Bone marrow cells. Medical search. Frequent questions

Tampa, Fla. (Dec, 19 2011) - Bone marrow-derived stem cells (BMDCs) have been recognized as a source for transplantation because they can contribute to different cell populations in a variety of organs under both normal and pathological conditions. (eurekalert.org)
Their results are published in the current issue of Cell Transplantation (20:8) now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ . (eurekalert.org)
Six weeks after transplantation, however, more bone marrow-derived microglial cells were observed in the olfactory bulbs of the test animals where the degeneration of mitral cells was still in progress. (eurekalert.org)
This study shows a potential new contribution of bone marrow derived cells following transplantation into the brain, making these cells highly versatile, in their ability to both differentiate into and fuse with endogenous neurons" said Dr. Paul R. Sanberg , coeditor-in-chief of CELL TRANSPLANTATION and distinguished professor of Neuroscience at the Center of Excellence for Aging and Brain Repair, University of South Florida. (eurekalert.org)
The editorial offices for CELL TRANSPLANTATION are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. (eurekalert.org)
This is a real breakthrough - the woman was in isolation due to low white blood cells and high susceptibility to infections and in addition her red blood cells and platelets were low, leading to a very dangerous and life-threatening situation," Reuven Or, director of bone marrow transplantation and cancer immunology at Hadassah, said in a statement. (foxnews.com)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. (nih.gov)
Here we describe the initial results of allogeneic bone marrow transplantation in three children with osteogenesis imperfecta, a genetic disorder in which osteoblasts produce defective type I collagen, leading to osteopenia, multiple fractures, severe bony deformities and considerably shortened stature. (nih.gov)
Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
Preliminary Study of Autologous Bone Marrow Nucleated Cells Transplantation in Children With Spinal Cord Injury. (stembook.org)
Using knockin mice expressing functionally stunted β 3 integrin, we show that bone marrow transplantation rescues impaired angiogenesis in these mice by normalizing BMDC recruitment. (rupress.org)
Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
We identified West Nile Virus RNA in spleen/lymph node homogenate, skin, fat, muscle, tendon, and bone marrow samples obtained postmortem from a donor associated with transmission of West Nile Virus through solid organ transplantation. (cdc.gov)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)

For this type of treatment, bone marrow is collected from a donor. (medlineplus.gov)
But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family. (medlineplus.gov)
Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)
Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
Then, a counselor meets with the donor to discuss the bone marrow donation process. (medlineplus.gov)
Donor stem cells can be collected in two ways. (medlineplus.gov)
Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
The red blood cells are returned to the donor through an IV in the other arm. (medlineplus.gov)
After a bone marrow harvest, the donor stays in the hospital until they're fully awake and can eat and drink. (medlineplus.gov)
Such transplants involve replacing damaged marrow with bone marrow stem cells from a healthy donor. (newscientist.com)
But first, the recipient must have their own bone marrow stem cells wiped out to make room for the transplanted donor cells. (newscientist.com)
It provides a home for donor cells to grow and proliferate, bypassing the need for any drug and radiation treatment. (newscientist.com)
The inner matrix creates a home for donor bone marrow stem cells. (newscientist.com)
Blood cells made by the donor stem cells inside the implant were able to get into circulation where they mixed with the host's own blood cells. (newscientist.com)
Six months later, blood cells from both the donor and host were still circulating around the body. (newscientist.com)
Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. (nih.gov)
If your child's brother or sister will be the bone marrow donor, it's important that his or her questions are answered as well. (bmtinfonet.org)
This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
The process is also less painful for the donor since a needle is not being placed into bone. (differencebetween.net)
The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
The procedure in which bone marrow is extracted from a donor does require the use of either a local or a general anesthetic. (differencebetween.net)
The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
This therapy involves taking stem cells from the bone marrow or peripheral blood from a cancer patient or from a donor. (tgh.org)
To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
Results: Cells from the BM after rasping were significantly more chondrogenic than the donor-matched aspirate, whereas no notable difference in their osteogenic or adipogenic potential was observed. (whiterose.ac.uk)
We are trying to create a state where instead of completely replacing bone marrow with that of their donors, we are creating a mixture of donor and patient cells because we now know that as low as 20% donor cells is enough to reverse sickle cell disease. (medlineplus.gov)

People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
Peripheral blood stem cell collection. (medlineplus.gov)
Pluristem Therapeutics said another patient suffering from bone marrow failure was saved using its placenta-based stem cell treatment. (foxnews.com)
These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
There are several types of bone marrow transplants, also referred to as stem-cell transplants. (emoryhealthcare.org)
This may result in clinicians opting out of pursuing this choice of stem cell therapy. (ivis.org)
We hope that this collection of inspirational stories, poems, and practical advice from bone marrow/stem cell transplant survivors, caregivers, and their families serves as a source of support and warming comfort. (nbmtlink.org)
The best time to discuss a bone marrow or stem cell transplant with your child varies, depending on your child's age. (bmtinfonet.org)
In vivo hematopoietic stem cell modification by mRNA delivery. (davidicke.com)
The process begins with a haematopoietic stem cell ("HSC"), which then goes through a series of steps to arrive at the final product - a mature blood cell. (davidicke.com)
These particles could be tailored to help treat heart disease or to boost the yield of stem cells in patients who need stem cell transplants, Penn Engineering Today wrote. (davidicke.com)
If we could develop technologies that could control cellular activity in bone marrow and the hematopoietic stem cell niche, it could be transformative for disease applications," said Michael Mitchell, one of the study's lead authors. (davidicke.com)
A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
What is Stem Cell Transplant? (differencebetween.net)
Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
A stem cell transplant is when stem cells are harvested from the bloodstream or the umbilical cord. (differencebetween.net)
Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)
Stem Cell Treatment in Puerto Vallarta Mexico presents regenerative medicine solutions based on proven medical innovation and research. (placidway.com)
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Dr. Omar (the owner) did my stem cell implants and It helps my digestion issues, I sleep as never before and it also helps my face skin, it looks smoother and with a nice glow. (placidway.com)
Holistic Care is one of the best stem cell clinics in Mexico and the top conventional and alternative medicine offering Stem Cell Therapy and Biological dentistry. (placidway.com)
To learn more about adipose stem cells (ASCs) and how they heal tissue and have the capacity to cure diseases visit our fat stem cell archives. (cosmeticsurg.net)
Bone marrow transplant (BMT), also known as stem cell therapy (SCT), is a proven treatment for patients with cancers of the blood for which the standard treatments have not been effective or those who have a high risk of relapsing after traditional therapies. (tgh.org)
Hypothesis: The harvest technique of BM may highly influence stem cell heterogeneity and, thus, cartilage formation because these cells have distinct spatial localization within BM from the same bone. (whiterose.ac.uk)
Introduction Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). (bioskinrevive.com)
In this study we asked if MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if artificial cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
DTCs occupy the hematopoietic stem cell niche within the bone marrow [ 5 ], often remaining dormant for years before becoming reactivated, leading to cancer recurrence [ 6 ]. (oncotarget.com)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)
All types of blood cells are derived from 1 common stem cell. (medscape.com)
The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)

Epidermal growth factor receptor (EGFR) and its ligand heparin-binding EGF-like growth factor (HB-EGF) sustain endothelial cell proliferation and angiogenesis in solid tumors, but little is known about the role of HB-EGF-EGFR signaling in bone marrow angiogenesis and multiple myeloma (MM) progression. (uni-wuerzburg.de)
We found that bone marrow endothelial cells from patients with MM express high levels of EGFR and HB-EGF, compared with cells from patients with monoclonal gammopathy of undetermined significance, and that overexpressed HB-EGF stimulates EGFR expression in an autocrine loop. (uni-wuerzburg.de)
Moreover, blockade of HB-EGF-EGFR signaling, by an anti-HB-EGF neutralizing antibody or the EGFR inhibitor erlotinib, limited the angiogenic potential of bone marrow endothelial cells and hampered tumor growth in an MM xenograft mouse model. (uni-wuerzburg.de)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Flow cytometry analysis showed a significantly higher number of hematopoietic stem/endothelial progenitor cell markers in concentrated BMMCs when compared with bone marrow aspirate indicating an enrichment of these cell types. (bioskinrevive.com)
Cytokines and growth factors (interleukin-8 transforming growth factor-beta stromal cell-derived factor-1alpha and vascular endothelial growth factor) that mediate endogenous bone regeneration were also produced by expanded MSCs from SCD patients. (bioskinrevive.com)
We demonstrate that α v β 3 integrin enhances BMDC recruitment and retention at angiogenic sites by mediating cellular adhesion and transmigration of BMDCs through the endothelial monolayer but not their release from the bone niche. (rupress.org)
adipocytes (fat cells) osteoblasts (synthesize bone) osteoclasts (resorb bone) endothelial cells, which form the sinusoids. (wikipedia.org)
These derive from endothelial stem cells, which are also present in the bone marrow. (wikipedia.org)
Intravenous and intranasal pathogenicity tests produced systemic disease with vascular endothelial cell tropism in chickens. (cdc.gov)

Bone marrow stromal cells (BMSC) are multipotent stem cells and are considered good candidates for cell restoration in injured brain tissue. (sld.cu)
These are multipotent stem cells that can differentiate into a variety of cell types. (wikipedia.org)

The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. (jci.org)
Thus the collagen-producing lung fibroblasts in pulmonary fibrosis can also be derived from BM progenitor cells. (jci.org)
The use of mesenchymal stem cells or progenitor cells has been advocated for treatment of many musculoskeletal diseases in the equine. (ivis.org)
Bone marrow and adipose tissue have emerged as excellent sources of progenitor cells. (ivis.org)
In summary our results indicate that infusion of BMMCs enriched with stem/progenitor cells is a safe and effective treatment for the early stages of ONFH in SCD patients. (bioskinrevive.com)
At the cellular level, the main functional component of bone marrow includes the progenitor cells which are destined to mature into blood and lymphoid cells. (wikipedia.org)
citation needed] The red bone marrow is a key element of the lymphatic system, being one of the primary lymphoid organs that generate lymphocytes from immature hematopoietic progenitor cells. (wikipedia.org)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

The goal of BMT is for the donated cells to enter your child's bone marrow and start making new blood cells. (uclahealth.org)
Rest assured that our skilled care team will work to minimize risks and optimize your child's bone marrow transplant recovery. (uclahealth.org)

The current study assessed the effects of bone marrow stromal cells (BMSCs) with forced expression of special AT-rich sequence-binding protein 2 (SATB2) on the osseointegration of titanium implants. (nih.gov)
To determine whether SATB2 overexpression in BMSCs can enhance the osseointegration of implants, BMSCs were infected with the retrovirus encoding Satb2 (pBABE-Satb2) and were locally applied to bone defects before implanting the titanium implants in the mouse femur. (nih.gov)
IHC staining analysis revealed that SATB2-overexpressing BMSCs were intensely distributed in the bone tissue surrounding the implant. (nih.gov)
Histological analysis showed that SATB2-overexpressing BMSCs significantly enhanced new bone formation and bone-to-implant contact 3 weeks after implantation. (nih.gov)
Real-time qRT-PCR results showed that the local delivery of SATB2-overexpressing BMSCs enhanced expression levels of potent osteogenic transcription factors and bone matrix proteins in the implantation sites. (nih.gov)
μCT analysis demonstrated that SATB2-overexpressing BMSCs significantly increased the density of the newly formed bone surrounding the implant 3 weeks post-operatively. (nih.gov)
Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
Bone marrow mesenchymal stem cells (BMSCs) have potential therapeutic benefits for the treatment of endometrial diseases and injury. (biologists.com)
BMSCs interact with uterus parenchymal cells by direct contact or indirect secretion of growth factors to promote functional recovery. (biologists.com)
Bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles have been applied in many diseases . (bvsalud.org)

Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)
A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)

Nature of mononuclear cells positive for acid phosphatase activity in bone marrow of patients with renal osteodystrophy. (bmj.com)

Bone marrow transplant (BMT) can strengthen the body to fight cancer by replacing the blood building cells in the body that are destroyed by chemotherapy and radiation treatments, which are used to kill the cancer cells, with healthy stem cells found in bone marrow. (emoryhealthcare.org)

It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
haematopoietic) is the medical term used to describe the process by which our blood cells are formed, develop and mature into their final "adult" types. (davidicke.com)
Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
If you are a plastic surgeon fascinated with adult stem cells from adipose fat, it gives one time to transcribe your thoughts. (cosmeticsurg.net)
Translation:adipose fat contains a higher population of adult stem cells than bone marrow. (cosmeticsurg.net)
Tampa, FL (Oct. 3, 2022) - As part of its commitment to world-class, innovative cancer care for the Tampa Bay region and beyond, Tampa General Hospital (TGH) Cancer Institute has established an adult Bone Marrow Transplant (BMT) and Cell Therapies unit that focuses on treating patients with aggressive blood cancers such as leukemias, lymphomas, multiple myeloma as well as other cancers. (tgh.org)
Bone marrow stromal cells (BMSC) are adult stem cells with characteristics that make them an attractive candidate in cellular therapy for neurological diseases (1). (sld.cu)
In an adult, roughly half of the bone marrow is still red. (medscape.com)
In adult humans, bone marrow is primarily located in the ribs, vertebrae, sternum, and bones of the pelvis. (wikipedia.org)
Bone marrow comprises approximately 5% of total body mass in healthy adult humans, such that a man weighing 73 kg (161 lbs) will have around 3.7 kg (8 lbs) of bone marrow. (wikipedia.org)

Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
Lymphoblast cells are immature white blood cells that develop into healthy immune cells called lymphocytes. (davidicke.com)
CXCL13 was not expressed by atypical lymphocytes in all cases but did stain stromal cells consistent with follicular dendritic cells in 1 case. (umn.edu)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)
The bone marrow and thymus constitute the primary lymphoid tissues involved in the production and early selection of lymphocytes. (wikipedia.org)

Cultured lung fibroblasts expressed the chemokine receptors CXCR4 and CCR7 and responded chemotactically to their cognate ligands, stromal cell-derived factor-1α and secondary lymphoid chemokine, respectively. (jci.org)
The stromal cell products responsible for these effects of estrogens have not been identified. (jci.org)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Each kit includes exosomes isolated from either HEK293 cells or JAWS II mouse bone marrow dendritic cells and Exo-Fect-a novel transfection reagent that enables the transfer of RNAs, DNAs (including plasmids), and small molecules directly into isolated exosomes. (reportergene.com)

If a person experiences serious blood loss, yellow bone marrow can be activated and transformed into red bone marrow. (medscape.com)
As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)

Here, we investigate the function of MM-derived MIF in the MM microenvironment by examining its effects on bone marrow stromal cells (BMSC). (biomedcentral.com)
To investigate the effects of MIF secretion by MM on its microenvironment, we used cytokine arrays to establish if cytokine changes occur when MM cells are cultured with primary BMSC. (biomedcentral.com)
This is most likely attributable to the very different microenvironment of the bone marrow relative to lymph nodes and, in particular, the absence of follicles in bone marrow. (umn.edu)
Stromal cells may be indirectly involved in hematopoiesis, providing a microenvironment that influences the function and differentiation of hematopoietic cells. (wikipedia.org)

The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)

It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. (wikipedia.org)

For the Pediatric Blood and Bone Marrow Transplant & Cellular Therapies Program, please call 310-825-6708 . (uclahealth.org)
However, we are just beginning to realize the power of an emerging field known as cell therapies. (tgh.org)
In our BMT and Cell Therapies unit, we aim to provide these therapies as well as make groundbreaking contributions to the field through innovative research. (tgh.org)
After several months of careful planning and designing, the TGH Cancer Institute BMT and Cell Therapies Unit opened in Spring 2022. (tgh.org)
Bone marrow transplant and now cell therapies can significantly increase the chance of recovery from blood cancers and, hopefully soon, of patients with solid malignancies," said Dr. Abraham Schwarzberg, chief of oncology and senior vice president of network development at Tampa General. (tgh.org)
The TGH Cancer Institute's BMT and Cell Therapies Unit reflects the Institute's philosophy of bringing together a range of multidisciplinary specialties that strongly emphasizes compassionate and personalized care focusing on the whole patient. (tgh.org)
Tampa General's cancer physicians offer a highly coordinated range of multidisciplinary specialties such as hematologic malignancies, thoracic, breast, colorectal, gynecologic oncology, and now bone marrow transplant and cell therapies. (tgh.org)
However, for cell therapies MSC have to be expanded and/or manipulated to obtain a sufficient amount of cells that can be subsequently used for treatment. (biomedcentral.com)

But we also have provided the first evidence that BMDCs can contribute simultaneously to different encephalic areas through different mechanisms of plasticity - cell fusion for Purkinje cells - among the largest and most elaborately dendritic neurons in the human brain - and differentiation for olfactory bulb interneurons. (eurekalert.org)
The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-foetal globin genes in human erythroleukemia K562 cells, bioRvix. (davidicke.com)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
In this work, for the first time, we adopt a multidisciplinary approach to characterize the morphological, biochemical, and molecular changes underlying the response of human bone marrow stromal cells to long-term simulated microgravity exposure during osteogenic differentiation. (lu.se)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

In this study, researchers grafted bone marrow cells into mutant mice suffering from the degeneration of specific neuronal populations at different ages, then compared them to similarly transplanted healthy controls. (eurekalert.org)
When placed beneath the skin in mice, the implant grew into a bone-like structure and produced a working marrow. (newscientist.com)
Induction of pulmonary fibrosis in such chimera mice by endotracheal bleomycin (BLM) injection caused large numbers of GFP+ cells to appear in active fibrotic lesions, while only a few GFP+ cells could be identified in control lungs. (jci.org)
Flow-cytometric analysis of lung cells confirmed the BLM-induced increase in GFP+ cells in chimera mice and revealed a significant increase in GFP+ cells that also express type I collagen. (jci.org)
Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
Because mouse models represent a crucial tool with which to study cancer metastasis, we developed a novel method for the simple selection-free detection and quantification of bone marrow DTCs in mice. (oncotarget.com)
We are able to detect and quantify bone marrow DTCs in mice that do not have overt bone metastasis. (oncotarget.com)
1 × 10 6 MM.1S-luc cells (ShE control n = 10, and ShMIF n = 7) were injected via the tail vein of 6-8-week-old NSG mice. (biomedcentral.com)
Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
QRT- PCR results indicated that miR-148a-5p was lowly expressed in both thioacetamide (TAA)-induced mice and TGF-ß1-activated hepatic stellate cells . (bvsalud.org)

Bone marrow contains stem cells, which are immature cells that become blood cells. (medlineplus.gov)
citation needed] The blood vessels of the bone marrow constitute a barrier, inhibiting immature blood cells from leaving the marrow. (wikipedia.org)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
Therefore, Fgfr3 + endosteal SSCs are abundant in young bone marrow and provide a robust source of osteoblasts, contributing to both normal and aberrant osteogenesis. (nature.com)
Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
MSCs have been shown to differentiate, in vitro or in vivo, into osteoblasts, chondrocytes, myocytes, marrow adipocytes and beta-pancreatic islets cells. (wikipedia.org)

Bone marrow is the soft, fatty tissue inside your bones. (medlineplus.gov)
Bone marrow is the spongy tissue present inside the centre of bones. (newscientist.com)
They have their own bone tissue and now an additional one that can be used if needed. (newscientist.com)
The study will test if these cells preserve injured brain tissue after traumatic injury. (childrenslearninginstitute.org)
Background: Connective tissue progenitors (CTPs) from native bone marrow (BM) or their culture-expanded progeny, often referred to as mesenchymal stem/stromal cells, represents a promising strategy for treatment of cartilage injuries. (whiterose.ac.uk)
Figure S2: Evaluation from the viral titer in dendritic cells from your skin and bone tissue marrow of C57BL/6 and HVEM? (mingsheng88.org)
One great advantage of MSC is that these cells may be directly obtained from individual patients, thereby eliminating the complications associated with immune rejection of allogenic tissue and infectious diseases. (biomedcentral.com)
Bone marrow is the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
Bone marrow can be 1 of 2 types, red or yellow, depending on whether it consists of mainly hematopoietic (and therefore, red-colored) tissue or fatty (and therefore a yellow-colored) tissue. (medscape.com)
Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. (wikipedia.org)
Hematopoietic stem cells in the bone marrow can give rise to hematopoietic lineage cells, and mesenchymal stem cells, which can be isolated from the primary culture of bone marrow stroma, can give rise to bone, adipose, and cartilage tissue. (wikipedia.org)
The composition of marrow is dynamic, as the mixture of cellular and non-cellular components (connective tissue) shifts with age and in response to systemic factors. (wikipedia.org)
The stroma of the bone marrow includes all tissue not directly involved in the marrow's primary function of hematopoiesis. (wikipedia.org)
Cell types that constitute the bone marrow stroma include: fibroblasts (reticular connective tissue) macrophages, which contribute especially to red blood cell production, as they deliver iron for hemoglobin production. (wikipedia.org)
Since the 1990s, to do a bone marrow transplant, a patient had to have a sibling with a complete tissue match and take a medication that suppresses their immune system (Cyclophosphamide), as well as high dose chemotherapy. (medlineplus.gov)
Eight weeks after the donor's death, skin samples that had been treated in cryopreservative solution containing an antibiotic and unprocessed fat, muscle, tendon, and bone samples, all of which had been stored frozen at -70° Celsius at a tissue bank, were transferred to CDC. (cdc.gov)

The pediatric bone marrow transplant team at UCLA Health provides compassionate care to help give your child the best possible recovery from bone marrow transplant (BMT). (uclahealth.org)

abstract = "Angioimmunoblastic T-cell lymphoma is known to frequently involve bone marrow. (umn.edu)

The dynamic titration of viruses during contamination suggested that HSV-1 offered a higher replication rate in untreated JAWSII dendritic cells than in cells treated with specific antibodies against HVEM or gD molecules (Physique 1A). (mingsheng88.org)
The upregulation of some surface markers of dendritic cell maturation, such as CD83 and MHC-I [20,21,22], was also observed in virus-infected JAWSII-dendritic cells compared with antibody-blocking cells (Physique 1D). (mingsheng88.org)
These results show that HSV-1 enables the infection of dendritic cells via the conversation between gD and HVEM, followed by viral replication. (mingsheng88.org)
This event prospects to an innate immune response of dendritic cells against the computer virus followed by their transfer of viral antigenic information to the adaptive immune system. (mingsheng88.org)
Open in a separate window Physique 1 HSV-1 enters dendritic cells via the binding of gD protein to the HVEM receptor and replicates in the cells. (mingsheng88.org)
The untreated JAWSII dendritic cells were deemed the experimental group, and the two groups of JAWSII dendritic cells treated with anti-gD specific antibody or anti-HVEM specific antibody were deemed the antibody blocking group. (mingsheng88.org)
The relative expression levels of inflammatory cytokines in JAWSII dendritic cells were normalized to their levels in the Bafilomycin A1 blank control group by using the comparative Ct (Ct) method. (mingsheng88.org)
Antibodies specific for CD21 and CD35 did not highlight follicular dendritic cells in any biopsy specimens. (umn.edu)
We conclude that the recognition and classification of angioimmunoblastic T-cell lymphoma in bone marrow are made difficult by the uncommon expression of CD10 (25%), rarity of follicular dendritic cells, and lack of CXCL13 expression at this site. (umn.edu)

Bone marrow is also an important part of the lymphatic system. (medscape.com)
Furthermore, bone marrow performs a valve-like function to prevent the backflow of lymphatic fluid in the lymphatic system. (wikipedia.org)

Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)

Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
The investigation of cell proteome highlighted how simulated microgravity affects a relatively low number of proteins compared to time and/or osteogenic factors and has allowed us to reconstruct a hypothetical pipeline for cell response to simulated microgravity. (lu.se)

Additionally, it will explain the techniques of collecting, packaging, and transporting bone marrow aspirates for collection, expansion, and 150 injections into diseased tissues. (ivis.org)

Use the EV Shuttle Kit for a range of applications including cargo delivery for therapeutic development, virus-free creation of stable cell lines, and gene delivery in hard-to-transfect cells. (reportergene.com)
With a variety of assays we could show that MSC represent a cell population which can be expanded for therapeutic applications. (biomedcentral.com)
In recent years mesenchymal stem cells (MSC) have generated a great deal of interest as a potential source for cell-based therapeutic strategies. (biomedcentral.com)

The authors feel that it is important to aspirate bone marrow at the region of the tuber coxae located one-half of the way between the dorsal, ventral, and cranial border and caudal border. (ivis.org)
Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)

high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
I wanted to develop a way to have half-match donors contribute bone marrow and for the outcomes to be successful. (medlineplus.gov)

We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
We also found that levels of EGFR and HB-EGF parallel MM plasma cell number, and that HB-EGF is a potent inducer of angiogenesis in vitro and in vivo. (uni-wuerzburg.de)
Following in vitro exposure to CTX, hBMSCs showed decreased cell growth in a dose- and time-dependent manner, accompanied by increased expressions of collagen-I/III, and CD31. (ijbs.com)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

The patient, a 54 year-old woman with lymphoma cancer, was treated with chemotherapy but her condition continued to deteriorate, necessitating a bone marrow transplant. (foxnews.com)
After the patient receives high-dose chemotherapy, the collected stem cells are thawed and given back to the cancer patient through an intravenous infusion (IV) to produce blood cells and to re-establish a healthier immune system. (tgh.org)
However, the fate of stem cells under chemotherapy has not been fully elucidated. (ijbs.com)
Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)

These cells are also tartrate resistant and non-specific esterase negative, and are believed to be precursors to osteoclasts and other acid phosphatase positive cells resorbing bone on the trabecular surface. (bmj.com)

Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. (oncotarget.com)
Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)

Bone marrow harvest. (medlineplus.gov)
How to Harvest Bone Marrow Derived Mesenchymal Stem Cells for Expansion and Injection. (ivis.org)
Methods: CTPs obtained from the femur of patients undergoing total hip replacement by 2 harvest techniques-BM aspiration and BM collection-after bone rasping were immunophenotyped by flow cytometry and evaluated for chondrogenic ability. (whiterose.ac.uk)
Since the iliac crest remains a frequent site of BM harvest for musculoskeletal regeneration, the authors also compared the spatial distribution of these subsets in trabeculae of femoral head and iliac crest and found CD2711CD561 bone-lining cells in both tissues. (whiterose.ac.uk)
Clinical Relevance: The harvest technique of BM may be of major importance in determining the clinical success of BM mesenchymal stem/stromal cells in cartilage repair. (whiterose.ac.uk)

Angiogenesis is dependent on the coordinated action of numerous cell types. (rupress.org)
Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β 3 integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. (rupress.org)

The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)
Previous studies indicated that exosomal miR-29a-3p derived from human bone mesenchymal stem cells (hBMSCs) could efficiently suppress cell migrative ability and vasculogenic mimicry in glioma [ 15 ]. (hindawi.com)
Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. (atsbio.com)
Caneva L, Soligo D, Cattoretti G, De Harven E, Deliliers GL (1995) Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. (atsbio.com)
Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)

But the cartilage regeneration capacity of these cells remains unpredictable because of cell heterogeneity. (whiterose.ac.uk)

Since the implant contributes to the host's blood supply, rather than replacing it altogether, it cannot be used to treat people who have blood cancers, who would still need to have their own bone marrow stem cells wiped out to cure the disease. (newscientist.com)
Emily Meier, MD, Director of the Sickle Cell Disease Program , discusses bone marrow transplants at Children's National and some of the complications of sickle cell disease. (childrensnational.org)
Introduction Sickle cell disease (SCD) is the most common inherited blood disease with a worldwide distribution. (bioskinrevive.com)
Depending upon the particular genotype and severity of the SCD the prevalence of ONFH ranges from 3 to 50 % among SCD patients [4 5 Osteonecrosis can be viewed as a vascular and bone disease with altered bone remodeling. (bioskinrevive.com)
Bone metastasis is a lethal and incurable disease. (oncotarget.com)
Beyond single DTCs, death from bone metastasis may also be due to dissemination of disease via metastatic re-seeding from other secondary sites [ 7 , 8 ]. (oncotarget.com)
however, little has been done to investigate the MM cell's ability to 're-program' cells within its environment to benefit disease progression. (biomedcentral.com)
Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, prior to any cell-cell contact. (biomedcentral.com)
Sickle cell disease (SCD) specialists have performed bone marrow transplants in children since the 1990s. (medlineplus.gov)
I'm hoping our research can go beyond sickle cell disease to have a bigger impact. (medlineplus.gov)
Then when we developed a half-matched protocol, half of the patients eventually rejected the cells, and the disease came back. (medlineplus.gov)
It's an exciting time for sickle cell disease research. (medlineplus.gov)
The number one disease among newborn babies is sickle cell disease. (medlineplus.gov)
B19 is the primary etiologic agent causing TAC in patients with chronic hemolytic anemias (e.g., sickle cell disease, hemoglobin SC disease, hereditary spherocytosis, alpha-thalassemia, and autoimmune hemolytic anemia) (22,23). (cdc.gov)

We assessed 27 bone marrow specimens involved by angioimmunoblastic T-cell lymphoma from 20 patients. (umn.edu)
West Nile Virus RNA was detected in samples from the spleen/lymph node, skin, and fat associated with the tibia bone, as well as 1 of 2 muscle specimens, 1 of 4 tendon specimens, and 1 of 2 bone marrow specimens. (cdc.gov)

Both types of bone marrow are highly vascular, being enriched with numerous blood vessels and capillaries. (medscape.com)

In this study, exosomes from bone marrow plasma were successfully extracted and identified. (techscience.com)
Put exosomes to work-directly transfect JAWS II exosomes with RNA, plasmids, metabolites, or other small molecules for delivery to recipient cells. (reportergene.com)
The Kit comes with all of the reagents you need to load cargo into exosomes and concentrate them for delivery to target cells. (reportergene.com)
JAWS II mouse dendritic cell exosomes were incubated with Exo-Fect and 100 pmol Texas Red-conjugated siRNA (non-targeting control included in the EV Shuttle Kits). (reportergene.com)

however, lymphoid cells must migrate to other lymphoid organs (e.g. thymus) in order to complete maturation. (wikipedia.org)

Previous studies revealed that inhibition of miR-744-3p could restore PTEN expression, and then suppressed laryngeal squamous cell carcinoma progression [ 20 ], suggesting that upregulation of PTEN could contribute to cancer development. (hindawi.com)
Bone marrow loss and a high proclivity to leukemic progression are the characteristics of myelodysplastic syndrome (MDS). (techscience.com)

However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The factors and cellular processes required for the induction of dormancy and subsequent tumor cell reactivation remain largely undefined [ 6 ]. (oncotarget.com)

When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)

Fifty two of 63 patients with renal osteodystrophy had one or more mononuclear cells positive for acid phosphatase in the marrow. (bmj.com)

These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)

The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)

The improvements observed in this and a previous patient treated with PLX cells demonstrate that these cells could potentially assist in the recovery of bone marrow following bone marrow transplant failure or other conditions where the bone marrow is significantly compromised, Pluristem said. (foxnews.com)

These may be attributed to the changes in the functional status of stem cells. (ijbs.com)

The cells or blood is then tested for special proteins, called human leukocytes antigens (HLAs). (medlineplus.gov)

Anatomy48

Organisms18

Diseases43

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes50

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Named Groups1

Health Care3

Transplantation24

Donor30

Stem cell31

Endothelial10

Multipotent stem2

Progenitor9

Child's bone marrow2

BMSCs11

Donor's bone marrow2

Activity in bone marrow1

Found in bone marrow1

Adult10

Lymphocytes5

Stromal cell3

Mouse bone marrow2

Yellow bone m2

Microenvironment4

BMSC1

Adipose tissue1

Therapies8

Differentiation10

Mice11

Immature3

Osteoblasts6

Tissue18

Pediatric bone1

Abstract1

Dendritic cells9

Lymphatic system2

Transplants involve1

Osteogenic3

Diseased tissues1

Therapeutic3

Aspirate2

Donors3

Vitro6

Chemotherapy5

Precursors1

Tumor cells2

Harvest5

Angiogenesis2

Human bone5

Cartilage1

Disease14

Specimens2

Vascular1

Exosomes4

Lymphoid cells1

Progression2

Vivo1

Cellular2

Stimulates1

Mononuclear1

Cytokines1

Spleen1

Significantly1

Functional1

Called human1