• Human CD49d molecules are integrin a4 chains that are expressed as heterodimers with CD29 (b1 integrin) or (b7 integrin) and function as adhesion receptors. (biosave.com)
  • CD49d is an integrin alpha subunit. (wikipedia.org)
  • Recognizes the α4 subunit of α4β1 integrin (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin. (enzolifesciences.com)
  • Recombinant monoclonal antibody to Integrin alpha-4/beta-7. (absoluteantibody.com)
  • BACKGROUND: Vedolizumab (VDZ), a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis (UC) patients. (ox.ac.uk)
  • The Company is also evaluating an orally delivered, gut-restricted alpha-4-beta-7 integrin specific antagonist peptide (PN-943) currently in a Phase 2 study in adults with moderate to severe active ulcerative colitis (UC). (biospace.com)
  • PN-943, an oral, alpha-4-beta-7 integrin-specific antagonist peptide, is in clinical trials. (whalewisdom.com)
  • Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways. (ox.ac.uk)
  • In the present study, we have characterized the ability of TNFalpha in inducing eosinophil accumulation in rat skin and have shown the inhibitory effects of anti-alpha4 integrin and anti-vascular cell adhesion molecule-1 (VCAM-1) antibodies on this response. (ox.ac.uk)
  • The adhesion of T cells to the endothelium of blood vessels through the molecule alpha-4 integrin is an important process at the beginning of transmigration. (news-medical.net)
  • Inhibition of α4 integrin and/or SLeX with blocking antibodies reduced rolling and adhesion in arterioles and increased embolism of hMSC. (mst.edu)
  • Integrin modulation and signaling in leukocyte adhesion and migration. (ucsd.edu)
  • Natalizumab binds to a specific adhesion molecule on the immune cell surface known as alpha-4 integrin. (idecpharm.com)
  • CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. (ucsd.edu)
  • 17 Von Andrian U.H., Engelhardt B. Alpha4 integrins as therapeutic targets in autoimmune disease. (thieme-connect.de)
  • New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation. (ucsd.edu)
  • Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. (ucsd.edu)
  • Surface protein gp120 (SU) may target the virus to gut- associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. (antikoerper-online.de)
  • By binding to alpha-4 integrin, natalizumab is thought to inhibit immune cells from leaving the bloodstream and prevent them from migrating into the inflamed gut tissue in Crohn's disease or the brain tissue in MS. (idecpharm.com)
  • Osteopontin mediates macrophage chemotaxis via a4 and a9 integrins and survival via the a4 integrin. (musc.edu)
  • p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion. (musc.edu)
  • This antibody exclusively binds alpha4 beta7 integrin and modulates inflammation in the gastrointestinal tract without inducing the systemic immunosuppression. (absoluteantibody.com)
  • Additionally, primate studies indicate that a4b7 integrin inhibition of HIV infection preserves gut-associated lymphoid tissue (GALT) generally destroyed during the acute phase of HIV infection. (nih.gov)
  • The product of this gene belongs to the integrin alpha chain family of proteins. (wikipedia.org)
  • Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (wikipedia.org)
  • Alpha-4 integrins are type l cAMP-dependent protein kinase-anchoring proteins. (ucsd.edu)
  • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. (absoluteantibody.com)
  • This study reports the results of treatment with MLN02, a humanized antibody to the alpha4beta7 integrin, in patients with active ulcerative colitis. (absoluteantibody.com)
  • We also replicated monocyte associations of genome-wide significance (P-value = 5.68×10(-17), β = -0.23) at the integrin, alpha 4 gene on chromosome 2. (ox.ac.uk)
  • The pharmacologic properties of vedolizumab, in conjunction with the gastrointestinal tropism of alpha(4)beta(7) integrin function, make it a suitable for treatment of patients with inflammatory bowel diseases (PMID: 19509315). (absoluteantibody.com)
  • An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits. (musc.edu)
  • These results show that TNFalpha is an effective inducer of eosinophil accumulation in vivo, with this response being dependent on an interaction between alpha4 integrins and VCAM-1. (ox.ac.uk)
  • This antibody is specific for human α4β7 integrin and does not cross react with alpha(4)beta(1) and alpha(E)beta(7) integrins. (absoluteantibody.com)
  • The binding characterization of this antibody for human alpha 4 beta 7 integrin was done using flow cytometry on Hut-78 cells (US7147851B1). (absoluteantibody.com)
  • This invention involves the use of inhibitors of alpha-4 beta-7 (a4b7) integrin to inhibit HIV transmission/infection, as a prophylactic to inhibit onset of the acute stage of HIV infection or to treat HIV infection. (nih.gov)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Integrin Alpha 4 (ITGa4) in samples from tissue homogenates, cell lysates or other biological fluids. (ibiomagazine.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Integrin Alpha 4 (ITGa4) in Tissue homogenates, cell lysates and other biological fluids. (ibiomagazine.org)
  • The antithrombotic potential of selective blockade of talin-dependent integrin {alpha}llb{beta}3 (platelet GPllb-llla) activation. (ucsd.edu)
  • Methods: Sialyl Lewis X (SLeX) and α4 integrin expression were determined by flow cytometry. (mst.edu)
  • The ex vivo expression of CNS-related integrins (α4β1 and α L subunit of LFA-1) and the gut-related integrin (α4β7) was assessed using flow cytometry on CD4 + and CD8 + T cells. (neurology.org)
  • Results: hMSC expressed α4 integrin, SLeX and fucosyltransferase 4 and adhered to human EC from arteries, veins and the microvasculature under static conditions in vitro. (mst.edu)
  • The presence of manganese partially restored the binding of these T cells to VCAM-1 in vitro, suggesting that FTY interferes with integrin activation. (neurology.org)
  • Reconstructing and deconstructing agonist-induced activation of integrin alphallbeta3. (ucsd.edu)
  • a4b7 integrin is a multifaceted target for HIV infection and recent studies indicate that it is important for establishing HIV infection through multiple paths. (nih.gov)
  • and 4) HIV acts on a4b7 integrin through an epitope in V2 loop of GP120, identified as important for HIV vaccine protection. (nih.gov)
  • NTZ decreased the frequency of α4β1 + and α4β7 + integrin expressing T cells and the binding of these cells to VCAM-1 and MAdCAM-1, respectively. (neurology.org)
  • Below are the most recent publications written about "Integrin alpha4" by people in Profiles. (musc.edu)
  • This graph shows the total number of publications written about "Integrin alpha4" by people in this website by year, and whether "Integrin alpha4" was a major or minor topic of these publications. (musc.edu)
  • Conclusions: The results demonstrated that rapidly self-renewing hMSC were retained in the CAM because they rolled on and adhered to respiratory arteriolar EC in an α4 integrin- and SLeX-dependent manner. (mst.edu)