• Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). (wikipedia.org)
  • Expression of major histocompatibility antigens in human chronic pancreatitis. (bmj.com)
  • As expression of major histocompatibility (MHC) antigens is a prerequisite for organ specific autoimmunity, the expression of HLA class I (beta 2-microglobulin) and class II (HLA-DR) determinants have been analysed, together with the presence of T-lymphocytes, in 93 patients (64 men and 29 women, mean age 40.6 years) having an operation for chronic pancreatitis. (bmj.com)
  • 1. Major histocompatibility complex class II antigens have the central role in the immune response of 'presenting' antigenic peptide to CD4 + T-cells. (portlandpress.com)
  • Histocompatibility testing involves the identification of HLA antigens/alleles (tissue typing), HLA antibody screening and identification, and flow cytometry based crossmatching. (uky.edu)
  • A role for the involvement of major histocompatibility complex class II antigens seems likely because of the association with human leukocyte antigens DR3 and DR4. (medscape.com)
  • Our identification of the first non-human primate-specific minor histocompatibility antigen now published at Frontiers in Immunology. (wisc.edu)
  • Edidin, M 1986, ' Major histocompatibility complex haplotypes and the cell physiology of peptide hormones ', Human Immunology , vol. 15, no. 4, pp. 357-365. (johnshopkins.edu)
  • The major histocompatibility complex ( MHC ) is a gene-dense genomic region within which many genes play a role in vertebrate immune response. (biomedcentral.com)
  • Here, we experimentally investigate whether this bias is driven by relatedness per se, or by similarity at the major histocompatibility complex (MHC), genes central to vertebrate acquired immunity, where polymorphism is critical to an individual's ability to combat pathogens. (uea.ac.uk)
  • Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate -induced asthma. (cdc.gov)
  • OBJECTIVE- HLA-DRB1* 03 -DQB1* 0201 /DRB1* 04 -DQB1* 0302 ( DR3/4-DQ8 ) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. (diabetesjournals.org)
  • This thesis is an investigation of the naturally processed and presented peptides (NPPPs) associated with chicken major histocompatibility complex ('MHC') class II molecules of 'B21' and ' B19' haplotypes. (uoguelph.ca)
  • Histocompatibility testing is a specialized area of clinical laboratory medicine. (uslegalforms.com)
  • Loyola University Health Systems' Department of Pathology and Laboratory Medicine is seeking a candidate with Ph.D., M.D. (or M.D. equivalent), or M.D./Ph.D. for a Clinical Pathology faculty position as Director of the ASHI-accredited Histocompatibility Laboratory located in Maywood, Illinois.The Loyola Medicine Transplant Center offers heart, lung, kidney, liver, pancreas, bone marrow and stem cell transplants, as well as multi-organ transplants. (uscap.org)
  • Snell coined the term "histocompatibility" to describe the relationship between the H-2 cell-surface proteins and transplant acceptance. (wikipedia.org)
  • BioMathProject 2016 : Understanding the molecular determinants of the Major histocompatibility complex I (MHC I) protein interactions with viral or cancer proteins. (unil.ch)
  • The major histocompatibility complex (MHC) is an essential set of cell surface proteins that allows the immune system to recognize foreign molecules on the surface of virus-infected or cancer cells. (unil.ch)
  • Description: A sandwich ELISA kit for detection of Major Histocompatibility Complex Class I G from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (agctsequencing.com)
  • Direct Staining with Major Histocompatibility Complex Class II Dextra" by Chandirasegaran Massilamany, Arunakumar Gangaplara et al. (unl.edu)
  • Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells. (oregonstate.edu)
  • Although previous work had found that host response against Mycobacterium tuberculosis involves major histocompatibility complex class I-restricted T cells, our results indicate that chronic deficiency of CD8(+) T cells does not lead to a different expression of the disease and that if CD8(+) T cells are involved in the host response, their function can be assumed by other immune cells. (oregonstate.edu)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Major Histocompatibility Complex Class I G (MHCG) in serum, plasma, tissue homogenates and other biological fluids. (agctsequencing.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Major Histocompatibility Complex Class I G (MHCG) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Major Histocompatibility Complex Class I A (MHCA) in Tissue homogenates and other biological fluids. (wannabe-anthropologist.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Major Histocompatibility Complex Class I B (MHCB) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (wannabe-anthropologist.com)
  • Abnormal expression of major histocompatibility complex class II molecules in the placenta may trigger the initiating immunologic event in this organ, which is followed by cross-reactivity with an antigen present in the skin and the characteristic cutaneous signs of the disease. (medscape.com)
  • Major histocompatibility complex class III associations have also been observed, as has a high frequency of anti-human leukocyte antigen antibodies. (medscape.com)
  • Class I major histocompatibility molecules (MHC) are 45 kilodalton (kD) glycoproteins that associate with a smaller 12 kD polypeptide, β₂-microglobulin. (caltech.edu)
  • The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. (bvsalud.org)
  • Histocompatibility testing is most relevant for topics related to whole organ, tissue, or stem cell transplants, where the similarity or difference between the donor's HLA alleles and the recipient's triggers the immune system to reject the transplant. (wikipedia.org)
  • Histocompatibility has a measurable effect on whole organ transplantation, increasing life expectancy of both the patient and organ. (wikipedia.org)
  • The goal of histocompatibility testing is to ensure that a transplanted organ remains viable in the recipient for the longest period of time. (uslegalforms.com)
  • The vast majority of histocompatibility testing is performed in the setting of solid organ and hematopoietic stem cell transplantation. (uky.edu)
  • Here, we describe class II major histocompatibility complex (MHCII) as an important component of high-fat-diet (HFD)-induced obesity. (nih.gov)
  • Genetic diversity in general has been linked to fitness and reproductive success, and genetic diversity within the major histocompatibility complex (MHC) has been linked to immunocompetence and mate preferences. (blogspot.com)
  • The human version of the histocompatibility complex was found by Jean Dausset in the 1950s, when he noticed that recipients of blood transfusions were producing antibodies directed against only the donor cells. (wikipedia.org)
  • HLA, the human form of the major histocompatibility complex (MHC), is located on chromosome 6 at 6p21.3. (wikipedia.org)
  • An association between Human Leukocyte Histocompatibility Antigen B-27 (HLA-B27) and major arthritis syndromes such as Ankylosing Spondylitis and Reactive Arthritis is well documented (Khan et al. (cdc.gov)
  • The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. (lu.se)
  • Recently, major histocompatibility complex (MHC) class II tetramers have emerged as a powerful tool for interrogating antigen-specific CD4 + T cells without relying on effector functions. (nih.gov)
  • We report here the utility of major histocompatibility complex (MHC) class II dextramers for in situ detection of self-reactive CD4 T cells in two target organs, the brain and heart. (unl.edu)
  • Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. (biomedcentral.com)
  • Genetics of the major histocompatibility complex: the final act. (wikidata.org)
  • Neutral Forces and Balancing Selection Interplay to Shape the Major Histocompatibility Complex Spatial Patterns in the Striped Hamster in Inner Mongolia: Suggestive of Broad-Scale Local Adaptation. (bvsalud.org)
  • To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate -induced asthma (DA). (cdc.gov)
  • Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. (cdc.gov)
  • Although this community pioneered the international sharing of data, protocols, methodologies and tools (biological tools or software ones) as early as in the 60th with organisation of International Histocompatibility Workshops and Conferences regularly, it seems that the vast movement of Open Science has not fully penetrated the field. (rd-alliance.org)
  • The National Marrow Donor Program Center for International Blood and Marrow Transplant Research partnered with Versiti, a histocompatibility testing lab. (cdc.gov)
  • The discovery of the MHC and role of histocompatibility in transplantation was a combined effort of many scientists in the 20th century. (wikipedia.org)
  • This testing is carried out by the Institute's state-of-the-art Histocompatibility and Immunogenetics Lab, which plays an important role in the transplant process. (uabmedicine.org)
  • BRISBANE, Calif.-(BUSINESS WIRE)-CareDx, Inc. (Nasdaq: CDNA), a leading precision medicine company focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers - today announced that it will showcase the latest developments across its AlloSeq®* portfolio during the 36th European Immunogenetics and Histocompatibility Conference taking place April 26-29 in Nantes, France. (portada-online.com)
  • We are committed to advancing the field of immunogenetics and histocompatibility and take great pride in supporting this important event as a platinum sponsor. (portada-online.com)
  • Fellows will be registered with the American College of Histocompatibility & Immunogenetics (ACHI) for a two-year "director-in-training" fellowship to become an American Society for Immunogenetics (ASHI) approved director. (chop.edu)
  • The histocompatibility lab is accredited by the American Society for Histocompatibility and Immunogenetics (ASHI) and College of American Pathologists (CAP). (uky.edu)