• A study also demonstrated how the autocrine production of the IL-7 cytokine mediated by T-cell acute lymphoblastic leukemia (T-ALL) can be involved in the oncogenic development of T-ALL and offer novel insights into T-ALL spreading. (wikipedia.org)
  • citation needed] IL-7 is a cytokine important for B and T cell development. (wikipedia.org)
  • A human study of IL-7 in patients with cancer demonstrated that administration of this cytokine can transiently disrupt the homeostasis of both CD8+ and CD4+ T cells with a commensurate decrease in the percentage of CD4+CD25+Foxp3+ T regulatory cells. (wikipedia.org)
  • No significant difference was found in plasma IL-7 concentrations between thalassemic patients and healthy controls and it was suggested that IL-7 is not a cytokine involved in cellular immunological alterations in beta-thalassemia. (nih.gov)
  • Interleukin-23 ( IL-23 ) is a heterodimeric cytokine composed of an IL12B ( IL-12p40 ) subunit (that is shared with IL12 ) and the IL23A ( IL-23p19 ) subunit. (wikidoc.org)
  • Interleukin-6, a mental cytokine. (uni-bielefeld.de)
  • Since interleukin-7 is a crucial cytokine for proliferation and differentiation of T cells in the thymus, the present study indicates that interleukin-7 may contribute to the disturbance of immune regulatory T cells in ulcerative colitis. (elsevierpure.com)
  • In vitro, long-term exposure to high glucose and the peptide hormone leptin secreted by adipose tissue induce β-cell apoptosis and production of the proinflammatory cytokine interleukin (IL)-1 in β-cells and pancreatic islets, respectively ( 7 , 8 ). (diabetesjournals.org)
  • In particular we are studying the role of eicosanoids in normal pregnancy and preeclampsia, the contribution of a purinergic receptor to the release of the cytokine interleukin-1beta in pregnancy as well as investigation of the inflammasome in coordinating inflammatory pathways coupled to cytokine release. (nottingham.ac.uk)
  • Human herpesvirus 8 (HHV-8) virus interleukin-6 (vIL-6) is a cytokine that is secreted and most poorly translated into the endoplasmic reticulum (ER). (ilgenetics.org)
  • Recombinant IL-7 has been safely administered to patients in several phase I and II clinical trials. (wikipedia.org)
  • IL-7 Human Recombinant produced in HEK cells is a glycosylated monomer, having a molecular weight range of 19-30kDa due to glycosylation. (prospecbio.com)
  • It is recommended to reconstitute the lyophilized IL-7 in sterile PBS containing 0.1% endotoxin-free recombinant HSA. (prospecbio.com)
  • IL-7 Human Recombinant produced in HEK cells is a glycosylated monomer, having a molecular weight range of 19-30kDa due to glycosylation.The IL-7 is purified by proprietary chromatographic techniques. (angioproteomie.com)
  • The recombinant Murine IL-7 is a 15.0 kDa protein containing 130 amino acid residues. (biovision.com)
  • Recombinant rat IL-7 induces the proliferation of PHA activated human peripheral blood lymphocytes. (biolegend.com)
  • Recombinant rat IL-7 was aliquoted in DPBS at 0.2 mg/mL and one aliquot was kept at 4°C (control) and another was frozen and thawed four times (4X Freeze/Thaws). (biolegend.com)
  • It was also found that O3 exposure dramatically enhanced the proliferation of CD4-CD8- thymocytes stimulated by recombinant mouse interleukin-7 (rmIL-7), which is usually observed during the mammal aging process. (cdc.gov)
  • Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjögren's syndrome. (quanterix.com)
  • Seder, R. A., Gazzinelli, R., Sher, A. & Paul, W. E. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. (nature.com)
  • This protein activates T cells and B cells by binding to IL-7 receptors, promoting the enhancement of immune response. (creativebiomart.net)
  • Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (ox.ac.uk)
  • Continuous interleukin-6 application in vivo via macroencapsulation of interleukin-6-expressing COS-7 cells induces massive gliosis. (uni-bielefeld.de)
  • Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. (diabetesjournals.org)
  • In vitro studies showed that IL-7 induces oocyte maturation and inhibits apoptosis in granulosa cells. (biolegend.com)
  • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (T h 1)-specific immune responses and inhibits the development of IL-4-producing Th cells. (nature.com)
  • Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. (wikipedia.org)
  • Lyophilized IL-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL7 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. (angioproteomie.com)
  • Angiopoietin‑like protein 7 (Angptl7) is one of the main paracrine cytokines in cord blood stem cells, and is capable of stimulating human hematopoietic stem and progenitor cell expansion. (spandidos-publications.com)
  • Angiopoietin-like protein 7 (Angptl7) is a glycoprotein that shares sequence homology with angiopoietins, important modulators of angiogenesis ( 13 , 14 ). (spandidos-publications.com)
  • TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
  • Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein. (curehunter.com)
  • Plasma levels of IL-3 and IL-7 were studied in 23 patients with homozygous beta-thalassemia in order to determine whether these cytokines are involved in abnormalities in erythropoiesis and immune responses as observed in thalassemic patients. (nih.gov)
  • Our findings show that both IL-7 and IL-4 can act as growth factors for human thymocytes, and that these cytokines stimulate proliferation through distinct mechanisms. (ox.ac.uk)
  • 1: In the haematopoietic microenvironment, bone marrow stromal cells play an important role in regulating haematopoiesis by expressing various cytokines, including leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). (unboundmedicine.com)
  • Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in the pathogenesis of inflammatory bowel disease. (nature.com)
  • Human and murine IL-7 is cross-species reactive. (biovision.com)
  • However, the presence of B cells in these individuals suggests important differences between the role of IL-7 in murine and human lymphocyte development. (biolegend.com)
  • IL‐7 serum level was increased in pSS patients versus controls and was associated with B‐cell biomarkers. (quanterix.com)
  • Purification and amino acid sequence analysis of the serum factor demonstrated that the N-terminal 12 sequence was homologous to that of interleukin-7. (elsevierpure.com)
  • SDS-PAGE and Western blot confirmed that purified serum factor was interleukin-7. (elsevierpure.com)
  • Enzyme immunoassay demonstrated that the serum interleukin-7 concentration was significantly increased in the patients. (elsevierpure.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 24 (IL24) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (orbitalbiosciences.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 24 (IL24) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
  • Description: A sandwich ELISA kit for detection of Interleukin 24 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (orbitalbiosciences.com)
  • The Quantikine Human Interleukin 6 Elisa Assay reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (genediag.com)
  • Description: A competitive ELISA for quantitative measurement of Human Interleukin 6 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (genediag.com)
  • The generation of IL-7-deficient and IL-7Rα-deficient mice and monoclonal antibody blocking experiments confirmed the requirement of IL-7 for B-cell development in mice. (biolegend.com)
  • Cloud-CloneDescription: A polyclonal antibody rasied in rabbit against human Interleukin 7Polyclonal Antibody to Interleukin 7 (IL7) is. (proteomecommons.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 24 (IL24). (orbitalbiosciences.com)
  • Human IgG antibody Laboratories manufactures the quantikine human interleukin 6 elisa assay reagents distributed by Genprice. (genediag.com)
  • IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. (wikipedia.org)
  • IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is stimulated by IL-3). (wikipedia.org)
  • Administration of IL-7 to mice results in an increase in recent thymic emigrants, increases in B and T cells, and increased recovery of T cells after cyclophosphamide administration or after bone marrow transplantation. (wikipedia.org)
  • The aim of this work was to study the interactions between SGECs and T cells in pSS and the role of the IL‐7/IFN axis. (quanterix.com)
  • T cells were sorted from blood and stimulated with IL‐7. (quanterix.com)
  • IL‐7 stimulation increased the activation of T cells, as well as IFNγ secretion. (quanterix.com)
  • These results suggest an IL‐7‐IFNγ amplification loop involving SGECs and T cells in pSS. (quanterix.com)
  • IL‐7 was secreted by SGECs stimulated with type 1 or type 2 IFN and, in turn, activate T cells that secrete type 2 IFN. (quanterix.com)
  • SCF in combination with interleukin-7 (IL-7) can also stimulate the combined myeloid and B-cell differentiation of uncommitted hematopoietic progenitor cells as well as the growth of early B-cell progenitor cells, although the involvement of c-kit in early B lymphopoiesis remains controversial. (ox.ac.uk)
  • 50 cells), whereas the combined stimulation with FL and IL-7 resulted in clonal growth of 10% of Lin-Sca-1+ bone marrow cells. (ox.ac.uk)
  • After 12 days of incubation of Lin-Sca-1+ cells in FL + IL-7, an almost 400-fold increase in cell production was observed. (ox.ac.uk)
  • Interestingly, although all FL + IL-7-responsive Lin-Sca-1+ progenitor cells and the resulting pro-B cells expressed c-kit, FL + IL-7 was much more potent (62-fold) than SCF + IL-7 in stimulating production of cells of the B-cell lineage. (ox.ac.uk)
  • In addition, whereas FL + IL-7 selectively stimulated the production of pro-B cells, SCF + IL-7 predominantly stimulated the production of mature granulocytes. (ox.ac.uk)
  • These results show that FL much more potently and selectively than SCF synergizes with IL-7 to enhance B-cell commitment and development from uncommitted progenitor cells. (ox.ac.uk)
  • Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not I?B degradation or tumour necrosis factor- release from monocytic THP-1 cells. (aston.ac.uk)
  • CD45RA+ CD27- CD4+ T cells have significantly reduced CD28, interleukin-7 receptor alpha (IL-7R alpha) and Bcl-2 expression, Akt (ser473) phosphorylation and reduced ability to survive after T-cell receptor activation compared with the other T-cell subsets in the same donors. (figshare.com)
  • CD4+ memory T cells re-expressing CD45RA can be generated from the CD45RA- CD27+ population by the addition of IL-7 and during this process these cells down-regulated expression of IL-7R and Bcl-2 and so resemble their counterparts in vivo. (figshare.com)
  • In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
  • We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 × 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs. (nature.com)
  • In mice, 7 × 19 CAR-T cells achieved complete regression of pre-established solid tumors and prolonged mouse survival, with superior anti-tumor activity compared to conventional CAR-T cells. (nature.com)
  • Histopathological analyses showed increased infiltration of dendritic cells (DC) and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. (nature.com)
  • Depletion of recipient T cells before 7 × 19 CAR-T cell administration dampened the therapeutic effects of 7 × 19 CAR-T cell treatment, suggesting that CAR-T cells and recipient immune cells collaborated to exert anti-tumor activity. (nature.com)
  • Following treatment of mice with 7 × 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors. (nature.com)
  • Figure 1: 7 × 19 CAR-T cells show improved immune function. (nature.com)
  • Figure 2: Complete regression of pre-established solid tumor by treatment with 7 × 19 CAR-T cells. (nature.com)
  • Figure 3: Infiltration of tumor tissues treated with 7 × 19 CAR-T cells by both T cells and DCs. (nature.com)
  • Further studies have shown that Th1 cells promote atherosclerosis initiation and progression [ 6 , 7 ]. (hindawi.com)
  • Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
  • Interleukin-7 (IL-7) is a potent lymphoid cell growth factor that affects Pre-B, Pro-B and early T cells. (biovision.com)
  • IL-7 was initially described as a stromal derived factor which is capable of inducing the growth of pre-B cells in vitro . (biolegend.com)
  • Thus, although human B-cell development does not appear to require IL-7, immature human B cells do proliferate in response to IL-7. (biolegend.com)
  • Microarray data identified IL-7 transcripts in preovulatory follicles in rats, while IL-7Rα (CD127) and γc chain (CD132) were detected in granulosa cells and preovulatory oocytes. (biolegend.com)
  • Rat IL-7, amino acids Asp26 - Ile154 (Accession # P56478) was expressed in CHO cells. (biolegend.com)
  • Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. (diabetesjournals.org)
  • Two signaling pathways viathe preB cell receptor (preBCR) and the interleukin 7 receptorα(IL-7Rα) chain govern thebalance between differentiation and proliferation at this stage and both receptor path-ways are routinely altered in human BCP-ALL. (catchall-kfo5010.com)
  • We have investigated the effects of interleukin 4 (IL-4) and interleukin 7 (IL-7) on human thymocyte proliferation. (ox.ac.uk)
  • Although maximal proliferation was dependent upon the presence of the mitogen phytohaemagglutinin (PHA), IL-7 alone stimulated thymocyte growth. (ox.ac.uk)
  • Proliferation induced with IL-7 plus PHA, but not that induced by IL-7 alone, could be blocked by this treatment. (ox.ac.uk)
  • Ozone exposure impairs antigen-specific immunity but activates IL-7-induced proliferation of CD4(-)CD8(-) thymocytes in BALB/c mice. (cdc.gov)
  • Knockout mice which genetically lack IL-7 receptor exhibit thymic atrophy, arrest of T-cell development at the double positive stage, and severe lymphopenia. (wikipedia.org)
  • Interleukin 7 and interleukin 4 stimulate human thymocyte growth through distinct mechanisms. (ox.ac.uk)
  • As products of cholesterol oxidation (oxysterols) accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery, we investigated the potential of 7-ketocholesterol (7-KC), 7β-hydroxycholesterol (7β-HC) and 25-hydroxycholesterol (25-HC) to stimulate inflammatory signalling via the lipid-recognising TLRs 1, 2, 4 and 6. (aston.ac.uk)
  • Mutations in IL-7Rα observed in patients with severe combined immunodeficiency (SCID) also underlies the importance of IL-7 signaling in T-cell development in humans. (biolegend.com)
  • Replating studies showed that FL + IL-7-responsive Lin-Sca-1+ progenitors were not committed to the B-cell lineage, because after 2 days of incubation in FL + IL-7, 80% of the progenitors retained a myeloid potential. (ox.ac.uk)
  • As much as 27% of the FL + IL-7-responsive progenitors remained uncommitted after 7 days of incubation, but all had committed to the B-cell lineage after 10 days of incubation in FL + IL-7. (ox.ac.uk)
  • Blood 2000(8): 2803-7 [ PubMed abstract ]. (lu.se)
  • Nat Genet 1998(4): 394-7 [ PubMed abstract ]. (lu.se)
  • Characterization of a novel nonsense mutation in the interleukin-7 receptor alpha gene in a Korean patient with severe combined immunodeficiency. (lu.se)
  • Hematology, transfusion and cell therapy 2018 7 40 (2): 136-142. (cdc.gov)
  • Nevertheless, most recent information suggests that IL-7 dependence in human lymphopoiesis increases during development in cord blood and bone marrow. (biolegend.com)
  • IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. (wikipedia.org)
  • 7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
  • 7 That multiple genes are involved in human lymphoma formation has also been suggested by experimental mouse models. (haematologica.org)
  • The amino acid sequence of rat IL-7 possesses approximately 89 % and 70 % identity with mouse and human, respectively. (biolegend.com)
  • previous analysis of vIL-6 activity.IMPORTANCE Human herpesvirus 8 (HHV-8) -encoded viral interleukin-6 (vIL-6) was the first viral IL-6 homologues to be identified. (ilgenetics.org)
  • IL-7 promotes hematological malignancies (acute lymphoblastic leukemia, T cell lymphoma). (wikipedia.org)
  • The purinergic P2X 7 receptor: regulation of uterine function in labour and preterm labour. (nottingham.ac.uk)
  • PCR and Southern blot hybridization demonstrated that interleukin- 7 mRNA expression was increased in the thymus tissues from patients but decreased in the colonic mucosa. (elsevierpure.com)
  • Fry, T.J. & Mackall, C.L. Interleukin-7: master regulator of peripheral T-cell homeostasis? (nature.com)
  • Associated with antiretroviral therapy, IL-7 administration decreased local and systemic inflammations in patients that had incomplete T-cell reconstitution. (wikipedia.org)
  • IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant. (wikipedia.org)
  • Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7. (prospecbio.com)
  • A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. (lu.se)
  • 3 - 7 The synergistic effect of BCL2 and MYC has also been implicated in the histological and clinical transformation of indolent follicular lymphoma into a more aggressive lymphoma. (haematologica.org)
  • Rag-1 and Rag-2 and initiation of Ig recombination events [7]. (lu.se)
  • These results suggest that IL-7 therapy can possibly improve the quality of life of those patients. (wikipedia.org)
  • Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties in immune diseases. (hindawi.com)
  • IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. (wikipedia.org)
  • Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
  • Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. (wikipedia.org)