• The left photograph shows an untreated 21-month-old girl with congenital hypopituitarism. (medscape.com)
  • Mutations in these genes are causes of congenital hypopituitarism and have specific pituitary hormone deficiencies associated with the involved gene. (medscape.com)
  • To describe a new patient with syndromic congenital hypopituitarism and diffuse brain atrophy due to RNPC3 mutations and to compare her clinical and molecular characteristics and pituitary functions with previously published patients. (istanbul.edu.tr)
  • The Y443C variant in RNPC3 associated with syndromic congenital hypopituitarism and abnormal brain development. (istanbul.edu.tr)
  • Context: Genetic defects affecting the expression and function of factors involved in pituitary development have been found to be associated with congenital hypopituitarism (CH). However, for most cases of CH, the etiology remains unknown. (cmich.edu)
  • Thakur, M, Taha, D & Misra, VK 2017, ' A case of congenital hypopituitarism associated with a 1p31 microdeletion: A possible role for LEPR and JAK1 ', Journal of the Endocrine Society , vol. 1, no. 4, pp. 278-282. (cmich.edu)
  • More severe hypopituitarism can lead to hypothyroidism or abnormally low cortisol levels, which may be life threatening. (uclahealth.org)
  • The overall incidence of new onset hypopituitarism was 22.9%, with hypothyroidism serving as the most common individual axis deficiency. (bvsalud.org)
  • Hypopituitarism is a partial or complete insufficiency of pituitary hormone secretion that may derive from pituitary or hypothalamic disease. (medscape.com)
  • Increased compression of the normal gland can cause hormone insufficiency, called hypopituitarism. (uclahealth.org)
  • Hypopituitarism refers to either partial or complete deficiency of the an-terior and/or posterior pituitary function. (brainkart.com)
  • The signs and symptoms of hypopituitarism will depend on the area of the pituitary gland that is affected and the deficiency of specific hormones. (healthhype.com)
  • Dr. Antal has experience treating conditions like Growth Hormone Deficiency and Hypopituitarism among other conditions at varying frequencies. (sharecare.com)
  • for instance, if the hypopituitarism is due to a growth hormone-producing tumor, there may be symptoms of acromegaly (enlargement of the hands and feet, coarse facial features), and if the tumor extends to the optic nerve or optic chiasm, there may be visual field defects. (wikipedia.org)
  • If hypopituitarism is caused by a tumor, you may need surgery to remove the tumor. (medlineplus.gov)
  • In view of visual disturbance and clinical hypopituitarism, transphenoidal resection of the tumor was performed and normal-looking pituitary tissue was preserved. (lww.com)
  • Question: What is the difference between panhypopituitarism vs. hypopituitarism? (csrf.net)
  • Hypopituitarism, also known as panhypopituitarism , is a complex syndrome marked by metabolic dysfunction, sexual immaturity, and growth retardation (when it occurs in childhood). (doctorlib.info)
  • Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain. (wikipedia.org)
  • The signs and symptoms of hypopituitarism vary, depending on which hormones are undersecreted and on the underlying cause of the abnormality. (wikipedia.org)
  • The hormones of the pituitary have different actions in the body, and the symptoms of hypopituitarism therefore depend on which hormone is deficient. (wikipedia.org)
  • Hypopituitarism is a condition in which the pituitary gland does not produce normal amounts of some or all of its hormones. (medlineplus.gov)
  • In hypopituitarism, there is a lack of one or more pituitary hormones. (medlineplus.gov)
  • Septo-optic dysplasia is often associated with abnormalities of the HYPOTHALAMUS and other diencephalic structures, and HYPOPITUITARISM. (bvsalud.org)
  • Hypopituitarism may be congen-ital or acquired, secondary to pituitary disease or to hypothalamic pathol-ogy that interferes with pituitary function. (brainkart.com)
  • What are the symptoms of hypopituitarism? (msdmanuals.com)
  • The signs and symptoms will vary accordingly although majority of the different pituitary cell types as described under pituitary gland function has to be destroyed or malfunctioning for hypopituitarism to ensue. (healthhype.com)
  • Several hormone deficiencies associated with hypopituitarism may lead to secondary diseases. (wikipedia.org)
  • The clinical presentation of hypopituitarism may vary, depending on patient age and on the specific hormone deficiencies, which may occur singly or in various combinations. (medscape.com)
  • Patients with hypopituitarism have complex endocrine deficiencies, and the mechanisms underpinning any excess mortality are unknown. (ox.ac.uk)
  • Patients with hypopituitarism have an increased mortality rate mostly related to cardiovascular disorders. (pituitaryworldnews.org)
  • Hypopituitarism is a rare disease, but may be significantly underdiagnosed in people with previous traumatic brain injury. (wikipedia.org)
  • Traumatic hypopituitarism was diagnosed in an 11-month-old male neutered cat. (avmi.net)
  • This is a higher frequency than previously thought and suggests that most cases of post traumatic hypopituitarism (PTHP) remain undiagnosed and untreated. (textbookrush.com)
  • The aim of the present study was to assess whether patients with hypopituitarism experience increased cardiovascular, in particular cerebrovascular, mortality. (lu.se)
  • DESIGN AND PATIENTS: Retrospective cohort study of mortality, 1952-1992, in 344 patients, of whom 130 were female, receiving conventional hormone replacement for hypopituitarism following neurosurgery for pituitary tumours. (lu.se)
  • Association between premature mortality and hypopituitarism. (ox.ac.uk)
  • BACKGROUND: Four retrospective studies have reported premature mortality in patients with hypopituitarism with standard mortality ratios (SMRs) varying between 1.20 and 2.17. (ox.ac.uk)
  • We aimed to clarify these issues by doing a large prospective study of total and specific-cause mortality in patients with hypopituitarism. (ox.ac.uk)
  • INTERPRETATION: Patients with hypopituitarism have excess mortality, predominantly from vascular and respiratory disease. (ox.ac.uk)
  • METHODS: We followed up 1014 UK patients (514 men, 500 women) with hypopituitarism from January, 1992, to January, 2000. (ox.ac.uk)
  • The diagnosis of hypopituitarism is made by blood tests, but often specific scans and other investigations are needed to find the underlying cause, such as tumors of the pituitary, and the ideal treatment. (wikipedia.org)
  • OBJECTIVE: An increased prevalence of atherosclerosis has been shown among patients with hypopituitarism. (lu.se)
  • If there is decreased secretion of one specific pituitary hormone, the condition is known as selective hypopituitarism. (wikipedia.org)
  • Hypopituitarism is also a rare complication caused by severe bleeding during pregnancy. (medlineplus.gov)
  • This report extends the RNPC3-related hypopituitarism phenotype with a severe neurodegenerative presentation. (istanbul.edu.tr)
  • Primary hypopituitarism usually develops in a predictable pattern. (doctorlib.info)
  • Medicine Central , im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816293/all/Hypopituitarism. (unboundmedicine.com)
  • Ichiyama T, Hayashi T, Nishikawa M, Furukawa S: Optic nerve hypoplasia with hypopituitarism and an arachnoid cyst. (karger.com)
  • When hypopituitarism follows surgical ablation or trauma, the pattern of hormonal events may not necessarily follow that sequence. (doctorlib.info)
  • [ 1 ] The focus of this article is childhood-onset hypopituitarism. (medscape.com)