• This proposal seeks to develop for the first time in humans a novel CD5 knocked out (KO) anti-CD5 chimeric antigen receptor T cell (CART) product for patients with relapsed or refractory T-cell lymphomas. (lls.org)
  • The present project seeks to translate this discovery into a first-in-human clinical trial to evaluate the feasibility, toxicity, and efficacy of CD5-deleted anti-CD5 chimeric antigen receptor CART for T-cell lymphoma. (lls.org)
  • CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions upon binding to ligands such as CD72. (biolegend.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • CD5 is a counter-receptor for CD72 and plays a role in the T-B cell interaction. (thermofisher.com)
  • CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). (exbio.cz)
  • CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. (exbio.cz)
  • CD5 Antigen-like (CD5L), also known as Sp alpha, is a secreted protein that is a member of the SCSR (scavenger receptor cysteine rich) superfamily. (rndsystems.com)
  • Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. (bvsalud.org)
  • The results suggest that the novel protein is a macrophage-specific membrane receptor with a role in host defense, as it shows postnatal expression in macrophages, which are considered responsible for the binding of bacterial antigens and phagocytosis. (embl.de)
  • The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. (embl.de)
  • 3. Stimulation of CD5 Enhances Signal Transduction by the T cell Antigen Receptor. (exalpha.com)
  • Occasional lymphocytes expressed CD4, CD5, CD8 and CD30, while staining for the B-cell marker CD20 and for CD56, activin receptor-like kinase 1 (Alk1) and T-cell receptor alpha/beta (TCR alpha/beta) was consistently negative. (upmc.edu)
  • Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. (ox.ac.uk)
  • The lymphocyte receptor CD5 influences cell activation by modifying the strength of the intracellular response initiated by antigen engagement. (ox.ac.uk)
  • Regulation through CD5 involves the interaction of one or more of its three scavenger receptor cysteine-rich domains present in the extracellular region. (ox.ac.uk)
  • The team adapted mRNA delivery technology seen in current COVID-19 vaccines and applied it to basic Chimeric Antigen Receptor design. (medika.life)
  • Engleman EG, Warnke R, Fox RI, Dilley J, Benike CJ, Levy R. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. (bdbiosciences.com)
  • The following product was used in this experiment: CD5 Monoclonal Antibody (53-7.3), NovaFluor™ Red 725, eBioscience™ from Thermo Fisher Scientific, catalog # M026T03R05, RRID AB_2926168. (thermofisher.com)
  • C57BL/6 mouse splenocytes were unstained (left) or stained with 0.2 µg of CD5 Monoclonal Antibody, NovaFluor Red 725 (Product # M026T03R05) (right). (thermofisher.com)
  • Description: The 53-7.3 monoclonal antibody reacts with mouse CD5, a 67 kDa protein expressed by a majority of thymocytes, mature T cells and a subset of B cells. (thermofisher.com)
  • The CD5 antibody, clone L17F12, is derived from the hybridization of NS-1/Ag4 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with human T-acute lymphoblastic leukemia (ALL) cells. (bdbiosciences.com)
  • The CD5 antibody is composed of mouse IgG2a heavy chains and kappa light chains. (bdbiosciences.com)
  • The mouse monoclonal antibody CRIS1 reacts with an extracellular epitope of CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes). (exbio.cz)
  • Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-CD5 monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody. (exbio.cz)
  • Purified Anti-Mouse CD5 antibody for use in flow cytometry assays. (southernbiotech.com)
  • 1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
  • Western blot: 10 µg of Jurkat cell lysate stained with ARG66751 anti-CD5 antibody [SQab20184] at 1:1000 dilution. (arigobio.cn)
  • The tissue section was stained with ARG66751 anti-CD5 antibody [SQab20184] at 18°C - 25°C for 30 minutes. (arigobio.cn)
  • 1. Anti-DNA Antibody Production by CD5+ and CD5- B Cells of Patients with Systemic Lupus Erythematosus. (exalpha.com)
  • 4. Surface Immunoglobulin Ligands and Cytokines Differentially Affect Proliferation and Antibody Production by Human CD5+ and CD5- B Lymphocytes. (nordicmubio.com)
  • Human T-cell antigens defined by monoclonal antibodies: The 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. (bdbiosciences.com)
  • Warnke RA, Levy R. Detection of T and B cell antigens with hybridoma monoclonal antibodies: a biotinavidin-horseradish peroxidase method. (bdbiosciences.com)
  • CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. (exbio.cz)
  • Western blotting analysis of human CD5 using mouse monoclonal antibodies MEM-32, CRIS1, and L17F12 on laurylmaltoside lysates of Jurkat cells and of K562 cells (negative control) under non-reducing conditions. (exbio.cz)
  • The team then decorated the lipid nanoparticle surface with CD5 targeting antibodies to direct lipid uptake. (medika.life)
  • CD5 is a 67 kD single chain type I glycoprotein also known as Leu-1, Ly-1 and T1. (biolegend.com)
  • CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. (thermofisher.com)
  • CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. (southernbiotech.com)
  • It has been identified as the major ligand of the B-cell antigen CD72. (southernbiotech.com)
  • Los anticuerpos específicos de los antígenos CD5 fomentan la activación de los linfocitos T mediada por los receptores de los linfocitos T. La molécula CD72 específica de los linfocitos B es un ligando natural de CD5. (bvsalud.org)
  • The B-cell-specific molecule CD72 is a natural ligand for CD5. (bvsalud.org)
  • CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. (exbio.cz)
  • About 30% to 40% of PTCL, NOS, express markers of cytotoxic T-cells such as T-cell intracellular antigen-1 (TIA-1). (webpathology.com)
  • Immunohistochemically, the vast majority of the infiltrating cells stained positive for CD3 (Figure 6 ) and over half of them were positive for CD2 and T-cell intracellular antigen 1 (TIA1). (upmc.edu)
  • May bind bacterial antigens in the protein MARCO. (embl.de)
  • Recombinant full length protein of Human CD5 (extracellular). (arigobio.cn)
  • Although CD5+ macrophages were not present in the peritoneal cavities of normal mice, approximately 30% of the peritoneal macrophages in viable motheaten (mev/mev) mice, deficient in SHP-1 protein tyrosine phosphatase, expressed cell surface CD5 and B220, markers for B cells. (jax.org)
  • This proposal seeks to develop a novel approach for patients with relapsed or refractory T cell lymphoma by developing a novel CAR-T cell immunotherapy to recognize the tumor-associated target CD5. (lls.org)
  • However, one challenge of targeting T cell lymphomas using CAR-T cell immunotherapy is that most targets expressed in tumor cells, like CD5, are also expressed by the CAR-T cells themselves, leading to the potential reduction of the CAR-T anti-tumor effect. (lls.org)
  • Indeed, this novel CAR-T cell product (CD5-deleted CART5) showed increased anti-tumor effect against T cell lymphoma in the laboratory. (lls.org)
  • B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
  • Furthermore, T cells and NK cells complement each other in that certain immune suppression mechanisms taken by tumor cells that are effective against T cells, such as the downregulation of human leukocyte antigens (HLA), have proven to be stimulatory for NK cells. (molcells.org)
  • Human peripheral blood lymphocytes were stained with purified CD5 (UCHT2) (solid line) or purified mouse IgG1, κ (dashed line), followed by anti-mouse IgG PE. (biolegend.com)
  • CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. (exbio.cz)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Summary of T-cell studies performed during the Second International Workshop and Conference on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)
  • Human Leu T-cell differentiation antigens: quantitative expression on normal lymphoid cells and cell lines. (bdbiosciences.com)
  • Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
  • Takahashi K, Miyakawa K, Wynn AA, Nakayama KI, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
  • Therefore, we developed a strategy to remove CD5 from CAR-T cells using the genetic engineering technology called CRISPR-Cas9. (lls.org)
  • Pan-T antigens are antigens found on all T cells. (wikipedia.org)
  • CD5 is intended for in vitro diagnostic use in the identification of cells expressing CD5 antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
  • Phenotypic and functional characterization of human Leu-1 (CD5) B cells. (bdbiosciences.com)
  • The expression of CD5 by a small subset of B cells characterizes a developmentally and functionally distinct lineage of B cells called B-1 cells. (thermofisher.com)
  • Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. (exbio.cz)
  • Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Levine H, Nadler LM: Expression and regulation of CD5 on in vitro activated human B cells. (exbio.cz)
  • The frequency of CD5 + B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5 + B cells suggest that they may represent a distinct lineage, known as B-1 cells. (southernbiotech.com)
  • The lymphocytic clusters in SM contained nearly equal numbers of mature T and B cells, the latter with no coexpression of aberrant antigens, such as CD5 or CD23. (bmj.com)
  • Identification of human helper/inducer T cells expressing the 67,000 M.W. surface antigen, 85% peripheral blood lyymphocytes that form rosettes with sheep red blood cells (E+), and a small subset of B cells. (exalpha.com)
  • 6. In Vivo and In Vitro Expression of Myeloid Antigens on B-lineage Acute Lymphoblastic Leukemia Cells. (nordicmubio.com)
  • These T cells target either CD19 or BCMA, two antigens found on malignant B cells. (medika.life)
  • In the peritoneal cavity of GM-CSF-treated mice, the percentages of hematopoietic progenitor cells doubly positive for CD5 and CD34 or c-kit and of macrophage precursor cells doubly positive for CD5 and ER-MP58 or ER-MP20 were increased significantly during the development of CD5+ macrophages and CD5 B cells, suggesting that CD5+ macrophages and B cells may share a bipotential progenitor in vivo. (jax.org)
  • In infected mice, there was a small increase in mIgM(lo)mIgD(+) mature B2 cells, but no enrichment of B cells with regulatory phenotype or function compared to the naïve hepatic B cell population, as assessed by CD1d and CD5 expression and by IL-10 production. (ox.ac.uk)
  • Using 2-photon microscopy to quantify the entire intra-granuloma B cell population, in conjunction with the adoptive transfer of polyclonal and HEL-specific BCR-transgenic B cells isolated from L. donovani-infected mice, we demonstrated that B cells accumulate in granulomas over time in an antigen-independent manner. (ox.ac.uk)
  • CD5L/Sp alpha exhibits a high degree of homology with the extracellular regions of CD5 and CD6, exhibiting three SCSR domains. (rndsystems.com)
  • CD5-like antigen (CD5L) was differentially expressed involving cirrhosis and HCC patients with HCV infection. (glucagon-receptor.com)
  • CD23 was positive in 16% of the cases (all CD5 negative and all CD40 positive). (aacrjournals.org)
  • Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. (southernbiotech.com)
  • The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. (exbio.cz)
  • Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc. (exbio.cz)
  • Immunochemical analysis of the T-cell-specific antigens. (bdbiosciences.com)
  • Chronic lymphocytic leukemia (CLL) represents the outgrowth of a CD5(+) B cell. (nih.gov)
  • 5. Evidence for Differential Responsiveness of Human CD5+ and CD5- B cell Subsets to T cell Independent Mitogens. (exalpha.com)
  • The exception are blasts with Auer Rod(s) which are unique to abnormal Myeloblast {16}s and abnormal promyelocytes as noted in some AMLs and APL Note: Abnormal lymphoblasts can show immunophenotypic abberancies (e.g. loss of T-cell antigens such as CD7, CD5 and CD2 or the gain of myeloid markers such as CD13, etc. (hematologyoutlines.com)
  • Then, we will test this novel CD5-deleted CART5 immunotherapy product in a first-in-human clinical trial. (lls.org)
  • Therefore, antigen binding and stimulation could contribute to clonal selection and expansion as well as disease promotion. (nih.gov)
  • Here, we present the 3D solution structure of a non-glycosylated double mutant of the N-terminal domain of human CD5 expressed in Escherichia coli (eCD5d1m), which has enhanced solubility compared to the non-glycosylated wild-type (eCD5d1). (ox.ac.uk)
  • BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD5-UNLB (SB Cat. (southernbiotech.com)
  • CD5, also known as Leu-1, Ly-1 and T1, is a 67 kD single chain type I glycoprotein that is a member of the scavenger receptor superfamily. (biolegend.com)
  • CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions. (biolegend.com)
  • The 53-7.3 monoclonal antibody specifically binds to a monomorphic epitope of CD5, a member of the scavenger receptor cysteine-rich protein superfamily and the major ligand of CD72, found on thymocytes, T lymphocytes, thymic NKT cells, and a subset of B lymphocytes, but not on NK cells or splenic NKT cells. (bdbiosciences.com)
  • Few, if any, intestinal intraepithelial lymphocytes bearing the γδ T-cell receptor express CD5. (bdbiosciences.com)
  • It has been proposed that CD5 is a costimulatory molecule which mediates interactions of cells in the immune system and negatively regulates signal transduction mediated by the T-cell receptor and B-cell receptor. (bdbiosciences.com)
  • CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. (bdbiosciences.com)
  • Bikah G, Carey J, Ciallella JR, Tarakhovsky A, Bondada S. CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. (bdbiosciences.com)
  • 10. Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor. (nih.gov)
  • Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein , is a protein that in humans is encoded by the CD79A gene . (wikidoc.org)
  • The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells , thus forming the B-cell antigen receptor (BCR). (wikidoc.org)
  • This occurs in a similar manner to the association of CD3 with the T-cell receptor , and enables the cell to respond to the presence of antigens on its surface. (wikidoc.org)
  • Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. (bvsalud.org)
  • CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. (thermofisher.com)
  • The inability to predict the foreign antigens that an organism will encounter in its lifetime creates a need for the immune system to generate and maintain a diverse T cell receptor repertoire ( 1 - 3 ). (frontiersin.org)
  • B cells antigen receptor is functionally part of multimolecular protein complexes at the cell surface. (statpearls.com)
  • The b-cell antigen receptor is a transmembrane receptor that extends to the cytoplasm. (statpearls.com)
  • Here, we compare the signaling pathways that are activated by the engagement of the B cell antigen receptor (BCR) in B-1 and B-2 cells. (nus.edu.sg)
  • Chimeric antigen receptor (CAR) T cell therapy, Oncolytic viruses, Immune-checkpoint inhibitors, and Dendritic cells (DC) vaccination were the most encouraging areas in glioma therapy [ 2 , 3 ]. (aging-us.com)
  • We then modify these cells with an artificial gene (chimeric antigen receptor or CAR for short) that makes them recognize and kill tumor cells when infused back to the patient. (tamest.org)
  • Description: A sandwich ELISA kit for detection of CD5 Antigen Like Protein from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (maracpe.org)
  • 3. Selection of the alternative exon 1 from the cd5 gene down-regulates membrane level of the protein in B lymphocytes. (nih.gov)
  • [1] [2] The Kell antigens are peptides found within the Kell protein , a 93- kilodalton transmembrane zinc -dependent endopeptidase which is responsible for cleaving endothelin-3 . (wikidoc.org)
  • The Kell glycoprotein links via a single disulfide bond to the XK membrane protein [6] that carries the Kx antigen . (wikidoc.org)
  • Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene [8] ), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • 90K, also known as galectin 3 binding protein, LGALS3BP, Mac-2-binding protein, has recently been identified as a tumor-associated antigen and a promising immunotherapy target. (aging-us.com)
  • This tonic signaling is also important in shaping T cell potential to mount immune responses to foreign antigens ( 12 ) and for homeostatic proliferation ( 1 ). (frontiersin.org)
  • By this process, B cells acquire two important features of adaptive immunity: (1) discrimination between self and non-self (the ability of B-cell to recognize foreign antigens rather than self-antigens) (2) memory (the ability to recall the previous contact with antigens, therefore, subsequent interaction leads to a more effective and quicker response). (statpearls.com)
  • Human serum usually contains natural IgG, IgM and IgA antibodies, generated independently of any exposure to foreign antigens or vaccines or elicited in the course of infectious or autoimmune diseases. (biomedcentral.com)
  • B-cell development constitutes of all the stages of early differentiation in the absence of antigen interaction until the maturation, antigen interaction, and, ultimately, antibodies synthesis. (statpearls.com)
  • Each of them responds to the antigen in a specific way, as it expresses specific antibodies on the membrane (IgM, CD79a, and CD79b). (statpearls.com)
  • Individuals lacking a specific Kell antigen may develop antibodies against Kell antigens when transfused with blood containing that antigen. (wikidoc.org)
  • Both AIHA and HDN may be severe when caused by anti-Kell antibodies, [10] as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems . (wikidoc.org)
  • B cell activation plays a central pathogenic role in the chronic, central nervous system autoimmune disease multiple sclerosis (MS) through several, non-mutually exclusive mechanisms that include the production of antibodies and other neurotoxic products, and antigen presentation with consequent propagation of neuroinflammation [ 1 ]. (biomedcentral.com)
  • B-1 cells are found in peritoneal and pleural cavities where they provide first-line defence through antibodies able to bind polysaccharide antigens and repeated motifs that are typically found in microbial cell walls and macromolecules [ 2 , 3 ]. (biomedcentral.com)
  • In other words, if the antigen-antibody reaction is compared to a "key-and-lock" model, natural antibodies found in human secretions act as "passe-partout" keys to offer a background protection against most pathogens, food antigens and microbes, before the antigen-specific response can develop [ 4 ]. (biomedcentral.com)
  • We have shown previously that only the CD11b + dendritic cell (DC) subset in the mouse responds to SBAs by cross-presentation of exogenous antigens to CD8 + T cells in a lipid-body dependent manner. (bmj.com)
  • CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. (thermofisher.com)
  • The expression of anaplastic lymphoma kinase (ALK), CD5, CD30, and C-Myc in tumor specimens from 109 patients was detected using IHC, and Epstein-Barr virus (EBV)-encoded RNAs (EBERs) were detected using fluorescence in situ hybridization. (biomedcentral.com)
  • No correlations were detected between PD-L1 expression and the expression of ALK, CD5, and CD30 as well as EBERs. (biomedcentral.com)
  • Bikah G, Lynd FM, Aruffo AA, Ledbetter JA, Bondada S. A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5. (bdbiosciences.com)
  • Antigens, CD43" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • This graph shows the total number of publications written about "Antigens, CD43" by people in UAMS Profiles by year, and whether "Antigens, CD43" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Antigens, CD43" by people in Profiles over the past ten years. (uams.edu)
  • The Second International Swine Cluster of Differentiation (CD) Workshop was organized to standardize the assignment of monoclonal antibody (mAb) reactivity to swine leukocyte antigens. (usda.gov)
  • Liau et al showed a clinical phase I trial of DC vaccines from patients' peripheral blood pulsed GBM antigen peptides successfully extended mean OS to 23.4 months [ 9 ]. (aging-us.com)
  • We have developed two approaches targeting proteins called CD5 and CD7 which are abundantly present in T-cell leukemia and lymphoma. (tamest.org)
  • 1. Exonal switch down-regulates the expression of CD5 on blasts of acute T cell leukaemia. (nih.gov)
  • 4. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. (nih.gov)
  • CD5 expression also regulates responsiveness to IL-7 in naïve T cells ( 16 ). (frontiersin.org)
  • In this study, we show CD5 is expressed on CD11c+ DC from murine thymus, lymph node, spleen, skin and lung. (nih.gov)
  • The level of surface CD5 expression is developmentally regulated in the thymus, starting with low levels on CD4-CD8- thymocytes and increasing as they mature to CD4+CD8+ then CD4+CD8- or CD4-CD8+ thymocytes. (bdbiosciences.com)
  • The role of CD5 as a regulator of T cell signaling and tolerance is well recognized. (nih.gov)
  • CD5 is a negative regulator of TCR signaling, and its expression reports the strength of interaction of TCR with self-pMHC ( 14 , 15 ). (frontiersin.org)
  • Results RNA sequencing of SBA-treated conventional type 1 DC (cDC1) and type 2 DC (cDC2) subsets uncovered that SBAs upregulated lipid-related pathways in CD11c + CD1c + cDC2s, especially in the CD5 − CD163 + CD14 + cDC2 subset. (bmj.com)
  • Hairy cell leukemia , which is moderately positive for surface membrane immunoglobulins of multiple heavy-chain classes and is typically negative for CD5 and CD21. (medscape.com)
  • Moreover, SBAs induced lipid bodies and enhanced endosomal antigen translocation into the cytosol in this particular cDC2 subset. (bmj.com)
  • 3. transfecting tumor cell-associated antigen-encoding gene into DC [ 10 - 13 ]. (aging-us.com)
  • The XK appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • Although the development of DC subpopulations in CD5-/- mice was normal, CD5-deficient DC produced significantly higher levels of IL-12 than wild type DC in response to LPS. (nih.gov)
  • Consequently, CD5-/- DC were significantly more potent than wild type DC in the induction of anti-tumor immunity and contact hypersensitivity responses in mice. (nih.gov)
  • LEPTOSPIRA BIFLEXA ANTIGEN (STRAIN PATOC 1) Leptospira biflexa antigen (strain Patoc 1) is a non-pathogenic organism, which can be used as a prototype antigen for the development and manufacturing of diagnostics reagents such as ELISA. (maxanim.com)
  • To improve the tumor-killing efficiency, a combination of tumor-specific antigen and apoptotic GBM tumor cell lysate was pulsed DC to improve the effect of immunotherapy. (aging-us.com)
  • Three patients had acquired copy-neutral LOH (CN-LOH) on 6p arms, which may disrupt antigen presentation and act as a mechanism for immune system evasion. (oncotarget.com)