Antigens cd4. Medical search. Frequent questions

Using a murine model of tolerance induced by repeated exposure to a low dose of aerosolized antigen, we show an important contribution by CD4(+) T cells in the establishment and maintenance of tolerance. (nih.gov)
The CD4(+) T cells expressed both cell surface and soluble TGF-beta and inhibited the development of an allergic phenotype when adoptively transferred to naive recipient mice. (nih.gov)
Strikingly, separation of the TGF-beta(+) cells from the rest of the cells allowed the TGF-beta(-) cells to proliferate in response to antigen. (nih.gov)
We propose a model of antigen-induced tolerance that involves cell-cell contact with regulatory CD4(+) T cells that coexpress membrane-bound TGF-beta and FOXP3. (nih.gov)
Our results suggest that the CD4 level for initiating CrAg screening and pre-emptive therapy should now definitely be raised to 200 cells/µL in these HIV-infected individuals. (researchsquare.com)
Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. (umassmed.edu)
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. (ox.ac.uk)
This was investigated by a series of adoptive transfer experiments in which mAb-treated cells were removed from therapeutic antibody at defined times after skin grafting, and exposed to fresh antigen in the absence of further mAb treatment. (ox.ac.uk)
In contrast, "parked" cells exposed to fresh antigen at any time up to 4 months remained tolerant and "resistant" indefinitely. (ox.ac.uk)
In response to transient antigen presence in the context of acute infections or vaccinations, antigen-specific naïve T cells clonally expand and differentiate. (wustl.edu)
Most of the expanded cells undergo terminally differentiation and die following antigen clearance to re-establish immune homeostasis. (wustl.edu)
The goal of my thesis work is to understand how protective T cell response is sustained at the cellular levels and molecular levels for CD8 T cells and CD4 T cells in the presence of persistent antigens. (wustl.edu)
The main model used is the mouse chronic lymphocytic choriomeningitis virus (LCMV-clone 13, c13) infection model, which causes viremia that lasts 3-4 months in immunocompetent mice and is subsequently resolved in a manner dependent on CD4 and CD8 T cells. (wustl.edu)
In studies of CD4 T cell responses, I demonstrated that in addition to the differentiated TH1 and follicular helper (Tfh) cells, activated CD4 T cells also differentiate into memory-like cells in a BCL6-dependent manner. (wustl.edu)
These findings reveal the heterogeneity and plasticity of CD4 T cells upon encountering persistent antigen and highlights their population dynamics through a stable and bipotent intermediate state. (wustl.edu)
A comparative analysis of gene expression arrays from antigen-specific CD4(+) T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg-selective expression of LAG-3, a CD4-related molecule that binds MHC class II. (nih.gov)
Natural CD4(+)CD25(+) Tregs express LAG-3 upon activation, which is significantly enhanced in the presence of effector cells, whereas CD4(+)CD25(+) Tregs from LAG-3(-/-) mice exhibit reduced regulatory activity. (nih.gov)
Lastly, ectopic expression of LAG-3 on CD4(+) T cells significantly reduces their proliferative capacity and confers on them suppressor activity toward effector T cells. (nih.gov)
The RM4-5 antibody blocks the binding of GK1.5 antibody and H129.19 antibody to CD4 + T cells, but not RM4-4 antibody. (biolegend.com)
Additional reported applications (for the relevant formats) include: blocking of ligand binding, in vivo depletion of CD4 + cells 1 , and immunohistochemistry of acetone-fixed frozen tissue sections 2,3,11 and paraffin-embedded sections 11 . (biolegend.com)
CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. (biolegend.com)
These tolerogenic NIMA effects were completely abolished by the depletion of CD4 + CD25 + cells from the donor inocula, thus suggesting the involvement of CD4 + CD25 + regulatory T cells in the tolerogenic NIMA effects. (elsevierpure.com)
The tumour cells are HLA class I- and II-positive and express a limited subset of EBV latent proteins, namely the nuclear antigen EBNA1 and the latent membrane proteins LMP2 and (in some cases) LMP1. (birmingham.ac.uk)
the therapeutic goal must therefore be to re-direct the existing memory repertoire more effectively against antigen-expressing tumour cells. (birmingham.ac.uk)
Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). (wikipedia.org)
Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
A deterministic model illustrating how CD4 T-cells can influence HIV infection. (ebi.ac.uk)
Infection dynamics in HIV-specific CD4 T cells: does a CD4 T cell boost benefit the host or the virus? (ebi.ac.uk)
Recent experimental data have shown that HIV-specific CD4 T cells provide a very important target for HIV replication. (ebi.ac.uk)
Infected CD4 T cells can provide antigen for their own stimulation. (ebi.ac.uk)
In addition, the initial number of HIV-specific CD4 T cells is an important determinant of acute infection dynamics. (ebi.ac.uk)
A high initial number of HIV-specific CD4 T cells can lead to a sudden and fast drop of the population of HIV-specific CD4 T cells which results quickly in their extinction. (ebi.ac.uk)
On the other hand, a low initial number of HIV-specific CD4 T cells can lead to a prolonged persistence of HIV-specific CD4 T cell help at higher levels. (ebi.ac.uk)
The model suggests that boosting the population of HIV-specific CD4 T cells can increase the amount of virus-induced immune impairment, lead to less efficient anti-viral effector responses, and thus speed up disease progression, especially if effector responses such as CTL have not been sufficiently boosted at the same time. (ebi.ac.uk)
CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T helper/inducer cells), and at lower levels on dendritic cells. (stemcell.com)
Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)
Figure 2: Sorted CD3 + CD4 + CD45RA + CD45RO + T cells respond to primary and secondary activation with IL-10 production. (nature.com)
Figure 3: Characteristics of CD3/CD46-activated, sorted CD3 + CD4 + CD45RA + CD45RO + T cells. (nature.com)
Figure 4: Suppressive and proliferative properties of CD3/CD46-activated CD4 + T cells. (nature.com)
Shevach, E. M. S. M. R., Piccirillo, C. A. & Thornton, A. M. Control of T-cell activation by CD4 + CD25 + suppressor T cells. (nature.com)
This association afforded us a unique opportunity to identify a sarcoidosis-specific antigen recognized by AV2S3+ T cells. (jci.org)
To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (jci.org)
peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
In addition, CD4 has also been reported to be detectable on pluripotent hematopoietic stem cells, bone marrow myeloid and B-lymphocyte precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells. (bdbiosciences.com)
CD4 has also been reported to be expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm. (bdbiosciences.com)
Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. (tcd.ie)
Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)
iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)
We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)
Description: The RPA-T4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. (thermofisher.com)
CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. (thermofisher.com)
Second, the adjuvant is able to increase the adaptability of the recalled cells to give improved specificity to the new vaccine antigen. (nature.com)
We report here the utility of major histocompatibility complex (MHC) class II dextramers for in situ detection of self-reactive CD4 T cells in two target organs, the brain and heart. (unl.edu)
Analysis of sections by laser scanning confocal microscope revealed detection of cells positive for PLP 139-151 but not for TMEV 70-86 dextramers to be colocalized with CD4-expressing T cells, indicating that the staining was specific to PLP 139-151 dextramers. (unl.edu)
Further, we devised a method to reliably enumerate the frequencies of antigenspecific T cells by counting the number of dextramer + CD4 + T cells in the 'Z' serial images acquired sequentially. (unl.edu)
the sections showed the infiltrations of Myhc-specific CD4 T cells. (unl.edu)
The data suggest that MHC class II dextramers are useful tools for enumerating the frequencies of antigen-specific CD4 T cells in situ by direct staining without having to amplify the fluorescent signals, an approach commonly employed with conventional MHC tetramers. (unl.edu)
95%CI 1.64, 3.80 for CD4 350-499 cells/μl compared to CD4≥500 cells/μl). (natap.org)
Cytoplasmic delivery and cross-presentation of proteins and peptides is necessary for processing and presentation of antigens for the generation of cytotoxic T cells. (edu.au)
We previously described the use of the 16 amino acid peptide penetratin from the Drosophila Antennapedia homeodomain (penetratin, Antp) to transport cytotoxic T lymphocyte epitopes derived from ovalbumin (OVA) or the Mucin-1 tumor-associated antigen into cells. (edu.au)
We have now shown that penetratin covalently conjugated to OVA protein and linked in tandem to CD4(+) and/or CD8(+) T-cell epitopes from OVA-stimulated T cells in vitro (B3Z T-cell hybridoma and OT-I and OT-II T cells). (edu.au)
Furthermore, interferon (IFN)-γ-secreting CD4(+) and CD8(+) T cells were induced which suppressed B16.OVA tumor growth in C57BL/6 mice. (edu.au)
Alternatively, 40 days after a boost immunization, the presence of CD4(+) help enhanced antigen-specific IFN-γ-secreting CD8(+) T cells and tumor protection in mice challenged with B16.OVA. (edu.au)
Antiviral CD8 + T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. (nationaljewish.org)
About 30% to 40% of PTCL, NOS, express markers of cytotoxic T-cells such as T-cell intracellular antigen-1 (TIA-1). (webpathology.com)
The roles of the M cells include absorption, transport, processing, and presentation of antigens to subepithelial lymphoid cells. (medscape.com)
the latter are antigen-presenting cells (APCs) that function as memory cells interacting with type 1 THCs. (medscape.com)
Under these M cells and in close proximity, B cells, CD4 + T cells, and APCs (including dendritic follicular cells [DFCs]) are found. (medscape.com)
M cells in the intestinal epithelium overlying Peyer patches allow transport of antigens to the lymphoid tissue beneath it. (medscape.com)
Kumar V, Rakha A, Saroa R, Bagai U (2015) CD4+T Cells Expansion in P. berghei (NK-65) Infected and Immunized BALB/C Mice. (omicsonline.org)
CD4 + T cells play an important role in conferring protective immunity towards the liver stages of the malaria parasite [ 3 ]. (omicsonline.org)
CD4 + T cells stimulate B cells to induce significant level of antimalarial antibody response and also help in the induction of CD8 + T-cell responses which help in arresting the growth of liver-stage parasites in the host. (omicsonline.org)
CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) are also involved in the mechanism of immune regulation against Plasmodium infection. (omicsonline.org)
Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 + T cells. (frontiersin.org)
Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
However, there is no clear evidence that adipocytes interact directly with CD8 + T cells through antigen:MHCI complex. (frontiersin.org)
Adipocytes can directly activate CD4 + T cells through antigen:MHCII complex in a contact-dependent manner. (frontiersin.org)
The antibody MEM-241 recognizes an extracellular epitope of CD4 antigen, a 55 kDa transmebrane glycoprotein expressed on a subset of T lymphocytes ("helper" T-cells) and also on monocytes, tissue macrophages and granulocytes. (exbio.cz)
Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency). (exbio.cz)
Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD4 (MEM-241) biotin, streptavidin-APC. (exbio.cz)
or from functionally distinct subsets such as CD4 and CD8 T-cells. (elifesciences.org)
The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. (lu.se)
However, when presented multivalently on magnetic beads, soluble CD4 bound pMHC II-expressing B cells, confirming that it is active and allowing mapping of the native coreceptor binding site on pMHC II. (lu.se)
Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8 + T cells but not CD4 + T cells. (bvsalud.org)
A Novel Immunogen Selectively Eliciting CD8 + T Cells but Not CD4 + T Cells Targeting Immunodeficiency Virus Antigens. (bvsalud.org)

Class II major histocompatibility complex mutant mice to study the germline bias of T cell antigen receptors. (nationaljewish.org)
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. (elifesciences.org)
T-cell receptors (TCR) and B-cell receptors (BCR) are hypervariable immunoglobulins that play a key role in recognizing antigens in the vertebrate immune system. (elifesciences.org)

CD4 is a 55 kD protein also known as L3T4 or T4. (biolegend.com)
The GK1.5 monoclonal antibody specifically binds to the mouse CD4 (L3T4) differentiation antigen. (bdbiosciences.com)

CBA/Ca mice may be made tolerant to minor histoincompatible B10.BR skin grafts by treatment with a short course of non-depleting anti-mouse CD4 and CD8 monoclonal antibodies (mAb), during the transplantation period. (ox.ac.uk)
DQ1 is a serotype, rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products. (wikipedia.org)
A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas. (nationaljewish.org)

The enhancing role of CD4 was further demonstrated by reduced levels of T cell adhesion and late responses of CD4- T cell hybridomas. (ox.ac.uk)
Our data suggest a link between antigen-induced T cell adhesion and late responses and also suggest that signals mediated by TCR and CD4 coengagement may induce a greater activation and/or recruitment of molecules involved in T cell adhesion. (ox.ac.uk)
This study used a transgenic murine model expressing human major histocompatibility complex (MHC) class II and human CD4 in which, without additional toxic sensitization, human-like responses to the bacterial superantigen (SAg) streptococcal pyrogenic exotoxin A (SpeA) could be simulated, as determined by studying multiple biologic effects of the SAgs in vivo. (elsevierpure.com)
We use mathematical models to explore the effect of specific CD4 T cell infection on the dynamics of virus spread and immune responses. (ebi.ac.uk)
The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. (nature.com)
A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. (nature.com)
AS03 and MF59 enhance innate immune responses by increasing antigen uptake and presentation in the local tissue. (nature.com)
Monocytes can also present fungal antigens to elicit adaptive immune responses. (frontiersin.org)
The induction of these responses was directly mediated by the penetratin peptide as linking a nonspecific 16-mer peptide to OVA or mixing did not induce CD8(+) or CD4(+) T-cell responses in vitro. (edu.au)
Long-term CD8 responses were equally enhanced by antigen-specific and universal CD4 help. (edu.au)
The QuantiFERON®-TB Gold Plus assay tests for Cell Mediated Immune (CMI) responses to peptide antigens that simulate mycobacterial proteins. (cdc.gov)
Nef-specific CD107a + CD4 + T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion. (bvsalud.org)

CD4 binds to a non-polymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the avidity of the association between the TCR and MHC II-antigen complex. (stemcell.com)
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
IL-16 (binds to CD4 domain 3), human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin. (exbio.cz)

The affinity of CD4/pMHC II therefore seems to be set at a value that increases T-cell sensitivity by enhancing phosphorylation, without compromising ligand discrimination. (lu.se)

If antibody therapy is continued for the full 5 weeks, T cell tolerance can still be established, suggesting that antibody therapy does not prevent lymphocytes from registering the presence of antigen. (ox.ac.uk)
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
CD4 is expressed on most thymocytes, a subpopulation of mature T lymphocytes (i.e. (bdbiosciences.com)
Individuals infected with M. tuberculosis complex organisms (M. tuberculosis, M. bovis, M. africanum, M. microti, M. canetti) usually have lymphocytes in their blood that recognize these and other mycobacterial antigens. (cdc.gov)

Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)

CD4 contains four extracellular Ig-like domains. (stemcell.com)

The aim of this study was to validate a MiraVista(®) Diagnostics (MVD) Histoplasma urine antigen lateral flow assay (MVD LFA) for the detection of H. capsulatum antigen (Ag) in urine and compare this LFA against the MVista(®) Histoplasma Ag quantitative enzyme immunoassays (MVD EIA). (cdc.gov)

In the mouse, CD4 is not expressed by monocytes/macrophages. (stemcell.com)

70 healthy controls on peptide epitope mini-panels, we found that T cell memory to CD4 epitopes in all three proteins was unimpaired in the blood of patients at diagnosis. (birmingham.ac.uk)

Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4. (ox.ac.uk)
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (exbio.cz)

Serum and CSF cryptococcal antigen negative. (uab.edu)

CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. (thermofisher.com)
Whole protein and defined CD8(+) and CD4(+) peptides linked to penetratin targets both MHC class I a. (edu.au)
The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. (exbio.cz)

Tissue Antigens. (wikipedia.org)

CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. (biolegend.com)
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. (thermofisher.com)

CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. (exbio.cz)

The maternal and fetal antigens that are transmitted through the bidirectional transplacental passage during pregnancy may induce tolerance to noninherited maternal antigens (NIMAs) in offspring and to inherited paternal antigens (IPAs) in the mother. (elsevierpure.com)

IGRAs are endowed with great specificity, as the antigens used are almost exclusively expressed by the Mycobacterium tuberculosis (MTB) complex, but not Mycobacterium bovis bacille Calmette-Guerin (BCG) [ 1 - 3 ]. (ersjournals.com)

CD4 acts as a primary receptor for HIV, binding to HIV gp120. (biolegend.com)
CD4 is primary receptor for HIV-1 surface glycoprotein gp120). (exbio.cz)

C57BL/6 mouse splenocytes stained with CD4 (clone RM4-5) FITC (solid line) or rat IgG2a, κ FITC isotype control (dotted line). (biolegend.com)
Multicolor flow cytometric analysis of CD4 expression on mouse splenocytes. (bdbiosciences.com)

Districts without a local service report prolonged CD4 turn-around times (TAT).Objective: This study documented the impact of a new CD4 laboratory in Tshwaragano in the remote John Taolo Gaetsewe district of the Northern Cape, South Africa.Methods: CD4 test volumes and TAT (total, pre-analytical, analytical, and post-analytical) data for the Northern Cape province were extracted for June 2018 to October 2019. (bvsalud.org)

A significant proportion have double negative (CD4-ve/CD8-ve) phenotype. (webpathology.com)

CD4, LFA-1 (CD11a/CD18), and CD28 were critical in the adhesion response. (ox.ac.uk)

Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts. (nationaljewish.org)

CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. (stemcell.com)

Whereas binding was undetectable in solution, the affinity of the CD4/pMHC II interaction could be measured in 2D using CD4- and adhesion molecule-functionalized, supported lipid bilayers, yielding a 2 D Kd of ∼5,000 molecules/μm 2 . (lu.se)

The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)

CD4 (T4) is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. (exbio.cz)

Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)
HIV infection can be diagnosed by antibody, nucleic acid (HIV RNA), or antigen (p24) testing. (msdmanuals.com)

The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. (elifesciences.org)

However, there remains little evidence for doing so in those HIV+ persons with this CD4 cell count. (researchsquare.com)
cryp tococcal antigen (CrAg) can be detected in blood several weeks to months (22 days on average) before the onset of signs and symptoms of men ingitis (6, 7) and therefore, can be used as a trigger for pre-emptive antifungal therapy in HIV-infected individuals with low CD4 cell counts. (researchsquare.com)
In response to tumors, an analogous CD4 T cell population develops in draining lymph nodes. (wustl.edu)
T cell adhesion induced after physiological stimulation by antigen was investigated using murine T cell hybridomas specific for a tetanus toxin peptide. (ox.ac.uk)
Despite this prototypical TCR repertoire gene usage, in recent years it has become apparent that there are variations within the iNKT cell repertoire that ultimately impact the antigen recognition capacity and consequently the functional outcomes during an immune response. (elifesciences.org)
In addition, patients with LR maintained pan-T-cell antigens (CD2, CD3, and CD5), whereas those with MF did not. (medscape.com)
IGRAs, commercially available as QuantiFERON-TB Gold In-Tube test (QFT) (QIAGEN, Germantown, MD, USA) and T-SPOT.TB (Oxford Immunotec Ltd, Abingdon, UK), are based on the detection of a T-cell immune response towards RD1 antigens (ESAT-6 and CFP-10), with the addition of the TB7.7 antigen for the QFT only [ 1 ]. (ersjournals.com)
Tumor protection was mediated by a CD8(+) T-cell-dependent mechanism and did not require CD4(+) help to protect mice 7 days after a boost immunization. (edu.au)
The adipocyte was reported as an antigen-presenting cell (APC) which expresses CD1d and MHC class I and II molecules. (frontiersin.org)
It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. (exbio.cz)
Millan J, Cerny J, Horejsi V, Alonso MA: CD4 segregates into specific detergent-resistant T-cell membrane microdomains. (exbio.cz)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Calculations indicated, however, that CD4/pMHC II binding would increase rates of T-cell receptor (TCR) complex phosphorylation by threefold via the recruitment of Lck, with only a small, 2-20% increase in the effective affinity of the TCR for pMHC II. (lu.se)
Antigen-Specific CD4 T-Cell Activation in Primary Antibody Deficiency After BNT162b2 mRNA COVID-19 Vaccination. (cdc.gov)

The following product was used in this experiment: CD4 Monoclonal Antibody (RPA-T4), PE-Cyanine7, eBioscience™ from Thermo Fisher Scientific, catalog # 25-0049-42, RRID AB_1659695. (thermofisher.com)

Reexpression of CD4 reversed these defects. (ox.ac.uk)

Expression of human leukocyte antigen (HLA)-DQ8 rendered the mice susceptible to SpeA-induced lethal shock that was accompanied by massive cytokine production and marked elevation of serum alanine and aspartate aminotransferase levels. (elsevierpure.com)

Left Panel) or BD Pharmingen™ FITC Rat Anti-Mouse CD4 antibody (Cat. (bdbiosciences.com)

antigen-specific-cd4+helper-t-lymphocyte-activation. (immunopaedia.org.za)

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