• If lymphocytes are cultured in the presence of Interleukin 2, it results in the development of effector cells which are cytotoxic to tumor cells. (wikipedia.org)
  • It has been shown that lymphocytes, when exposed to Interleukin 2, are capable of lysing fresh, non-cultured cancer cells, both primary and metastatic. (wikipedia.org)
  • LAK cells, along with the administration of IL-2 have been experimentally used to treat cancer in mice and humans, but there is very high toxicity with this treatment - Severe fluid retention was the major side effect of therapy, although all side effects resolved after interleukin-2 administration was stopped. (wikipedia.org)
  • LAK cell therapy is a method that uses interleukin 2 (IL-2) to enhance the number of lymphocytes in an in vitro setting, and it has formed the foundation of many immunotherapy assays that are now in use. (wikipedia.org)
  • Interleukin-2 (IL-2) and the adoptive transfer of lymphokine-activated killer (LAK) cells have been used to reduce tumor mass in intraperitoneal, pulmonary, and hepatic models. (prinsesmaximacentrum.nl)
  • Sugarbaker, Paul H. / Lymphokine-activated killer cell and interleukin-2 inhibitors : Their role in adoptive immunotherapy . (prinsesmaximacentrum.nl)
  • We determined the capacity of the leukemia cell line K562 modified to express a membrane-bound form of interleukin (IL)-15 and 41BB ligand (K562-mb15-41BBL) to generate human NK cells with enhanced cytotoxicity. (aacrjournals.org)
  • Cell surface receptors are able to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon gamma (IFN-gamma), and C5a which these cells use to direct the path of their migration. (bionity.com)
  • Also, it was observed that production of interleukin-1 (which activates Tcells),and super-oxideanion(which damages tumor cells) were enhanced. (orthomolecular.org)
  • Immunomodulatory studies (n = 26) showed a significant increase in serum interleukin (IL) -2, IL-15, granulocyte-macrophage colony-stimulating factor, natural killer (NK) cells, NK cytotoxicity, and lymphokine activated killer (LAK) cytoxicity, and a significant decrease in CD4(+)/CD25(+) regulatory T cells. (nih.gov)
  • Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. (rndsystems.com)
  • Normal splenocytes that are cultured in the lymphokine, interleukin 2 (IL-2), for as short as 2 days develop lytic activity for fresh syngeneic natural killer-resistant tumor cells as well as natural killer-sensitive YAC cells in a 4-hr 51Cr release assay. (archive.org)
  • Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. (uchc.edu)
  • 4,5 LEM has also shown that it increases lymphokine-activated killer (LAK ) cell activity by 42-56.9% in vitro (when combined with interleukin 2), which may be of importance in the complementary support of cancer therapy. (meschinohealth.com)
  • His primary areas of study are Receptor, Immunology, Cell biology, Interleukin 21 and Lymphokine-activated killer cell. (research.com)
  • In Interleukin 21, Alessandro Moretta works on issues like Interleukin 12, which are connected to Natural killer T cell, Antigen-presenting cell, Lysis and Tumor cells. (research.com)
  • His scientific interests lie mostly in Immunology, Receptor, Molecular biology, Interleukin 21 and Cell biology. (research.com)
  • His Interleukin 21 course of study focuses on Interleukin 12 and Natural killer T cell and Innate lymphoid cell. (research.com)
  • His Interleukin 21 research is multidisciplinary, incorporating elements of Antigen-presenting cell and Cell biology. (research.com)
  • Alessandro Moretta interconnects Natural killer T cell, CXCL14, Trogocytosis and CXCR3 in the investigation of issues within Interleukin 12. (research.com)
  • Immunology, Interleukin 21, Interleukin 12, Lymphokine-activated killer cell and NK-92 are his primary areas of study. (research.com)
  • Mohamed SG, Sugiyama E, Shinoda K, Taki H, Hounoki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Ogawa H, Miyahara T. Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. (shinjonaikaclinic-toyama.com)
  • Lymphokine-activated killer (LAK) cells are produced from the patient's T cells which are extracted from the tumor and grown in a cell culture system with the lymphokine interleukin-2 (IL-2). (msdmanuals.com)
  • These findings suggest that two lytic pathways may coexist in the same effector cells: a second messenger-dependent pathway involving degranulation, which is activated after TCR interaction with specific targets, and another pathway, independent of any known second messenger generation, responsible for unrelated target cell lysis. (ox.ac.uk)
  • Feng and Navaratna demonstrated that the initial ratio between regulatory T cells and effector T cells impacts the tumour recurrence time and that the effectiveness of IL-2 use may reverse the immunotherapy outcome [ 15 ]. (hindawi.com)
  • The phenomenon of target cell destruction by immunologically active effector cells. (bvsalud.org)
  • I. Isolation of circulating Leu-19+ lymphokine-activated killer effector cells from cancer patients receiving recombinant IL-2. (aai.org)
  • What are the effector cells in adoptive immunotherapy? (richardvigilantebooks.com)
  • Adoptive immunotherapy involves administration of immune effector cells into a patient to produce antitumor effects. (richardvigilantebooks.com)
  • The first effector cells that gained notoriety in adoptive immunotherapy were autologous lymphocytes activated by IL-2, i.e., lymphokine-activated killer (LAK) cells. (richardvigilantebooks.com)
  • Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+) CD25(-) and CD8(+) T cells attenuates effector function. (uchc.edu)
  • CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. (uchc.edu)
  • A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity. (unige.it)
  • Evidence that lymphokine-activated killer cells express this molecule and use it in their effector function. (unige.it)
  • In passive cellular immunotherapy, specific effector cells are directly infused and are not induced within the patient. (msdmanuals.com)
  • In passive cellular immunotherapy, specific effector cells. (msdmanuals.com)
  • Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
  • In contrast, when therapy with anti-B16 Mab was combined with the administration of C3H lymphokine-activated killer (LAK) cells, which were shown to exhibit antibody dependent cellular cytotoxicity (ADCC) activity, a significant enhancement in the antitumor efficacy of LAK cells was seen. (johnshopkins.edu)
  • Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • NK cells cytokine expression, signaling and cytotoxicity has been evaluated in vitro. (bmj.com)
  • The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. (uams.edu)
  • Adoptive immunotherapy using genetically engineered T cells seeks to induce expression of novel genes in cytotoxic T cells that facilitate tumor recognition, enhance T-cell activation, induce tumor-specific cytotoxicity, and/or augment immune memory. (richardvigilantebooks.com)
  • Furthermore, LAK cell-mediated lysis could be inhibited by the addition of anti-Lyt-2 or LFA-1 monoclonal antibody to cytotoxicity assays. (archive.org)
  • Combining computational predictions with experimental BH3 profiling, we identified a therapeutically-exploitable dependence of medulloblastoma cells on BCL-XL, and experimentally validated that BCL-XL targeting, and not targeting of BCL-2 or MCL-1, can potentiate cisplatin-induced cytotoxicity in medulloblastoma cell lines with low sensitivity to cisplatin treatment. (bvsalud.org)
  • His Cell biology study deals with Natural Cytotoxicity Triggering Receptor 1 intersecting with Natural Cytotoxicity Triggering Receptor 3 and Cytolysis. (research.com)
  • The Receptor study combines topics in areas such as Cell, Human leukocyte antigen, Natural Cytotoxicity Triggering Receptor 1 and Cytolysis, Cytotoxicity. (research.com)
  • LAK cells are also capable of acting against cells that do not display the major histocompatibility complex, as has been shown by the ability to cause lysis in non-immunogenic, allogeneic and syngeneic tumors. (wikipedia.org)
  • In melanoma and gastric cancer cells, intercellular adhesion molecule 1 (ICAM-1) antibody can significantly inhibit in vitro LAK-induced lysis of cancer cells. (wikipedia.org)
  • Serum from these treated mice would cause lysis of LAK cells or cultured lymphocytes in the presence of complement. (prinsesmaximacentrum.nl)
  • Moreover, LAK cell-mediated lysis was not associated with an increase in cytotoxic granule exocytosis, as evaluated by BLT-esterase release into the culture supernatant. (ox.ac.uk)
  • Furthermore, using an antigen-specific CTL clone, which acquires LAK-like activity when cultured in medium containing high IL-2 doses, second messenger generation and cytolytic granule content secretion were not detected during lysis of unrelated target cells, while killing of specific targets triggered both these processes. (ox.ac.uk)
  • The activation appears universal in that lymphocytes from all strains of mice activated in this manner exhibited similar patterns of lysis for fresh tumor target cells. (archive.org)
  • To characterize the cells responsible for this lysis, we analyzed the phenotypic expression of surface markers on these cells with depletion techniques using monoclonal antibody and complement. (archive.org)
  • Lysis of syngeneic tumor was inhibited when LAK cells were treated with an anti-Thy-1.2, or anti-Lyt-2.2 monoclonal antibody and complement but not with anti-Lyt-1.2 monoclonal antibody and complement, indicating that the observed lytic activity was due to a Thy-1+ Lyt-1-2+ cell. (archive.org)
  • This lysis of fresh solid tumor cells by lymphoid cells grown in IL-2 may be of value in the study of tumor-host immunological interactions. (archive.org)
  • The biological significance of tumor lysis by IL-2-activated cells requires further study. (archive.org)
  • LAK cells respond to these lymphokines, particularly IL-2, by lysing tumor cells that were already known to be resistant to NK cell activity. (wikipedia.org)
  • In a small subgroup of the prod- resistant to nk cell lymphokine-activated killer (lak) cells. (themauimiracle.org)
  • Specifically, they cover the following areas: a) cellular vaccine approaches using tumor cell-based or dendritic cell (DC)-based vaccines, and b) adoptive cell transfer (ACT) approaches, including lymphokine-activated killer (LAK) cells, γδ T cells, tumor-infiltrating lymphocytes (TIL), chimeric antigen receptor (CAR)-T cells and T-cell receptor (TCR) transduced T cells. (escholarship.org)
  • We found that LAK cells cytolysis could not be generated if serum from IL-2-pretreated mice was present in vitro with splenocytes and IL-2. (prinsesmaximacentrum.nl)
  • The expanded NK cells were significantly more potent than unstimulated or IL-2-stimulated NK cells against acute myeloid leukemia cells in vitro . (aacrjournals.org)
  • The rat anti-mouse CD45R antibody (clone RA3-6B2) has been reported to enhance isotype switching during in vitro B-cell responses and to inhibit in vivo B-cell responses. (bdbiosciences.com)
  • In vitro , overexpression of the mdr-1 gene product, P-glycoprotein (Pgp), in tumor cells can confer high-level resistance to natural product-derived cytotoxics-anthracyclines, vinca alkaloids, epipodophyllotoxins, and taxanes. (cancer.gov)
  • To investigate whether carbamate pesticides also induce apoptosis in human T lymphocytes, in the present study Jurkat human T cells were treated in vitro with thiram, maneb, carbaryl or ziram. (researchgate.net)
  • Experimental evidence has shown that a purified fraction of LEM, rich in shiitake lignans, stimulates the immune system by activating macrophage cells and increasing the proliferation of bone marrow cells, and it inhibits the cytopathic effects of HIV-1 virus in vitro. (meschinohealth.com)
  • Because alcohol blocks airway epithelial cell release of IL-6 in vitro , we hypothesized that alcohol exposure would alter mouse lung inflammatory responses to HDE. (cdc.gov)
  • Recombinant Human IL‑12 (Catalog # 219-IL ) stimulates proliferation in PHA-activated human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner (orange line). (rndsystems.com)
  • A lymphokine activated killer (LAK) cell assay has been developed utilizing a clonogenic microassay in agar-containing capillaries with KB tumor goal cells. (expressionpathology.com)
  • By means of MTT-based cell viability assay, we examined the susceptibility of OTS964 to cells overexpressed ABCB1 and found that the effectiveness of OTS964 was restricted in both drug-selected and gene-transfected cells, which overexpress ABCB1, compared to those of the corresponding parental cells (Fig. 1 A-C and Table S 1 ). (biomedcentral.com)
  • A high-resolution view of NK-cell receptors: structure and function. (unige.it)
  • A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. (unige.it)
  • Activating and inhibitory killer immunoglobulin-like receptors (KIR) in haploidentical haemopoietic stem cell transplantation to cure high-risk leukaemias. (unige.it)
  • Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
  • Being highly motile, neutrophils quickly congregate at a focus of infection , attracted by cytokines expressed by activated endothelium , mast cells and macrophages . (bionity.com)
  • T cell repopulation can be influenced by cytokines, including IL-2 and IL-6. (cancer.gov)
  • In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour. (bioseek.eu)
  • Brain parenchymal macrophages, known as microglial cells, are more quiescent in comparison with other tissue macrophages but can respond to inflammatory stimuli by producing pro-inflammatory cytokines and prostaglandins. (bioseek.eu)
  • Cytokines are regulatory compounds produced by cells of the immune system [T(H)1 and T(H)2] and act as intracellular mediators and control the immune and inflammatory reponses 9 . (bvsalud.org)
  • T(H)1 control the cell-mediated response and produce a number of proinflammatory cytokines, e.g. (bvsalud.org)
  • The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. (bdbiosciences.com)
  • CISH deletion favors NK cell accumulation to the primary tumor, optimizes NK cell killing properties and decreases TIGIT immune checkpoint receptor expression, limiting NK cell exhaustion. (bmj.com)
  • The development of chimeric antigen receptor T cells has provided hope for patients with hematologic malignancies, but their commercial use has been limited to an option of last resort. (richardvigilantebooks.com)
  • Death receptor-independent activation-induced cell death in human melanoma antigen-specific MHC class I-restricted TCR-engineered CD4 T cells. (uchc.edu)
  • Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death. (uchc.edu)
  • A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s). (unige.it)
  • His research integrates issues of T cell, T-cell receptor, Antigen and Antibody, Monoclonal antibody in his study of Molecular biology. (research.com)
  • The study incorporates disciplines such as NKG2D and Immune receptor in addition to Cell biology. (research.com)
  • His Immunology research includes themes of Receptor, Cancer research, Natural killer cell and Hematopoietic stem cell transplantation. (research.com)
  • His work carried out in the field of Receptor brings together such families of science as Acquired immune system, GiST and Cell biology. (research.com)
  • Hounoki H, Sugiyama E, Mohamed SG, Shinoda K, Taki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Miyahara T. Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. (shinjonaikaclinic-toyama.com)
  • [ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)
  • Inflammation and tissue infiltration by various immune cells, which can penetrate into the spinal cord tissue through damage to the blood-brain barrier, play a significant role in the pathogenesis of secondary damage. (frontiersin.org)
  • Background The success and limitations of current immunotherapies have pushed research toward the development of alternative approaches and the possibility to manipulate other cytotoxic immune cells such as natural killer (NK) cells. (bmj.com)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • They all use immune cells that are grown in the lab to large numbers followed by administering them to the body to fight the cancer. (richardvigilantebooks.com)
  • As ASCO President Bruce E. Johnson, MD, FASCO, describes it, this technique "allows clinicians to genetically reprogram patients' own immune cells to find and attack cancer cells throughout the body. (richardvigilantebooks.com)
  • Moreover, the brain contains immune cells, such as macrophages and dendritic cells, which are present in the choroid plexus and meninges. (bioseek.eu)
  • These data suggest that antibody against absorbed antigens on LAK cells and serum inhibitors of IL-2 are generated following repeated challenge. (prinsesmaximacentrum.nl)
  • however, CD19 expression, detectable by the rat anti-mouse CD19 antibody (clone 1D3), is reported to be more restricted to the B-cell lineage. (bdbiosciences.com)
  • It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. (bvsalud.org)
  • Cell Proliferation Induced by IL‑12 and Neutralization by Human IL‑12 Antibody. (rndsystems.com)
  • Antibody production is severely impaired even when mature B cells are present, because of the lack of T-cell help. (medscape.com)
  • We then tested human NK cells functions. (bmj.com)
  • In human NK cells, CISH deletion also favors NCR signaling and antitumor functions. (bmj.com)
  • To investigate whether other carbamate pesticides also show similar toxicity on human NK cells, we conducted further exp. (researchgate.net)
  • Unfortunately, repeated cycles of IL-2 plus LAK cells have not been demonstrated to exert additive antitumor effects. (prinsesmaximacentrum.nl)
  • These findings demonstrate the potential of specific antitumor Mab to affect not only established liver metastases but, when combined with LAK cells that mediate ADCC activity to enhance the eradication of lung metastases as well. (johnshopkins.edu)
  • Additionally, in animal models, mature T cell precursors present in the PBSC can promote return of immunocompetence and possibly antitumor effects. (cancer.gov)
  • Here, we targeted an intracellular inhibiting protein 'cytokine inducible SH2-containing protein' (CISH) in NK cells to evaluate the impact on their functions and antitumor properties. (bmj.com)
  • Conclusion This study represents a crucial step in the mechanistic understanding and safety of Cish targeting to unleash NK cell antitumor function in solid tumors. (bmj.com)
  • It can strongly activate Cell Actin Cytoskeleton, T-LAK (T-Lymphokine-Activated Killer) and PMN (Polymorphonuclear) Leukocytes involved in tumor rejection, suppress tumor cell proliferation, mediate antitumor and oncocytic activity, and to activate bacteriolysis, bacteriophagy and rivustatic activity. (hum-molgen.org)
  • A novel mechanism of antitumor response involving the expansion of CD3+/CD56+ large granular lymphocytes triggered by a tumor-expressed activating ligand. (unige.it)
  • Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)
  • An important component is the study of immune modulation with IL-2 and peripheral blood stem cells (PBSC) on the generation of natural killer (NK) and lymphokine-activated killer cells (LAK), immune recovery, and eradication of microscopic disease posttherapy. (cancer.gov)
  • Measured by its ability to neutralize IL‑12-induced proliferation in PHA-activated human peripheral blood mononuclear cells (PBMC) [Yokota, T. et al . (rndsystems.com)
  • Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting pbmc. (lu.se)
  • The effect of C3H LAK cells was apparently not the result of administration of allogeneic cells, since fresh C3H splenocytes had no effect on lung metastases when given together with Mab. (johnshopkins.edu)
  • [ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)
  • IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. (rndsystems.com)
  • Current evidence indicates that IL-12, produced by macrophages in response to infectious agents, is a central mediator of the cell-mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. (rndsystems.com)
  • We investigated the responses that repeated challenge with LAK cells and IL-2 provoked in normal BL/6 mice. (prinsesmaximacentrum.nl)
  • Results In Cish fl/fl Ncr1 Ki/+ mice, we detected no developmental or homeostatic difference in NK cells. (bmj.com)
  • Cish fl/fl Ncr1 Ki/+ NK cells display lower activation thresholds and Cish fl/fl Ncr1 Ki/+ mice are more resistant to tumor metastasis and to primary breast cancer growth. (bmj.com)
  • Nakao T, Inomata T, Blanco T, Musayeva A, Tahvildari M, Amouzegar A, Yin J, Chauhan SK, Chen Y, Dana R. Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice. (uams.edu)
  • OTS964 is a potent inhibitor targeting to PDZ-binding kinase (PBK)/T-lymphokine-activated killer cell-originated protein kinase (TOPK). (biomedcentral.com)
  • Interaction of lymphokine-activated killer cells with susceptible targets does not induce second messenger generation and cytolytic granule exocytosis. (ox.ac.uk)
  • Lymphokine-activated killer cells: determination of their tumor cytolytic capacity by a clonogenic microassay using agar capillaries. (expressionpathology.com)
  • Role in cell activation and regulation of cytolytic function. (unige.it)
  • Global gene expression of Cish fl/fl Ncr1 Ki/+ NK cells compared with Cish +/+ Ncr1 Ki/+ NK cells revealed upregulation of pathways and genes associated with NK cell cycling and activation. (bmj.com)
  • Therefore CAR T cells and TCR T cells may represent complementary approaches to cancer therapy. (msdmanuals.com)
  • LAK cells have anticancer efficacy against homologous carcinoma cells and can grow ex vivo in the presence of IL-2. (wikipedia.org)
  • Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
  • vivo activation and expansion of T cells or NK cells and passive transfer of these cells into the cancer patient. (richardvigilantebooks.com)
  • As a result, modern techniques, such as surgery, chemotherapy, and radiotherapy, fail to destroy cancerous cells due to a lack of effective treatment strategies. (hindawi.com)
  • In addition, chemotherapy harms cells in the bone marrow (myelosuppression), hair follicles (alopecia), and digestive tract (mucositis) under normal conditions. (hindawi.com)
  • Several days (usually 2-14 days) before you receive your CAR T cells, you will return to the hospital or clinic to receive one or more chemotherapy agents. (richardvigilantebooks.com)
  • This chemotherapy decreases the number of T cells in your body to make room for the new CAR T cells. (richardvigilantebooks.com)
  • Chemotherapy reduces T-cell count. (zenius-labs.com)
  • Here, we demonstrated that systems-level analysis of basal apoptosis protein expression and their signalling interactions can differentiate between medulloblastoma cell lines that undergo apoptosis in response to chemotherapy, and those that do not. (bvsalud.org)
  • Echinacea may help protect white blood cell (WBC) counts in chemotherapy-induced myelosuppression. (interactionsguide.com)
  • LAK cells are specific to tumor cells and do not display activity against normal cells. (wikipedia.org)
  • The inability of C57BL/6 LAK cells, which exhibited low if any ADCC activity to mediate a similar effect, suggested that an ADCC-like mechanism was involved in this therapy. (johnshopkins.edu)
  • The activity of Natural Killer cells, cytotoxic T-cells and delayed-hypersensitive T-cells were all increased by 1.5-2.2times by Maitake D-fraction. (orthomolecular.org)
  • This interaction induces IFN-gamma gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. (rndsystems.com)
  • The cytotoxic activity of OTS964 was limited in B1/G2 cells relative to that in parental PEL cells, and that this effect can be partially re-sensitized by a known inhibitor of ABCB1 or ABCG2. (biomedcentral.com)
  • A - D Cytotoxic activity of OTS964 in drug-selected, gene-transfected, or gene-knockout cells and their respective parental cells. (biomedcentral.com)
  • Overall, lentinan treatment produced an increase in the number of CD4 cells ( T-helper cells ) and, in some patients, neutrophil activity. (meschinohealth.com)
  • Activity and phenotype of natural killer cells in peptide transporter (TAP)-deficient patients (type I bare lymphocyte syndrome). (unige.it)
  • Natural killer (NK) cell number and activity increased by long-term administration. (interactionsguide.com)
  • and experiments showing that PRL stimulates natural killer cell activity and the development of lymphokine-activated killer cells. (beatingcancercenter.com)
  • Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
  • With the eosinophil and the basophil , they form the class of polymorphonuclear cells (PMNs), named for the nucleus 's characteristic multilobulated shape (as compared to lymphocytes and monocytes , the other types of white cells). (bionity.com)
  • His study in Lymphokine-activated killer cell is interdisciplinary in nature, drawing from both Natural killer cell, Tumor progression and Natural killer cell cytokine production. (research.com)
  • Using intravenous injection of B16F10 melanoma cell line and EO711 triple negative breast cancer cell line, metastasis evaluation was performed. (bmj.com)
  • Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53. (uchc.edu)
  • Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-1 27-35. (uchc.edu)
  • Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor. (uchc.edu)
  • Neutrophil granulocytes , generally referred to as neutrophils , are the most abundant type of white blood cells in humans and form an integral part of the immune system . (bionity.com)
  • The average halflife of a non-activated neutrophil in the circulation is about 4-10 hours. (bionity.com)
  • A study has shown that ICAM1 in lung cancer cells increases LAK cell-mediated tumor cell death as a new anti-tumor mechanism. (wikipedia.org)
  • Yet, the maturation and activations of these cells occurs throughout the body, either in secondary lymphoid organs or the blood itself. (brainimmune.com)
  • In this report, Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibition of formation of the secondary focus due to metastasis of tumor cells in lymph and/or blood. (orthomolecular.org)
  • Cold target inhibition analysis revealed that the syngeneic tumor cells were lysed by recognition of a determinant not present on normal lymphocytes or lymphocyte blasts. (archive.org)
  • Allogeneic mixed lymphocyte reactions in humans: pretreatment of either the stimulator or the responder cell population with monoclonal anti-Ia antibodies leads to an inhibition of cell proliferation. (unige.it)
  • While BCL-XL has a first-line role in protecting cells from apoptosis basally, MCL-1 represents a second line of defence that compensates for BCL-XL upon its inhibition. (bvsalud.org)
  • LAK cells have shown potential as a cellular agent for cancer therapy and have been utilized therapeutically in association with IL-2 for the treatment of various cancers. (wikipedia.org)
  • The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
  • Natural killer (NK) cells can kill cancer cells in the absence of prior stimulation and hold considerable potential for cell-based therapies targeting human malignancies ( 1 - 4 ). (aacrjournals.org)
  • Host cells, or normal cells, should be kept above their minimum level throughout the entire body during cancer remission. (hindawi.com)
  • and (ii) tumour-infiltrating lymphocyte (TIL) therapy, in which cells are extracted from lymphocytes recovered from the patient with cancer and incubated with high concentrations of IL-2 before being injected back into the patient. (hindawi.com)
  • The use of ACI slows or stops the spread of cancer cells to other parts of the body and helps the immune system become more effective by eliminating cancer cells. (hindawi.com)
  • Activate T cells (T cells play a key role in the immune system in fighting cancer. (zenius-labs.com)
  • Within the bone marrow, the tachykinins have been shown to have critical effects on the microenvironment, including metastasis and dormancy of cancer cells during clinical remission. (brainimmune.com)
  • His Immunology research includes elements of Natural killer cell, Cancer research and NKG2D. (research.com)
  • Alessandro Moretta has included themes like Cell, Hematopoietic stem cell transplantation and Cancer research in his Immunology study. (research.com)
  • Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
  • Animal studies have shown that LAK cells are more effective against cancer cells than are the original endogenous T cells, presumably because of their greater number. (msdmanuals.com)
  • We observed that lymphokine-activated killer (LAK) cells, obtained after stimulation with supraoptimal concentrations of IL-2 in short- or long-term cultures, kill susceptible targets in the absence of a [Ca2+]i rise and InsP3 formation. (ox.ac.uk)
  • We therefore adapted the K562-mb15-41BBL stimulation method to large-scale clinical-grade conditions, generating large numbers of highly cytotoxic NK cells. (aacrjournals.org)
  • Primed Cish fl/fl Ncr1 Ki/+ NK cells display increased activation upon NCR stimulation. (bmj.com)
  • The CD45 isoforms detected in the mouse are cell type-, maturation, and activation state-specific. (bdbiosciences.com)
  • During ACI, tissue cells are cultured to enhance and expand the immune system. (hindawi.com)
  • In this study, we have shown that hypoxia treatment enhances normal peritoneal fibroblast elimination by lymphokine-activated killer cells to the level of adhesion tissue fibroblasts, suggesting a pivotal role of hypoxia in the adhesion development. (elsevierpure.com)
  • The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)
  • However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)
  • The mechanism of LAK cells is distinctive from that of natural killer cells because they can lyse cells that NK cells cannot. (wikipedia.org)
  • We previously found that carbamate pesticides induced significant apoptosis in human natural killer cells. (researchgate.net)
  • A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. (unige.it)
  • It is expressed on B lymphocytes at all stages from pro-B through mature and activated B cell, but it is decreased on plasma cells and a subset of memory B cells. (bdbiosciences.com)
  • IL-2 treatment acutely increased the CD4 cells, all within the CD4RO subset, and increased NK and LAK cells. (cancer.gov)
  • A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. (uams.edu)
  • The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
  • Go to Renal Cell Carcinoma Treatment Protocols , Clear Cell Renal Cell Carcinoma , and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
  • To view a multidisciplinary tumor board case discussion, see Memorial Sloan Kettering e-Tumor Boards: Metastatic Clear Cell Renal Cell Carcinoma . (medscape.com)
  • Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)
  • Renal cell carcinoma is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)
  • The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)
  • The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
  • This applies as well in the adjuvant treatment of surgically resected renal cell carcinoma, for which no therapy has yet been found to offer survival benefit. (medscape.com)
  • See Renal Cell Carcinoma: Recognition and Follow-up , a Critical Images slideshow, to help evaluate renal masses and determine when and what type of follow-up is necessary. (medscape.com)
  • Renal cell carcinoma may remain clinically occult for most of its course. (medscape.com)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)