• The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. (hindawi.com)
  • Specific autoantibodies against 15 autoantigens were identified by line immunoassay. (unboundmedicine.com)
  • We therefore sought to determine whether antibodies produced by onchocerciasis patients might crossreact with the human 46-kD Ro/SS-A autoantigen (calreticulin). (jci.org)
  • These results strongly suggest that onchocerciasis patients produce antibodies that crossreact with the 46-kD human Ro/SS-A autoantigen (calreticulin) and raise the possibility that infectious organisms such as O. volvulus might play a triggering or exacerbating role in the human Ro/SS-A autoimmune response. (jci.org)
  • A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. (rupress.org)
  • New-onset pSLE patients have a broad spectrum of antibodies directed against many autoantigens, including those not classically associated with SLE. (biomedcentral.com)
  • Since apoptosis can make autoantigens accessible for recognition by antibodies, and also create neo-epitopes by chemical modifications occurring naturally during this process, we sought to determine if CLL mAbs recognize autoantigens associated with apoptosis. (nih.gov)
  • Autoimmune Disorders In autoimmune disorders, the immune system produces antibodies to an endogenous antigen (autoantigen). (msdmanuals.com)
  • Many of the autoantigens generated by neutrophils in NETs, including double-stranded deoxyribonucleic acid (DNA), citrullinated peptides, histones, myeloperoxidase (MPO), and proteinase 3 (PRTN3), are known to be attacked by the adaptive immune system observed in systemic autoimmunity. (news-medical.net)
  • Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
  • Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions. (childrensmercy.org)
  • Leeder JS, Lu X, Timsit Y, Gaedigk A. Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions. (childrensmercy.org)
  • Serological cross-reactivity between a human Ro/SS-A autoantigen (calreticulin) and the lambda Ral-1 antigen of Onchocerca volvulus. (jci.org)
  • Do epitopes derived from autoantigens display low affinity for MHC class I? (ox.ac.uk)
  • We have cloned and sequenced a 46-kD Ro/SS-A autoantigen gene that is the human homologue of the calcium-binding protein, calreticulin. (jci.org)
  • Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. (jci.org)
  • In summary, these data strongly indicate that RA33 and A2 are the same protein, and thus identify on a molecular level a new autoantigen. (jci.org)
  • Kazerounian, Shideh, "Periplakin, an autoantigen in paraneoplastic pemphigus and pemphigus foliaceus, an intermediate filament-binding protein, and a component of the insoluble structures of epidermal keratinocytes" (2002). (jefferson.edu)
  • An autoantigen is usually a normal protein or complex of proteins (and sometimes DNA or RNA) that is recognized by the immune system of patients suffering from a specific autoimmune disease . (wikidoc.org)
  • In 1997 Haneji and colleagues recognized a 120 kDa fragment of the ubiquitous cytoskeletal protein -fodrin as an autoantigen in the NFS/sld mouse model of human SS [1]. (asiatox.org)
  • Subgroup analysis comparing patients with class III or IV Iupus nephritis to patients without significant nephritis demonstrated increased reactivity against several autoantigens including double stranded DNA, C1q and several types of collagen in patients with nephritis. (biomedcentral.com)
  • Particular IGHV and IGHV/D/J rearrangements contributed to autoantigen binding, although the presence and degree of reactivity varied based on specific structural elements. (nih.gov)
  • 353:765-769), selective expression of mHEL autoantigen on thyroid cells did not trigger elimination or inactivation of circulating HEL-reactive B cells. (silverchair.com)
  • Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
  • The next wave of truly transformative therapeutics should aspire to provide a cure by selectively suppressing pathogenic autoantigen-specific immune responses while leaving the rest of the immune system intact to control infectious diseases and malignancies. (frontiersin.org)
  • Autoantigens can be altered and presented to the adaptive immune system due to dysregulated neutrophil cell death. (news-medical.net)
  • Efficient uptake of dying cells and handling of their DNA is important for preventing intracellular autoantigens from coming into contact with the immune system. (lu.se)
  • Homologies between proteins of Borrelia burgdorferi and thyroid autoantigens. (qxmd.com)
  • Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
  • RA33 is a nuclear autoantigen with an apparent molecular mass of 33 kD. (jci.org)
  • Mutations in the gene encoding one autoantigen within the PML-Sp100 nuclear body, designated Sp110, were found to cause an immunodeficiency disorder known as "VODI" (veno-occlusive disease with immunodeficiency). (massgeneral.org)
  • The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. (nih.gov)
  • This is the first case of IgA pemphigus where Dsg1 has been identified as the autoantigen. (elsevierpure.com)
  • Ein signifikant erhöhter Anteil an Memory T-Zellen sowie CXCR3+/CCR6+ (Th1/Th17) Zellen im Myelin-spezifischen Repertoire von MS-Patienten spiegelte sich aber auch in der totalen CD4+ T-Zell-Population wieder und lässt daher eher auf generelle Veränderungen im Differenzierungs- und Funktionsstatus der CD4+ T-Zellen von MS-Patienten und weniger auf eine Autoantigen-spezifische Modulation schließen. (tu-berlin.de)
  • A cDNA clone encoding an immunoreactive autoantigen (Ngp-1) was isolated by screening λgt11 human ductal breast tumor expression libraries with autologous patient serum. (elsevierpure.com)
  • Methods: We replaced DCs by peripheral mononuclear cells and myelin autoantigens by glatiramer acetate (Copaxone (R)), a drug approved for the treatment of MS. Spleen cells were loaded with Copaxone (R), incubated with mitomycin C (MICCop) and injected into mice after the first bout of relapsing-remitting EAE. (uni-koeln.de)
  • CIA + LPS-induced lung histopathology changes and the expression of lung autoantigens including malondialdehyde acetaldehyde (MAA)- and citrulline (CIT)-modified proteins and vimentin were reduced in castrated animals. (cdc.gov)
  • We discovered that one of these antimicrobial peptide called LL37 not only triggers innate immune activation but also acts as an epidermal autoantigen targeted by autoimmune T cells in psoriasis Lande et al . (chuv.ch)
  • Thus, clonal expansion in CLL may be stimulated by autoantigens occurring naturally during apoptosis. (nih.gov)
  • Diese Tatsache spricht gegen eine Autoantigen-induzierte klonale Expansion von Memory T Zellen und weist auf eine initiale Aktivierung durch ein mögliches Fremdantigen hin. (tu-berlin.de)
  • We propose that this resonance may be a critical principle underlying disease propagation, with specific autoantigens functioning as the hubs around which amplification occurs. (bvsalud.org)
  • For clinical application such DCs are difficult to generate and autoantigens hold the risk of exacerbating the disease. (uni-koeln.de)
  • Initial studies suggest that CLL mAbs bind autoantigens. (nih.gov)
  • We propose that this common motif shared by both autoantigens could be an epitope involved in the initial B-cell triggering event in MN. (manchester.ac.uk)
  • The immunoreactivity of each of these potential autoantigens was tested in radioligand binding assays against 48 alopecia areata patient sera and was detected in 8 (16.7%), 21 (43.8%), and 10 (20.8%) patient serum samples, respectively. (bl.uk)
  • There is evidence to suggest that hair follicle melanocytes are targeted by T lymphocytes, but major pigment cell autoantigens remain unidentified. (bl.uk)
  • Seminal vesicle autoantigen (SVA) is a 19 kDa glycoprotein purified from mouse seminal vesicle secretion. (tmu.edu.tw)