastAP Thermosensitive Alkaline Phosphatase is active in all restriction enzyme buffers and may be added directly to digested DNA. (biogen.cz)
- Alkaline Phosphatase (ALP) is an enzyme found in the human body. (stedmandiagnostics.com)
- ALP" stands for "alkaline phosphatase," another name for this enzyme. (cura4u.com)
- Serum total acid phosphatase is an osteoclastic enzyme that may be elevated in active Paget disease. (medscape.com)
Coli alkaline phosphatase1
- In Gram-negative bacteria, such as Escherichia coli, alkaline phosphatase is located in the periplasmic space, external to the inner cell membrane and within the peptidoglycan portion of the cell wall. (wikipedia.org)
Placental alkaline phosphatase2
- Recombinant SEAP (secreted embryonic alkaline phosphatase) protein is a truncated form of human placental alkaline phosphatase that comprises 520 amino acids. (invivogen.com)
- SPECIFICITY: Human placental alkaline phosphatase (Regan and Nagao isoenzymes). (researchd.com)
Assay Kit2
- QuantiChrom™ Alkaline Phosphatase Assay Kit - 250 tests - 1 kit is backordered and will ship as soon as it is back in stock. (dnamethsoc.com)
- BioAssay Systems' QuantiChromTM Alkaline Phosphatase Assay Kit is designed to measure ALP activity directly in biological samples without pretreatment. (gentaur.be)
Antibody2
- Human Antibody Laboratories manufactures the antibody to human alkaline phosphatase reagents distributed by Genprice. (apoptosises.com)
- The Antibody To Human Alkaline Phosphatase reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (apoptosises.com)
Intestine2
- The majority of alkaline phosphatase in serum (more than 80%) is released from the liver and bone, and in small amounts from the intestine. (statpearls.com)
- Alkaline phosphatases found in the intestine, placenta, and germinal tissue are tissue-specific. (statpearls.com)
Dephosphorylation1
- As such, the main purpose of dephosphorylation by alkaline phosphatase is to increase the rate of diffusion of phosphorylated molecules into the cells while inhibiting them from diffusing out. (wikipedia.org)
Osteoblastic activity2
- For NHANES 2001, the HybritechTandem-MP Ostase ImmunoEnzymetric assay was used for quantitative measurement of Bone Alkaline Phosphatase (BAP), an indicator of osteoblastic activity, in human serum. (cdc.gov)
- Because of increased osteoblastic activity and bone formation, bone-specific alkaline phosphatase (BSAP) levels are elevated. (medscape.com)
Substrate2
- The mechanism of action of alkaline phosphatase involves the geometric coordination of the substrate between the Zn ions in the active sites, whereas the Mg site doesn't appear to be close enough to directly partake in the hydrolysis mechanism, however, it may contribute to the shape of the electrostatic potential around the active center. (wikipedia.org)
- Sections 12 to 32 micra thick were incubated in a substrate solution for the histochemical demonstration of non-specific alkaline phosphatase activity. (rupress.org)
Colorimetric2
- Quantitative (colorimetric) determination of the Psilocin formed showed that about 5 x 10-4 micromole was liberated per unit phosphatase per hour. (erowid.org)
- This paper discusses the fabrication and testing of a paper-based Point-of-care testing (POCT) device for the colorimetric detection of alkaline phosphatase (ALP). (amrita.edu)
Physiological function2
- Even though alkaline phosphatases are present in many tissues throughout the body, their precise physiological function remains largely unknown. (statpearls.com)
- The exact physiological function of the alkaline phosphatases is not known. (apoptosises.com)
Embryonic2
- 10 μg lyophilized recombinant human secreted embryonic alkaline phosphatase (SEAP). (invivogen.com)
- A mixed population of neuronal and glial restricted precursors (NRP/GRP) derived from the embryonic spinal cord of alkaline phosphatase (AP) transgenic rats were grafted acutely into a DC lesion at C1. (jneurosci.org)
Tissue2
- Alkaline phosphatases are classified as tissue-specific and tissue-nonspecific types. (statpearls.com)
- The tissue-nonspecific alkaline phosphatases form most of the fraction circulating in serum and, therefore, are of clinical interest. (statpearls.com)
Protein1
Gene1
- In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. (apoptosises.com)
Electrophoresis1
- Separation of the alkaline phosphatases by starch grain electrophoresis was used as an aid to differential diagnosis. (bmj.com)
Marker2
- Serum bone alkaline phosphatase is a marker of bone formation and urinary N-telopeptides are markers of bone resorption. (cdc.gov)
- While elevated alkaline phosphatase levels can sometimes be seen in kidney cancer, it is not the most common or specific marker for this condition. (cura4u.com)
Phosphate3
- Thermosensitive Alkaline Phosphatase catalyzes the removal of 5'- and 3'-phosphate groups from DNA, RNA, nucleotides, and proteins. (biogen.cz)
- Alkaline Phosphatase catalyzes the hydrolysis of phosphate esters yielding alcohols and phosphate. (scrippslabs.com)
- Alkaline phosphatase (ALP) catalyzes the hydrolysis of phosphate esters in an alkaline environment, resulting in the formation of an organic radical and inorganic phosphate. (gentaur.be)
Isoenzymes1
- Although alkaline phosphatases are present in different body tissues and have different physiochemical properties, they are true isoenzymes because they catalyze the same reaction. (statpearls.com)
Preparations2
- Preparations for an alkaline phosphatase test depend on the lab doing the test. (medlineplus.gov)
- You don't need any special preparations for an alkaline phosphatase test. (healthpediaindia.com)
Alanine1
- A liver panel typically includes tests for alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, albumin, and alkaline phosphatase (ALP). (cura4u.com)
Proteins1
- Alkaline phosphatase in E. coli is uncommonly soluble and active within elevated temperature conditions such as 80 °C. Due to the kinetic energy induced by this temperature the weak hydrogen bonds and hydrophobic interactions of common proteins become degraded and therefore coalesce and precipitate. (wikipedia.org)
Hepatitis1
- Other possible causes of high alkaline phosphatase (ALP) levels includes liver diseases such as hepatitis or cirrhosis, bone's diseases like Paget's disease or osteomalacia, infections, malnutrition, problems in the intestines or pancreas, or even kidney tumors. (cura4u.com)
Degradation1
- Since the periplasmic gap is more prone to environmental variation than the inner cell, alkaline phosphatase is suitably resistant to inactivation, denaturation, or degradation. (wikipedia.org)
Laboratories1
- Scripps Laboratories is a leading supplier of Alkaline Phosphatase. (scrippslabs.com)
Abnormal2
- Kidney tumors and infections as well as malnutrition have also shown abnormal level of alkaline phosphatase in blood. (wikipedia.org)
- In patients with abnormal liver function or other causes of elevated alkaline phosphatase activity not due to bone, BSAP is a reasonable means of assessing Paget disease activity. (medscape.com)
Concentrations1
- [1] Alkaline phosphatase is present in decreasing concentrations in the placenta, ileal mucosa, kidney, bone, and liver. (statpearls.com)
Activity2
- A strong relationship exists between the extent of disease activity measured by scintigraphy and the degree of the elevation of alkaline phosphatase in persons with untreated Paget disease. (medscape.com)
- To investigate the expression of alkaline phosphatase (ALP) activity in gingival fibroblasts from individuals with chronic periodontitis (CP) and drug-induced gingival hyperplasia (DGH) induced by diphenylhydantoin. (bvsalud.org)
Diagnosis2
- But an alkaline phosphatase test alone can't identify the source of ALP in your blood, so other tests are usually needed to make a diagnosis. (medlineplus.gov)
- Alkaline phosphatase (ALP) serves as an important biomarker for the diagnosis of various diseases including liver malfunction, bone diseases, breast and prostate cancers, and diabetes. (amrita.edu)
Liver function1
- Measuring total alkaline phosphatase levels may be useful in patients with normal liver function. (medscape.com)
Detection1
- Elevated levels of alkaline phosphatase can be seen in the detection of liver disease, bone disorders, or gallbladder disease. (anylabtestnow.com)
Disease4
- If alkaline phosphatase levels are high and the results of liver tests are normal, the problem may be a bone disorder, such as Paget's disease of bone . (medlineplus.gov)
- However, BSAP is more specific than total alkaline phosphatase for Paget disease. (medscape.com)
- In patients with monostotic disease or local disease, the total alkaline phosphatase level may be normal. (medscape.com)
- Because aminotransferases and alkaline phosphatase are included in commonly done laboratory test panels, abnormalities are often detected in patients without symptoms or signs of liver disease. (msdmanuals.com)
Acid1
- In males, however, the clinical value of this finding is compromised, as acid phosphatase levels also may be elevated in the presence of metastatic prostate carcinoma. (medscape.com)
Prone1
High8
- High alkaline phosphatase (ALP) levels may be a sign of a liver problem or a bone disorder. (medlineplus.gov)
- High alkaline phosphatase levels may mean there is damage to your liver or that you have a type of bone disorder. (healthpediaindia.com)
- If the test results show high alkaline phosphatase levels, your health care provider may order additional tests to find out where the extra ALP is coming from. (healthpediaindia.com)
- If these results are normal and your alkaline phosphatase levels are high, it may mean the problem is not in your liver. (healthpediaindia.com)
- Have you ever had a test for alkaline phosphatase (ALP) and had a high result? (cura4u.com)
- Let's dive in and learn more about high alkaline phosphatase levels and the cause of high alkaline phosphatase levels. (cura4u.com)
- High alkaline phosphatase levels can be associated with various medical conditions affecting the liver, bones, or other organs. (cura4u.com)
- The blood test is performed by drawing blood from the arm and sending the sample to the lab for analysis.You'll find that out from the results if your alkaline phosphatase levels are low, high, or within the normal range. (cura4u.com)
Results3
- Identical results were obtained using the Gomori technique for alkaline phosphatase. (rupress.org)
- Once you receive your LAP Score Leucocyte Alkaline Phosphatase test results, your physician might advise you with corrective measures if they are not in the normal range. (bajajfinservhealth.in)
- This page shows results related to Acetazolamide and Blood Alkaline Phosphatase Increased from the FDA Adverse Event Reporting System (AERS). (drugcite.com)
Health care provider may1
- Your health care provider may order an alkaline phosphatase test as part of a routine checkup. (medlineplus.gov)
Symptoms2
- An alkaline phosphatase test may also be ordered if you have symptoms of liver damage or a bone disorder. (medlineplus.gov)
- Your health care provider may have ordered an alkaline phosphatase test as part of a routine checkup or if you have symptoms of liver damage or a bone disorder. (healthpediaindia.com)
Bones1
- An alkaline phosphatase test is often used to screen for or help diagnose diseases of the liver or bones. (medlineplus.gov)
Test measures the amount1
- An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. (medlineplus.gov)
Human1
- The human alkaline phosphatases (hALP) are found anchored on the cell membrane by glycosylphosphatidylinositol. (statpearls.com)