Antigens cd40. Medical search. Frequent questions

Immunoglobulin class switching from immunoglobulin M (IgM) to IgG and IgA is central to immunity against viruses and requires the activation of B cells by T cells via CD154 (CD40 ligand) and cytokines. (nih.gov)
The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. (wikipedia.org)
activated CD4+ T cells primarily exhibit its ligand CD154, antigen-presenting cells including dendritic cells (DCs), B cells, macrophages, classical and non-classical monocytes, on a variety of non-immune cells including platelets and endothelial cells, and on several types of tumor cells. (wikipedia.org)
Furthermore, many features and purposes of the CD40 signaling pathway in B cells were made determined to the detection of CD40 ligand (CD154) which was determined as a T cell surface molecule which is capable of induction of contact dependent differentiation of B cells. (wikipedia.org)
The secondary signal is CD40L (CD154) on the Th1 cell which binds CD40 on the macrophage cell surface. (wikipedia.org)
Early evidence for these effects were that in CD40 or CD154 deficient mice, there is little class switching or germinal centre formation, and immune responses are severely inhibited. (wikipedia.org)
CD40 is also expressed on B cell precursors in the bone marrow, and there is some evidence that CD40-CD154 interactions may play a role in the control of B cell haematopoiesis. (wikipedia.org)
Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1. (nih.gov)
Treatment with CD154, the ligand for CD40, upregulated the expression of IL-6, IL-8, and MCP-1 in TAO fibroblasts but failed to do so in control cultures. (nih.gov)
Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation. (thermofisher.com)
The following product was used in this experiment: CD154 (CD40 Ligand) Monoclonal Antibody (24-31), PerCP-eFluor™ 710, eBioscience™ from Thermo Fisher Scientific, catalog # 46-1548-42, RRID AB_10670357. (thermofisher.com)
Description: The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). (thermofisher.com)
Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. (thermofisher.com)
CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. (thermofisher.com)
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. (thermofisher.com)
The ligand of CD40 is CD154 (CD40 ligand). (biolegend.com)
Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. (birmingham.ac.uk)
In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells. (birmingham.ac.uk)
The expression of CD154 by activated T-helper cells costimulates B-cell activation and proliferation through binding to CD40 expressed on B cells. (bdbiosciences.com)
In response to T-dependent antigens, the CD154 and CD40 interaction is required for B-lymphocyte differentiation, including immunoglobulin production and isotype switching and memory B cell generation. (bdbiosciences.com)
L'interaction du CD40 avec son principal ligand, le CD154, joue un rôle primordial dans la régulation de la réponse immunitaire et le maintien de l'homéostasie. (umontreal.ca)
L'interaction CD40/CD154 peut avoir un rôle direct dans l'immunothérapie par l'induction de l'apoptose de certaines cellules cancéreuses ou un rôle indirect en activant les cellules présentatrices d'antigènes (CPA) afin d'augmenter l'efficacité de l'activation des cellules T cytotoxiques. (umontreal.ca)
The interaction of CD40 with its main ligand, CD154, plays an important role in regulating the immune response and homeostasis. (umontreal.ca)
More recently, it was shown that the formation of the CD40 homodimer is the result of the engagement of CD40 on B cells by CD154. (umontreal.ca)
The CD40/CD154 interaction can have a direct role in immunotherapy by inducing apoptosis of some cancer cells or an indirect role in activating antigen-presenting cells (APCs), thereby increasing the effectiveness of activation of cytotoxic T cells. (umontreal.ca)
Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients. (cdc.gov)

The activation of dendritic cells (DCs) is pivotal for generating antigen -specific T-cell responses to eradicate tumor cells . (bvsalud.org)
CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. (wikipedia.org)
CD40 also interacts with CD40L, due to the role of CD40 in stimulating immune synapses when this interaction happens with CD40L activates dendritic cells to activate antigen specific T cells. (wikipedia.org)
CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. (thermofisher.com)
CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. (thermofisher.com)
In the case of the former, comprehensive in-vitro analysis of the mechanism of action revealed that HERA-CD40L induced the development of pro-inflammatory antigen-presenting cells, including B cells, macrophages and dendritic cells. (drugdiscoverynews.com)
The membrane receptor CD40 is expressed in cells from the immune system (monocytes, lymphocytes, macrophages, dendritic cells) and from the vascular wall (endothelia and smooth muscle cells). (usp.br)
A major reason for this is believed to be defective activation of antigen-presenting cells (APCs), particularly dendritic cells (DCs), which are responsible for priming T-cells. (mskcc.org)
Influenza virus-laden sneeze → Healthy, Se-adequate host inhales influenza virus → Virus infects lung epithelium → Induces ROS (inflammation) → Chemoattracts GPx1 → Stimulates host proinflammatory chemokines → Induces dendritic cell activity, including polypeptide C1q [ 7 ] → Primes viral antigen-specific T cells → ↑ anti-inflammatory interferon-gamma (IFN-γ) and antibody immunoglobulin G (IgG) neutralization of viral antigen → inhibits virus replication and clears virus from host. (springer.com)
Dendritic cells (DCs), which are a major subtype of antigen-presenting cells (APCs), serve a key role in the immunopathogenesis of AR ( 1 , 2 ). (spandidos-publications.com)
Here, we generated antigenic peptides into non-linear trimers by solid phase peptide synthesis, thereby enhancing antigen presentation by dendritic cells to CD8+ T cells in vitro and in vivo. (eur.nl)
LinKinVax's vaccine platform is built around a humanized monoclonal antibody, which is fused with regions of pathogens of interest, targeting the CD40 molecule expressed by dendritic cells, DC, which play a key role in stimulating the immune system. (businesswire.com)
it serves as a ligand for CD40 that is expressed on B cells, macrophages, and dendritic cells. (bdbiosciences.com)
Furthermore, immature dendritic cells (iDC) responded to mCD40L with enhanced maturation and activation over sCD40L evidenced by higher expression levels of CD83, CD86, HLA-DR and CD54, increased secretion of IL12 and IL10 and higher tumour-antigen (TA) uptake capacity. (whiterose.ac.uk)
Antigen-driven interaction of dendritic cells (DC) with CD4(+) T(h) cells results in the exchange of bidirectional activating signals. (nih.gov)

CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. (medlineplus.gov)
If an activated T cell recognizes the peptide presented by the B cell, the CD40L on the T cell binds to the B cell's CD40 receptor, causing B cell activation. (wikipedia.org)
In fact, agents which block co-stimulatory signals (anti-CD40L, CTLA4-Ig) or cytokines (anti-TNF-alpha, TNFR:Fc, IL-1Ra), interrupt or alter binding of antigen to MHC (antigen peptides, MHC peptides, peptide oligomers), or modulate the appearance and activity of regulatory cells (various cytokines and anti- cytokines) are now being evaluated for treatment of multiple autoimmune diseases. (nih.gov)
The results indicate potent antitumor efficacy of Apogenix's HERA-CD40L, which acts directly on cells of the innate immune system as well as on antigen-presenting cells, thereby promoting specific T cell-mediated antitumor immunity. (drugdiscoverynews.com)
As the company notes, HERA-CD40L-in contrast to antibodies-does not depend on Fcγ receptor-mediated crosslinking for activity, adding, "As the first pure CD40 receptor agonist with a well-defined mechanism of action, HERA-CD40L is not restrained by dose-limiting toxicities observed with anti-CD40 antibodies. (drugdiscoverynews.com)
As explained in the company news release about the published data, "The potent antigen-specific activation of T cells by HERA-CD40L-treated macrophages led to an immune response specifically directed against the tumor. (drugdiscoverynews.com)
Mecanismos de modulação da via de sinalização CD40/CD40L. (usp.br)
Demonstramos que angiotensina II é indutor da expressão de CD40, mas não de CD40L, na parede vascular e espécies reativas de oxigênio agem como segundos mensageiros nesse fenômeno. (usp.br)
Descrevemos um aumento importante da expressão de CD40 e CD40L em leucócitos circulantes de pacientes em sepse grave ou choque séptico e por último, mostramos que o receptor CD40 pode sofrer ntirosilação em resíduo de cisteína, diminuido sua atividade, tanto in vitro, quanto in vivo. (usp.br)
Devido à importância da via de sinalização CD40/CD40L e a ausência de uma terapêutica direta eficaz para seu controle, o conhecimento sobre os meios de manipulação dessa via por meios indiretos é essencial. (usp.br)
Control mechanisms of CD40/CD40L signaling pathway. (usp.br)
Dysfunction in CD40/CD40L function is reported in autoimmune diseases, atherosclerosis and sepsis. (usp.br)
We demonstrate that angiotensin II induces CD40, but not CD40L expression in vascular cells, and that reactive oxygen species act as seconfd messengers in this phenomenon. (usp.br)
We also show that there is a functional crosstalk between CD40/CD40L and peroxisome proliferator activated receptors signaling, both in cell cultures and in monocytes from patients with diagnosis of systemic eritematous lupus. (usp.br)
We describe a marked increase in CD40 and CD40L expression in leukocytes from patients in severe sepsis and that the receptor CD40 can be moduylated by nitrosylation of cysteine residues in its extracellular domain, which decreases its activity. (usp.br)
Due to its importance and absence of a direct approach to control its function, knowledge about indirect manners to modulate CD40/CD40L function is essential. (usp.br)
The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis. (biolegend.com)
Additional reported applications (for the relevant formats) include: costimulation of B cell proliferation 1 , partial inhibition of CD40 binding to CD40L 3 , and B cell rescue from apoptosis 1 . (biolegend.com)
Researchers enhanced the anti-tumor efficacy of chimeric antigen receptor T cells through the constitutive expression of CD40 ligand (CD40L). (celltherapynews.com)
The company's lead SL-172154 (SIRPα-Fc-CD40L) program, which is designed to block the CD47 immune checkpoint and simultaneously agonize the CD40 pathway, is being evaluated in multiple Phase 1 trials. (canadianinsider.com)

The following product was used in this experiment: CD40 Monoclonal Antibody (1C10), PE-Cyanine5, eBioscience™ from Thermo Fisher Scientific, catalog # 15-0401-82, RRID AB_468747. (thermofisher.com)
Description: The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50 kDa type I transmembrane glycoprotein. (thermofisher.com)
Anti-human CD3 monoclonal antibody OKT3, combined with 5C3 antibody against CD40, was used as stimulant. (hindawi.com)
for instance, the use of CD40 agonist antibody plus antigen showed remarkably rapid immune response and protection in a murine model of anthrax. (cdc.gov)
MSK investigators have shown that a CD40 agonist antibody can effectively treat tumors as monotherapy and overcome resistance to PD-1 blockade in an immunocompetent mouse model that is resistant to immune checkpoint blockade. (mskcc.org)
Moreover, we show that agonistic CD40 antibody combined with MF59 (AddaVax) emulsion synergistically improves the antigen-specific T cell response of the AMAX in vivo. (eur.nl)
In both H1N1 influenza and SARS-CoV-2 vaccines, rMASE significantly increased antigen-specific antibody secretion, memory T cell engagement, and Th1-biased immune response, which diminished viral loads after lethal challenge. (enlibio.com)

The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. (medlineplus.gov)
CD40 ligand attaches like a key in a lock to its receptor protein, CD40, which is located on the surface of immune system cells known as B cells. (medlineplus.gov)
In order for B cells to mature into the cells that produce antibodies of a different class, the CD40 receptor must interact with CD40 ligand. (medlineplus.gov)
CD40 ligand is also necessary for T cells to interact with other cells of the immune system, and it plays a key role in T cell differentiation (the process by which cells mature to carry out specific functions). (medlineplus.gov)
If CD40 ligand does not attach to its receptor on B cells, these cells cannot produce IgG, IgA, or IgE antibodies. (medlineplus.gov)
Oncolytic viral therapy presents an opportunity to overcome the immunosuppression in tumors by destroying tumor cells and thereby releasing antigens and immunostimulatory factors. (bvsalud.org)
The activation profiles of DCs were investigated in co-cultures with tumor cells or in an autologous antigen -specific T cell model by flow cytometry and multiplex proteomic analysis . (bvsalud.org)
Furthermore, these DCs were capable of expanding and stimulating antigen -specific T cells in addition to natural killer (NK) cells . (bvsalud.org)
Strikingly, the addition of immunosuppressive cytokines TGF-ß1 and IL-10 did not affect the ability of LOAd732-matured DCs to expand antigen -specific T cells and these cells retained an enhanced activation profile. (bvsalud.org)
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. (wikipedia.org)
While doing the experiments method they used to make an mAbs is now called CD40 which is a surface receptor of B cells which is able to that can be polyclonally activated by a binding ligand. (wikipedia.org)
The B cell can present antigens to helper T cells. (wikipedia.org)
Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. (wikipedia.org)
CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. (thermofisher.com)
Exposure to PM 2.5 can enhance antigen-presenting cell phenotypes on circulating cells, which may have consequences in the development of allergic or autoimmune diseases. (nih.gov)
While studies of peptide and protein antigens have been facilitated by the rapid advances in genomics and proteomics, studies of sugar chains, which are abundantly expressed on the outer surfaces of viral, bacterial, protozoan, and fungal pathogens and on the membranes of mammalian cells, have not kept pace with technologic advances. (cdc.gov)
A number of presentations were focused on the role of CD1 proteins, which present lipid antigens (e.g., from mycobacteria or Francisella tularensis , a potential weapon of bioterrorism) to T cells. (cdc.gov)
In antigen presenting cells, CD40 activation is necessary for the immune system to decide between an efficient immune response or tolerance. (usp.br)
In B cells, CD40 is known to enhance both antigen-presenting capacity and sensitivity to pro-apoptotic signals. (eur.nl)
CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. (biolegend.com)
They primarily initiate immune responses by presenting antigens to naive T cells in lymphoid tissues ( 20 , 21 ). (spandidos-publications.com)
CD8+ T cells from mice vaccinated with trimers showed an KLRG1+ effector phenotype and were able to recognize and kill antigen-expressing tumor cells ex vivo. (eur.nl)
Hence, we provide pre-clinical support for the induction of effector CD8+ T cells through the adaptable AMAX platform as easy implementable peptidic vaccination strategy against any antigen of choice, including neoantigens for anti-tumor immunity. (eur.nl)
APC) capture, process and present antigen to effector T and B cells (adaptive immunity). (nih.gov)
Upregulation of activation and costimulatory markers in antigen presenting cells are key events in the sensitization process and have been reported to serve as indicators of skin sensitization. (cdc.gov)
The present study evaluated the effect of hapten and prohapten exposure on cell surface marker expression (CD86, CD54, CD44 and CD40) on THP-1 cells. (cdc.gov)
Expression of the adhesion molecule CD54 (ICAM-1) and the antigen presenting cell costimulatory molecule CD40 were also significantly elevated in both hapten and prohapten (+ S9) treated cells, however S9 alone also upregulated CD54. (cdc.gov)
Preclinical data incidate that APX005M mimics the endogenous immune activation process through activation of CD40, a receptor on the surface of antigen presenting cells of the immune system which plays a fundamental role in the activation of both innate and adaptive immune system mechanisms. (pharmatimes.com)
The companies will assess the potential of combining these two agents with the goal of effectively activating antigen presenting cells (APC) in the tumour microenvironment to drive a more productive and sustained immune response. (pharmatimes.com)
Targeting the tumor microenvironment through activation of antigen-presenting cells is a novel approach that we are excited to add to our Immuno-Oncology strategy as we continue to advance research for cancers with limited treatment options," stated Fouad Namouni, head of Oncology Development at BMS. (pharmatimes.com)
Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. (bvsalud.org)
CD40 is a type I transmembrane glycoprotein belonging to the TNFRs family, which is expressed on the surface of immune, hematopoietic cells, vascular, epithelial, and other cell types, including a wide range of tumour cells. (umontreal.ca)
The activation of CD40 on the surface of B cells increases its ability to promote antigen presentation, in addition to inducing proliferation, isotype switching, and apoptosis. (umontreal.ca)
TNFSF18 is expressed on murine splenic B cells by IL4 & CD40, LPS, CpG and oligonucleotide GITRL is also produced in retinal pigment epithelial cells by IFNG, TNFA and IL1A. (prospecbio.com)
Regarding internal T cell mechanics, Anjana Rao, PhD -a former CRI fellow who is now a CRI Scientific Advisory Council member at the La Jolla Institute for Immunology-highlighted her team's work showing how knocking out genes for certain pathways in chimeric antigen receptor (CAR) T cells could improve their anti-cancer activity and the survival of mice. (cancerresearch.org)
Cross-linking of TCR by MHC class II-bound antigen activates T(h) cells, resulting in their up-regulation of CD40 ligand. (nih.gov)
Further analysis revealed that the same IL-10(+)IFN-gamma(gamma) population displayed potent effector function against the parasite while, paradoxically, also inducing profound suppression of IL-12 production by antigen-presenting cells. (indexindex.com)
The aim of this project is to address the most important of these questions:1)To characterize, in depth CD8 memory cells ge nerated against soluble proteins by cross-priming compared to those generated after viral or bacterial infection against the same antigen2) To study the effect of antigen localisation on the development of memory CD8 T cells. (europa.eu)
Anti-tumour T cells are initially formed during their first contact (priming) with tumour antigens by antigen-presenting cells (APCs). (nature.com)
Desert tumours disturb antigen processing and priming of T cells by targeting APCs with suppressive tumour factors derived from their genetic instabilities. (nature.com)
The manufacturing technology enables a patient's T cells to be genetically modified using a gammaretroviral vector to express a chimeric antigen receptor designed to target the antigen CD19, a protein expressed on the cell surface of B cell lymphomas and leukemias. (celltherapynews.com)
Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies" doi: 10.1136/jitc-2022-005018. (ancell.com)
By this process, B cells acquire two important features of adaptive immunity: (1) discrimination between self and non-self (the ability of B-cell to recognize foreign antigens rather than self-antigens) (2) memory (the ability to recall the previous contact with antigens, therefore, subsequent interaction leads to a more effective and quicker response). (statpearls.com)
B cells antigen receptor is functionally part of multimolecular protein complexes at the cell surface. (statpearls.com)
Additionally, the company is advancing a proprietary Gamma Delta T Cell Engager, GADLEN™, platform, which is designed to bridge gamma delta T cells to tumor antigens for the treatment of patients with cancer. (canadianinsider.com)

CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. (thermofisher.com)
The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. (thermofisher.com)

These mutations lead to the production of an abnormal CD40 ligand or prevent production of this protein. (medlineplus.gov)
CD40 (protein) has been shown to interact with TRAF2, TRAF3, TRAF6, TRAF5 and TTRAP. (wikipedia.org)
This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. (cancerindex.org)
In the present study the authors investigated the role of CD40 ligation on macrophage chemoattractant protein-1 (MCP-1), IL-6, and IL-8 expression in fibroblasts from patients with TAO.Human orbital fibroblasts were cultured from tissues obtained with informed consent from patients with TAO and from patients undergoing surgery for other noninflammatory conditions. (nih.gov)
Whole microbes, microbial subunits and extracts, and peptide and protein antigens have been the focus of much vaccine research and development. (cdc.gov)
Detection of JC virus DNA sequences and expression of the viral regulatory protein T-Antigen in tumors of the central nervous system. (lsuhsc.edu)
In the case of enveloped RNA viruses, it is the natural dissemination of nucleocapsid protein (NP, core antigen) and surface antigen that delays NP exposure to immune surveillance. (enlibio.com)
In this manner, the receptor-binding domain (RBD, surface antigen) of the spike protein was trapped inside the nanocavity, while NP was absorbed on the outside of the droplets, enabling the burst release of NP before RBD. (enlibio.com)

OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier. (aaem.pl)
Gray D, Dullforce P, Jainandunsing S. Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction. (bdbiosciences.com)
Nos résultats montrent que l'induction de la mort cellulaire par le CD40 requiert la perméabilisation du lysosome, la libération de la cathepsine B, la présence de ROS et une interaction avec le TRAF6, cette mort cellulaire programmée est plus importante en présence de la forme monomérique du CD40, muté au niveau de la cystéine 238. (umontreal.ca)
Our results show that the induction of cell death by CD40 requires permeabilization of the lysosome, the release of cathepsin B, the presence of ROS and interaction with TRAF6, this programmed cell death is greater in the presence of the monomeric form of CD40, due to a mutation at the level of the cysteine 238. (umontreal.ca)
The human AITR expression of is not induced by the treatment with dexamethasone as found in mouse species, but is controlled by antigen-receptor interaction or by soluble anti-CD3 and anti-CD28 or PMA with addition of ionomycin. (prospecbio.com)
B-cell development constitutes of all the stages of early differentiation in the absence of antigen interaction until the maturation, antigen interaction, and, ultimately, antibodies synthesis. (statpearls.com)

CYLD inhibits activation of NF-kappaB by the TNFR family members CD40, XEDAR and EDAR in a manner that depends on the deubiquitinating activity of CYLD. (nih.gov)
CD40 and CD27, members of the tumor necrosis factor receptor (TNFR) family, are critical regulators of lymphocyte growth and differentiation. (eur.nl)

Studies were also presented on novel molecules involved in the recognition of carbohydrate antigens such as specific intercellular adhesion molecule (ICAM)-grabbing nonintegrins, which are C-type lectins that show substantial expression in many tissues, and toll-like receptors, which function as pattern recognition receptors for conserved pathogen structures and serve as key links between innate and adaptive immunity. (cdc.gov)
Cross-linking of MHC class II molecules on human monocyte-derived DC results in the up-regulation of the surface expression of CD83, CD80, CD86, CD54, CD1a and CD40 molecules, the typical DC maturation-associated markers. (nih.gov)

A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. (cdc.gov)
Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis. (cdc.gov)

The design of optimal vaccines against such pathogens should include lipid and peptide antigens. (cdc.gov)

Yet, although CD40 ligation does result in significant up-regulation of CD80/CD86 in our cohort, it is up-regulation of the death receptor CD95 that significantly correlates with the percentage of CD40+blasts. (eur.nl)
In carcinomas, the nature of CD40 ligand shapes the outcome of CD40 ligation. (whiterose.ac.uk)

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. (thermofisher.com)
CD40 is a 48 kD type I glycoprotein also known as BP50. (biolegend.com)

Stimulation of CD40 on APCs has been recognized as a highly effective way to activate APCs. (mskcc.org)

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models. (bvsalud.org)
Patients affected by mutations in the gene encoding the CD40 or its ligand are immunosuppressed and susceptible to opportunistic infections. (umontreal.ca)
The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study. (cdc.gov)
Single nucleotide polymorphisms in the CD40 gene associate with the disease susceptibility and severity in knee osteoarthritis in the Chinese Han population: a case-control study. (cdc.gov)

Each of them responds to the antigen in a specific way, as it expresses specific antibodies on the membrane (IgM, CD79a, and CD79b). (statpearls.com)

Thus, to induce a signal, CD40 interacts directly or indirectly with adapter proteins such as TRAFs and Jaks. (umontreal.ca)

Downregulation of CYLD by RNA-mediated interference augments both basal and CD40-mediated activation of NF-kappaB. (nih.gov)
As a result, the macrophage expresses more CD40 and TNF receptors on its surface which helps increase the level of activation. (wikipedia.org)
The upcoming paragraphs will describe the most critical external structures of B-cell responsible for cell activation, antigen recognition, and signal transduction. (statpearls.com)

CD40 is a key target because it has a unique role in initiating an antigen-specific immune response against tumors. (drugdiscoverynews.com)
In addition, the investigators have described a novel way to use CD40 therapy to restore sensitivity to PD-1 blockade, confer persistent anti-tumor immunity, and overcome the challenge of T-cell exhaustion within tumors. (mskcc.org)
Neoantigens are tumor-specific antigens, which play a critical role in the growth and maintenance of tumors. (kark.com)

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. (bvsalud.org)

Les patients souffrant de mutations au niveau du gène codant pour le CD40 ou de son ligand sont immunosupprimés et sensibles à des infections opportunistes. (umontreal.ca)

La evidencia sugiere que la activación de células-B dependiente del CD40 es importante para generar memoria en las células-B en los centros germinales. (bvsalud.org)
Plus récemment, on a montré que la formation du CD40 homodimère est le résultat de son engagement sur les cellules B. En plus, cette homodimérisation du CD40 est importante pour la phosphorylation de l'Akt. (umontreal.ca)
Cette homodimérisation du CD40 semble être importante pour l'activation des cellules B par le biais de l'induction de l'expression du CD23, CD69 et CD80. (umontreal.ca)

We found significantly increased monocyte expression (mean fluorescent intensity) of CD80, CD40, CD86, HLA-DR, and CD23 per 10-μg/m 3 increase in PM 2.5 at 2- to 4-day lag times after exposure. (nih.gov)

Furthermore, the ability of mCD40L to also directly induce cell death in CD40-expressing carcinomas, subsequently releasing tumour-specific antigens into the tumour microenvironment highlights the potential for mCD40L as a multi-faceted anti-cancer immunotherapeutic. (whiterose.ac.uk)

Experimental Design: Bcl -6, CD10, and CD40 were chosen as markers for a germinal center phenotype, CD23 as a marker of pre/early germinal center origin, and CD138 as a marker for postgerminal center origin. (aacrjournals.org)
CD23 was positive in 16% of the cases (all CD5 negative and all CD40 positive). (aacrjournals.org)
CD23 and CD40 expression seems to be prognostically favorable in DLBCL. (aacrjournals.org)
De plus, nos résultats montrent pour la première fois une implication du CD40 homodimère dans l'induction du CD23 par le biais du TLR4. (umontreal.ca)

Therefore, the first conditional rule for ICT response is the successful MHC-dependent presentation of tumour antigen in the format of peptides to T-cell receptors (TCR), which results in the generation of a clonally expanded population of anti-tumour effector lymphocytes, as shown in the wheel diagram of Fig. 1 (orange, Stages 1-3). (nature.com)

In humans, the MHC is called the human leukocyte antigen (HLA) system and is located on the short arm of chromosome 6, near the complement genes. (medscape.com)
Polymorphisms of the genes CTLA4, PTPN22, CD40, and PPARG and their roles in Graves' disease: susceptibility and clinical features. (cdc.gov)

Early reports dubbed increases in B cell antigen sensitivity a "neuraminidase effect," ( Cowing and Chapdelaine, 1983 ) and recent evidence has ascribed this phenomenon to sialic acid acting as a negative regulator of immune cell interactions ( Bagriacik and Miller, 1999 ). (frontiersin.org)
This assay has high sensitivity and excellent specificity for detection of human CD40/TNFRSF5. (assaysolution.com)

The expression of CD40 is diverse. (wikipedia.org)
AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. (thermofisher.com)
CD40 expression correlated with bax but not with bcl -2 expression. (aacrjournals.org)
Expression of both CD40 and CD27 was found to be significantly higher in low- than in high-risk patients as defined by standard clinical risk parameters such as age and white blood cell count. (eur.nl)
Of note, high CD40 expression particularly protected against late relapse. (eur.nl)
Thus very high expression of CD40 on BCP-ALL blasts is an independent prognostic marker indicative of superior relapse-free survival that may in part be due to CD40- dependent death receptor up-regulation. (eur.nl)
Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. (bdbiosciences.com)
Expression of JC virus T-Antigen in a multiple sclerosis patient with a Glioblastoma multiforme. (lsuhsc.edu)
In the presence of the surface antigen, higher doses of NP resulted in the up-regulated expression of IFN-α, suggesting a robust anti-viral effect (Supplementary Fig. (enlibio.com)

Additionally, CD40 is important for T cell-B cell interactions. (biolegend.com)

The meeting was organized into 7 sessions on such topics as genetic and cellular mechanisms of carbohydrate immunity, carbohydrate antigens for vaccines, and new tools for studying carbohydrates. (cdc.gov)

ELISA: Human CD40/TNFRSF5 ELISA Kit (Colorimetric) - These standard curves are provided for demonstration only. (assaysolution.com)

The results obtained demonstrate the benefits of this strategy owing to the small quantity of antigens required to activate the immune system, with or without an adjuvant, and its ability to trigger a lasting cellular and humoral and immune response. (businesswire.com)

No significant cross-reactivity or interference between human CD40/TNFRSF5 and analogues was observed. (assaysolution.com)

CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. (thermofisher.com)

Upon antigen stimulation they rapidly upregulate glycolysis and oxygen to produce high levels of ATP and nucleotides required for cell proliferation and effector functions. (nih.gov)

The remaining member of TRAF4 family, namely TRAF4, positively regulates CD40 signalling, but interacts with CD40 indirectly. (wikipedia.org)

Anatomy29

Organisms10

Diseases3

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes31

Disciplines and Occupations1

Information Science3

Health Care3

CD15426

Dendritic15

CD40L20

Antibody7

Cells45

Immunoglobulin2

Protein8

Interaction6

TNFR2

Molecules2

Single Nucleotide P2

Peptide1

Ligation2

Glycoprotein2

APCs1

Gene4

Antibodies1

Proteins1

Activation3

Tumors3

Superfamily1

Mutations1

Importante3

CD861

Carcinomas1

CD234

Peptides1

Genes2

Sensitivity2

Expression9

Interactions1

Immunity1

ELISA Kit1

Immune system1

TNFRSF51

Induce1

Proliferation1

Regulates1