• Demeclocycline, doxycycline, and minocycline also may be used for other problems as determined by your doctor. (mayoclinic.org)
  • Doxycycline belongs to a broad spectrum of antibiotics in the tetracycline group and must not be taken by individuals with allergic sensitivities to doxycycline and other tetracycline antibiotics like minocycline, demeclocycline, and tigecycline. (anytimedoctor.co.uk)
  • Demeclocycline (INN, BAN, USAN, brand name Declomycin) is a tetracycline antibiotic which was derived from a mutant strain of Streptomyces aureofaciens. (wikipedia.org)
  • Demeclocycline (marketed as Declomycin® , Declostatin® and Ledermycin® ) is a member of the tetracycline antibiotics group used in various types of bacterial infections. (the-medical-dictionary.com)
  • Definition Demeclocycline, more accurately demeclocycline hydrochloride, is a broad-spectrum antibiotic of the tetracycline family. (the-medical-dictionary.com)
  • As with related tetracycline antibiotics, demeclocycline acts by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA which impairs protein synthesis by bacteria. (wikipedia.org)
  • Demeclocycline inhibits the renal action of antidiuretic hormone by interfering with the intracellular second messenger cascade (specifically, inhibiting adenylyl cyclase activation) after the hormone binds to vasopressin V2 receptors in the kidney. (wikipedia.org)
  • It is not completely understood why demeclocycline impairs the action of antidiuretic hormone, but it is thought that it blocks the binding of the hormone to its receptor. (the-medical-dictionary.com)
  • Demeclocycline is officially indicated for the treatment of various types of bacterial infections. (wikipedia.org)
  • The use of demeclocycline in SIADH was first reported in 1975, and, in 1978, a larger study found it to be more effective and better tolerated than lithium carbonate, the only available treatment at the time. (wikipedia.org)
  • Furthermore demeclocycline might have psychotropic side effects similar to lithium. (wikipedia.org)
  • Some medications, such as lithium and demeclocycline, may cause nephrogenic DI. (logicalimages.com)
  • The Urology Care Foundation notes that nocturia can also be caused by the timing or dose of certain medications (such as diuretic medicine, cardiac glyocides, demeclocycline, lithium, methoxyflurane, and excessive vitamin D) and sleep disorders like insomnia and sleep apnea. (vitacost.com)
  • demeclocycline induces nephrogenic diabetes insipidus (dehydration due to the inability to concentrate urine). (wikipedia.org)
  • Like only few other known tetracycline derivatives, demeclocycline causes nephrogenic diabetes insipidus. (wikipedia.org)
  • Resistance, though, is gradually becoming more common, and demeclocycline is now rarely used for treatment of infections. (wikipedia.org)
  • Demeclocycline is rarely used for infections. (the-medical-dictionary.com)
  • Barr Laboratories received approval and began shipment of demeclocycline HCl tablets USP, in 150 mg and 300 mg doses. (the-medical-dictionary.com)
  • Demeclocycline used to be the drug of choice for treating SIADH. (wikipedia.org)
  • While demeclocycline has not been linked specifically to liver injury in the published literature, it is an orally available semisynthetic tetracycline and is likely to cause injury similar to that described for tetracycline, oxytetracycline, and doxycycline. (nih.gov)
  • Demeclocycline inhibits the renal action of antidiuretic hormone by interfering with the intracellular second messenger cascade (specifically, inhibiting adenylyl cyclase activation) after the hormone binds to vasopressin V2 receptors in the kidney. (wikipedia.org)
  • Demeclocycline is a semisynthetic tetracycline derived from Streptococcus aureofaciens that is used as an antibiotic, but perhaps more frequently as an inhibitor of arginine vasopressin in the therapy of hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). (nih.gov)
  • Effective demeclocycline therapy in a patient with over-secretion of antidiuretic hormone following head trauma]. (nih.gov)
  • Demeclocycline (dem" e kloe sye' kleen) is a tetracycline antibiotic that is used for therapy of mild-to-moderate infections due to susceptible organisms. (nih.gov)
  • Demeclocycline comes as a tablet to take by mouth. (medlineplus.gov)
  • After a 150 mg oral dose of demeclocycline tablet, the mean concentrations at 1 hour and 3 hours are 0.46 and 1.22 mcg/mL (n = 6), respectively. (nih.gov)
  • The use of demeclocycline in SIADH was first reported in 1975, and, in 1978, a larger study found it to be more effective and better tolerated than lithium carbonate, the only available treatment at the time. (wikipedia.org)
  • Demeclocycline used to be the drug of choice for treating SIADH. (wikipedia.org)
  • Demeclocycline has been shown to be active against most isolates of the following bacteria, in vitro and/or in clinical infections as described in the INDICATIONS AND USAGE section. (nih.gov)
  • Demeclocycline is bacteriostatic (it impairs bacterial growth but does not kill bacteria directly). (pharmacycode.com)
  • Demeclocycline inhibits cell growth by inhibiting translation. (pharmacycode.com)
  • Antibiotics such as demeclocycline will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • Demeclocycline should not be taken with food (particularly milk and other dairy products) or antacids. (wikipedia.org)
  • Finally, demeclocycline causes worsening of kidney function in patients with cirrhosis and should not be used for hyponatremia associated with chronic liver disease. (nih.gov)
  • Take demeclocycline 2 hours before or6 hours after antacids, calcium supplements, and laxatives containing magnesium. (medlineplus.gov)
  • Demeclocycline is officially indicated for the treatment of various types of bacterial infections. (wikipedia.org)
  • Demeclocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. (pharmacycode.com)
  • you should know that demeclocycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). (medlineplus.gov)
  • demeclocycline induces nephrogenic diabetes insipidus (dehydration due to the inability to concentrate urine). (wikipedia.org)
  • Like only few other known tetracycline derivatives, demeclocycline causes nephrogenic diabetes insipidus. (wikipedia.org)
  • Demeclocycline-induced phosphate diabetes in a patient with inappropriate ADH secretion and systemic sarcoidosis. (nih.gov)
  • If you become pregnant while taking demeclocycline, call your doctor immediately. (medlineplus.gov)
  • No reports of liver injury due to demeclocycline have been published. (nih.gov)
  • Both hepatitis and liver failure are mentioned in the product label for demeclocycline, but details of the liver injury are not provided. (nih.gov)
  • you should know that when demeclocycline is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained. (medlineplus.gov)
  • Take demeclocycline on an empty stomach at least 1 hour before or 2 hours after meals. (medlineplus.gov)
  • Take demeclocycline 2 hours before or4 hours after iron preparations and vitamin products that contain iron. (medlineplus.gov)
  • 4 hit compounds, including 3'-Azido-3'-deoxythymidine, auranofin, polymyxin B and demeclocycline, not only exhibited single therapeutic effect, but also showed significant synergistic effect with gentamicin, which is sensitive for both of these two strains. (nih.gov)
  • Demeclocycline should not be used in children under age 8 unless your doctor decides it is needed. (medlineplus.gov)