Cell survival. Medical search. Frequent questions

Of the different cells isolated from the submandibular gland, this specific population, Lin - CD24 + c-Kit + Sca1 + , possessed the highest capacity for proliferation, self renewal, and differentiation during serial passage in vitro. (jci.org)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
We have conducted extensive in vitro studies to confirm its efficacy in supporting stem cell viability, proliferation and new tissue deposition. (ca.gov)
These scaffolds combine the injectability and cell encapsulation of conventional hydrogels with macroporosity, which facilitates nutrient transfer, cell survival, proliferation, and tissue formation. (ca.gov)
We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)
Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF- κ B survival pathways. (hindawi.com)
However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. (hindawi.com)
Among them and over decades of research, it was shown that the PI3K/Akt/mTOR pathway is one of the most frequently hyperactive pathways in OC as well as other types of solid tumors and is associated with increased cell growth, proliferation, migration, protein synthesis, survival, and chemotherapy resistance [ 7 - 9 ]. (hindawi.com)
Taken together, this study has provided new evidence that mNSCs show the unique cell proliferation, cell survival, dopaminergic neuronal differentiation and neurotrophic properties, suggesting that midbrain-derived NSCs may present an ideal cell source or reliable tissue candidate for therapeutic cell transplantation or neuroprotective treatment of PD in human beings. (omicsonline.org)
MTT analysis, PI/Annexin V staining, transwell and metabolic flux assays were performed to examine the effects of C1QBP on proliferation, apoptosis, migration, invasion, and oxidative phosphorylation of HCC cells. (jcancer.org)
Loss-of-function assays showed that proliferation, migration and invasion of HCC cells were mitigated while cell apoptosis was augmented upon the loos of C1QBP. (jcancer.org)

More work is also needed to understand how to protect the microbiome during intensive cancer treatments such as stem cell transplantation, he added. (cancer.gov)
Previous studies from single hospitals have shown that people undergoing allogeneic stem-cell transplantation often have disruptions in their gut microbiome, including an increase in numbers of potentially disease-causing species of bacteria and an overall loss of diversity. (cancer.gov)
The researchers collected almost 9,000 fecal samples from about 1,350 people undergoing allogeneic stem-cell transplantation, both before and after the procedure. (cancer.gov)
They then looked for associations between diversity of the gut microbiome and survival following transplantation, as well as the incidence of graft-versus-host disease. (cancer.gov)
The long-term goal of this grant is to accelerate clinical translation of stem cell-based therapy for regenerative medicine by enhancing cell delivery, survival, and integration, thus improving therapeutic outcomes, substantially reducing the number of cells needed for transplantation, and reducing the associated time and cost to produce these cells. (ca.gov)
However, the majority of transplanted cells die shortly after transplantation, which greatly diminishes the efficacy of stem cell-based therapies. (ca.gov)
OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Relapse and graft- versus -host disease (GvHD) are the main impediments to the clinical success of allogeneic hematopoietic cell transplantation (HCT) in curing malignant blood disorders. (haematologica.org)
We tested this novel hypothesis in over 6,000 HCT from 8/8 HLA-matched UD reported to the European Group for Blood and Marrow Transplantation (EBMT), to demonstrate that HLA-DPB1 non-TPHE mismatches were associated with worse relapse-free survival and overall survival than TPHE mismatches, present in 21.7% of single HLA-DPB1 disparate pairs. (haematologica.org)
ZUMA-3 is an ongoing international multicenter (US, Canada, Europe), single arm, open label, registrational Phase 1/2 study of Tecartus in adult patients (≥18 years old) with ALL whose disease is refractory to or has relapsed following standard systemic therapy or hematopoietic stem cell transplantation. (gilead.com)
The findings support future studies of assessing the safety and efficacy of the novel drug-chemotherapy combination as a maintenance strategy following stem cell transplantation across a range of blood cancers, according to the study authors. (curetoday.com)
Maintenance treatment with eprenetapopt, a novel drug, plus the chemotherapy Vidaza (azacitidine) following allogeneic hematopoietic stem cell transplantation was associated with improved survival outcomes in a group of patients with TP53-mutant, high-risk acute myeloid leukemia and myelodysplastic syndromes, according to new study findings. (curetoday.com)
A total of 84 patients were screened to determine if they were eligible for an allogeneic hematopoietic stem cell transplantation. (curetoday.com)
We are interested in therapeutic potential of neural stem cell in transplantation treatment against PD, the midbrain-derived neural stem cells (mNSCs) were studied by in vitro culture in focusing on their proliferative, differentiation and neurotrophic properties and in comparing with hippocampus-derived NSCs (hNSCs). (omicsonline.org)
Hepatocytes derived from iPS cells are suitable for transplantation into patients with liver insufficiency and for use in toxicity tests ( 2 ). (spandidos-publications.com)
Although allogeneic hematopoietic cell transplantation (alloHCT) is the treatment of choice, patient eligibility criteria and optimal conditioning regimen remain under study. (confex.com)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)

In an allogeneic stem cell transplant, the blood-forming stem cells in a patient's bone marrow are destroyed using high doses of chemotherapy or radiation therapy. (cancer.gov)
The TROPION-Lung01 results demonstrate for the first time that an antibody drug conjugate can delay disease progression or death for longer than conventional chemotherapy in patients with advanced non-small cell lung cancer. (businesswire.com)
Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
Combination with other treatment modalities such as chemotherapy may overcome immunoresistance of cancer cells. (uni-muenchen.de)
Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
Therefore, we implemented a short interfering RNA (siRNA) screen with 16,560 siRNAs targeting 5,520 unique druggable human genes aimed at identifying these survival genes in the T98G glioma cell line because glioblastoma represents a challenging form of cancer for chemotherapy. (aspetjournals.org)
Of note, an allogeneic hematopoietic stem cell transplant is a procedure where a patient with cancer receives healthy blood-forming stem cells from a donor to replace their own stem cells that have been damaged by other cancer treatments such as radiation or chemotherapy. (curetoday.com)
Although drugs, for example a MEK inhibitor Refametinib [ 5 ], targeting key driver genes involved in HCC progression are being utilized for the clinical intervene, chemotherapy-resistance and the following cancer recurrence or metastasis still hinder the improvement of patient survival rates. (jcancer.org)
The following factors were studied in the whole cohort: age, type of disease (treatment-related or post myelodysplastic syndrome/MDS), previous intensive chemotherapy cycles, cytogenetic risk, overall (OS) and disease-free survival (DFS). (confex.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)

Median (95% CI) relapse-free survival (RFS) censored and not censored at subsequent alloSCT were both 11.6 (2.7-20.5) and 11.7 months (2.8-20.5), respectively. (gilead.com)
Duration of remission and relapse-free survival, overall survival, minimal residual disease (MRD) negativity rate, and alloSCT rate were assessed as secondary endpoints. (gilead.com)
They conducted a phase 2, multicenter trial to analyze if post-transplant eprenetapopt plus Vidaza improved relapse-free survival (which is the length of time following completion of primary treatment that a patient survives without signs or symptoms of that cancer). (curetoday.com)
Based on prior results, the study investigators determined that a one-year relapse-free survival rate of 50% or greater would be considered successful. (curetoday.com)

BUSINESS WIRE )--Positive results from the pivotal TROPION-Lung01 Phase III trial showed that datopotamab deruxtecan (Dato-DXd) demonstrated a statistically significant improvement for the primary endpoint of progression-free survival (PFS) compared to docetaxel, the current standard of care, in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with at least one prior line of therapy. (businesswire.com)
The improvement in progression-free survival observed with datopotamab deruxtecan, particularly in patients with non-squamous tumors, and the improved tolerability of this antibody drug conjugate compared to docetaxel, represent a meaningful advance for patients with lung cancer. (businesswire.com)
A personalized immunotherapy (AGS-003) nearly doubled expected progression-free survival and overall survival when added to standard sunitinib (Sutent) in patients with unfavorable-risk metastatic renal cell carcinoma, according to results from a single-arm phase II study. (urologytimes.com)
For the overall study population, median progression-free survival was 11.2 months and the final median overall survival was 30.2 months. (urologytimes.com)
When analyzed by baseline Heng risk status, the median progression-free survival was 19.4 months for intermediate-risk patients and 5.8 months for subjects with poor-risk features at baseline. (urologytimes.com)
Both of the newer combination regimens showed marked advances in progression-free survival in patients with kidney cancer and were considered giant leaps forward," he explained. (ascopost.com)

Molecular Cell paper provides evidence that FOXO3a triggers transcription of HIF1 target gene, which in turn inhibits HIF-1 induced apoptosis. (genengnews.com)
HIF-1 induced apoptosis in normal and breast cancer cells was inhibited due to FOXO3a stimulating the transcription of the HIF1 target gene, CITED2, according to Dr. Mak. (genengnews.com)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. (cshlpress.com)
Conclusion: For the protection of stem cells against apoptosis, different pathways, namely Phosphoinositide 3-Kinase (PI3K/AKT), Hypoxia-Inducible Factor (HIF1), Mitogen-Activated Protein Kinases (MAPK) and Hippo, are discussed. (benthamscience.com)
Complement C11 binding protein (C1QBP, also named p32 and HABP1) is a multifunctional protein which plays a pivotal role in diverse cellular processes such autophagy and cell apoptosis [ 7 , 8 ]. (jcancer.org)
To discover miR-BARTs that can inhibit apoptosis, I individually expressed miR-BARTs in the EBV- GaCa cell line AGS, and identified five miR-BARTs that conferred this phenotype. (duke.edu)
Finally, analysis of the mechanism by which multimeric alpha-lactalbumin induces apoptosis in transformed epithelial cells could lead to the design of antitumor agents. (lu.se)

The ongoing phase III ADAPT (The Autologous Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma) study is using this approach to personalized immunotherapy, with the goal of randomizing 450 patients. (urologytimes.com)
Are you surprised that targeted therapeutics for metastatic renal cell carcinoma (RCC) have not improved survival? (renalandurologynews.com)
A study published recently in Urologia Internationalis (online ahead of print) found that the advent of targeted therapeutic agents for treating metastatic renal cell carcinoma (RCC) -which began with the FDA approval of sorafenib in 2005-has not led to an improvement in survival rates. (renalandurologynews.com)
A large retrospective study of real-world patients with renal cell carcinoma (RCC) showed similar survival outcomes for patients with intermediate- or poor-risk disease regardless of whether they were treated with the combination of axitinib plus pembrolizumab or ipilimumab plus nivolumab. (ascopost.com)

The estimated median overall survival is 39.5 months for intermediate- and 9.1 months for poor-risk subjects. (urologytimes.com)
By comparison, in a pivotal trial, treatment with sunitinib yielded a median overall survival of 20.7 months for intermediate-risk and 5.3 months for poor-risk subjects. (urologytimes.com)
Results from the analysis showed a median overall survival (OS) of 26 months and demonstrated that responses remained durable in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) with a consistent safety profile observed since the two-year analysis. (gilead.com)
Additionally, the median overall survival (time from treatment to death of any cause) was 20.6 months at a median follow-up of 17 months. (curetoday.com)
The median overall survival was not reached for axitinib plus pembrolizumab and was 22 months for ipilimumab plus nivolumab. (ascopost.com)
In the United States of America median survival was estimated in 1994 to be 42 years for men and 48 years for women, whereas comparable figures for Jamaica published in 2001 suggested 53 years for men and 58.5 years for women. (who.int)

They also appear to affect the risk of dying after a hematopoietic stem cell transplant. (cancer.gov)
In a new NCI-funded study, researchers found that, in people with blood cancers who had received an allogeneic hematopoietic stem cell transplant, the health of their gut bacteria was linked with their survival. (cancer.gov)
DAPI negative, single living cells were first separated with epithelial marker CD24 and hematopoietic and endothelial lineage marker CD45/31. (jci.org)
Stem cells differentiate into different types of cells, such as neural, hematopoietic, adipose, etc. and are used for the treatment of various conditions like myocardial infarction, spinal cord injury, Parkinson's disease and diabetes. (benthamscience.com)
Disease relapse is the primary reason why allogeneic hematopoietic stem cell transplants fail, according to the study authors, who noted that novel strategies for stem cell transplant to reduce the risk for disease relapse are severely needed. (curetoday.com)
Currently, maintenance strategies (which are used to reduce the risk for disease recurrence) are not standard of care in allogeneic (hematopoietic stem cell transplant) for (acute myeloid leukemia and myelodysplastic syndromes)," the study authors wrote. (curetoday.com)

Furthermore, in silico analysis from The Cancer Genome Atlas (TCGA) database suggests that overexpression of ALKBH6 provides better survival outcomes in patients with pancreatic cancer. (frontiersin.org)
Patients with Merkel cell carcinoma (MCC) may have different sites of disease, stage at diagnosis, and survival outcomes according to their racial or ethnic group, a new study suggests. (oncologynurseadvisor.com)
The study showed that Hispanic patients had the best survival outcomes, and Black patients were more likely than White patients to present with advanced disease. (oncologynurseadvisor.com)

The results support an ongoing phase III study of the approach in which patients with metastatic clear-cell RCC are being randomized to personalized immunotherapy plus sunitinib or sunitinib alone, with overall survival as the primary endpoint, said first author Asim Amin, MD, PhD. (urologytimes.com)

Benavides-Montaño JA , Vadyvaloo V . Yersinia pestis resists predation by Acanthamoeba castellanii and exhibits prolonged intracellular survival. (cdc.gov)
Peptidyl-Prolyl Isomerases Are Immunogenic, Alter Cytokine Profile and Aid in Intracellular Survival. (bvsalud.org)

After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
Sandwalk: How many human protein-coding genes are essential for cell survival? (blogspot.com)
We would like to know how many of those genes are essential for the survival of an individual and for long-term survival of the species. (blogspot.com)
The ability to knock out human genes using CRISPR technology has opened to door to testing for essential genes in tissue culture cells. (blogspot.com)
Each group identified between 1500 and 2000 protein-coding genes that are essential in their chosen cell lines. (blogspot.com)
By looking only at genes that are essential for cell survival, they are ignoring all those genes that are specifically required in other cell types. (blogspot.com)
These are the genes activated by heat shock and other forms of stress and they churn out a lot of HSP70 chaperone in order to save the cells. (blogspot.com)
Target identification and validation remain difficult steps in the drug discovery process, and uncovering the core genes and pathways that are fundamental for cancer cell survival may facilitate this process. (aspetjournals.org)
We analyzed cell viability at 96 hr after siRNA transfection with two orthogonal statistical methods and identified 55 survival genes that encoded proteases, kinases, and transferases. (aspetjournals.org)
Interestingly, 22% (12/55) of the survival genes were constituents of the 20S and 26S proteasome subunits. (aspetjournals.org)
Biological networks were built with the other survival genes using a protein-protein interaction network, which identified clusters of cellular processes, including protein ubiquitination, purine and pyrimidine metabolism, nucleotide excision repair, and NF-κB signaling. (aspetjournals.org)
The results of this study should broaden our understanding of the core genes and pathways that regulate cell survival, and we highlight the potential significance of proteasome inhibition, through either small molecule inhibition or RNA interference. (aspetjournals.org)
To identify pro-apoptotic genes targeted by the five anti-apoptotic miRNAs, I validated one previously published target and identified nine novel targets by performing photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in the EBV+ NPC cell line C666. (duke.edu)
On the other hand, in order to identify miR-BARTs that can activate the Wnt signaling pathway, I analyzed the PAR-CLIP data set of C666 cells and discovered nine anti-Wnt signaling targets of miR-BARTs, including seven novel genes and two pro-apoptotic genes identified above. (duke.edu)
After knocking out specific genes, they could also demonstrate which genes are required for the maturation of memory killer cells in tissue. (technologynetworks.com)
Sickle-cell anaemia is a common genetic condition due to a haemoglobin disorder - inheritance of mutant haemoglobin genes from both parents. (who.int)
About 5% of the world's population carries genes responsible for haemoglobinopathies and each year about 300 000 infants are born with major haemoglobin disorders - in more than 200 000 cases sickle-cell anaemia in Africa. (who.int)
Although a single abnormal gene may protect against malaria, inheritance of two abnormal genes leads to sickle-cell anaemia and confers no such protection, and malaria is a major cause of ill-health and death in children with sickle-cell anaemia. (who.int)

Methods: This article focuses on recent research development that addresses the viability issues of stem cells. (benthamscience.com)
Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)
The idea is to disrupt every gene and screen to see if it's required for cell viability in culture. (blogspot.com)

Gene-expression analysis of Sin1 knockout cortical neurons demonstrated an important down-regulation of transcription factors, cytoskeletal proteins and components of signalling pathways involved in neuronal survival, aiding to uncover the mechanism by which Sin1 promotes neuronal survival. (bl.uk)

Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. (nature.com)

CHICAGO -- An immunotherapy drug improved survival in patients with advanced nonsquamous non-small cell lung cancer (NSCLC), a researcher said here. (medpagetoday.com)
An immunotherapy drug (nivolumab, known as Opdivo) improved survival in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) compared with docetaxel. (medpagetoday.com)
Rosenberg, S.A. & Restifo, N.P. Adoptive cell transfer as personalized immunotherapy for human cancer. (nature.com)
At the Genitourinary Cancers Symposium in Orlando, FL, Dr. Amin described long-term survival in 21 patients with intermediate- or poor-risk metastatic RCC who were treated with autologous dendritic cell immunotherapy in combination with sunitinib. (urologytimes.com)
The memory killer cells have been shown to respond to immunotherapy, a Nobel Prize-winning cancer therapy involving the tweaking/activation of the immune system. (technologynetworks.com)
Finding out how these cells develop enables us to contribute to the development of more efficacious immunotherapy for diseases like melanoma. (technologynetworks.com)
The researchers now aim to harness their findings to optimise the immunotherapy-induced T-cell response to make it even better at eliminating cancer cells in tissues. (technologynetworks.com)

Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on tumor growth depending on whether or not the tumor cells have enough oxygen. (genengnews.com)

Because a virus may play a role in the development of Merkel cell carcinoma, researchers believe that the cancer might respond favorably to treatments that utilize the body's immune system. (moffitt.org)
Patients with localized Merkel cell carcinoma have a 78% survival rate while those whose cancer has spread to the lymph nodes or other nearby structures have a 52% survival rate. (moffitt.org)
It should be noted that survival rates for cancer are simply estimates and based on a large number of people. (moffitt.org)
At Moffitt Cancer Center, our expert oncologists take a comprehensive approach to Merkel cell carcinoma treatment. (moffitt.org)
There are so many variables in play locally, including how we treat our patients, and environmental and genetic influences on the microbiome that vary across geographical regions," said Steven Pavletic, M.D., a stem-cell transplant specialist at NCI's Center for Cancer Research , who was not involved in the study. (cancer.gov)
Our results reveal a pro-survival role for FOXO3a in normal cells and cancer cells that are adapting to hypoxic stress," explains Dr. Mak. (genengnews.com)
Stem cell-based regenerative therapy is a promising treatment for head and neck cancer patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from radiation therapy. (jci.org)
Administration of GDNF improved saliva production and enriched the number of functional acini in submandibular glands of irradiated animals and enhanced salisphere formation in cultured salivary stem cells, but did not accelerate growth of head and neck cancer cells. (jci.org)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Although regulatory element rearrangements and copy number alterations resulting from these structural variants are known to lead to transcriptional dysregulation across cancers, the extent to which these events result in functional dependencies with an impact on cancer cell survival is variable. (nih.gov)
Here we used CRISPR-Cas9 dependency screens to evaluate the fitness impact of 3,277 fusions across 645 cell lines from the Cancer Dependency Map. (nih.gov)
The aim of the present study was to evaluate the influence of Ang II on human endometrial cancer cells. (spandidos-publications.com)
Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases. (cshlpress.com)
This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs. (cshlpress.com)
Cancer and neurodegeneration are detrimental conditions associated with an inappropriate regulation of cell survival and cell death, causing compromised cells to evade death or excessive death of healthy neurons. (bl.uk)
For patients with advanced non-small cell lung cancer, current standard of care second-line docetaxel is associated with limited benefit and substantial toxicity. (businesswire.com)
The benefit seen in patients with non-squamous tumors is particularly impressive and, coupled with the data from TROPION-Lung05, provides promising evidence that datopotamab deruxtecan may play an important role in treating patients with non-small cell lung cancer who currently have limited effective options following initial treatment. (businesswire.com)
Hürthle-cell cancer (HCC) is a rare type of thyroid cancer, representing 3-5% of all thyroid cancers. (thyroid.org)
Wang X et al 2022 Radioactive iodine therapy does not improve cancer-specific survival in Hürthle cell carcinoma of the thyroid. (thyroid.org)
The primary study outcome was cancer-specific survival (CSS), calculated as the time from the initial diagnosis to death from thyroid cancer, last follow-up or 12/31/2018, the first occurring event being chosen for each patient. (thyroid.org)
In this large SEER-based study, patients with HCC who underwent total thyroidectomy had overall an excellent cancer-specific survival. (thyroid.org)
prostate cancer cell lines and a synergistic effect between both was also o bserved. (researchgate.net)
Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. (hindawi.com)
Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. (benthamscience.com)
Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
Overall, our data suggest that ALKBH6 is required to maintain the integrity of the genome and promote cell survival of pancreatic cancer cells. (frontiersin.org)
The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
Objectives - We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. (ices.on.ca)
Lung signet ring cell carcinoma (LSRCC) is a very rare type of lung cancer, the clinical characteristics, and prognosis of which remain to be clarified. (physiciansweekly.com)
Cancer cells continue to produce lactate via glycolysis when oxygen is abundant (the Warburg effect) ( 14 ). (spandidos-publications.com)
Clinicians can take some reassurance that both combinations provide a survival benefit, and there seems to be no harm in choosing one combination over the other based on this analysis," said Kevin Zarrabi, MD , a second-year hematology/oncology fellow at Fox Chase Cancer Center and lead author of the study. (ascopost.com)
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. (atsbio.com)
Researchers at Karolinska Institutet in Sweden and the University of Copenhagen in Denmark have now identified how these cells are formed, and shown that high levels of memory killer cells in cancer tissue correlate with a better survival rate in people with melanoma. (technologynetworks.com)
We don't know so much about how and why memory killer cells are formed in the skin and what it means for cancer patients," says Professor Yenan Bryceson at the Department of Medicine (Huddinge), Karolinska Institutet. (technologynetworks.com)
Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human metastatic colorectal cancer (mCRC).Initial analyses identified marker-defined subsets of PC, including cells expressing PDGFR-β or α-SMA or both markers. (lu.se)
Cindy took action after precancerous cells were found during her routine cervical cancer screening. (cdc.gov)
While investigating the effect of human milk on bacterial adherence to a human lung cancer cell line, we were surprised to discover that the milk killed the cells. (lu.se)
these abnormal chromosomes are often observed in cancer cells. (cdc.gov)
Although it is normally inactive in most other cells in the body, telomerase is activated in cancer cells, making them "immortal. (cdc.gov)

They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components. (cshlpress.com)
Depletion of recipient T cells before 7 × 19 CAR-T cell administration dampened the therapeutic effects of 7 × 19 CAR-T cell treatment, suggesting that CAR-T cells and recipient immune cells collaborated to exert anti-tumor activity. (nature.com)
In spite of the big improvement in the clinical field for OC therapy, an overlall low survival and high recurrence rates still exist and were attributed to the poor screening approach, inadequate therapeutic options, and development of drug resistance [ 3 , 4 ]. (hindawi.com)
Targeted therapeutic agents for treating metastatic RCC has not led to an improved survival. (renalandurologynews.com)
Although patients with HCC have been benefiting from the development of various effective therapeutic approaches, the five-year survival rate is still rather low (around 12% as reported in China) [ 2 ]. (jcancer.org)

This process can potentially eliminate some cancers derived from cells in the bone marrow, such as leukemia and lymphoma. (cancer.gov)
Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)

Front-line treatment for patients with metastatic clear cell RCC has changed rapidly in the last few years, first with the approval of targeted agents like sunitinib and everolimus, and later with the approval of combination axitinib plus pembrolizumab and ipilimumab plus nivolumab, Dr. Zarrabi said. (ascopost.com)
To evaluate that question, Dr. Zarrabi and colleagues used data from 821 patients with metastatic clear cell RCC treated with either axitinib plus pembrolizumab (n = 259) or ipilimumab plus nivolumab (n = 562) taken from the nationwide Flatiron Health electronic health records-derived, de-identified database. (ascopost.com)
This large, real-world retrospective analysis-with the caveat of limited follow-up-shows that both therapies are appropriate for [International Metastatic RCC Database Consortium] intermediate- and poor-risk disease, and appear to confer similar survival," said Daniel M. Geynisman, MD , Associate Professor in the Department of Hematology/Oncology at Fox Chase and senior author of the study. (ascopost.com)

We hypothesized that patients transplanted with FluTreo would have a long-term survival advantage over other treatment alternatives. (confex.com)

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput "omics" technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. (governmentgrant.com)
We have previously shown that gemcitabine sensitizes human pancreatic carcinoma cells against CTL-mediated lysis. (uni-muenchen.de)

Mitchell et al used a microarray to compare gene expression in T cells activated either with antigen alone or antigen in the presence of two different adjuvants (VV or LPS). (the-scientist.com)
1 In unrelated donor (UD)-HCT, frequent human leukocyte antigen (HLA)-DPB1 disparity is the target of T-cell alloreactivity, contributing to both leukemia control and GvHD. (haematologica.org)

It's difficult to assess the true Merkel cell carcinoma survival rate due to the rarity of the disease. (moffitt.org)
Because Merkel cell carcinoma is quick to spread, patients should promptly report any unusual symptoms to a physician to accelerate the diagnostic process. (moffitt.org)
New drugs that target hormone-producing cells also show promise in the treatment of Merkel cell carcinoma. (moffitt.org)
The five-year survival rate for Merkel cell carcinoma is improving. (moffitt.org)
And, behind the scenes, our dedicated researchers are continually evaluating new treatments that could ultimately improve the Merkel cell carcinoma survival rate. (moffitt.org)
Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model. (uni-muenchen.de)
Methods: Bone marrow-derived DC from C57BL/6 mice were loaded with UV-irradiated, syngeneic Panc02 carcinoma cells and were administered subcutaneously. (uni-muenchen.de)
Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study. (physiciansweekly.com)
Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)
In EBV latently infected epithelial cells, such as nasopharyngeal carcinoma (NPC) and gastric carcinoma (GaCa) cells, viral protein expression is low. (duke.edu)

Immunological adjuvants may improve survival of activated T cells via induction of the Bcl-3 gene. (the-scientist.com)
In the May Nature Immunology Thomas Mitchell and colleagues from the National Jewish Medical and Research Center , Denver show that adjuvants may improve survival of activated T cells via induction of the Bcl-3 gene. (the-scientist.com)
Our work provides a synthesis of previous algorithms, mechanistically based on HLA-DPB1 immunopeptidome divergence 5 and expression by residual leukemia cells, 6 , 7 respectively, into a new and integrative model for intelligent mismatching in UD-HCT, to improve survival for future patients. (haematologica.org)

The loss of Sin1 significantly affected the phosphorylation and activity of Akt in fibroblasts and caused a reduction in cell survival by potentially inducing premature senescence. (bl.uk)
In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF- κ B. Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. (hindawi.com)
Combination of the two strategies significantly increased survival of tumor-bearing mice (50 % at day 58 after tumor challenge). (uni-muenchen.de)
The galactose‑1‑phosphate concentration was significantly higher in cells cultured in HDI than in those cultured with ReproFF. (spandidos-publications.com)

The requirement of Sin1 in cell survival, and in particular in neuronal survival, has not been established due to the early embryonic lethality of mice with a targeted deletion of the Sin1 gene. (bl.uk)
Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. (benthamscience.com)
Melton, D.A. "Stemness": Transcriptional profiling of embryonic and adult stem cells. (benthamscience.com)
Human embryonic stem cells also exhibit the Warburg effect ( 15 ). (spandidos-publications.com)
Multimeric alpha-lactalbumin killed all transformed, embryonic, and lymphoid cells tested but spared mature epithelial elements. (lu.se)

Glucose is essential for cell survival and is metabolized to pyruvate ( 13 ). (spandidos-publications.com)

D ) Quantification of salisphere number to seeding-cell number of each population at D7 and D14 in vitro. (jci.org)

In a multivariate analysis, Hispanic ethnicity was independently associated with improved survival. (oncologynurseadvisor.com)

Taken together, the results presented in this study show a key role of the scaffold protein Sin1 in regulating neuronal survival. (bl.uk)
Parkinson's disease (PD) is one severe debilitating neurological disease that results from massive and progressive degenerative loss of dopaminergic neurons in the substantial nigra, and new cell therapy appeal hopeful functional recovery of injured dopaminergic neuronal system and cure of PD. (omicsonline.org)

In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF- κ B, and requires GHS-R1a. (hindawi.com)

Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (nature.com)

The drug, which blocks ligand activation of the programmed cell death 1 (PD-1) receptor on activated T cells, was approved in March for squamous NSCLC , after earlier getting the FDA nod for melanoma. (medpagetoday.com)

In the next report period, we will focus on measuring the functional improvement by monitoring stem cell survival using BLI and fat volume retention using micro-CT imaging over time. (ca.gov)
Zhang, Y. Integrin β1 increases stem cell survival and cardiac function after myocardial infarction. (benthamscience.com)

Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. (governmentgrant.com)

The key finding, he told reporters at the annual meeting of the American Society of Clinical Oncology, is that the drug extended overall survival compared with docetaxel. (medpagetoday.com)
BACKGROUND--The relationship between cell types in bronchoalveolar lavage (BAL) fluid and the clinical course of patients with idiopathic pulmonary fibrosis (IPF) has been the subject of several studies. (bmj.com)

95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. (duke.edu)
It is likely that miR-BARTs play a crucial role in EBV-infected epithelial cells, however a comprehensive understanding of miR-BARTs is currently lacking. (duke.edu)
Bronchiolar epithelial hyperplasia, alveolar septal thickening, and alveolar septal infiltration by inflammatory cells were seen in the lungs of ozone exposed hamsters. (cdc.gov)

The linear quadratic model is now most often used to describe the cell survival curve, assuming that there are two mechanisms to cell death by radiation: A single lethal event or an accumulation of harmful but non-lethal events. (wikipedia.org)
The mechanisms by which cell death occurs are genetically encoded and carefully controlled. (cshlpress.com)
Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. (cshlpress.com)

Histopathological analyses showed increased infiltration of dendritic cells (DC) and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. (nature.com)

Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)
Protocols for hepatocyte differentiation from iPS cells have been studied. (spandidos-publications.com)
It was hypothesized that the addition of glucose and galactose promoted hepatocyte differentiation of iPS cell. (spandidos-publications.com)

The aim of this study was to evaluate whether radioactive iodine therapy after total thyroidectomy improves prognosis and survival in patients with HCC. (thyroid.org)
However, there was no difference in cancerspecific survival noted between patients who received and those who did not receive radioactive iodine therapy after total thyroidectomy. (thyroid.org)
SANTA MONICA, Calif.--(BUSINESS WIRE)-- Kite, a Gilead Company (Nasdaq: GILD), today announced the three-year follow-up results from the pivotal ZUMA-3 study of the CAR T-cell therapy Tecartus ® (brexucabtagene autoleucel). (gilead.com)

A biochemical pathway that keeps cells alive when oxygen is low has now been showed to play a role in longevity and resistance against some diseases of old age. (sciencedaily.com)
Discussion: Activation of the PI3K/AKT pathway decreases the concentration of apoptotic factors, while the HIF pathway protects stem cells against the micro-environment of tissue (hypoxia). (benthamscience.com)
Concomitant with the reduction of HH pathway activity, Tctn2 mutants exhibited increased cell death in the neurectoderm and facial ectoderm, culminating in a collapse of the facial midline. (elifesciences.org)
Enhancing HH signaling by decreasing the gene dosage of a negative regulator of the pathway, Ptch1 , decreased cell death and rescued the midface defect in both Tctn2 and Cc2d2a mutants. (elifesciences.org)

That is electroporated into the patient's own dendritic cells. (urologytimes.com)
The hope is that those dendritic cells will then express the patient's own tumor antigens to the T cells. (urologytimes.com)

Despite the great promise stem cells hold for regenerative medicine, the efficacy of stem cell-based therapies is greatly limited by poor cell engraftment and survival. (ca.gov)
Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)

C1QBP is correlated with a poor prognosis of HCC patients and promotes the survival, migration and invasion of HCC cells. (jcancer.org)
Sickle-cell anaemia is particularly common among people whose ancestors come from sub-Saharan Africa, India, Saudi Arabia and Mediterranean countries, and migration raised the frequency of the gene in the American continent. (who.int)

The researchers then went on to study tumour samples from melanoma patients and found that those with a higher rate of survival also had a larger accumulation of epidermal memory killer cells. (technologynetworks.com)

mRNA of ghrelin receptors(GHS-R1a and GHS-R1b), as well as, protein levels of GHS-R1a, were expressed abundantly in A2780 cells. (hindawi.com)
AG treatment did not affect the mRNA and protein levels of GHS-R1a and GHS-R1b in both control and Cis-treated cells. (hindawi.com)
Bioinformatic approaches were employed for checking the expression of C1QBP in HCC patient samples and the association between C1QBP mRNA expression and survival rates of patients with HCC or the promoter methylation of C1QBP . (jcancer.org)

Stem cells from a donor, called a graft , are then infused to replace the destroyed cells, produce new marrow, and rebuild the recipient's immune system. (cancer.gov)
It also carries risks of potential harms, including infection, graft-versus-host disease (where certain immune cells from the donor attack the normal tissue of the transplant recipient), and death. (cancer.gov)
Alloreactive donor T cells are important mediators of both relapse control by graft- versus -leukemia (GvL) effects, and of GvHD. (haematologica.org)
Alloreactive donor T cells recognizing patient-specific genetic polymorphisms, including mismatched HLA allotypes, play a major role in both beneficial GvL and severe GvHD after UD-HCT. (haematologica.org)

The difference led to a hazard ratio for survival of 0.73 in favor of nivolumab (95% CI 0.59 to 0.89, P =0.00155), the researchers reported. (medpagetoday.com)
Although lysosomes perform a number of essential cellular functions, damaged lysosomes represent a potential hazard to the cell. (biorxiv.org)

Multiplacenta derived stem cell/cytokine treatment increases survival time in a mouse model with radiation-induced bone marrow damage. (stembook.org)

Thus, here we propose to validate the efficacy of µRB-like hydrogels with tunable stiffness and macroporosity as cell-delivery matrices that enhance the engraftment and survival of stem cells for both soft and hard tissue reconstruction using relevant animal models in vivo. (ca.gov)
Stem cell-based therapies hold great promise for treating tissue loss and enhancing tissue regeneration, often via direct injection of cells at the target site. (ca.gov)
Certain immune T cells called tissue-resident memory cells are formed locally in the skin and other tissue, and protect against infections that they have encountered before. (technologynetworks.com)

In some cases, cisplatin+AG-treated cells were pre-incubated either with [D-Lys3]-GHRP-6, a ghrelin receptor antagonist, or with LY294002, a PI3K inhibitor. (hindawi.com)

Front Cell Infect Microbiol;7: 38, 2017. (bvsalud.org)

Anatomy19

Organisms8

Diseases34

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes58

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care21

Proliferation15

Transplantation21

Chemotherapy10

Relapse-free survival4

Progression-free sur6

Apoptosis7

Renal Cell Carc4

Median6

Hematopoietic6

Outcomes3

Primary endpoint1

Intracellular survival2

Genes19

Viability3

Pathways1

Chimeric antigen receptor1

Immunotherapy7

Tumor cells1

Cancer41

Therapeutic5

Lymphoma10

Metastatic3

Long-term survival1

Human pancreatic2

Antigen2

Carcinoma10

Improve survival3

Significantly4

Embryonic5

Essential for cell survival1

Vitro1

Associated with improved survival1

Neuronal2

Promotes cell survival1

Dendritic cell1

Squamous1

Stem cell survival2

Death and Survival1

Clinical2

Epithelial3

Mechanisms3

Analyses1

Differentiation3

Therapy3

Pathway4

Patient's2

Regenerative medicine2

Migration2

Accumulation1

MRNA3

Donor4

Hazard2

Increases survival1

Tissue3

Receptor1

20171