• Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and thus interfering with DNA replication. (medscape.com)
  • Aim To investigate the efficacy and safety of cyclophosphamide and other immunosuppressive agents (ISAs) in the treatment of necrotising scleritis. (bmj.com)
  • The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, platinum compounds, and others. (wikipedia.org)
  • Cyclophosphamide (Baxter's Cytoxan) is probably the most potent immunosuppressive compound. (wikipedia.org)
  • Immunosuppressive agents or cytotoxics such as cyclophosphamide (CTX or Cytoxan) may also be used. (cochrane.org)
  • It has potent immunosuppressive activity. (medscape.com)
  • Antibodies are sometimes used as a quick and potent immunosuppressive therapy to prevent the acute rejection reactions as well as a targeted treatment of lymphoproliferative or autoimmune disorders (e.g., anti-CD20 monoclonals). (wikipedia.org)
  • Many of the medical complications that arise are the direct consequence of the need to administer potent immunosuppressive agents, with their attendant risks of infection, malignancy and drug toxicity. (ersjournals.com)
  • However, the success of second-generation direct-acting antiviral (DAA) agents has significantly reduced the number of HCV-related registrations. (medscape.com)
  • Antiviral treatment(s) for mpox have minimal interaction with antiretroviral therapy and with common immunosuppressive medications. (cdc.gov)
  • Any antiviral agent which inhibits the activity of coronaviruses. (ebi.ac.uk)
  • Núñez M. Hepatic toxicity of antiviral agents. (nih.gov)
  • Randomized intervention trials including antiviral, immunomodulating, or immunosuppressive agents are lacking. (intechopen.com)
  • Rheumatologists need to become familiar with PML and feel able to help patients make shared and informed decisions about the risks when starting treatment with immunosuppressive therapies. (bmj.com)
  • Consider potential additive immunosuppressive effects in patients receiving or who previously received antineoplastic, immunosuppressive, or immunomodulating therapies. (drugs.com)
  • Vaccination with JYNNEOS is considered safe for people who are immunocompromised, including those with HIV or primary immunodeficiency or from immunosuppressive therapies. (cdc.gov)
  • Long-term transplant acceptance in the absence of immunosuppressive therapy remains the ultimate goal in the field of transplantation and many studies are exploring potential therapies. (lu.se)
  • Immunosuppressive agents encompassed a large number of drugs, mainly represented by anti-tumour necrosis factor (TNF)-α, anti-retroviral therapy (ARV), azathioprine (AZT), methotrexate (MTX), mycophenolate mofetil (MMF), non-steroidal anti-inflammatory drugs (NSAIDs), rituximab and steroids. (ersjournals.com)
  • Azathioprine (Prometheus' Imuran), is the main immunosuppressive cytotoxic substance. (wikipedia.org)
  • Patients receiving other medications, not directly interfering with the immune system, were classified in the "no immunosuppressives" group. (ersjournals.com)
  • Immunosuppressive agents are drugs which inhibit the immune system and are used to treat autoimmune diseases including lupus and multiple sclerosis, and to prevent the body's rejection of transplanted organs. (avivadirectory.com)
  • Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent the activity of the immune system. (wikipedia.org)
  • Immune response - Physiological response of the body controlled by the immune system that involves the production of antibodies to fight off specific foreign substances or agents (antigens). (encyclopedia.com)
  • It is an antibiotic, immunosupressive and antineoplastic agent. (ebi.ac.uk)
  • Immunosuppressive agent use was not associated with malignancy. (nature.com)
  • In this article, we report three patients treated with immunosuppressive drugs and chemotherapy (vincristine, methotrexate) in whom cortical laminar necrosis developed. (ajnr.org)
  • If a patient is unable to tolerate steroid therapy, other immunosuppressive therapy may be considered. (medscape.com)
  • To describe the response to first-line immunosuppressive therapy with or without pulmonary vasodilators in pulmonary arterial hypertension (PAH) associated with systemic lupus erythematosus (SLE) or mixed connective tissue disease (MCTD). (nih.gov)
  • Twenty-three consecutive patients with SLE- or MCTD-associated PAH treated with first-line immunosuppressive therapy either alone (n = 16) or in combination with pulmonary vasodilators (n = 7) were evaluated according to clinical and hemodynamic criteria before and after immunosuppressive therapy. (nih.gov)
  • Among the 16 patients treated with first-line immunosuppressive therapy alone, 8 (50%) were responders. (nih.gov)
  • 3.1 liters/minute/m(2) at baseline were more likely to benefit from immunosuppressive therapy. (nih.gov)
  • Among the 7 patients who were initially treated with immunosuppressive therapy and pulmonary vasodilators, 4 (57.1%) were responders. (nih.gov)
  • Patients who could benefit from this immunosuppressive therapy could be those who have less severe disease at baseline. (nih.gov)
  • Initial immunosuppressive therapy consisted of FK 506 and steroids. (ajnr.org)
  • During the acute phase, while immunosuppressive therapy is initiated, venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is commonly used as a bridge to heart transplantation or recovery. (hindawi.com)
  • Advances in immunosuppressive therapy have put increasing pressure on the supply of donor organs, and medical personnel sometimes find themselves having to determine who among the potential recipients should receive a lifesaving graft. (britannica.com)
  • Ibalizumab was approved for use in the United States in 2018 for therapy (in combination with other antiretroviral agents) of patients with multidrug resistant HIV-1 infection. (nih.gov)
  • Treatment is to discontinue the inciting antimicrobial agent and start therapy with oral fidaxomicin or vancomycin (metronidazole may be used as an alternative option in certain patients and some locations). (bmj.com)
  • Acute neurologic effects produced by immunosuppressive agents have been widely described. (ajnr.org)
  • The contributions of predisposing factors such as underlying disease and immunosuppressive drug selection are incompletely understood but it would appear that patients with systemic lupus erythematosus may be at highest risk. (bmj.com)
  • Immunosuppressive drugs can be classified into five groups:[citation needed] glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. (wikipedia.org)
  • Reuben A. Hepatotoxicity of immunosuppressive drugs. (nih.gov)
  • These drugs are very powerful antiinflammatory agents. (encyclopedia.com)
  • tsDMARDs would then constitute only those that were specifically developed to target a particular molecular structure (such as tofacitinib, fostamatinib, baricitinib or apremilast, or agents not focused primarily on rheumatic diseases, such as imatinib or ibrutinib), while csDMARDs would comprise the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts and others). (bmj.com)
  • For many years, rheumatologists have used the term 'disease-modifying antirheumatic drugs' (DMARDs) to distinguish agents that interfere with the disease process leading to rheumatoid arthritis (RA) and influence the natural course of the disease. (bmj.com)
  • Slow acting antirheumatic drugs' (SAARDs) 4 was an alternative term because-in contrast to the symptomatic drugs-it frequently took several weeks to months until the efficacy of these agents became recognisable, 3 and even longer to reach maximal effects. (bmj.com)
  • It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (bvsalud.org)
  • Transplantation is the most effective treatment for end-stage organ failure, but organ survival is limited by immune rejection and the side effects of immunosuppressive regimens. (lu.se)
  • Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)
  • https://en.wikipedia.org/wiki/Organ_transplantation. (who.int)
  • Anti-inflammatory and immunosuppressive agents are used to treat mucocutaneous lesions and arthritis associated with this disease. (medscape.com)
  • These agents modify the body's immune response to diverse stimuli and therefore have anti-inflammatory properties. (medscape.com)
  • Amlexanox is a topical mucosal anti-inflammatory agent paste at 5% concentration. (medscape.com)
  • They rank among the most powerful anti-inflammatory agents. (encyclopedia.com)
  • Cortisone is a steroid and has anti-inflammatory and immunosuppressive properties. (encyclopedia.com)
  • As the risk associated with second-generation APs is not lower than that of first-generation agents, sedation and resulting hypoventilation, anticholinergic effects, and their effects on immunity have been proposed as the main mechanisms, rather than their extrapyramidal effects. (rxisk.org)
  • An agent that suppresses immune function by one of several mechanisms of action. (ebi.ac.uk)
  • These agents are used for topical treatment for aphthae. (medscape.com)
  • A new era of interest and investigation of PML arrived when, during clinical trials of the immunomodulator natalizumab, an agent directed against α4 integrin approved for treatment of multiple sclerosis (MS), three patients (two with MS and one with Crohn's disease) developed PML. (bmj.com)
  • Summary: We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). (ajnr.org)
  • In view of the harms induced by the use of antipsychotic agents (APs) for the symptomatic treatment of aggression and psychotic symptoms in elderly patients in residential facilities, [7] , [8] in 2008 the European national regulatory agencies recommended limiting their use to patients not responding to other interventions, and to reconsider their prescription at every follow up visit, with close patient follow up. (rxisk.org)
  • In patients with cardiac sarcoidosis, giant cell myocarditis or eosinophilic myocarditis the use of immunosuppressive treatment is recommended, as is the case in myocarditis associated with autoimmune disorders. (intechopen.com)
  • Immunosuppressive agent that works primarily on T cells. (medscape.com)
  • However, they are added primarily to other immunosuppressives to diminish their dosage and toxicity. (wikipedia.org)
  • Any antifungal agent used to prevent or treat fungal infections in humans or animals. (ebi.ac.uk)
  • More recently (8 April 2008), the same agency issued an additional warning about reports of PML occurring in patients with a liver transplant treated with mycophenolate, an agent increasingly used in rheumatic disorders. (bmj.com)
  • The most common cause of inflammatory cardiomyopathy is lymphocytic myocarditis, which is most usually triggered by a viral infection, and occasionally by other infectious agents. (intechopen.com)
  • An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. (ebi.ac.uk)
  • Inopha is supplier of GMP quality API Mycophenolate Mofetil powder, raw material of immunosuppressive agents medicine mainly used for the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. (inopha.net)
  • Prophylactic or early intervention strategies with anti-viral agent and regular monitoring of aminotransferases and viral load are needed for patient with evidence of chronic HBV infection. (koreamed.org)
  • In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. (ebi.ac.uk)
  • In addition, Dr. Fauci is widely recognized for delineating the precise ways that immunosuppressive agents modulate the human immune response. (nih.gov)
  • Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. (mayo.edu)
  • People who are immunocompromised from other conditions or using immunosuppressive agents may be at increased risk of severe mpox. (cdc.gov)
  • Natalizumab, a biological agent approved for multiple sclerosis and Crohn's disease has the clearest pattern of small but definite risk. (bmj.com)
  • Prior to administration of DTP-Hib, health care personnel should inform the patient or guardian of the patient the benefits and es una suspensión estéril, opaca, uniforme del toxoide diftérico, toxoide tetánico y los bacilos matados de Bordetella Pertussis y adsorbido en gel de aluminio y suspendido en una solución de cloruro sódico isotónico. (who.int)
  • Patients (N=110) had been diagnosed more than six months prior to first study agent administration with a Psoriasis Area Severity Index (PASI) score greater than or equal to 12, a Physician's Global Assessment (PGA) score greater than or equal to 3 and body surface area (BSA) involvement of at least 10 percent. (jnj.com)