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LectinsPlant LectinsLectins, C-TypeCytochrome c GroupMolecular Sequence DataAmino Acid SequenceMannose-Binding LectinsWheat Germ AgglutininsGalectinsGlycoconjugatesPeanut AgglutininCarbohydratesConcanavalin AGalactosidesGalanthusAcetylgalactosamineFetuinsReceptors, MitogenHemagglutinationCarbohydrate MetabolismAgglutinationMannoseCarbohydrate SequenceCanavaliaArtocarpusRicinusPolysaccharidesGalactoseRibosome Inactivating Proteins, Type 2HemagglutininsAgglutininsHemagglutination TestsFucoseAsialoglycoproteinsMannosidesGlycoproteinsAcetylglucosamineMistletoeChromatography, AffinityRibosome Inactivating ProteinsPlants, MedicinalOligosaccharidesFabaceaeN-Acetylneuraminic AcidReceptors, N-AcetylglucosamineGlycosylationMethylmannosidesAbrinPhytohemagglutininsMonosaccharidesErythrinaGalectin 1HistocytochemistrySambucusProtein BindingSialic AcidsBinding SitesReceptors, Concanavalin AGalectin 3Electrophoresis, Polyacrylamide GelCarbohydrate ConformationAgglutination TestsGlycosidesCollectinsGalectin 4Castor BeanAraliaSea CucumbersNeuraminidaseLactoseDatura stramoniumRicinLiliaceaeMusaSeedsSoybean ProteinsGlycopeptidesArachis hypogaeaABO Blood-Group SystemMolecular WeightBauhiniaHorseshoe CrabsPlantsToxins, Biologicalalpha-FetoproteinsMannose-Binding LectinGlycomicsSequence Homology, Amino AcidAmino Sugars
ReceptorsReceptorProteinsMannose-bindinProteinAnimal lectinsSpecificityGlycanMacrophagesMediatesReagentsRecombinantCarbohydrate recognitionMoleculesLarvalImmunity1999LymphocytesDomain FamilyGlutenEpithelial cellsDifferentialInhibitorsFamilyFunctionsIntestinalReactBacteriaStructuralBindBlood TypeWeakCarbohydratesHumanArticleAgglutinateContrastUnderstandingCellExpression
Receptors9
  • A peptide mimetic of a ligand for the galactose/N-acetylgalactosamine-specific C-type lectin receptors (GCLR) exhibited monocyte-stimulating activity, but did not extend survival when applied alone against a syngeneic murine malignant glioma. (dovepress.com)
  • Other lectins can interact with the surface receptors of white blood cells, often programming them to multiply rapidly. (4yourtype.com)
  • The myeloid C-type lectin receptors (CLRs) are one of the most prominent families of receptors involved in tailoring immunity after sensing dead cells. (immunomodulationlab-idipaz.es)
  • C-type lectin-like receptors (CTLRs) play critical roles in immunity and homeostasis by recognising a great variety of microbial or endogenous ligands [ 1 ]. (biomedcentral.com)
  • Kerscher B, Willment JA, Brown GD: The Dectin-2 family of C-type lectin-like receptors: an update. (biomedcentral.com)
  • We compared the lectin activity of Dectin-2 with that of two other C-type lectin receptors (mannose receptor and SIGNR1) known to bind fungal mannans. (elsevierpure.com)
  • The differences in the specificity of these three mannose-specific lectins indicate that mannose recognition is mediated by distinct receptors, with unique specificity, that are expressed by discrete subpopulations of cells, and this further highlights the complex nature of carbohydrate recognition by immune cells. (elsevierpure.com)
  • C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens including, viruses such as SARS, SARS-CoV-2, bacteria, fungi and parasites. (preprints.org)
  • A class of oxidized LDL receptors that contain C-type lectin-like extracellular domains. (bvsalud.org)
Receptor9
  • CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al. (nih.gov)
  • The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells. (nih.gov)
  • Monocyte galactose/N-acetylgalactosamine-specific C-type lectin receptor stimulant immunotherapy of an experimental glioma. (dovepress.com)
  • We examined the carbohydrate-binding potential of the C-type lectin-like receptor Dectin-2 (Clecf4n). (elsevierpure.com)
  • The carbohydrate-recognition domain (CRD) of Dectin-2 exhibited cation-dependent mannose/fucose-like lectin activity, with an IC50 for mannose of approximately 20 mM compared to an IC50 of 1.5 mM for the macrophage mannose receptor when assayed by similar methodology. (elsevierpure.com)
  • Using single cell technologies and conditional ablation via a LysMCre+Clec4a2flox/DTR mouse strain, we demonstrate that the expression of the C-type lectin receptor CLEC4A2 is a distinguishing feature of vascular resident macrophages endowed with athero-protective properties. (ox.ac.uk)
  • Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. (leibniz-hki.de)
  • The C-Type Lectin receptor (CRL) is known as the major β-glucan receptor expressed in myeloid cells and is responsible for targeting respiratory fungal pathogens. (lu.se)
  • Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients. (cdc.gov)
Proteins6
  • Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. (wikipedia.org)
  • Lectins are unique proteins of varying biological importance. (nih.gov)
  • At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
  • Specifically, the dissertation will describe 1) investigating the assay's effectiveness with secreted proteins, rather than membrane proteins, to develop a fluid-based diagnostic, 2) the investigation of the metastatic reversion of an isogenic cell line, 3) the use of the synthetic lectin array to diagnose colon cancer in a longitudinal mouse study, and 4) the application of statistical methods to the sensor array data to draw biochemical information. (sc.edu)
  • The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. (ox.ac.uk)
  • Lectins are glycan binding proteins and each lectin will only bind to particular glycans. (bmgrp.com)
Mannose-bindin1
  • Is Plasma Level of Mannose Binding Lectin Associated With Reproductive Failure? (who.int)
Protein7
  • A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. (wikipedia.org)
  • classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein. (wikipedia.org)
  • In the simplest of terms, a lectin is a type of protein that acts as a selective Velcro-like material. (4yourtype.com)
  • Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. (musc.edu)
  • C-type lectin (CTL) is a protein that binds to saccharides and plays an important role in parasite adhesion, host cell invasion and immune evasion . (bvsalud.org)
  • Genetic Variation in the Syntaxin-Binding Protein STXBP5 in Type 1 von Willebrand Disease Patients. (cdc.gov)
  • Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)
Animal lectins1
  • The emergence of functional studies on animal lectins during the 1990s has provided the appropriate framework to better understand their roles in cell death. (nature.com)
Specificity2
  • The M-cell specificity of the lectin binding was further demonstrated by localization of horseradish peroxidase (HRP)-conjugated lectins under the transmission electron microscope (TEM). (nih.gov)
  • Besides their specificity, lectins are excellent reagents because of their lower cost and indigenous production. (nih.gov)
Glycan7
  • Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
  • Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
  • We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
  • Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
  • The principle of glycan structure profiling analysis using LecChip™ is based on the lectin to glycan binding affinity. (bmgrp.com)
  • Lectin-glycan interactions are known to be relatively weak compared to antigen-antibody and biotin-avidin interactions. (bmgrp.com)
  • Fortunately, evanescent-field fluorescence excitation allows for generation of lectin-glycan affinity data from unwashed samples by taking advantage of the higher signal strength of specifically bound glycans. (bmgrp.com)
Macrophages1
  • Further analyses on wild-type and CLECSF8 -/- primary macrophages in vitro , or cells harvested after intra-peritoneal and intra-tracheal instillation of BCG demonstrated a lack of Mincle-upregulation in the absence of CLECSF8. (biomedcentral.com)
Mediates1
  • Binding of Trichinella spiralis C-type lectin with syndecan-1 on intestinal epithelial cells mediates larval invasion of intestinal epithelium. (bvsalud.org)
Reagents1
  • A handful of lectins may be considered excellent reagents for anti-A, anti-B, anti-N etc, but the anti-A and anti-M are not yet regarded as commercially suitable antisera. (nih.gov)
Recombinant1
  • Previous studies showed that recombinant T. spiralis C-type lectin (rTsCTL) promotes larval invasion of intestinal epithelium cells (IEC), whereas anti-rTsCTL antibodies inhibits larval invasion. (bvsalud.org)
Carbohydrate recognition1
  • G3 is implicated in the intracellular processing of aggrecan and contains a C-type lectin carbohydrate recognition domain (CRD), frequent occurrences of a C-terminal short complement repeat (SCR) domain, and occasionally an N-terminal epidermal growth factor domain. (brighton.ac.uk)
Molecules1
  • The Cy3 molecules attached to glycans that have successfully bound to lectins will fluoresce and the total LecChip™ fluorescence pattern can be captured with the scanner. (bmgrp.com)
Larval1
  • Bacterial community composition differed by sample type (larval stage vs. adult stage) and water sampling date (day 3 vs. day 7), but not by pesticide treatment. (nature.com)
Immunity2
19991
  • C-Type+Lectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Drickamer K (October 1999). (wikipedia.org)
Lymphocytes1
  • In the present review, we provide evidence for how the interaction of dietary lectins with enterocytes and lymphocytes may facilitate the translocation of both dietary and gut-derived pathogenic antigens to peripheral tissues, which in turn causes persistent peripheral antigenic stimulation. (cambridge.org)
Domain Family3
  • Description: A competitive ELISA for quantitative measurement of Canine C type lectin domain family 10 member A(CLEC10A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (ibiomagazine.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human C-Type Lectin Domain Family 2, Member C (CLEC2C) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (allelisakits.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human C-Type Lectin Domain Family 2, Member C (CLEC2C) in samples from serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (allelisakits.com)
Gluten1
  • Though gluten isn't a lectin like a WGA they both can cause similar issues in the body such as a leaky gut. (4yourtype.com)
Epithelial cells2
  • Since that time, many other much less numerous and even more local populations of astrocytes have already been described, such as for example velate astrocytes, perivascular astrocytes, marginal glia, tanycytes, and different types of ependymal glia (e.g., ependymocytes, choroid plexus cells, and retinal pigment epithelial cells) (Reichenbach and Wolburg 2009). (antiviralbiologic.com)
  • The mammalian zoom lens comprises of just two cell types: epithelial cells, which comprise a monolayer of cells that series the anterior hemisphere from the zoom lens, and fibers cells, which will make up the rest from the zoom lens mass. (antiviralbiologic.com)
Differential1
  • To your knowledge, this is actually the initial study determining the appearance of 254 lengthy intergenic non-coding RNAs (lincRNAs) within the zoom lens, which 86 lincRNAs shown differential expression between your two cell types. (antiviralbiologic.com)
Inhibitors1
  • Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. (mdpi.com)
Family3
  • Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface. (ox.ac.uk)
  • We show that the group 14 C-type lectins CLEC14A, CD93 and CD248 directly bind to MMRN2 and only thrombomodulin of the family does not. (ox.ac.uk)
  • Simple to assemble and good for all types, turkey is a family favorite on the Blood Type Diet! (4yourtype.com)
Functions2
  • Legume Lectins: Structures, Functions, and Carbohydrate-binding Specificities. (gr.jp)
  • Central questions are whether all astrocytes or just specific types share these functions and what the relevance is of these differences to human disease. (antiviralbiologic.com)
Intestinal1
  • We investigated the binding of four lectins to the follicle-associated epithelium (FAE) overlying fixed mouse small intestinal Peyer's patches to identify M-cell-specific surface markers. (nih.gov)
React3
  • The source of the lectin itself also has a great bearing on how it will react. (4yourtype.com)
  • Some foods have lectins that react specifically to particular blood types. (4yourtype.com)
  • Astrocytes react to all types of CNS disease and insult by becoming reactive, a nonspecific but feature response which involves various morphological and molecular adjustments highly. (antiviralbiologic.com)
Bacteria1
  • Cells in the liver have this type of lectin on their surfaces to snatch up harmful bacteria and parasites that may be present. (4yourtype.com)
Structural1
  • The Dectin-2 CRD exhibited only weak interactions to some of these capsular polysaccharides, indicative of different structural or affinity requirements for binding, when compared with the other two lectins. (elsevierpure.com)
Bind2
  • Each lectin has a certain type of material it is meant to bind to and this changes depending on what species the reaction is occurring inside as well as the blood type of the person or animal involved. (4yourtype.com)
  • Cy3 labeled glycoproteins are applied to the LecChip™ surface which then bind to specific lectins on the chip. (bmgrp.com)
Blood Type1
  • Understanding the way lectins work is paramount to understanding the positive impact The Blood Type Diet can have on you. (4yourtype.com)
Weak1
  • In deceased donors, genotyping found 65% more A 2 donors than lectin testing, most with weak lectin reactivity, a finding supported in living donors and samples sent for reference testing. (lu.se)
Carbohydrates2
  • From the earliest onset of cancer, changes can be detected in the type and amount of carbohydrates expressed by the cancer cells, i.e., aberrant glycosylation. (sc.edu)
  • Lectin microarrays using LecChip™ allows the highly sensitive analysis of carbohydrates in various sample types (purified and crude samples, e.g. cell/tissue extracts, living cells, virus particles, cell culture supernatants, serum, urine). (bmgrp.com)
Human2
  • While it has been consistently proven harmful to animals when administered in large doses, for human beings it disproportionately affects Type O Blood Types. (4yourtype.com)
  • The application of lectins as an anti-B reagent has proven to be as useful as human polyclonal or mouse monoclonal antibodies. (nih.gov)
Article1
  • While this article is a great summary of how lectins work, it only scratches the surface of the depth behind their function. (4yourtype.com)
Agglutinate2
  • This conclusion isn't hard to rationalize, as these food types are very high in lectins that agglutinate aggressively, thus aggravating the already inflamed areas in the joints suffering from arthritis. (4yourtype.com)
  • Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
Contrast1
  • By contrast, Cy3-tagged glycans that interact with the lectins located on the LecChip™ are contained in the stronger part of the evanescent field and are effectively excited. (bmgrp.com)
Understanding1
  • Understanding the source of the lectin and the chemistry of the person consuming it is at the center of eating right for your blood type. (4yourtype.com)
Cell5
  • Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)
  • We will also explore how myeloid cells develop their sentinel function, exploring how some of these CLRs identify cell death and the type of responses triggered thereof. (immunomodulationlab-idipaz.es)
  • solid course="kwd-title" Keywords: protoplasmic, fibrous, reactive astrocytes, examine, GFAP, glial scar tissue Astrocytes will be the most abundant nonneuronal cell type within the mind. (antiviralbiologic.com)
  • The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
  • Rather, its genotoxic effects are limited to indirect clastogenicity occurring in select cell types, and only when high dose and time thresholds are exceeded. (cdc.gov)
Expression1