MonocytesPhagocytosisNeutrophil chemotaxisPolymorphonuclear leukocyteInhibitionMigrationAdhesionEndothelial cellsInflammationChemokineCCR5ModulationMonocytePhagocyticAssayMechanismsCXCL12ProteasesProliferationBiologyProteinRecruitmentInducesInflammatoryLTB4MovementCellPatientsFunctionWorkDirectlyEffect
Monocytes2
- Diabetes results in changes in the function of host defense cells such as polymorphonuclear leukocytes (PMNs), monocytes, and macrophages. (health.am)
- In turn, oxidized lipoproteins in the tunica intima of the vessel work as attractants for chemotaxis of leukocytes and monocytes that start to produce pro-inflammatory cytokines in big amounts. (intechopen.com)
Phagocytosis2
- PMN adherence, chemotaxis, and phagocytosis are impaired. (health.am)
- Anomalies of chemotaxis and phagocytosis by polymorphonuclear leukocytes have been observed. (lu.se)
Neutrophil chemotaxis2
- Although the principal stimulus that triggers the phenomenon of massive PMNL migration from the vasculature to the epidermis is unknown, several new pathways involved directly and indirectly with neutrophil chemotaxis have been the topic of recent investigations. (medscape.com)
- The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. (cdc.gov)
Polymorphonuclear leukocyte3
- Polymorphonuclear leukocyte chemotaxis was investigated in 35 patients with recurrent polyserositis during attacks and during spontaneous or colchicine-induced remissions. (tau.ac.il)
- Enhanced polymorphonuclear leukocyte (PMNL) chemotaxis is much more pronounced in pustular psoriasis than in psoriasis vulgaris. (medscape.com)
- The polymorphonuclear leukocyte-neutrophil is a key cell type and an essential part of the host's inflammatory response. (bvsalud.org)
Inhibition1
- HDPs are seen as true multifunctional peptides with activities as diverse as chemotaxis, inhibition of LPS-induced inflammation, modulation of leukocyte differentiation and promotion of wound healing. (unina.it)
Migration3
- These products, acting in concert with one another, contribute to inflammation and associated sensitivity and pain, as evidenced by increased vascular permeability, increased leukocyte migration, and increased sensitivity of nociceptors. (nationalacademies.org)
- Although migration of cells was detected from the early days of the development of microscopy ( Leeuwenhoek ) , erudite description of chemotaxis was first made by T.W. Engelmann (1881) and W.F. Pfeffer (1884) in bacteria and H.S. Jennings (1906) in ciliates . (wikidoc.org)
- Slit2 is a member of the Slit family that signals through the Roundabout (Robo) receptor as a repellent for axon guidance and neuronal migration, and also acts as a chemoattractant to vascular endothelial cells and a chemotaxis inhibitor for leukocytes. (peprotech.com)
Adhesion16
- When it is altered by various stimuli, it may cause localized alterations or "endothelial dysfunction" having antihemostatic properties, regulating vascular tone, determining a heightened leukocyte adhesion, and increase production of cytokines and growth factors [ 16 ]. (hindawi.com)
- Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. (medscape.com)
- Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
- Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
- This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
- This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
- Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
- In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
- Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
- However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
- Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
- Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
- Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
- Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
- Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
- This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
Endothelial cells3
- These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
- This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
- CCL4, also known as macrophage inflammatory protein 1 beta (MIP-1 beta ) is a 7.8 kDa beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells (1, 2). (rndsystems.com)
Inflammation3
- Proteolytic cascades trigger blood clotting, fibrinolysis, and complement activation, while proteases released upon leukocyte degranulation are integral to the processes of inflammation and immunity. (nih.gov)
- Secreted glucocorticoids regulate leukocyte-endothelial interactions in inflammation. (google.no)
- I have been interested in understanding leukocyte biology, specifically how leukocytes migrate to sites of cell death and how sterile inflammation damages tissues. (nikonsmallworld.com)
Chemokine2
- In the current study, we showed one of its components, andrograpanin, could enhance chemokine stromal cell-derived factor-1α (SDF-1α) induced chemotaxis in Jurkat and THP-1 cells. (utmb.edu)
- Further study demonstrated that this kind of effect was CXC chemokine receptor-4 (CXCR4) specific, since andrograpanin could not enhance other chemokines, such as RANTES, monocyte chemotactic protein-1 (MCP-1), etc. induced cell chemotaxis. (utmb.edu)
CCR51
- CCR5 plays a role in mediating leukocyte chemotaxis in tient age was 40.35 years. (cdc.gov)
Modulation1
- As chemoattractants are critical for both systemic leukocyte positioning by triggering integrin activation and subsequent recruitment from circulation, and local intratissue leukocyte positioning via chemotaxis, modulation of attractant activities by proteases may have profound effects on the immune response. (nih.gov)
Monocyte2
- Human monocyte chemotaxis: migrating cells are a subpopulation with multiple chemotaxin specificities on each cell. (uni-regensburg.de)
- It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. (lookformedical.com)
Phagocytic2
- Data suggest impaired leukocyte function, including altered chemotaxis and phagocytic activity. (medscape.com)
- DS patients also present a T cell immunodeficiency causing functional defects of polymorphonuclear leukocytes, reduced chemotaxis, diminished phagocytic ability, defective oxidative response and abnormal bactericidal activity 3 . (bvsalud.org)
Assay2
- Scholars@Duke publication: Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors. (duke.edu)
- The rank order potency of these analogs was equivalent to that of the pharmacological activity of LTB4 agonists in the PMN chemotaxis assay. (aspetjournals.org)
Mechanisms2
- In addition, it has been recognized that mechanisms that allow chemotaxis in animals can be subverted during cancer metastasis . (wikidoc.org)
- During my master's and Ph.D., I investigated mechanisms involved in leukocyte chemotaxis and started to work on the visualization of leukocyte trafficking in vivo . (nikonsmallworld.com)
CXCL122
- Ultra-LEAF™ purified anti-CXCL12 (SDF-1β) antibody (clone W15149B) (purple squares) neutralizes the chemotaxis of recombinant mouse CXCL12 (SDF-1β) at 0.25 ng/mL on mouse Baf3-hCXCR4 cells in a dose-dependent manner. (biolegend.com)
- CXCL12α is inactivated by other enzymes such as metalloproteases, serine proteases, and leukocyte elastase. (biolegend.com)
Proteases1
- This report reviews the emerging literature describing a novel class of proteolytic targets, leukocyte chemoattractants, and, in particular, chemerin, a dendritic cell and macrophage chemoattractant activated by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. (nih.gov)
Proliferation1
- These proteolytic processes affect the chemokine's ability to bind to heparin and cells as well as its ability to stimulate proliferation and chemotaxis. (biolegend.com)
Biology1
- The significance of chemotaxis in biology and clinical pathology was widely accepted in the 1930s. (wikidoc.org)
Protein1
- It acts as a co-receptor for human immunodeficiency virus (HIV) entry in cells.The protein also has a role in leukocyte chemotaxis. (sigmaaldrich.com)
Recruitment1
- [ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)
Induces2
- Leukotriene B4 induces formation of inositol phosphates in rat peritoneal polymorphonuclear leukocytes. (aspetjournals.org)
- No. 589806) (black circles) induces the chemotaxis of mouse Baf3-hCXCR4 transfectant chemoattractant cells. (biolegend.com)
Inflammatory1
- Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. (lookformedical.com)
LTB41
- Leukotriene B4 (LTB4) induced rapid breakdown of prelabeled inositol phospholipids in rat peritoneal polymorphonuclear leukocytes (PMNs). (aspetjournals.org)
Movement1
- Chemotaxis is called positive if movement is in the direction of a higher concentration of the chemical in question, and negative if the direction is opposite. (wikidoc.org)
Cell2
- Chemotaxis , a kind of taxis , is the phenomenon in which bodily cells, bacteria , and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. (wikidoc.org)
- Chemotaxis is one of the most basic cell physiological responses. (wikidoc.org)
Patients1
- Chemotaxis was found to be unchanged in the attack-free period in untreated patients, increased by about 50% during attacks, and decreased by about 50% during colchicine treatment. (tau.ac.il)
Function1
- In multicellular organisms, chemotaxis is critical to development as well as normal function. (wikidoc.org)
Work1
- On November 3 , 2006 , Dr. Dennis Bray of University of Cambridge was awarded the Microsoft European Science Award for his work on chemotaxis on E. coli . (wikidoc.org)
Directly1
- Over a wide range, the number of cells migrating toward a given concentration of chemotaxin was directly proportional to the number added to the chemotaxis chamber. (uni-regensburg.de)
Effect1
- The effect of chemotherapeutic agents - cytosine arabinoside, methotrexate, procarbazine, vinblastine and vincristine - generally applied in the treatment of human cancer were tested on the motility of polymorphonuclear leukocytes. (karger.com)