Antigens cd3. Medical search. Frequent questions

Receptor-CD3 Complex, Antigen, T-Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Molecule composed of the non-covalent association of the T-cell antigen receptor (RECEPTORS, ANTIGEN, T-CELL) with the CD3 complex (CD3 COMPLEX). (ouhsc.edu)
The molecule consists of up to seven chains: either the alpha/beta or gamma/delta chains of the T-cell receptor, and four or five chains in the CD3 complex. (ouhsc.edu)
This graph shows the total number of publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in this website by year, and whether "Receptor-CD3 Complex, Antigen, T-Cell" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in Profiles. (ouhsc.edu)
Our findings underline the importance of the dual actions of kinases and phosphatases as potential regulators of T cell antigen-receptor complex function. (ox.ac.uk)
Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways. (ox.ac.uk)
In 1989, Zelig Eshhar and colleagues realized that the inability of T cells to recognize surface tumour antigens could be overcome by replacing domains of the T cell receptor (TCR) with antibody parts with specificity towards proteins on these cells. (nature.com)
Recognizes the epsilon -chain of the CD3/T cell antigen receptor complex (McMichael, A.J. et al . (rndsystems.com)
CD3 epsilon is one of at least four invariant proteins that associate with the variable antigen recognition chains of the T cell receptor and function in signal transduction. (rndsystems.com)
By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
The SK7 (Leu-4) monoclonal antibody specifically binds to the epsilon chain of the CD3 antigen/T-cell antigen receptor (TCR) complex. (bdbiosciences.com)
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. (nature.com)
Teplizumab targets the epsilon chain, which is part of the CD3 receptor protein complex. (yaledailynews.com)
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta (CD247). (exbio.cz)
Alarcón B, Swamy M, van Santen HM, Schamel WW: T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity. (exbio.cz)
Vossen AC, Tibbe GJ, Kroos MJ, van de Winkel JG, Benner R, Savelkoul HF: Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects. (exbio.cz)
Several types of ACT round out the immunotherapy arsenal, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy. (aacr.org)
The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. (elifesciences.org)
The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. (prospecbio.com)
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. (nih.gov)
A low dose (approximately 1.5×10(5) cells per kilogram of body weight) of autologous chimeric antigen receptor-modified T cells reinfused into a patient with refractory chronic lymphocytic leukemia (CLL) expanded to a level that was more than 1000 times as high as the initial engraftment level in vivo, with delayed development of the tumor lysis syndrome and with complete remission. (nih.gov)
Apart from the tumor lysis syndrome, the only other grade 3/4 toxic effect related to chimeric antigen receptor T cells was lymphopenia. (nih.gov)
Engineered cells persisted at high levels for 6 months in the blood and bone marrow and continued to express the chimeric antigen receptor. (nih.gov)
Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
Chimeric antigen receptor (CAR) T-cell therapy is designed to enhance the body's immune system to effectively kill malignant cells. (ajmc.com)
The T cell receptor/CD3 complex: a dynamic protein ensemble. (histoprime.com)
Evidence for the T3-associated 90k heterodimer as the T cell antigen receptor. (histoprime.com)
The result is crisp, strong staining of antibody targets, especially nuclear and membrane antigens (such as Ki67, estrogen receptor, bcl-2, CD3, CD8 and CD10) and greater sensitivity than other polymer systems. (vectorlabs.com)
TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. (lu.se)
The basic principles of chimeric antigen receptor design. (msdmanuals.com)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
Complejo formado al menos por cinco polipéptidos de unión a la membrana de los linfocitos T maduros que se asocian de forma no covalente con otro y con el receptor del linfocito T (RECEPTORES DE ANTÍGENOS DE LOS LINFOCITOS T). El complejo CD3 incluye las cadenas (subunidades) gamma, delta, épsilon, zeta y eta. (bvsalud.org)
Cuando el antígeno se une al receptor del linfocito T, el complejo CD3 transduce las señales activadoras al citoplasma del linfocito T. Las cadenas (subunidades) gamma y delta del antígeno CD3 están separadas de las cadenas gamma/delta del receptor del linfocito T (CADENAS GAMMA-DELTA DE LOS RECEPTORES DE ANTÍGENOS DE LOS LINFOCITOS T) y no están relacionadas con ellas. (bvsalud.org)
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). (bvsalud.org)
When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. (bvsalud.org)
The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA). (bvsalud.org)

Triggering of NK-cell effector functions through these receptors depends on physically associated transmembrane signaling adaptors, such as FcRγ (also known as FcεRIγ) and CD3ζ, both of which have been traditionally believed to be expressed by all mature NK cells. (nih.gov)
These findings also illustrate a differential contribution of FcRγ and CD3ζ for the expression and functional activity of their associated receptors. (nih.gov)
They combined the variable region of an antibody with the constant regions of the TCR chains, thus producing chimeric antigen receptors (CARs) that provided T cells with antibody-type specificity. (nature.com)
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. (elifesciences.org)
T-cell receptors (TCR) and B-cell receptors (BCR) are hypervariable immunoglobulins that play a key role in recognizing antigens in the vertebrate immune system. (elifesciences.org)
These HDI-responsive T cells expressed unique oligoclonal gamma/delta rather than alpha/beta T-cell receptors, with characteristics suggestive of antigen-mediated selection and specificity. (cdc.gov)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)

We have investigated the role of the CD2 protein in the negative regulation of immune function and report that similar to antigen and anti-CD3, the monoclonal anti-CD2 antibodies (T112 and T113) can induce specific unresponsiveness. (ox.ac.uk)
We actually create 2 individual antibodies: 1 targets CD3 and 1 targets BCMA. (ajmc.com)
Contents: Antibody Cocktail (IFN-γ FITC, CD69 PE, CD8 PerCP-Cy™5.5, CD3 APC), Isotype Ctrl Cocktail, Co-Stimulatory Antibodies (CD28/CD49d), Brefeldin A (BFA) Solution, EDTA Solution, BD FACS™ Lysing Solution (10x), BD FACS Permeabilizing Solution 2 (10x). (bdbiosciences.com)
Henrickson M, Reid J, Bellet JS, Sawchuk SS, Hirsch R: Comparison of in vivo efficacy and mechanism of action of antimurine monoclonal antibodies directed against TCR alpha beta (H57-597) and CD3 (145-2C11). (exbio.cz)
Kinnaert P, Pradier O, Bournonville B, Habrant C, Goldman M, Van Geertruyden N: Role of CD18-dependent and CD18-independent mechanisms in the increased leukocyte adhesiveness and in the variations of circulating white blood cell populations induced by anti-CD3 monoclonal antibodies. (exbio.cz)
The polyclonal antibody E053 recognizes the cytoplasmic part of the epsilon subunits of the CD3 complex on thymocytes and on peripheral T lymphocytes and, in contrast to many monoclonal antibodies of the same specificity, is suitable for cryostat material and kerosene sections. (histoprime.com)

Activation of T cells through the TCR is mediated by the TCR-CD3 signaling complex. (johnshopkins.edu)
Cross linking of this complex with Abs directed against CD3 leads to potent activation of T cells. (johnshopkins.edu)
We exploited the observation that the TCR-CD3 complex is clustered on T cells that have been activated by Ag by using anti-CD3 nanoparticles to selectively activate Ag-experienced mouse T cells. (johnshopkins.edu)
Physiologic recognition of tumour antigens by T cells is mediated by the TCR-CD3 complex. (nature.com)
Description: The 17A2 monoclonal antibody reacts with the mouse CD3 complex. (thermofisher.com)
CD3 subunits gamma, delta and epsilon are required for proper assembly, trafficking and surface expression of the TCR complex. (thermofisher.com)
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. (thermofisher.com)
Smallpox Vaccination antigens are added to blood cells, allowing the simultane- ous analysis of both major histocompatibility complex class I and II restricted T-cell responses (7). (cdc.gov)
CD3g molecule, gamma (CD3-TCR complex). (invivogen.com)
Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
T cells recognize antigens presented to them by the major histocompatibility complex of antigen-presenting cells via the TCRs expressed on their surface. (hindawi.com)
The CD3 complex is a component of the T-cell membrane responsible for recognizing the respective targets of that T-cell, which is a type of immune cell. (yaledailynews.com)
The signal created when the CD3 complex encounters a viral antigen is much stronger than the signal from teplizumab reception. (yaledailynews.com)
The Armenian hamster antibody H146-968 reacts with an intracellular epitope (amino acids 151-164) of CD3 zeta chain (CD247), which is a component of TCR/CD3 complex expressed on T cells. (exbio.cz)
Kuhns MS, Davis MM, Garcia KC: Deconstructing the form and function of the TCR/CD3 complex. (exbio.cz)
Along with the other CD3 subunits gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. (thermofisher.com)
The CD3 complex is experimented on the cell membrane of T lymphocytes. (histoprime.com)
Epsilon subunit of the human CD3 complex Collagen IV alpha! (histoprime.com)
Clevers H, Dunlap S and Terhorst C. The transmembrane orientation of the epsilon chain of the TcR/CD3 complex. (histoprime.com)
Cis ligation of CD137 relative to the TCR-CD3 complex results in more intense canonical and non-canonical NF-κB signaling and provides a more robust induction of cell cycle and DNA damage repair gene expression programs. (lu.se)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
The combination of electrophoretic separation of complex mixtures of antigens with the highly sensitive immunoblotting technique has been useful in characterizing the antigenic profile of HIV-1 and describing the immune response to this virus in exposed or infected persons. (cdc.gov)

We find that constraining anti-CD3 on the surface of a nanoparticle markedly and selectively enhances proliferation and cytokine production of Ag-experienced T cells but does not activate naive T cells. (johnshopkins.edu)
Furthermore, in vivo anti-CD3-coated nanoparticles increased the expansion of Ag-specific T cells following vaccination. (johnshopkins.edu)
Overall, these findings indicate that anti-CD3-coated nanoparticles could be use to enhance the efficacy of vaccines and immunotherapy. (johnshopkins.edu)
Flow cytometry analysis (surface staining) of CD3 in murine splenocytes with anti-CD3 (145-2C11) PE(red), and blank (black). (exbio.cz)
TCR stimulation via antigen/MHC presentation or anti-CD3 mAb induces T-ALL cell death. (aacrjournals.org)
Anti-CD3 mAb reactivates a program similar to thymic negative selection during development. (aacrjournals.org)
The first US Food and Drug Administration-approved immunotherapy for type 1 diabetes, the anti-CD3 antibody teplizumab, delays symptomatic type 1 diabetes onset by 2-3 years [ 4 ], opening the door for the future clinical application of antigen-specific approaches with potentially superior immunoregulatory properties [ 5 ]. (springer.com)

Cross-linking the CD2 and CD3 antigens with a bivalent monoclonal antibody in the absence of cytosolic phosphatases induced marked phosphorylation of the CD3 gamma-chain, immunoprecipitated using a novel gamma-chain peptide analogue directed antiserum (TG1). (ox.ac.uk)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
The following product was used in this experiment: CD3 Monoclonal Antibody (17A2), Brilliant Violet™ 480, eBioscience™ from Thermo Fisher Scientific, catalog # 414-0032-82, RRID AB_2925604. (thermofisher.com)
C57BL/6 mouse splenocytes were stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and 0.25 µg of Rat IgG2b kappa Isotype Control, Brilliant Violet 480 (Product # 414-4031-81) (left) or 0.25 µg of CD3 Monoclonal Antibody, Brilliant Violet 480 (right). (thermofisher.com)
In a study of the specific pattern of flea antigen recognition by IgG subclass and IgE during the progression of papular urticaria caused by flea bite, variations in the antibody responses of both subclasses to flea antigens were identified. (medscape.com)
Whole blood was stained with BD Horizon™ BV421 Mouse Anti-Human CD3 antibody (Cat. (bdbiosciences.com)
It essentially picks up the T cell on the monoclonal antibody and then it binds to the BCMA antigen that's expressed on the myeloma cells. (ajmc.com)
Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human CD3 zeta (H146-968) PE-Cy™7 antibody (concentration in sample 12 μg/ml). (exbio.cz)
Flow cytometry multicolor surface staining pattern of human lymphocytes using anti-human CD3 (UCHT1) APC antibody (10 μl reagent / 100 μl of peripheral whole blood) and intracellular staining of human lymphocytes using anti-human CD3 zeta (H146-968) PE-Cy™7 antibody (concentration in sample 12 μg/ml). (exbio.cz)
Separation of human CD3 zeta positive CD3 positive T cells (red-filled) from CD3 zeta negative CD3 negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD3 zeta (H146-968) PE-Cy™7 antibody (concentration in sample 12 μg/ml). (exbio.cz)
The Armenian hamster monoclonal antibody 145-2C11 reacts with an extracellular epitope of murine CD3 (epsilon subunit). (exbio.cz)
The following product was used in this experiment: CD3 Monoclonal Antibody (UCHT1), Brilliant Ultra Violet™ 805, eBioscience™ from Thermo Fisher Scientific, catalog # 368-0038-42, RRID AB_2896070. (thermofisher.com)
It is an extended bi-specific monoclonal antibody which contains both tumor antigen binding domain CD123 and cytotoxic T-cell binding domain (CD3 binding domain). (pharmaceutical-technology.com)
Its Plamotamab is a tumor-targeted antibody that contains both a CD20 binding domain and a cytotoxic T-cell binding domain (CD3). (pharmaceutical-technology.com)
The position of bands on the nitrocellulose strips allows this antibody reactivity to be associated with specific viral antigens. (cdc.gov)

Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)

However, we have identified a distinct subset of human NK cells that are deficient for FcRγ expression but express normal levels of CD3ζ. (nih.gov)
Pan-T antigens are antigens found on all T cells. (wikipedia.org)
NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
CD3 and CD2 antigen-mediated CD3 gamma-chain phosphorylation in permeabilized human T cells. (ox.ac.uk)
The role of cytosolic and membrane-associated phosphatases in regulating dephosphorylation of the CD3 antigen gamma-chain has been investigated using streptolysin-O-permeabilized T lymphoblasts and Jurkat T leukaemia cells. (ox.ac.uk)
The membrane-associated type 2A phosphatase in permeabilized cells did not dephosphorylate the CD3 antigen gamma-chain, suggesting that cytosolic phosphatases dephosphorylate the gamma-chain in situ. (ox.ac.uk)
Activation of T cells either with phorbol 12,13-dibutyrate or by CD2-CD3 cross-linking caused [32P]Pi incorporation into the same gamma-chain Ser residues. (ox.ac.uk)
The T cells expressing CARs recognized and eliminated target cells, and produced interleukin 2 in the presence of the antigen, providing a proof of concept that this approach triggers a cellular immune response. (nature.com)
In 2010, James Kochenderfer and colleagues achieved a breakthrough with a CAR T cell therapy, reporting tumour regression in a patient with advanced follicular lymphoma, who received two infusions of autologous T cells genetically engineered to express a CAR specifically recognizing the antigen CD19 expressed on B cells. (nature.com)
Another ACT developed in parallel to CAR T cells is engineering T cells to express TCRs that recognize tumour-associated antigens. (nature.com)
In 2006, Rosenberg and colleagues transferred TCR T cells specifically recognizing the melanoma antigen MART-1 in 15 patients, two of whom achieved regression and still showed high levels of engineered cells in circulation one year after the infusion. (nature.com)
Other successful studies quickly followed, such as those demonstrating sustained complete and partial responses in patients with melanoma and treatment of synovial cell sarcoma with TCR T cells against the NY-ESO-1 antigen. (nature.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. (thermofisher.com)
This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)
iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2 b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins. (biolegend.com)
MHC class I antigens associated with β2-microglobulin are expressed by all human nucleated cells. (biolegend.com)
MHC class I molecules are involved in presentation of antigens to CD8 + T cells. (biolegend.com)
BCMA is essentially an antigen target that's almost ubiquitously expressed on myeloma cells. (ajmc.com)
CD3 is essentially picking up T cells, which express CD3. (ajmc.com)
Stimulation of TCRs upon antigen binding triggers downstream signalling pathways which enables various physiological functions of the T cells. (hindawi.com)
The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. (exbio.cz)
Jacobs H, Vandeputte D, Tolkamp L, de Vries E, Borst J, Berns A: CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. (exbio.cz)
These strategies rely on the isolation of T cells, which are either genetically modified to target tumor-specific antigens or are expanded from an endogenous population that recognizes tumor neoantigens. (aacr.org)
To improve this therapeutic strategy, Rosenberg and colleagues developed a method to identify the exact antigens that the T cells could recognize. (aacr.org)
Antigen presenting cells (APC) are a class of immune cells that mediate the immune response. (labroots.com)
APCs process foreign antigen and present the antigen to T cells, the immune cells with kill foreign cells. (labroots.com)
Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)
We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)
Human T-cell lines were generated and characterized from peripheral blood of HDI-exposed and HDI-unexposed subjects, using two different HDI antigens, HDI-conjugated albumin and HDI-exposed human airway epithelial cells (NCI-H292). (cdc.gov)
HDI antigen preparations but not "mock exposed" control antigens lead to increased proliferation of specific cell types, CD3+CD4-CD8(dim) and/ or CD3+CD4-CD8- cells, from HDI-exposed but not from HDI-unexposed subjects. (cdc.gov)
No other peripheral cells experiment CD3 (except possibly Purkinje cells in the cerebellum). (histoprime.com)
The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage. (histoprime.com)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)

The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. (exbio.cz)
The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. (prospecbio.com)
The CD3- molecules are involved in signal transduction after antigen binding to the TCR. (histoprime.com)

The BD FastImmune™ CD8 Intracellular Cytokine Detection Kit is designed for the detection of intracellular cytokines and the activation marker CD69 in antigen-activated CD8 + T lymphocytes in whole blood. (bdbiosciences.com)

Detection of CD3 epsilon in Human Blood Lymphocytes by Flow Cytometry. (rndsystems.com)
HHcy in Cbs -/- mice reinforced inflammatory features in Ly6C high MC by upregulating inflammatory TFs ( Ets1 and Tbx21 ) and strengthened lymphocytes functional adaptation in Ly6C low MC by increased expression of CD3, DR3, ICOS, and Fos . (frontiersin.org)
Flow cytometric analysis of CD3 expression on human peripheral blood lymphocytes. (bdbiosciences.com)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
CD3 is experimented by cortical thymocytes and by peripheral T lymphocytes. (histoprime.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

Prokaryotic fusion protein corresponding to the human CD3 epsilon chain. (histoprime.com)

Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

Additional reported applications (for the relevant formats) include: immunoprecipitation 1 , immunohistochemistry of frozen sections 2,3,6 , in vitro and in vivo blocking of antigen presentation or ligand binding 4-7 , and spatial biology (IBEX) 17,18 . (biolegend.com)

Binding of 17A2 to CD3 initiates the intracellular biochemical pathway resulting in cellular activation and proliferation. (thermofisher.com)

CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. (exbio.cz)
In this study, side-by-side comparisons show that provision of CD137 costimulation in-cis with regard to the TCR-CD3-ligating cell is superior to that provided in-trans in terms of T cell activation, proliferation, survival, cytokine secretion and mitochondrial fitness in mouse and human. (lu.se)

T-cell surface glycoprotein CD3 zeta chain (CD247) is a member of the CD3Z/FCER1G family. (prospecbio.com)

Applications include studies of T-cell responses to antigens, such as herpes viruses, HIV, and tumor antigens. (bdbiosciences.com)

With amivantamab you're targeting 2 distinct antigen targets. (ajmc.com)

Leucocyte Typing III, White Cell Differentiation Antigens. (histoprime.com)

This approach offers the advantage of targeting antigens not present on the cell surface. (nature.com)

Synthetic human epsilon-chain CD3 peptide (AS 156-168) was used to immunize rabbits after coupling to thyroglobulin. (histoprime.com)

Synthetic peptide corresponding to amino acids 151-164 of mouse CD3 zeta. (exbio.cz)

Despite this prototypical TCR repertoire gene usage, in recent years it has become apparent that there are variations within the iNKT cell repertoire that ultimately impact the antigen recognition capacity and consequently the functional outcomes during an immune response. (elifesciences.org)

Phosphorylation was inhibited by a protein kinase C (PKC) pseudosubstrate inhibitor, indicating that CD2/CD3-induced gamma-chain phosphorylation is a PKC-mediated event. (ox.ac.uk)

Any molecule capable of being recognized by the immune system is considered an antigen. (msdmanuals.com)

or both chains is convergent selection in response to a common antigen. (elifesciences.org)

As the name suggests, these therapies are manufactured proteins that can bind to 2 separate antigens at the same time, bringing extra power to the fight against cancer. (ajmc.com)

These phenotypic changes could only be partly explained by variations in the levels of the transcripts encoding the CD3-Ti and CD2 molecules. (ox.ac.uk)
Activation of human thymocytes via CD3 and CD2 molecules. (histoprime.com)

1993. The Leukocyte Antigen FactsBook. (biolegend.com)

Moreover, overnight incubation with 10 µg/mL of the secretion antigen-specific T-cell responses could be detected in inhibitor Brefeldin-A (Sigma-Aldrich Corporation, St. exposed, but uninfected persons, as shown in those with Louis, MO). (cdc.gov)
The BCMA-CD3 teclistamab is really what we would call a T-cell redirector. (ajmc.com)
The human immune response to isocyanate , a leading cause of occupational asthma, remains incompletely characterized, including the cell types involved and the form of the chemical that acts as an antigen. (cdc.gov)

Cis ligation of CD137 relative to the TCR-CD3. (lu.se)

The company product pipeline includes Vudalimab (PD1 x CTLA4), Plamotamab (CD20 x CD3), XmAb819 (ENPP3 x CD3), XmAb564 (IL-2-Fc) and XmAb104 (PD1 x ICOS). (pharmaceutical-technology.com)

Low expression of the CD247 antigen causes impaired immune response. (prospecbio.com)

CD3g antigen. (invivogen.com)

Antigen and anti-CD2 tolerogenic signals both down-regulated the phenotypic expression of CD3-Ti. (ox.ac.uk)
We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)

Anatomy29

Organisms10

Diseases3

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes31

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Receptor39

Receptors8

Antibodies6

Complex23

Anti-CD37

Antibody15

Specificity1

Cells35

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Lymphocytes6

Human CD31

CD431

Ligand1

Intracellular1

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Surface1

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19931

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CD1371

CD201

CD2471

CD3G1

Expression2