• A diffuse subtype of classic Hodgkin lymphoma which is rich in Hodgkin and Reed-Sternberg cells and/or depleted in non-neoplastic lymphocytes. (nih.gov)
  • How I treat nodular lymphocyte-predominant Hodgkin lymphoma. (nih.gov)
  • For therapeutic purposes, nodular lymphocyte-predominant HL is managed in the same way as indolent non-Hodgkin lymphoma (see Follicular Lymphoma [non-Hodgkin Lymphoma] ). (medscape.com)
  • The models suggest that an efficient cytotoxic T lymphocyte (CTL) memory response is required to control the virus. (nih.gov)
  • Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
  • A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage. (bvsalud.org)
  • As vaccine -induced non- neutralizing antibodies may cause antibody-dependent enhancement of Zika virus ( ZIKV ) infection , we test a vaccine that induces only specific cytotoxic T lymphocytes (CTLs) without specific antibodies . (bvsalud.org)
  • Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
  • Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
  • HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
  • Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
  • Regulatory T cells (Treg) play an important role in suppressing anti- immunity and their depletion has been linked to improved outcomes. (nih.gov)
  • Tumor regression was dependent on Teffs as depletion of both CD4 and CD8 T cells completely abrogated any survival benefit. (nih.gov)
  • Moreover, our results suggest that this Nef-dependent enhancement in depletion occurred predominately in uninfected bystander CD4 + T cells. (biomedcentral.com)
  • Our findings suggest that Nef facilitates depletion of CD4 + T lymphocytes in HIV-1-infected lymphoid tissue ex vivo by increasing the pool of productively infected cells and by sensitizing bystander cells for killing. (biomedcentral.com)
  • This problem is partially answered by more selective depletion, such as depletion of CD3+ or αβT-cell and CD19 B cell, which preserves other important cells of the immune system. (wikipedia.org)
  • HIV has been confirmed to target CD4+ T cells and destroy them, making T cell depletion an important hallmark of HIV. (wikipedia.org)
  • Depletion of regulatory T cells increases immune activation. (wikipedia.org)
  • The body responds to T cell depletion by producing an equal amount of T cells. (wikipedia.org)
  • In a mammary carcinoma model, depletion of CD25+ regulatory T cells increase the amount of CD8+CD11c+PD110, which target and kill the tumors. (wikipedia.org)
  • Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)
  • Safe allogeneic hematopoietic stem cell transplantation for renal cell carcinoma: Novel approach using selective depletion of alloreactive donor T cells. (muni.cz)
  • Infection and depletion of CD4(+) T helper cells interfere with CTL memory generation, resulting in persistent viral replication and disease progression. (nih.gov)
  • Depletion of human T and B lymphocytes and NK cells. (bdbiosciences.com)
  • T lymphocytes (or T cells) are a class of immune cells that play an important role in the clearance of lung tumors. (fredhutch.org)
  • However, many of these environments contain large numbers of non-lymphocyte immune cells from the myeloid lineage. (fredhutch.org)
  • Our results found that PBC stimulated a greater change in numbers of CD16 + NK cells and CD8 + T cells in comparison to CWI, suggesting a larger catecholamine response after PBC could result in a morepronounced mobilisation of lymphocytes than CWI. (researchgate.net)
  • An increase in circulating leukocyte subsets such as CD8⁺ T cells and CD56loCD16⁺ natural killer cells suggests that PBC may induce a transient mobilisation of lymphocytes. (researchgate.net)
  • Glucocorticoid effects were assessed in vivo by depletion of endogenous glucocorticoids after oral administration of 1.5 g metyrapone (MET) and subsequent glucocorticoid replacement, and in vitro by incubation of the cells with different doses of dexamethasone (DEX). (karger.com)
  • Dr Hohlfeld explained that alemtuzumab works by binding to CD52 expressed by many types of immune cells, including T lymphocytes, B lymphocytes, monocytes, macrophages, and eosinophils, which are then cleared from the blood and are gradually replaced at different rates. (medscape.com)
  • The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)
  • The COX-2 gene promoter polymorphism -765 delays CD4 T-cell reconstitution after lymphocyte depletion with antithymocyte globulins. (cdc.gov)
  • Dr Penkert and coauthors report that the current patient had no signs of lymphocyte reconstitution at 5 months after alemtuzumab treatment, suggesting that she experienced prolonged immunodeficiency. (medscape.com)
  • This lesion is characterized by depletion of small lymphocytes and a diffuse change with loss of the normal thymic corticomedullary junction. (nih.gov)
  • The most significant histologic abnormality was diffuse depletion of B-lymphocytes in both fawns. (fao.org)
  • Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition (PEM) and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. (who.int)
  • For IL-2, NK cell cytotoxicity, and lymphocyte proliferation, maximum responses were observed during depletion periods. (karger.com)
  • To further explore the link between the HPA and the immune system in relation to glucocorticoid receptor function, dose-response curves were obtained for Con A-and PHA-induced T-cell mitogenesis, PWM-generated B-cell mitogenesis and spontaneous lymphocyte proliferation in 13 healthy controls. (karger.com)
  • There was a significant decrease in PWM-induced B-cell mitogenesis and a more pronounced effect of DEX administered in vitro on spontaneous lymphocyte proliferation after MET treatment when compared with the DEX plus MET pretreated condition in vivo. (karger.com)
  • These data suggest that the inhibition of spontaneous lymphocyte proliferation by glucocorticoids in vitro is related to glucocorticoid receptor function. (karger.com)
  • The decrease in PWM-generated B-cell proliferation following cortisol depletion by MET may be seen in connection with impaired glucocorticoid-mediated induction of interleukin-1 receptor synthesis. (karger.com)
  • The human lymphoid aggregate culture (HLAC) from tonsil maintains the cell populations and cytokine milieu found in vivo , supports a productive infection without exogenous stimulation, and Nef contributes to efficient HIV-1 replication as well as CD4 + T cell depletion in this experimental ex vivo -model. (biomedcentral.com)
  • In vivo depletion often uses monoclonal antibodies (eg, alemtuzumab) or heteroantisera. (wikipedia.org)
  • In haploidentical hematopoietic stem cell transplantation, in vivo TCD suppressed lymphocytes early on. (wikipedia.org)
  • In vivo, we analyzed the effect of macrophage depletion on concordant and discordant islet xenograft survival to assess in which combination this strategy can be used as therapeutic tool. (unige.ch)
  • Positive selection and depletion of mouse CD8a-positive splenocytes. (bdbiosciences.com)
  • Experimental groups were treated with a lymphocyte depletional agent, porcine polyclonal anti-thymocyte globulin (PATG) (n = 8) and compared to a vehicle control group (n = 9). (usuhs.edu)
  • Conclusions: Lymphocyte manipulation with a depletional (PATG) strategy improves reperfusion survival in experimental hemorrhagic shock using a porcine liver injury model. (usuhs.edu)
  • Tumor bearing BALB/c FoxP3.dtr transgenic mice were subjected to different treatment protocols, with or without Treg depletion and tumor growth and survival monitored. (nih.gov)
  • BALB/c.FoxP3.dtr mice are an ideal model to investigate the full therapeutic potential of Treg depletion to boost anti-tumor immunity. (nih.gov)
  • Atypical hyperplasia of the thymic lymphocytes has been described in chemically treated B6C3F1 and p53-deficient mice. (nih.gov)
  • DTX-mediated Treg depletion is transient, dose-dependent, and leads to strong anti-tumor immunity and complete tumor regression at high doses, while enhancing the efficacy of tumor-specific vaccination at low doses. (nih.gov)
  • Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. (prolekarniky.cz)
  • Treg depletion correlated with delayed tumor growth, increased effector T cell (Teff) activation, and enhanced survival in a range of solid tumors. (nih.gov)
  • Finally, we show that even minimal Treg depletion is sufficient to significantly improve the efficacy of tumor-peptide vaccination. (nih.gov)
  • Previous research analyzing gene expression in the tumor noted that a "lymphocyte-depleted" environment is associated with a poorer prognosis. (fredhutch.org)
  • Both belong to the oncovirus subfamily of retroviruses and can transform human lymphocytes so that they are self-sustaining in vitro. (cdc.gov)
  • A study published in Neurology by Genzyme researchers in April 2017 showed that GZ402668 worked by binding to a different epitope on CD52 than Lemtrada-achieving similar levels of lymphocyte depletion as Lemtrada but with reduced cytokine release in vitro , suggesting a potentially improved infusion-associated reaction profile. (genengnews.com)
  • Circulating CD3 lymphocytes in the blood and in central lymphoid organs (spleen/lymph node) were stained and evaluated using FACS analysis. (usuhs.edu)
  • However, the mechanisms leading to T-cell depletion remain largely unknown. (prolekarniky.cz)
  • Despite our expanding knowledge on the molecular details of the multi-faceted interactions of HIV with its host, the basic question of which viral factors and cell death mechanisms contribute to the loss of CD4 + T lymphocytes in HIV infected patients has not been entirely solved. (biomedcentral.com)
  • The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. (scielo.br)
  • Besides eliminating circulating mononuclear cell subsets, alemtuzumab might have depleted lymphocytes in compartments (eg, intraepithelial lymphocytes) that are normally spared," they suggest. (medscape.com)
  • Thymus - Atypical hyperplasia, Lymphocyte in a female p53+/- (C57Bl/6) mouse from a subchronic study. (nih.gov)
  • The editorialists agree that the prolonged lymphocyte depletion in this case may indicate that the regular dose of alemtuzumab is too high for a person with a very low body mass index. (medscape.com)
  • 7. Younan P, Iampietro M, Bukreyev A. Disabling of lymphocyte immune response by Ebola virus. (prolekarniky.cz)
  • Lymphocytes have been identified as critical mediators of the early innate immune response to ischemia-reperfusion injury, and immunomodulation of lymphocytes may prevent secondary immunologic injury in surgical and trauma patients. (usuhs.edu)
  • Depletion can occur naturally (i.e. in HIV) or be induced for treatment purposes. (wikipedia.org)
  • There are reports of oligoclonal bands in the CSF of stroke patients, suggesting that in some people a B-lymphocyte response to stroke may occur in the CNS. (jneurosci.org)
  • Atypical hyperplasia of the thymic lymphocytes is regarded as a proliferative change that may progress to lymphoma, although it may occur without progression. (nih.gov)
  • B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
  • T-cell depletion (TCD) is the process of T cell removal or reduction, which alters the immune system and its responses. (wikipedia.org)
  • OVA exposure causes significant depletion of intracellular GSH in lymphocytes, which may play a key role in OVA-mediated immune responses. (cdc.gov)
  • Hypothermic stress as a result of exposure to cold environments and cold water has been shown to increase circulating catecholamine concentration and subsequently influence lymphocyte mobilisation (Jansky et al. (researchgate.net)
  • In combined DEP-OVA exposure, the level of GSH in lymphocytes was further decreased, indicating a possible interactive effect between DEP and OVA exposures. (cdc.gov)
  • High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)
  • Severe morbidity following Treg depletion was only observed, when consecutive doses of DTX were given during peak CD8 T cell activation, demonstrating that Treg can be depleted on multiple occasions, but only when CD8 T cell activation has returned to base line levels. (nih.gov)
  • In contrast, increased CD4 + T lymphocyte depletion depended on only two protein interaction surfaces in Nef that mediate either downregulation of cell surface CD4 or interaction with the NAKC signalosome. (biomedcentral.com)
  • Consistently, in HLAC from 9 out of 14 donors, Nef enhanced CD4 + T cell depletion in the absence of a significant effect on virus replication. (biomedcentral.com)
  • T cell depletion methods can be broadly categorized into either physical or immunological. (wikipedia.org)
  • The Cambridge Biotech HIV-1 Western Blot Kit is manufactured by Calypte Corporation from HIV-I propagated in an H9/HTLV-IIIb T-lymphocyte cell line. (cdc.gov)
  • Please refer to the Depletion Flow Chart to identify the separated cell populations represented in this figure. (bdbiosciences.com)
  • In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)
  • HIV illness prospects to depletion of CD4 lymphocytes and defects in cell-mediated immunity. (fabretp.org)
  • The present exploratory work aimed to demonstrate how biomedical technology, such as phylogenetics and quantification of viral load and CD4+ T lymphocytes, can be used to produce technical evidence that brings more certainty in determining the authorship and materiality of these criminal behaviors. (scielo.sa.cr)
  • In particular, a strongly reduced body mass index, as seen in patients with anorexia nervosa, may be accompanied by a functionally immunocompromised state despite normal lymphocyte counts. (medscape.com)
  • Circulating CD3 + CD4 + lymphocytes were significantly depleted in the PATG group compared to control. (usuhs.edu)
  • Enumeration of CD4+ lymphocytes in HIV-positive participants and age-matched controls was performed on cryopreserved whole blood using the method reported by Fiebig et. (cdc.gov)
  • The clinical manifestation of AIDS results from continuous replication of HIV in infected individuals that causes slow but steady decline of CD4 + T lymphocytes to levels that no longer control opportunistic infections [ 1 ]. (biomedcentral.com)
  • La microbiología forense es un área científica que ha surgido con la necesidad de investigar los delitos biológicos, como en el caso de la transmisión intencional del virus de la inmunodeficiencia humana (VIH). (scielo.sa.cr)
  • In a blinded, randomized, cross-over study, male subjects on a low-carotenoid diet consumed 330 ml/day of either tomato juice (37.0 mg/day lycopene) or carrot juice (27.1 mg/day β-carotene and 13.1 mg/day α-carotene) for 2 weeks with a 2-week depletion period after juice intervention. (karger.com)
  • We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)
  • Tumour infiltrating lymphocyte clonality was not influenced by HIV status.ConclusionsHIV-associated HCC harbours a profoundly immune-exhausted tumour microenvironment, warranting prospective testing of immunotherapy in this treatment-deprived patient population. (imperial.ac.uk)