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Cell Adhesion MoleculesCell AdhesionNeural Cell Adhesion MoleculesCell Adhesion Molecules, NeuronalVascular Cell Adhesion Molecule-1Neural Cell Adhesion Molecule L1Intercellular Adhesion Molecule-1Activated-Leukocyte Cell Adhesion MoleculeE-SelectinLeukocyte L1 Antigen ComplexCadherinsIntegrinsEndothelium, VascularCells, CulturedCell MovementAntigens, CD31Sialic AcidsMolecular Sequence DataAntigens, CDCell Adhesion Molecules, Neuron-GliaFocal AdhesionsTissue AdhesionsP-SelectinIntegrin alpha4beta1Cell AggregationAntigens, CD146Lymphocyte Function-Associated Antigen-1Antibodies, MonoclonalAmino Acid SequenceContactin 2Cell LineReceptors, Lymphocyte HomingFibronectinsLeukocytesProtein BindingContactinsSignal TransductionAntigens, SurfaceEndothelial CellsImmunoglobulinsImmunohistochemistryFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesAntigens, CD18Junctional Adhesion MoleculesMembrane GlycoproteinsCell CommunicationL-SelectinUmbilical VeinsBacterial AdhesionAntigens, CD29RNA, MessengerIntegrin alpha4Mice, Inbred C57BLNeuritesTransfectionBase SequenceMembrane ProteinsMucoproteinsFlow CytometryChick EmbryoProtein Structure, TertiaryFluorescent Antibody TechniqueTumor Necrosis Factor-alphaSelectinsLamininTumor Cells, CulturedCell MembraneMonocytesMice, KnockoutUp-RegulationReceptors, Very Late AntigenIntercellular JunctionsGene Expression RegulationExtracellular MatrixRecombinant ProteinsBlotting, WesternSialyltransferasesCytoskeletal ProteinsInflammationEpithelial CellsRecombinant Fusion ProteinsBinding SitesCell Line, TumorNeutrophilsAxonsAntigens, NeoplasmLeukocyte RollingGene ExpressionCell DifferentiationCytoskeletonNeuronsAnkyrinsAntigens, CD44alpha CateninMicroscopy, FluorescenceAntibodiesLigandsMacrophage-1 AntigenReverse Transcriptase Polymerase Chain Reaction
Endothelial cell adhesionDifferentiationProteinsVascular Cell AdhesionExpressionEpithelialNCAMMucosal addressin cellAbstractELISA KitProteinCytokinesLeukocyte adhesion and transmigrationReceptorsALCAMTumorExtracellular regionMigrationTransmigrationCD56JunctionalMediatesHomophilicEndotheliumTissuesMolecularIntegrinsVitroPeptideNeuronsApoptosisAntibodiesLigandsSurfaceInflammationSynapticCellularMembraneNeural cellProliferationEmbryonic stemMononuclear cellHeterophilicTissueDysfunctionInhibitorSuperfamilyMicroscopyFunctionalGeneGlial cells
Endothelial cell adhesion3
  • Elevated lavels of soluble tumour necrosis factor receptor 1, thrombomodulin and soluble endothelial cell adhesion molecules in patients with dengue haemorrhagic fever. (who.int)
  • The endothelial cell adhesion molecules like the integrin alpha v beta 3 (αvβ3) and E-selectin get excited about the procedure of angiogenesis necessary for tumour growth cell migration and metastasis. (biopaqc.com)
  • Concentrating on nanocarriers (NC to endothelial cell adhesion molecules including Platelet-Endothelial Cell Adhesion Molecule-1 (PECAM-1 or CD31) improves drug delivery and pharmacotherapy of inflammation Sodium Channel inhibitor 1 oxidative stress thrombosis and ischemia in animal models. (biomasswars.com)
Differentiation10
  • Integrins provide essential links between the extracellular environment and the intracellular signalling pathways, which can play roles in cell behaviours such as apoptosis, differentiation, survival, and transcription. (wikipedia.org)
  • The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. (nih.gov)
  • TGF-β1 plays a crucial role in a wide variety of cellular processes, such as cell proliferation, differentiation, adhesion, and apoptosis [ 12 ]. (biomedcentral.com)
  • EpICD travels to the nucleus and joins with other proteins, forming a group (complex) that regulates the activity of several genes that are involved in many cell processes, including growth and division (proliferation), maturation (differentiation), and movement (migration), all of which are important processes for the proper development of cells and tissues. (medlineplus.gov)
  • 2004 In human being and mouse EpCAM is definitely indicated in embryonic epithelia but the levels usually drop as cells reach terminal differentiation (Trzpis et al. (techblessing.com)
  • Adhesion molecule signaling is crucial to individual pluripotent stem cell (hPSC) success self-renewal and differentiation. (research-in-field.com)
  • We have generated a murine embryonic stem cell line constitutively expressing L1 at all stages of neural differentiation to investigate the effects of L1 overexpression on stem cell proliferation, migration, differentiation, cell death, and ability to influence drug-induced rotation behavior in an animal model of Huntington's disease. (johnshopkins.edu)
  • L1-transfected cells showed decreased cell proliferation in vitro, enhanced neuronal differentiation in vitro and in vivo, and decreased astrocytic differentiation in vivo without influencing cell death compared with nontransfected cells. (johnshopkins.edu)
  • A la I Conferència i Taller Internacional sobre diferenciació dels antígens leucocitaris humans , celebrada a París el 1982, fou aprovada la terminologia CD (cúmul o grup de diferenciació [18] o cluster of differentiation en anglès). (wikipedia.org)
  • This program is also seeking to capitalize on the latest advances in single cell omics and data science to better understand cellular functions in the normal lung (progenitor cell differentiation, proteostasis, mitochondrial function, cytoskeletal function, etc.) and to determine how specific functions of lung cells are altered in particular pulmonary diseases. (nih.gov)
Proteins14
  • Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. (wikipedia.org)
  • There are four major superfamilies or groups of CAMs: the immunoglobulin super family of cell adhesion molecules (IgCAMs), Cadherins, Integrins, and the Superfamily of C-type of lectin-like domains proteins (CTLDs). (wikipedia.org)
  • The classic cadherins (E-, N- and P-) are concentrated at the intermediate cell junctions, which link to the actin filament network through specific linking proteins called catenins. (wikipedia.org)
  • These fascinating proteins illustrate how a better understanding of the CEACAM family of cell adhesion molecules reveals their functional link to the underlying disease and lead to new monitoring and targeting opportunities. (nih.gov)
  • Specifically, changes in the types of transmembrane proteins that serve as neuronal adhesion molecules, as described below, have been measured in models of brain injury ( Table 1 ). (medscape.com)
  • Beyond the scope of this review are non-neuronal vascular and glial cell adhesion proteins, extracellular matrix adhesion proteins and a variety of secreted proteins that have been implicated in TBI-associated changes in histopathology, physiology or behavior in animals. (medscape.com)
  • This study demonstrates that MFG-hESC lines overexpress cell attachment proteins but retain the typical characteristics of undifferentiated feeder-cultured hESCs. (benthamopen.com)
  • Neural Cell Adhesion Molecule L1 Proteins manufacturer Effects of Injection of a Plasmid Encoding rhVEGF165 on Esophageal Ulcer HealingIn rats undergoing gene therapy, promptly following ulcer induction either one hundred g of plasmid DNA encoding the full-length cDNA of rhVEGF165 (VEGF group) or 100 g of plasmid devoid of cDNA insert (control group) was injected in to the esophageal muscle layers around the area of ulcer induction. (bet-bromodomain.com)
  • The identified proteins fall into several functional clusters including calcium homeostasis, transporters, vesicular proteins/exocytosis, regulatory proteins and cell surface proteins which points to pleiotropism of Neuroplastin in various cellular functions. (edu.sa)
  • CheKine™ microquantitative test kits and recombinant proteins help you explore cells with ease! (abbkine.com)
  • E-cadherin belongs to a family of proteins called cadherins whose function is to help neighboring cells stick to one another (cell adhesion) to form organized tissues. (nih.gov)
  • We examined representative proteins in several of these categories using super-resolution imaging, including previously unknown MPS structural components, as well as motor proteins, cell adhesion molecules, ion channels, and signaling proteins, and observed periodic distributions characteristic of the MPS along the neurites for ~20 proteins. (nature.com)
  • Genetic perturbations of the MPS and its interacting proteins further suggested functional roles of the MPS in axon-axon and axon-dendrite interactions and in axon diameter regulation, and implicated the involvement of MPS interactions with cell adhesion molecules and non-muscle myosin in these roles. (nature.com)
  • 7. Cell adhesion proteins as tumor suppressors. (nih.gov)
Vascular Cell Adhesion2
Expression23
  • One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. (nih.gov)
  • For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. (nih.gov)
  • 1 Among haematological malignancies, CD56 expression has been described mainly in NK/T cell lymphoma, plasma cell myeloma and acute myeloid leukaemia, and rarely in B cell lymphomas, accounting for no more than 0.5% of all B lymphomas. (bmj.com)
  • The upregulation of epithelial cell adhesion molecule (EpCAM) expression, found in a substantial fraction of renal cell carcinomas (RCCs), renders it a potential molecular target for the treatment of disseminated RCC. (spandidos-publications.com)
  • Monolayers were subsequently washed and incubated with medium alone or containing the pro-inflammatory cytokine IL-1β (5 ng/mL) for 6 h to upregulate pro-atherosclerotic adhesion molecules (AM). AM expression was assayed by ELISA and binding of U937 human monocytes pre-loaded with fluorescent dye was determined. (biomedcentral.com)
  • These data provide evidence that dietary mushrooms can inhibit cellular processes such as adhesion molecule expression and ultimate binding of monocytes to the endothelium under pro-inflammatory conditions, which are associated with CVD. (biomedcentral.com)
  • The enhanced cell adhesion observed upon activation of leukocytes is associated with increased surface membrane expression of CD11/CD18, as well as a qualitative upregulation of CD11/CD18 functions. (rupress.org)
  • Treatment of endometriotic cyst stromal cells with TGF-β1 resulted in an obvious promotion of cell proliferation, migration, and invasion, and strikingly increased the protein expression of VCAM-1. (biomedcentral.com)
  • TGFβ-RI activates the intracellular Smad signaling system and in turn regulates the expression of the TGF-β1-responsive genes, which are involved in cell proliferation, motility, invasion, and metastasis [ 14 , 15 ]. (biomedcentral.com)
  • In addition, cancer cells of gastric and pancreatic origins were used to create cell models with decreased or increased levels of ALCAM expression by genetic knocking down or overexpression, respectively. (glos.ac.uk)
  • Human peritoneal mesothelial cells were also genetically transfected to generate cell models with different profiles of ALCAM expression. (glos.ac.uk)
  • The extra methyl groups attached to the MSH2 promoter reduce the expression of the MSH2 gene, which means that less protein is produced in epithelial cells. (medlineplus.gov)
  • Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen. (bvsalud.org)
  • Analysis of JAM-C subcellular expression by immunoelectron microscopy indicated that in I/R-injured tissues, EC JAM-C was redistributed from cytoplasmic vesicles and EC junctional sites to nonjunctional plasma membranes, a response that may account for the role of JAM-C in both leukocyte adhesion and transmigration under conditions of I/R injury. (unige.ch)
  • Altered expression of neuronal cell adhesion molecules induced by nerve damage and repair. (pradeepyogi.com)
  • Immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) expression was examined in the rat with repeated exposure to amygdaloid kindled generalized seizures (GS). (elsevierpure.com)
  • As PSA-NCAM is involved in neural plasticity as well as migration of neural stem cells (NSC), expression of PSA-NCAM in the SVZ suggests that the recurrent GS may mainly contribute to reconstruction of synaptic network and could also contribute to NSC migration after kindling. (elsevierpure.com)
  • Gene expression of E- and P-selectin, ICAM-1, PECAM-1, VCAM-1, tissue factor, and vWF in human cerebral microvascular endothelial cells was quantified by RT-qPCR at different radiation doses and time points. (hindawi.com)
  • Following radiosurgery, AVM endothelial cells undergo apoptosis release IL-1 β which acts as an autocrine signal to enhance endothelial cell apoptosis and also as a paracrine signal to induce expression of endothelial adhesion molecules and proinflammatory cytokines on surrounding endothelial cells [ 7 ]. (hindawi.com)
  • Expression of adhesion molecules including E-selectin, P-selectin, ICAM-1, PECAM-1, and VCAM-1 is upregulated following irradiation [ 8 ]. (hindawi.com)
  • Subsequently, we characterized Schwann cell migration and gene expression in vitro . (frontiersin.org)
  • Furthermore, the 0.02% fingolimod-loaded fibers enhanced neurite outgrowth from whole and dissociated DRG neurons, increased Schwann cell migration, and reduced the Schwann cell expression of promyelinating factors. (frontiersin.org)
  • 9. Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis. (nih.gov)
Epithelial8
  • In epithelial cell lines, overexpression of GlialCAM increases cell adhesion and motility but also inhibits cell growth in tumor cell lines, leading to senescence. (nih.gov)
  • The EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). (medlineplus.gov)
  • This protein is found in epithelial cells, which are the cells that line the surfaces and cavities of the body. (medlineplus.gov)
  • The EpCAM protein is found spanning the membrane that surrounds epithelial cells, where it helps cells stick to one another (cell adhesion). (medlineplus.gov)
  • This condition is characterized by abnormal development of epithelial cells in the intestines. (medlineplus.gov)
  • In particular, they have "tufts" of extra epithelial cells on their tips. (medlineplus.gov)
  • The resulting loss of EpICD signaling leads to abnormal development of intestinal epithelial cells, causing congenital tufting enteropathy. (medlineplus.gov)
  • This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body, such as the inside of the eyelids and mouth. (nih.gov)
NCAM7
  • CD56, the neural cell adhesion molecule (NCAM), is a member of the immunoglobulin superfamily and is associated with cell-to-cell adhesion and migration. (bmj.com)
  • The neural cell adhesion molecule 1 (NCAM-1) has been implicated in several brain-related biological processes, including neuronal migration, axonal branching, fasciculation, and synaptogenesis, with a pivotal role in synaptic plasticity. (uni-bielefeld.de)
  • A synthetic peptide termed FGL derived from the neural cell adhesion molecule (NCAM) was able to prevent or, if already manifest, strongly reduce all investigated signs of Abeta25-35-induced neuropathology and cognitive impairment. (nih.gov)
  • Le Gal La Salle G, Rougon G, Valin A. The embryonic type of neural cell surface molecule (E-NCAM) in the rat hippocampus and its reexpression on glial cells following kainic acid-induced standing epilepticus. (pradeepyogi.com)
  • Le Gal La Salle G, Rougon G, Valin A. The embryonic form of neural cell floor molecule (E-NCAM) within the rat hippocampus and its reexpression on glial cells following kainic acid-induced status epilepticus. (bntintl.com.sg)
  • The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these changes, because it is known to influence the dendritic organization of adult cortical interneurons. (nih.gov)
  • The number of PSA-NCAM positive cells increased four times in the bilateral SVZ after three consecutive GS, with a further increase after 30 consecutive GS. (elsevierpure.com)
Mucosal addressin cell3
  • Gentaur/Genprice team of specialist recommend you to follow strickly the protocol for storage of the EIA kit for Human Mucosal Addressin Cell Adhesion Molecule-1,Madcam-1 .Prepare small work solutions from the standard reagents to avoid processes of freezing and thawing. (th1cells.com)
  • The product EIA kit for Human Mucosal Addressin Cell Adhesion Molecule-1,Madcam-1 is manufactured for research purposes only and it is not intented to be used for in vitro diagnostic procedures. (th1cells.com)
  • In the present study, mucosal addressin cell adhesion molecule-1 was selectively expressed on α- smooth muscle actin -positive reticular framework. (bvsalud.org)
Abstract1
  • Abstract: DESCRIPTION (provided by applicant): Sickle cell disease (SCD) is characterized by acute clinical manifestations, including painful crisis, acute chest syndrome, priapism, and stroke, as well as chronic irreversible damage to the heart, lungs, kidneys, eyes, spleen and femoral heads. (nih.gov)
ELISA Kit3
  • You need info about Human Activated Leukocyte Cell Adhesion Molecule (ALCAM) ELISA Kit or any other Gentaur produtct? (gentaurshop.com)
  • cell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the Mucosal Addressin Adhesion Molecule-1,Madcam-1 ELISA Kit.For cells, cell lines and tissues in culture till half confluency.Whole adhesion and interacting molecules are present in lysates used as reference for ELISA quantification of these molecules and their subunits. (th1cells.com)
  • Description: A sandwich ELISA kit for detection of L1-Cell Adhesion Molecule from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
Protein18
  • This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. (nih.gov)
  • The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. (nih.gov)
  • This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. (nih.gov)
  • This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). (nih.gov)
  • Background: Junctional adhesion molecule (JAM-) A is a transmembrane protein expressed in many cell types and maintains junctional integrity in endothelial cells. (maastrichtuniversity.nl)
  • Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a cell-cell adhesion protein conferring heterotypic and homotypic interactions between cells of the same type and different types. (glos.ac.uk)
  • Pool of 102 peptides derived from a peptide scan (15mers with 11 aa overlap) through Hepatocyte cell adhesion molecule protein (Uni-Prot ID Q14CZ8) of Homo sapiens (Human). (peptides.de)
  • In addition, the protein in the cell membrane can be cut at a specific location, releasing a piece called the intracellular domain (EpICD), which helps relay signals from outside the cell to the nucleus of the cell. (medlineplus.gov)
  • loss of this protein prevents proper DNA repair, and errors accumulate as the cells continue to divide. (medlineplus.gov)
  • Furthermore, FGL-treatment was shown to inhibit the activity of GSK3beta, a kinase implicated in signaling regulating cell survival, tau phosphorylation and the processing of the amyloid precursor protein (APP). (nih.gov)
  • 1999 The protein can act as a homophilic Ca2+-self-employed cell-cell adhesion molecule (Litvinov et al. (techblessing.com)
  • Armadillo (Arm), an element from the Wg pathway, may be the homolog from the cell junction protein -catenin (kitty) and plakoglobin (McCrea et al. (researchensemble.com)
  • Janeczko K. The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat mind. (bntintl.com.sg)
  • Another protein called p120-catenin, produced from the CTNND1 gene, helps keep E-cadherin in its proper place in the cell membrane, preventing it from being taken into the cell through a process called endocytosis and broken down prematurely. (nih.gov)
  • E-cadherin also acts as a tumor suppressor protein, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. (nih.gov)
  • Researchers believe that the resulting loss of E-cadherin protein may allow breast cells to grow and divide unchecked, leading to a cancerous tumor. (nih.gov)
  • A lack of this protein, which is critical for cell adhesion, may also make it easier for cancer cells to detach from a primary tumor and spread (metastasize) to other parts of the body. (nih.gov)
  • A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. (embl-heidelberg.de)
Cytokines1
Leukocyte adhesion and transmigration3
  • Redistribution of JAM-A resulted in an increased leukocyte adhesion and transmigration, which could be inhibited with antibodies against JAM-A or by lovastatin-treatment, but not with the peroxisome proliferator activated receptor gamma-agonist pioglitazone. (maastrichtuniversity.nl)
  • Furthermore, in the cremaster muscle model (studied by intravital microscopy), both leukocyte adhesion and transmigration were suppressed in JAM-C-deficient mice (JAM-C(-/-)) and enhanced in mice overexpressing JAM-C in their endothelial cells (ECs). (unige.ch)
  • CONCLUSIONS: The findings demonstrate a role for EC JAM-C in mediating leukocyte adhesion and transmigration in response to I/R injury and indicate the existence of a novel regulatory mechanism for redistribution and hence function of EC JAM-C in vivo. (unige.ch)
Receptors6
ALCAM6
  • Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis. (nih.gov)
  • Specifically, we studied whether ALCAM acts as both a 'seed' receptor in these tumour cells and a 'soil' receptor in peritoneal mesothelial cells during cancer metastasis. (glos.ac.uk)
  • These cell models were used in the tumour-mesothelial interaction assay to assess if and how the interaction was influenced by ALCAM. (glos.ac.uk)
  • ALCAM knockdown of the mesothelial cell line MET5A rendered the cells with reduced interaction with both gastric cancer cells and pancreatic cancer cells. (glos.ac.uk)
  • Likewise, levels of ALCAM in both human gastric and pancreatic cancer cells were also a determining factor for their adhesiveness to mesothelial cells, a process that was likely to be triggered the phosphorylation of the SRC kinase. (glos.ac.uk)
  • A soluble ALCAM (sALCAM) was found to be able to inhibit the adhesiveness between cancer cells and mesothelial cells, mechanistically behaving like a SRC kinase inhibitor. (glos.ac.uk)
Tumor7
  • The discovery of the carcinoembryonic antigen (CEA) as a tumor marker for colorectal cancer some 50 years ago became the first step in the identification of a much larger family of 12 carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) with surprisingly diverse functions in cell adhesion, in intracellular and intercellular signaling, and during complex biological processes such as cancer progression, inflammation, angiogenesis, and metastasis. (nih.gov)
  • Furthermore, CADM1 perform as a tumor suppressor in non-small-cell lung cancer, NSCLC, cells. (neuromics.com)
  • Renal cell carcinoma (RCC) is the leading type of malignant tumor originating from the kidneys, and makes up about 90% of all malignant renal tumors ( 1 ). (spandidos-publications.com)
  • The loss of normal E-cadherin prevents it from acting as a tumor suppressor, contributing to the uncontrollable growth and division of cells. (nih.gov)
  • Cell senescence is a fundamental mechanism of aging and appears to play vital roles in the onset and prognosis of cardiovascular disease, fibrotic pulmonary disease, liver disease and tumor. (degruyter.com)
  • 6. Cell adhesion: implication in tumor progression. (nih.gov)
  • Scatchard analysis of the binding of recombinant HRG to a breast tumor cell line expressing p185erbB2 showed a single high affinity binding site [dissociation constant (Kd) = 105 +/- 15 picomolar]. (embl-heidelberg.de)
Extracellular region1
  • The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. (ox.ac.uk)
Migration7
  • Human endometriotic cells were cultured and their responsiveness to TGF-β1 was evaluated by Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine, and transwell migration and invasion assays. (biomedcentral.com)
  • Knockdown of TGF-β1 in endometriotic cyst stromal cells caused a marked inhibition of cell proliferation, migration, and invasion. (biomedcentral.com)
  • Furthermore, the promoting effects of TGF-β1 on the proliferation, migration, and invasion of endometriotic cyst stromal cells were blocked by silencing of VCAM-1. (biomedcentral.com)
  • Knockdown of VCAM-1 impedes TGF-β1-mediated proliferation, migration, and invasion of endometrial cells, thereby indicating that VCAM-1 may serve as a therapeutic target for endometriosis. (biomedcentral.com)
  • 1998 Therefore it was in the beginning proposed that enhanced proliferation and migration in cells expressing high levels of EpCAM resulted from sequestering α-catenin away from E-cadherin (Litvinov et al. (techblessing.com)
  • L1 overexpression also resulted in an increased yield of GABAergic neurons and enhanced migration of embryonic stem cell-derived neural precursor cells into the lesioned striatum. (johnshopkins.edu)
  • ICAM-1 is constitutively expressed on the cell surface of endothelial cells and leukocytes and functionally activates leukocyte-endothelial adhesion and migration [ 12 ]. (hindawi.com)
Transmigration5
  • Objective: Although inflammatory JAM-A redistribution is an established process, further effort is required to understand its exact role in the transmigration of mononuclear cells, particularly under atherogenic conditions. (maastrichtuniversity.nl)
  • Methods: By the use of RNA interference and genetic deletion, the role of JAM-A in the transmigration of T cells and monocytes through aortic endothelial cells was investigated. (maastrichtuniversity.nl)
  • Results: RNA interference or genetic deletion of JAM-A in aortic endothelial cells resulted in a decreased transmigration of mononuclear cells. (maastrichtuniversity.nl)
  • Conclusions: This study demonstrates that redistribution of JAM-A in endothelial cells after stimulation with pro-atherogenic oxidized lipoproteins results in increased transmigration of mononuclear cells. (maastrichtuniversity.nl)
  • E-selectin is exclusively expressed on the surface of activated endothelial cells [ 8 ] and is a critical mediator of leukocyte rolling-the first step in the cascade of events that lead to firm adhesion and transmigration into the inflamed tissues [ 9 ]. (hindawi.com)
CD561
  • 9 Herein, we describe the first case of primary CD56-positive B cell lymphoma (diffuse large B cell lymphoma, DLBCL) of the urinary system. (bmj.com)
Junctional2
  • Junctional adhesion molecule-C me. (unige.ch)
  • OBJECTIVE: Junctional adhesion molecule-C (JAM-C) is an adhesion molecule that has multiple roles in inflammation and vascular biology, but many aspects of its functions under pathological conditions are unknown. (unige.ch)
Mediates1
  • CADM1 mediates homophilic cell-cell adhesion in a Ca2+-independent manner as well as mediating heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. (neuromics.com)
Homophilic1
Endothelium4
Tissues5
  • These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue. (umassmed.edu)
  • Because there is very little cell division and no increase in total cell mass at this stage the whole process relies purely on rearrangement of preexisting tissues. (techblessing.com)
  • More generally we show that EpCAM levels crucially regulate movements of cells in embryonic tissues. (techblessing.com)
  • A lack of E-cadherin impairs cell adhesion, increasing the likelihood that cancer cells will invade the stomach wall and small clusters of cancer cells will metastasize into nearby tissues. (nih.gov)
  • Heregulin transcripts were identified in several normal tissues and cancer cell lines. (embl-heidelberg.de)
Molecular4
  • This review summarizes the characteristics of cell senescence and updates the molecular mechanisms underlying cell senescence. (degruyter.com)
  • They refer to the rules by which these molecules construct circuits as the molecular logic of neural circuits. (nih.gov)
  • Several cell-surface and signaling molecules contributing to the molecular logic of neural circuits have been characterized, most prominently presynaptic neurexin cell-adhesion molecules and their various ligands. (nih.gov)
  • 8. [Molecular adhesion]. (nih.gov)
Integrins4
Vitro3
  • The interaction with CRTAM promotes natural killer (NK) cell cytotoxicity & IFN-gamma secretion by CD8+ cells in vitro over and above NK cell-mediated rejection of tumors expressing CADM3 in vivo. (neuromics.com)
  • Latest research in vitro and in vivo exposed that movement circumstances modulate endothelial endocytosis of Ab/NC Sodium CNOT4 Channel inhibitor 1 geared to the cell adhesion substances ICAM-1 and PECAM-1 [12 18 Medication delivery using Ab/NC geared to these determinants boosts therapeutic ramifications of experimental medicines and biotherapeutics in pet versions [19-22]. (biomasswars.com)
  • We have just lately shown that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. (pradeepyogi.com)
Peptide2
  • To elucidate the nature of the qualitative modifications that occur, we examined the phosphorylation status of these molecules in resting human leukocytes and upon activation with PMA or with the chemotactic peptide F-met-leu-phe (FMLP). (rupress.org)
  • Having chosen an effective focus we investigated the result of longterm pre-treatment with 50μM QHREDGS in the colony-forming performance of single-cellsby dissociating the hiPSCs to one cells plating them on MEFs at a minimal thickness and culturing the cells Ramelteon (TAK-375) for seven days Ramelteon (TAK-375) in moderate formulated with 50μM QHREDGS 0 QHREDGS or 50μM DGQESHR (scrambled) peptide. (research-in-field.com)
Neurons1
  • Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton (MPS) in neurons. (nature.com)
Apoptosis3
  • Body 1 QHREDGS boosts hiPSC colony amount and size during clump and single-cell passaging in serum-free feeder level lifestyle conditions QHREDGS-mediated influence on caspase-dependent apoptosis We after that sought to comprehend the mechanism where QHREDGS promoted elevated hiPSC colony amount and size. (research-in-field.com)
  • To help expand deconstruct the system we chosen the intermediate 50μM QHREDGS focus and investigated the result of QHREDGS treatment in the functions of apoptosis and proliferation: both possible functions resulting in elevated cell amounts. (research-in-field.com)
  • We discovered that all groupings contained equivalent percentages of BrdU-positive cells (Body 2D-E). As a result QHREDGS treatment improved cell viability because of increased cell success resulting from reduced caspase-dependent apoptosis instead of increased proliferation. (research-in-field.com)
Antibodies1
Ligands2
  • Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. (umassmed.edu)
  • Using ligands of binding to distinct epitopes on the same target molecule may enable fine-tuning of intracellular delivery based on the hemodynamic conditions in the vascular area of interest. (biomasswars.com)
Surface4
  • Considerable proportion of MPMs are shown to express cell adhesion molecule 1 (CADM1), and to use CADM1 to bind to and proliferate on the pleural mesothelial surface, suggesting that CADM1 is a possible therapeutic target. (frontiersin.org)
  • PREPARING FOR DEPARTUREPOSTTRANSLATIONAL WNT MODIFICATIONS After signal sequence cleavage and translocation into the endoplasmic reticulum (ER), Wnts are transported through the endomembrane system to the cell surface and undergo several modifications. (researchensemble.com)
  • The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. (ox.ac.uk)
  • He and his lab members hypothesize that the number, location, and properties of synapses are determined by interactions between presynaptic and postsynaptic cell-surface recognition molecules and/or signaling molecules. (nih.gov)
Inflammation1
Synaptic1
  • For his presentation, Dr. Sudhof will describe his lab's work on testing the hypotheses inherent in this conceptual framework, focusing on families of synaptic cell-adhesion molecules such as neurexins and latrophilins. (nih.gov)
Cellular1
  • The Lung Cell Biology Program supports and promotes cutting-edge experimental approaches to investigate lung cellular function and dysfunction in a wide range of conditions. (nih.gov)
Membrane1
  • 9D2 suppressed the cell growth of CADM1-positive MPM cells with the loss and aggregation of CADM1 molecules on the MPM cell membrane, but not of CADM1-negative MPM cells. (frontiersin.org)
Neural cell5
Proliferation2
  • 2009 This short segment can be cleaved and is then able to form a complex with FHL2 PNU-120596 β-catenin and Lef-1 that induces gene transcription of oncogenes such as C-myc and cyclins A/E. Thus the role of EpCAM in cell-cell adhesion and the relative contributions of its potential adhesive and signaling activities in morphogenesis and proliferation remain unclear. (techblessing.com)
  • To measure the aftereffect of QHREDGS treatment on cell proliferation hiPSCs had been pulsed with BrdU and assayed for incorporation by immunohistochemistry. (research-in-field.com)
Embryonic stem2
  • Despite recent advances in culture techniques for undifferentiated human Embryonic Stem Cells (hESCs), further improvements are required to facilitate research and translation of these cells in clinical settings. (benthamopen.com)
  • Human embryonic stem cells derived by somatic cell nuclear transfer. (benthamopen.com)
Mononuclear cell1
  • 20. Imbalance of mononuclear cell infiltrates in the placental tissue from foetuses after spontaneous abortion versus therapeutic termination from 8th to 12th weeks of gestational age. (nih.gov)
Heterophilic1
  • They are also capable of heterophilic binding, meaning a CAM on one cell will bind with different CAMs on another cell. (wikipedia.org)
Tissue3
Dysfunction1
  • Cell senescence is a physiological process of irreversible cell cycle arrest that contributes to various stress conditions, telomere shortening, DNA damage, reactive oxygen species (ROS) production, and mitochondrial dysfunction are main characteristic of cell senescence [ 1 ]. (degruyter.com)
Inhibitor1
  • For example the functional status of endothelial cells lining the vascular lumen an important target for drug delivery is greatly influenced by fluid shear stress of blood flow that varies under Sodium Channel inhibitor 1 physiological and pathological conditions [9]. (biomasswars.com)
Superfamily1
  • Neuroplastin, a member of the Ig superfamily of cell adhesion molecules, has been implicated in neurophysiological and pathophysiological phenomena. (edu.sa)
Microscopy1
  • Treatment of the endothelial cells with oxLDL resulted in an increase of both permeability and apical JAM-A presentation, as shown by bead adhesion and confocal microscopy experiments. (maastrichtuniversity.nl)
Functional2
  • Additionally, GlialCAM also works as an auxiliary subunit of the chloride channel ClC-2, regulating its targeting to cell-cell junctions and modifying its functional properties. (nih.gov)
  • Mice grafted with L1-transfected cells showed recovery in rotation behavior 1 and 4 weeks, but not 8 weeks, after transplantation compared with mice that had received nontransfected cells, thus demonstrating for the first time that a recognition molecule is capable of improving functional recovery during the initial phase in a syngeneic transplantation paradigm. (johnshopkins.edu)
Gene4
  • People with congenital tufting enteropathy have two copies of the altered EPCAM gene in each cell. (medlineplus.gov)
  • Results Identification of EpCAM as a promoter of cell mixing between ectoderm-mesoderm We recognized a orthologue of human EpCAM in a gain-of-function screen for gene products perturbing the ectoderm-mesoderm boundary called Brachets' cleft. (techblessing.com)
  • Somatic gene mutations are acquired during a person's lifetime and occur only in certain cells in the breast. (nih.gov)
  • People with HDGC caused by CDH1 gene mutations are born with one mutated copy of the gene in each cell. (nih.gov)
Glial cells2
  • GlialCAM (also named HepaCAM) is a cell adhesion molecule expressed mainly in glial cells from the central nervous system and the liver. (nih.gov)
  • In glial cells, however, its function is quite different. (nih.gov)