Dendritic cells. Medical search. Frequent questions

The most common division of dendritic cells is conventional dendritic cells (a.k.a. myeloid dendritic cells) vs. plasmacytoid dendritic cell (most likely of lymphoid lineage) as described in the table below: The markers BDCA-2, BDCA-3, and BDCA-4 can be used to discriminate among the types. (wikipedia.org)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive disease with historically poor outcomes. (medpagetoday.com)
For years the disease known as BPDCN had many different names, including natural killer cell leukemia/lymphoma, and only with the discovery that the disease is derived from plasmacytoid dendritic cells was the term established as blastic plasmacytoid dendritic cell neoplasm by the World Health Organization in 2008, and listed as its own entity in 2016. (medpagetoday.com)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) was previously known as natural killer (NK) cell leukemia/lymphoma. (lls.org)
As understanding of the biology and origin of this malignancy has improved, the World Health Organization (WHO) established the term blastic plasmacytoid dendritic cell neoplasm (BPDCN) in 2008. (lls.org)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is very often misdiagnosed and under-reported. (lls.org)
These subtypes include conventional dendritic cells (cDC1 and cDC2), plasmacytoid dendritic cells (pDCs), monocyte-derived dendritic cells (moDCs), and Langerhans cells (LCs). (origene.com)
Plasmacytoid dendritic cells (pDCs), are round plasma-shaped cells specialized for the production of large amounts of type I and type III interferon in response to viral infection. (origene.com)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy derived from plasmacyoid dendritic cells. (medscape.com)
[ 1 ] Within the 2016 World Health Organization (WHO) category of "acute myeloid leukemia and related neoplasms," the related neoplasms derive from immature cells with evidence of myeloid differentiation, or from precursors of plasmacytoid dendritic cells. (medscape.com)
The precursors of plasmacytoid dendritic cells are the cells of origin for blastic plasmacytoid dendritic cell neoplasm (BPDCN), a clinically aggressive disease with a proclivity for the skin and leukemic involvement and for which no consensus currently exists regarding optimal treatment modalities. (medscape.com)
Frequent sites of occurrence of blastic plasmacytoid dendritic cell neoplasm (BPDCN) include the skin, as well as the peripheral blood (PB) and bone marrow (BM). (medscape.com)
A diffuse infiltrate of medium-sized cells with dispersed chromatin ("blastic") is characteristic of blastic plasmacytoid dendritic cell neoplasm (BPDCN). (medscape.com)
Pathology of blastic plasmacytoid dendritic cell neoplasm (BPDCN).Skin involvement by blastic plasmacytoid dendritic cell neoplasm. (medscape.com)
The neoplastic cells in blastic plasmacytoid dendritic cell neoplasm (BPDCN) are typically positive for CD45, HLA-DR, CD43, CD4, CD56, and cutaneous lymphocyte-associated antigen (CLA). (medscape.com)
Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)
NICE is unable to make a recommendation on tagraxofusp (Elzonris) for treating blastic plasmacytoid dendritic cell neoplasm. (nice.org.uk)
Importantly, activated MDMs in turn mediate strong activation of plasmacytoid dendritic cells (pDCs), leading to the secretion of high levels of IFN-α and TNF. (nature.com)
These cells have a plasmacytoid dendritic cell phenotype, a distinct response to TLR ligation and present antigen to T cells far less efficiently on comparison to conventional CD11c(hi) dendritic cells. (cam.ac.uk)
My research is now focusing on manipulating plasmacytoid dendritic cell populations in vivo and determining the cause for the changes in the CDllc(lo) and Foxp3+ T cell populations following infection. (cam.ac.uk)
How much do you know about the presentation and diagnosis of blastic plasmacytoid dendritic cell neoplasm (BPDCN)? (medscape.com)
the tumor derives from the precursors of plasmacytoid dendritic cells (ie, plasmacytoid monocytes). (medscape.com)

In fact, in patients suffering from severe COVID-19, massive infiltration of proinflammatory immune cells, including activated macrophages, was detected in infected lung tissue. (nature.com)
These cells, including macrophages and neutrophils, were found to provide a rapid response to virtually all pathogens and to initiate inflammation at sites of local infection. (aacrjournals.org)
Antigen Presenting Cells (APc's - dendritic cells, monocytes, and macrophages) are the key to provoking a robust adaptive immune response. (shu.edu)
Dendritic cells (DCs) and macrophages (Mph) share many characteristics as components of the innate immune system. (uni-wuerzburg.de)
More recently, ontogenetic, transcriptional, and proteomic research approaches uncovered major developmental differences between Flt3L-dependent conventional DCs as compared with Mphs and monocyte-derived DCs (MoDCs), the latter mainly generated in Dendritic cells (DCs) and macrophages (Mph) share many characteristics as components of the innate immune system. (uni-wuerzburg.de)
Dendritic cells and macrophages have been attributed with stimulatory capacity for in vivo and in vitro immune responses. (diabetesjournals.org)
Therefore, the differential ability of dendritic cells and macrophages (splenic adherent cells [SACs]) to stimulate pancreatic islet allograft rejection in reversed alloxan-induced diabetic rats was examined. (diabetesjournals.org)
Internalization of bim Bm or bim Bp isolates by CD11c + dendritic cells and F4/80 + macrophages was comparable (not shown). (cdc.gov)
C) However, persistence of bim Bm strains was significantly higher in dendritic cells and macrophages after 24 hours of culture. (cdc.gov)
We also noted that CD11c positive dendritic cells but not F4/80 positive macrophages retained SWCNT in the lungs 9 days after pharyngeal aspiration. (cdc.gov)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)

Mo-DC or MDDC refers to cells matured from monocytes. (wikipedia.org)
Infiltrating monocytes take up the modified low-density lipoproteins and become foam cells, which make plaques unstable, resulting in acute myocardial infarction [ 5 ]. (hindawi.com)
This kit contains the following optimized proteins and reagents to drive the efficient differentiation of mouse monocytes into dendritic cells. (rndsystems.com)
Based in Prague, Czech Republic, Sotio is developing personalised dendritic cell vaccines (DCVACs) based on dendritic cells cultivated from a patient's blood monocytes and used to induce an immune response against tumour cells. (outsourcing-pharma.com)
Results: The presence of MMF during the differentiation of monocytes into iDCs resulted in cells that retained low levels of CD14 and hardly expressed CD1a. (eur.nl)
Autologous mature dendritic cells derived from peripheral blood monocytes were pulsed with the HLA-A2-binding MUC1 peptides (M1.1 and M1.2). (aacrjournals.org)
These cells include dermal resident dendritic cells (DC), epidermal Langerhans cells, neutrophils and monocytes, which are released from the blood when the dermal capillary is disrupted and a reputed blood lake is formed [ 3 - 6 ]. (biomedcentral.com)

Moffitt Cancer Center continues to distinguish itself as a world leader in the development of novel immunotherapy treatments, capitalizing on the natural power of the body's immune system to defend itself against the growth and spread of cancerous cells. (moffitt.org)
It is a phase 2b randomized trial of autologous dendritic cell immunotherapy (CMN-001) plus standard treatment for advanced renal cell carcinoma after a nephrectomy ( MCC 21083 ). (moffitt.org)
This CMN-001 is an autologous, tumor antigen-loaded dendritic cell immunotherapy. (moffitt.org)
Its new mesothelioma clinical trial is called DENIM (Dendritic cell immunotherapy for mesothelioma). (survivingmesothelioma.com)
Martin Cannon, PhD, discusses the phase 1 investigation of the Th17 dendritic cell vaccine in ovarian cancer, and how it could potentially improve suboptimal responses when treated with immunotherapy alone in this population. (onclive.com)
Martin Cannon, PhD, professor, Department of Microbiology and Immunology, University of Arkansas for Medical Sciences (UAMS) College of Medicine, discusses the phase 1 investigation of the Th17 dendritic cell vaccine in ovarian cancer, and how it could potentially improve suboptimal responses when treated with immunotherapy alone in this population. (onclive.com)
Janssen Biotech acquired a worldwide license to Alligator Bioscience's Phase I immunotherapy ADC-1013 , an agonistic monoclonal antibody that targets CD40, an immuno-stimulatory receptor found on antigen-presenting cells, which can spur an increase in T cells attacking a tumor. (shu.edu)
Monocyte-derived dendritic cell (DC)-based anti-cancer immunotherapy represents a promising treatment modality in these neoplasias. (muni.cz)
Immunotherapy can fail in patients with cancer when certain cancer cells can hide from the immune system. (lu.se)
However, cDC1 can be compromised in cancer patients and some cancer cells lack these antigen-presenting proteins on their surface, impacting immunotherapy response. (lu.se)

[ 4 , 5 ] Previously used terms for this disorder have included CD4+CD56+ hematodermic tumor and blastic natural killer (NK) cell lymphoma. (medscape.com)
Previous terms for this disorder have included CD4+CD56+ hematodermic tumor (HDT) and blastic natural killer (NK) cell lymphoma. (medscape.com)

Once they have come into contact with a presentable antigen, they become activated into mature dendritic cells and begin to migrate to a lymph node. (wikipedia.org)
The CellXVivo ™ Mouse Dendritic Cell Differentiation Kit contains the media and cytokine components to generate immature and mature dendritic cells from mouse bone marrow. (rndsystems.com)
Immature dendritic cells (left, blue) and TNF-α-treated mature dendritic cells (right, red), derived from bone marrow cells cultured with the CellXVivo ™ Mouse Dendritic Cell Differentiation Kit, were stained for flow cytometry with antibodies for CD11c, B7-2/CD86, MHC class II (I-A/I-E), or CD40 (open histograms). (rndsystems.com)
Mature dendritic cells have the phenotype of CD11c + , with increased expression of B7-2/CD86, MHC class II, and CD40. (rndsystems.com)
Serial dilutions of TNF-α-treated mature dendritic cells were incubated with allogeneic mouse T cells for 3 days. (rndsystems.com)

Here they act as antigen-presenting cells: they activate helper T-cells and killer T-cells as well as B-cells by presenting them with antigens derived from the pathogen, alongside non-antigen specific costimulatory signals. (wikipedia.org)
Dendritic cells can be used as a vaccine by preparing together with either peptides or small portions of tumor antigens and they can then be injected into the body. (moffitt.org)
First discovered by Ralph Steinman and Zanvil A. Cohn in the 1970s, named for their tree-like branches or "dendrites", these cells patrol our bodies, ingest pathogens, process them, and present fragments (antigens) to T-cells, thus initiating a targeted immune response [2]. (origene.com)
cDC1: These cells are very effective at presenting antigens to CD8+ T cells, a type of cytotoxic T cell that can kill infected or cancerous cells. (origene.com)
cDC2: These cells are specialized in presenting antigens to CD4+ T cells, a type of helper T cell that helps coordinate the immune response. (origene.com)
DCs present antigens to T cells and stimulate potent cytotoxic T-cell responses. (nih.gov)
Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)
Once the intruder has been digested, dendritic cells also expose on their surface fragments of the pathogen: the antigens. (univ-mrs.fr)
From there, researchers isolate immature dendritic cells and "program" them to present certain key antigens to the immune system. (survivingmesothelioma.com)
Our approach serves as a platform for the development of immunotherapies that endow cancer cells with the capability to process and present endogenous tumor antigens. (lu.se)
To establish whether these cells were differentiated into iDCs, we analysed the expression of cell surface molecules on these cells and the capacity to capture antigens using flow cytometry. (eur.nl)
Dendritic cell vaccines are normally created by force-feeding dendritic cells with tumor antigens. (issels.com)
Scientists at the Swiss Institute for Experimental Cancer Research have developed a modification that allows dendritic cells to acquire antigens from a patient's tumor. (issels.com)
De Palma explained the phenomenon of cross-dressing, in which dendritic cells display the acquired antigens directly on their surface. (issels.com)
Dendritic cells are part of the immune system, serving as advance sentries that recognize the presence of foreign antigens. (issels.com)
Once the dendritic cells process the antigens, they are presented to T cells, another part of the immune system. (issels.com)
Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
By using direct reprogramming strategies, I could induce the expression of tumor antigens on the surface of cancer cells, making them visible to the immune system again. (lu.se)
when it comes to cancer they are critical as they present tumor antigens to the killer cells of the immune system and orchestrate the anti-tumor immune response. (lu.se)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)

Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. (hindawi.com)
Cytokines produced by DCs can also promote the differentiation of CD4 + T helper cells as part of immune activation. (rndsystems.com)

Dendritic cells are present in tissues that are in contact with the body's external environment, such as the skin (where there is a specialized dendritic cell type called the Langerhans cell), and the inner lining of the nose, lungs, stomach and intestines. (wikipedia.org)
citation needed] Dendritic cells were first described by Paul Langerhans (hence Langerhans cells) in the late nineteenth century. (wikipedia.org)
In the natural infection, DV is introduced into human skin by an infected mosquito vector where it is believed to target immature dendritic cells (DCs) and Langerhans cells (LCs). (unboundmedicine.com)
Conversely, in vitro GM-CSF-dependent monocyte-derived Mphs largely resemble MoDCs whereas tissue-resident Mphs show a common embryonic origin from yolk sac and fetal liver with Langerhans cells (LCs). (uni-wuerzburg.de)
Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology, lacking an animal model, that cumulates symptoms that are found separately in various IL-17A-related diseases, such as aggressive chronic granuloma formation, bone resorption and soft tissue lesions with occasional neurodegeneration(11,12). (dtu.dk)
We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)
Langerhans cell granulomatosis (LCG) is a clonal disorder characterized by lesions containing histiocyte-like cells, giant cells, and eosinophils. (medscape.com)
[ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
Cite this: Langerhans Cell Granulomatosis Manifested as Pigmented Villonodular Synovitis - Medscape - Dec 01, 2001. (medscape.com)
Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)

Dendritic cells are derived from hematopoietic bone marrow progenitor cells (HSC). (wikipedia.org)
While the skin is the most commonly involved site of the disease (usually presenting as dark and purplish skin lesions) it can progress with bone marrow involvement and a decrease in red blood cell, white blood cell, and platelet counts, as well as possible lymph node and spleen involvement, and the involvement of other extramedullary organs. (medpagetoday.com)
However, BPDCN usually progresses with bone marrow involvement and a decrease in red blood cell, white blood cell and platelet counts. (lls.org)
Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
Conventional dendritic cells (cDCs), also known as myeloid dendritic cells or classical dendritic cells, are a type of antigen-presenting cell (APC), cDCs originate from hematopoietic stem cells, specifically from the common myeloid progenitor in the bone marrow. (origene.com)
On bone marrow aspirate smear preparations, the neoplastic cells may display cytoplasmic vacuoles that have been likened to a pearl necklace. (medscape.com)
In lymph nodes, the tumor cells infiltrate the interfollicular areas and medullary areas, often diffusely, whereas bone marrow evaluation may show variable degrees of infiltration ranging from sparse to significant. (medscape.com)
For the differentiation of dendritic cells from mouse bone marrow. (rndsystems.com)
Methods: Bone marrow-derived DC from C57BL/6 mice were loaded with UV-irradiated, syngeneic Panc02 carcinoma cells and were administered subcutaneously. (uni-muenchen.de)
Each kit includes exosomes isolated from either HEK293 cells or JAWS II mouse bone marrow dendritic cells and Exo-Fect-a novel transfection reagent that enables the transfer of RNAs, DNAs (including plasmids), and small molecules directly into isolated exosomes. (reportergene.com)

We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
In 2018, our research group identified the three transcription factors that allow us to convert fibroblasts, for example from the skin, into type 1 conventional dendritic cells (cDC1). (lu.se)

The fluorescence histogram showing Dendritic Cells antigen expression (or Ig Isotype control staining) were derived from either CD11b+ CD11c- (Left Panel) or CD11b [intermediate] CD11c+ (Right Panel) gated events, as indicated, with the forward and side light-scatter characteristics of intact leucocytes. (bdbiosciences.com)
I have found that chronic helminth infection is associated with the expansion of CD11c(lo) dendritic cells in the draining lymph nodes of the gut. (cam.ac.uk)
CD11c(lo) cells polarise naive T cells to distinct T cells lineages, encouraging the expansion of antigen-specific Foxp3 T cells and polarisation away from Th17 cells. (cam.ac.uk)
Immature dendritic cells have the phenotype of CD11c + , with intermediate expression of B7-2/CD86, MHC class II, and little to no CD40. (rndsystems.com)
However, co-localization of T. gondii with CD11c or F4/80 positive cells could not be observed in lungs or spleen. (cdc.gov)

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
IL-27 binds to IL-27ra and gp-130 complex, which is expressed on multiple cell types, including T lymphocytes [ 2 ]. (hindawi.com)
Paradoxically, while we have known for a long time the key role played by these cells in the activation of B and T lymphocytes, and we identified the sensors that allow them to detect danger signals emitted by pathogens, operation of this interface remains partly a mystery. (univ-mrs.fr)
To deliver these immunological instructions, antigen (in practice a peptide a few amino acids in length) is not presented in isolation to T lymphocytes by dendritic cells but is nestled in a pocket formed by a molecule, known as the Major Histocompatibility Complex (called HLA in humans). (univ-mrs.fr)
Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)
Objectives: As dendritic cells (DCs) present in these skin lesions play a key role in the activation of Th lymphocytes, we investigated the effects of MMF on monocyte-derived DC differentiation. (eur.nl)
For this purpose we measured cytokine production by these LPS-stimulated cells (MMF-DCs) using enzyme-linked immunosorbent assays as well as their ability to activate naive Th lymphocytes. (eur.nl)
The production of IL-4 and IL-10 by naive Th lymphocytes cocultured with MMF-DCs did not differ from that by T cells cocultured with control DCs. (eur.nl)
Background: Tumor-specific cytotoxic T lymphocytes (CTL) can be activated in vivo by vaccination with dendritic cells (DC). (uni-muenchen.de)
We now understand that adaptive immunity is the purview of a second set of leukocytes, T and B lymphocytes, which are responsible not only for antibody production but also for the generation of T cells that can directly identify and kill host cells infected by pathogens (e.g., viruses). (aacrjournals.org)
For the activation of CD4 + T-helper lymphocytes, dendritic cells were further incubated with the PAN-DR-binding peptide PADRE. (aacrjournals.org)

In humans and mice, conventional dendritic cells are divided into two main subtypes: cDC1 and cDC2, each with distinct functions and markers [2]. (origene.com)
Here, we mapped metabolomic and lipidomic signatures associated with the activation phenotype of human conventional DC type 1, a DC subset specialized in cross-presentation and therefore of major importance for the stimulation of CD8 + T cells. (nih.gov)
Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
It has been reported that IL-27 performs an anti-inflammatory function by acting on conventional CD4 + T cells to induce IL-10-producing cells that are implicated in controlling inflammatory responses [ 3 ]. (hindawi.com)
Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

Immature dendritic cells are also called veiled cells, as they possess large cytoplasmic 'veils' rather than dendrites. (wikipedia.org)
These progenitor cells initially transform into immature dendritic cells. (wikipedia.org)
Immature dendritic cells constantly sample the surrounding environment for pathogens such as viruses and bacteria. (wikipedia.org)
Immature dendritic cells may also phagocytose small quantities of membrane from live own cells, in a process called nibbling. (wikipedia.org)
Immature dendritic cells phagocytose pathogens and degrade their proteins into small pieces and upon maturation present those fragments at their cell surface using MHC molecules. (wikipedia.org)
Upon activation, immature dendritic cells mature and increase the expression of class II MHC and co-stimulatory molecules important for effective antigen presentation to naïve T cells. (rndsystems.com)
Mouse PBMCs were differentiated into immature mouse dendritic cells by culturing for 5 days in reagents included in the CellXVivo ™ Mouse Monocyte-derived Dendritic Cells Differentiation Kit. (rndsystems.com)
Immature dendritic cells exhibit characteristic dendritic cell morphology. (rndsystems.com)
Phenotypic Analysis of Cultured Immature and Mature Mouse Dendritic Cells. (rndsystems.com)

In some respects, dendritic cells cultured in vitro do not show the same behaviour or capability as dendritic cells isolated ex vivo. (wikipedia.org)
In addition, administration of DCs treated ex vivo with an A2AR agonist protected the kidneys of WT mice from IRI by suppressing NKT production of IFN-γ and by regulating DC costimulatory molecules that are important for NKT cell activation. (jci.org)
We conclude that ex vivo A2AR-induced tolerized DCs suppress NKT cell activation in vivo and provide a unique and potent cell-based strategy to attenuate organ IRI. (jci.org)
I am interested in the mechanisms underlying this Foxp3+ regulatory T cell expansion in vivo and have focused on whether antigen presenting cells such as dendritic cells are re-programmed to a tolerogenic, regulatory T cell inducing, phenotype following infection. (cam.ac.uk)
Why Differentiate Dendritic Cells ex vivo ? (rndsystems.com)
Coincubation with Leishmania changes the migratory pattern of dendritic cells in vivo . (biomedcentral.com)
These findings indicate that dendritic cells are potent stimulator cells for in vivo immune responses. (diabetesjournals.org)

The latest addition to oncotherapy is the use of dendritic cell (DC) vaccine therapy. (moffitt.org)
A dendritic cell vaccine is a cross between a vaccine and a cell therapy. (moffitt.org)
Now researchers at Moffitt are working to develop a dendritic cell vaccine targeting HER3, a protein involved in the growth and spread of many different cancer types. (moffitt.org)
Tumour cells (from cancer cell lines) killed by High Hydrostatic Pressure (HHP) are engulfed in these dendritic cells, before being reintroduced into the patient's body in the form of immunotherapeutic vaccine to trigger the required response from the patient's immune system against the harmful tumour cells. (outsourcing-pharma.com)
The dendritic cell vaccine is one of the most potent weapons in our cancer-fighting arsenal, succeeding in many late-stage patients for whom other treatments had failed. (issels.com)
Accordingly, a Th17-stimulating dendritic cell vaccine was developed to potentially improve immune responses and clinical outcomes in this space, Cannon begins. (onclive.com)
The immunogenicity and safety of the Th17-stimulating dendritic cell vaccine in patients with stage IIIC-IV ovarian cancer was evaluated in a single-arm, open-label, phase 1 clinical trial (NCT02111941), Cannon details. (onclive.com)
Patients received the dendritic cell vaccine in the maintenance setting following the completion of upfront surgery and chemotherapy, he says. (onclive.com)
A comparison of T-cell frequency before and after vaccination showed that the vaccine successfully stimulated Th1, Th17, and antibody responses to FRα in most patients with ovarian cancer. (onclive.com)
A dendritic cell vaccine administered before and after autologous stem cell transplant (ASCT) was safe and immunogenic and was associated with durable clinical responses in patients with high-risk multiple myeloma, according to research published in Clinical Cancer Research . (medicalxpress.com)
To produce the vaccine, the researchers engineered the patients' own dendritic cells to express survivin and induce an immune response against the protein. (medicalxpress.com)
Locke and colleagues designed a dendritic cell vaccine targeting a protein called survivin and tested this vaccine in a phase I clinical trial involving 13 patients with multiple myeloma. (medicalxpress.com)
Baxalta, the biopharmaceutical spinoff of Baxter, entered into a $1.7 B deal with Precision BioSceinces for 6 CAR-T (Chimeric Antigen Receptor T-cell) projects, and Saronic Biotechnology announced positive data in preclinical studies of its autologous dendritic cell vaccine for hepatocellular carcinoma. (shu.edu)
DC vaccine quality was assessed in terms of DC yield, viability, immunophenotype, production of IL-12 and IL-10, and stimulation of allogenic donor T-cells and autologous T-cells in allo-MLR and auto-MLR, respectively. (muni.cz)

Dendritic cells (DCs) bridge the connection between innate and adaptive immunity. (nih.gov)
Restoring antitumor immunity with dendritic cell reprogramming strategies. (lu.se)
Initial results from the study were reported in 2020, and demonstrated that vaccination with Th17-inducing folate-receptor alpha (FRα)-loaded dendritic cells was safe, generated antigen-specific immunity, and was associated with increased remission, Cannon reports. (onclive.com)
Understanding the paradoxical importance of dendritic cells in immunity and tolerance will inform the development of successful cancer immunotherapies. (aacrjournals.org)
Alexandra Gabriela Barros Ferreira defends her Ph.D. thesis "Restoring antitumor immunity with dendritic cell reprogramming strategies" on Friday, 17 November, 2023. (lu.se)
My Ph.D. studies have focused on restoring anti-tumor immunity with dendritic cell reprogramming strategies. (lu.se)

Several models are proposed to describe the development and differentiation of dendritic cells (DCs). (origene.com)
Conclusions: MMF inhibited the monocyte-derived DC differentiation resulting in cells that cannot be appropriately matured to DCs. (eur.nl)
Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. (medscape.com)
The presence of the characteristic chromosomal translocation always involving the fibroblast growth factor receptor 1 ( FGFR1 ) gene at chromosome 8p11 in both the myeloid and lymphoid malignancies suggests bilineage differentiation from an affected pluripotent stem cell. (medscape.com)

The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)

Under polarizing inflammatory conditions, cDC2 induce Th2 responses in the lung ( 9 , 10 ), drive Th17 responses through IL-23 secretion ( 11 - 17 ), and initiate SIRPα dependent induction of T follicular helper cells (T FH ) and germinal center (GC) formation ( 18 ). (frontiersin.org)
Kit-derived Mature Mouse Dendritic Cells Induce Proliferation of Allogeneic T Cells. (rndsystems.com)
The company says the dendritic cells pulsed with the dead tumour cells have an increased ability to induce cytotoxic T cell responses, which increases the probability of inducing efficient immune response in the body. (outsourcing-pharma.com)
Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors. (lu.se)
ASCT is typically preceded by induction therapy with chemotherapy to kill as many cancer cells as possible and induce a remission. (medicalxpress.com)
Challenge stimuli consisting of ≤ 10 5 SACs or ≤10 4 dendritic cells failed to induce graft rejection. (diabetesjournals.org)
We focused particularly on harnessing reprogramming, or direct cellular reprogramming, to induce antigen presentation in cancer cells. (lu.se)
Direct reprogramming strategies with cDC1-specific factors can induce antigen-presentation in cancer cells, making cancer cells visible to the immune system and easier to fight. (lu.se)

Once activated, they migrate to the lymph nodes, where they interact with T cells and B cells to initiate and shape the adaptive immune response. (wikipedia.org)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)

Immunotherapies include checkpoint inhibitory antibodies, chimeric antigen receptor (CAR) T-cells, cancer vaccines, and oncolytic viruses. (moffitt.org)
Dendritic cell vaccines can potentially be used to treat different cancer types. (moffitt.org)
Sotio has selected local CRO Accord Research to carry out Phase I/II trials on its dendritic cell vaccines to treat patients with lung cancer in the Czech Republic. (outsourcing-pharma.com)
Scientists in Switzerland have now developed a method of modifying dendritic cell vaccines that makes them easier to personalize. (issels.com)
Dendritic cell vaccines are an effective method of increasing their numbers. (issels.com)
Dendritic cell vaccines are only one of the innovative treatments we use for patients with all forms of cancer. (issels.com)
Dendritic cell vaccines have the potential to harness the patients ' own immune system to get them into remission and potentially keep the cancer from coming back. (medicalxpress.com)

In this sequence of events, the team of Philippe Pierre and Evelina Gatti is particularly interested in the key stage of maturation of dendritic cells. (univ-mrs.fr)
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. (bvsalud.org)

An independent data monitoring committee (IDMC) has recommended the continuation of Argos' pivotal phase 3 ADAPT clinical trial of AGS-003 for the treatment of metastatic renal cell carcinoma (mRCC) based on results of the committee's second planned interim data analysis . (shu.edu)
A phase I trial was conducted to evaluate the feasibility, safety, and efficacy of a dendritic cell-based vaccination in patients with metastatic renal cell carcinoma (RCC). (aacrjournals.org)

dashed line histograms) or BD Horizon BB515 Rat Anti-Mouse Dendritic Cells antibody (Cat. (bdbiosciences.com)
Opened or reconstituted Mouse Dendritic Cell Base Media, Recombinant Mouse GM-CSF, Recombinant Mouse IL-4, or Recombinant Human TNF-alpha should be stored at 2-8 ° C under sterile conditions for up to 30 days or at -20 ° C to -70 ° C in a manual defrost freezer for up to 3 months. (rndsystems.com)
Morphology of Mouse Dendritic Cells Derived from PBMCs. (rndsystems.com)
JAWS II mouse dendritic cell exosomes were incubated with Exo-Fect and 100 pmol Texas Red-conjugated siRNA (non-targeting control included in the EV Shuttle Kits). (reportergene.com)

By contrast, follicular dendritic cells (FDC) are probably of mesenchymal rather than hematopoietic origin and do not express MHC class II, but are so named because they are located in lymphoid follicles and have long "dendritic" processes. (wikipedia.org)
As a consequence, cDC2 dependent CD4 + T cell proliferation and T follicular helper cell responses are increased. (frontiersin.org)
Meanwhile IL-27 exerts proinflammatory effects by promoting Th1, CD8, natural killer (NK), T follicular helper (Tfh), and B cell proliferation/functions and by inhibiting Treg and Th2 cell generation in parasites infection [ 4 ]. (hindawi.com)

Multicolor flow cytometric analysis of mouse splenic dendritic cells. (bdbiosciences.com)

Overall, the present study describes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected cells. (nature.com)
In comparison, cDC2s are potent activators of CD4 + T cells ( 8 ). (frontiersin.org)
Individually, dendritic cells are extremely potent, but the problem is that they're not usually present in large enough quantities. (issels.com)

Within 9 days of reprogramming, tumor-APCs acquired transcriptional and epigenetic programs associated with cDC1 cells. (lu.se)

In humans, pDCs can be identified by the expression of several specific cell surface proteins, including CD123 (the IL-3 receptor alpha chain), BDCA-2, and BDCA-4. (origene.com)

CMN-001 is indicated for the treatment of intermediate/poor-risk patients with advanced renal cell carcinoma (RCC) in combination with nivolumab plus ipilimumab as first-line therapy and in combination with lenvatinib plus everolimus as 2nd line therapy post-first-line failure. (moffitt.org)

The EVIR helps dendritic cells target the exosomes more precisely and present them to killer T-cells for a more efficient immune response. (issels.com)
Put exosomes to work-directly transfect JAWS II exosomes with RNA, plasmids, metabolites, or other small molecules for delivery to recipient cells. (reportergene.com)
The Kit comes with all of the reagents you need to load cargo into exosomes and concentrate them for delivery to target cells. (reportergene.com)

In the blood, mucous membranes and lymphoid organs, dendritic cells provide a dual role as sentinels, but also as conductors of the immune orchestra. (univ-mrs.fr)
This is the moment when the cells detect the microbes or danger, change their biological functions and begin their migration to secondary lymphoid organs. (univ-mrs.fr)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

They are known to secrete interleukin-12, as well as type I and type III interferons, and are believed to promote Th1 helper T cell and natural killer responses. (origene.com)
Here we comment briefly upon the characterization of an emerging regulatory pathway that enhances Th-1 polarization and CD8(+) CTL responses by a mechanism dependent upon CD40L-mediated T-cell help. (nih.gov)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
Collectively, our data demonstrate that PTPN22 controls cDC2 homeostasis, which in turn ensures appropriate cDC2-dependent T cell responses under antigenic challenge. (frontiersin.org)
Most notably, some gut helminths can also downregulate T cell responses to inflammatory stimuli including asthmatic and allergic reactions through stimulation and expansion of Foxp3+ regulatory T cells. (cam.ac.uk)
Dendritic cells (DCs) are key mediators of both innate and adaptive immune responses. (rndsystems.com)
Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)

These dendritic cells are like immune system factories and make other molecules that activate critical parts of the innate and adaptive immune system. (moffitt.org)
These cells process antigen material and present it on the cell surface to the T cells of the immune system, acting as messengers between the innate and the adaptive immune systems. (outsourcing-pharma.com)
The cellular or innate immune system was first described by the pathologist Elie Metchnikoff who recognized the existence of cells in the blood and tissues whose role was to identify, capture, and destroy invading pathogens. (aacrjournals.org)
It has long been appreciated that the innate and adaptive arms of the immune system must be coordinated, but it was not until the discovery of dendritic cells (DC) by Ralph Steinman at The Rockefeller University in the early 1980s that we truly understood conceptually how the immune system functions as a coherent unit. (aacrjournals.org)

The active components of CMN-001 are autologous, matured dendritic cells, which have been co-electroporated with both in vitro transcribed (IVT) RNA from an autologous tumor specimen and CD40L RNA. (moffitt.org)
Experiments in our lab have shown that Foxp3+ regulatory T cell expansion in vitro can be linked to a TGF -beta-like activity present in the excretory/secretory products of the rodent gut helminth Heligmosomoides Polygyrus. (cam.ac.uk)
The treatments involved a personalised preparation of the drug candidate using the dendritic cells, taken from the patient and manufactured by Sotio in vitro in large quantities. (outsourcing-pharma.com)
Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (cdc.gov)

This kind of pDC activation was dependent on direct integrin-mediated cell‒cell contacts and involved stimulation of the TLR7 and STING signaling pathways. (nature.com)
Since these observations, our team has collected an enormous amount of new data on the biochemical pathways involve with the acquisition by dendritic cells of unmatched immunomodulatory functions. (univ-mrs.fr)
The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found 16 significant regulated pathways in imDCs and 10 significant regulated pathways in mDCs, including the phagosome, cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. (frontiersin.org)

abstract = "IL-17A is a T cell-specific cytokine(1) that is involved in chronic inflammations, such as Mycobacterium infection(2), Crohn's disease(3), rheumatoid arthritis(4) and multiple sclerosis(5). (dtu.dk)

Logically, the team is interested in finding out whether and by what means the dendritic cell redirects the transport of MHC molecules depending on the nature of microbial products that it has detected. (univ-mrs.fr)
By looking under the microscope at the behavior of MHC molecules in dendritic cells we found that the addition of microbial products induces dramatic changes in all cells in our culture," says Evelina Gatti, co-leader on this team subject. (univ-mrs.fr)
Initially on the inside of the cells, MHC molecules were suddenly exposed on the outside of the cell. (univ-mrs.fr)
We tried to understand how the dendritic cell organized trafficking of MHC molecules. (univ-mrs.fr)
Dendritic cell activation (MHC II molecules in green, Lysosomes in red, nuclei in grey). (univ-mrs.fr)
This allows the molecules to have a "ticket" for restricted access into specialized compartments of the cell. (univ-mrs.fr)
Change in the distribution of MHC class II molecules within a dendritic cell in the presence (top) or absence (bottom) of the ubiquitin ligase MARCH1. (univ-mrs.fr)
Reprogramming restored the expression of antigen presentation complexes and costimulatory molecules on the surfaces of tumor cells, allowing the. (lu.se)
Upon maturation, these MMF-iDCs upregulated CD83 and costimulatory molecules and HLA-DR on their surface, indicating that these cells respond to LPS, albeit less than control iDCs. (eur.nl)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

The morphology of dendritic cells results in a very large surface-to-volume ratio. (wikipedia.org)

All cases are otherwise negative for Epstein-Barr virus (EBV) (assayed using in situ hybridization for EBV-encoded ribonucleic acid [RNA] [EBER-ISH]), B-cell, T-cell, myeloid, and natural killer (NK) cell markers, as well as for cytotoxic proteins (assayed using IHC). (medscape.com)

They also upregulate CCR7, a chemotactic receptor that induces the dendritic cell to travel through the blood stream to the spleen or through the lymphatic system to a lymph node. (wikipedia.org)
In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP + or Foxp3 + ) in the spleen and peripheral blood was increased. (hindawi.com)

The cells were then stained with APC Rat Anti-Mouse CD11b (Cat. (bdbiosciences.com)

They take up foreign proteins, break them down, and present the fragments (peptides) to other immune cells to stimulate an immune response, Locke explained. (medicalxpress.com)

Unlike other immune cells, dendritic cells are not just a single entity, but a complex assortment of subtypes with varying functions. (origene.com)
Many studies have indicated that numerous immune cells promote chronic inflammation and progressive plaque growth [ 4 ]. (hindawi.com)
They use these instructions not only for themselves - because the encounter with microbial products is not a trivial event and generates natural stress in the cells - but also for immune cells with which they cooperate. (univ-mrs.fr)

Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)
It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)

Hiding in the entryways used by pathogens, dendritic cells locate infectious agents, ingest them and release biochemical signals to alert the first line of defensive cells in the body and draw them to the site of the infection. (univ-mrs.fr)

We find that Isl2+ RGCs have distinct morphologies and dendritic stratification patterns within the retina and project to selective visual nuclei in the brain. (ca.gov)
Isl2-GFP RGCs have distinct morphologies and dendritic stratification patterns within the inner plexiform layer and project to selective visual nuclei. (ca.gov)

We have used serial electron microscopy and 3-dimensional reconstructions of dendritic spines from Purkinje spiny branchlets of normal adult rats to evaluate 2 questions about the relationship of spine geometry to synaptic efficacy. (jneurosci.org)
Active dendritic spines isolate themselves from the outside world, say Brenda Bloodgood and Bernando Sabatini (Harvard Medical School, Boston, MA). (rupress.org)
Bloodgood and Sabatini were "playing around" with a sensitive and photoactivatable fluorophore when they noticed that some dendritic spines seemed to be decoupled from the rest of the dendrite. (rupress.org)

Anatomy41

Organisms12

Diseases11

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes37

Disciplines and Occupations1

Health Care2

Plasmacytoid22

Macrophages12

Monocytes7

Immunotherapy10

Blastic2

Mature dendritic cells5

Antigens22

Cytokines2

Langerhans11

Bone marrow10

Type 1 conventional dendritic cells2

CD11c5

Lymphocytes11

Conventional5

Immature9

Vivo7

Vaccine14

Immunity6

Differentiation4

Monocyte-derived dendritic1

Induce8

Lymph nodes2

Vaccines7

Maturation of dendritic2

Metastatic renal cell carc2

Mouse dendritic4

Follicular3

Splenic dendritic1

Potent3

CDC11

PDCs1

Renal cell carc1

Exosomes3

Lymphoid organs3

Responses8

Innate4

Vitro4

Pathways3

Abstract1

Molecules10

Morphology1

Cytotoxic1

Spleen2

CD11B1

Proteins1

Immune cells3

Proliferation2

Pathogens1

Distinct2

Spines3