Lymphocyte function associated antigen 1. Medical search. Frequent questions

N-Linked glycosylation regulate both conformation and immune related functions of ICAM receptors. (nih.gov)
Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3. (bdbiosciences.com)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
Three counter-receptors have been described for LFA-1, intercellular adhesion molecule 1 (ICAM-1), ICAM-2 and ICAM-3. (biovendor.com)
Chronic T-cell exhaustion is marked by the progressive upregulation of coinhibitory receptors, PD-1 being one of the most prominent, but also other coregulated receptors such as LAG-3 ( 4, 5 ). (aacrjournals.org)

LAD1, a subtype of LAD, is caused by a lack of integrins that contain the beta subunit, including LFA-1. (wikipedia.org)
The interactions between melanoma cells and PMNs are mediated by the β 2 -integrins expressed by PMNs and intercellular adhesion molecules (ICAM-1) expressed on melanoma cells. (psu.edu)
The dissociation rates were calculated under low force conditions for ICAM-1 interactions with both β 2 -integrins, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), together and separately by using functional blocking antibodies on PMNs. (psu.edu)
It was concluded that the small number of constitutively expressed active β 2 -integrins on PMNs are sufficient to bind to ICAM-1 expressed on melanoma cells and that the intrinsic dissociation rate for these adhesion molecules appear to be more dependent on what method is used to determine them than on what cells express them. (psu.edu)

Human CD50 is an adhesion molecule that interacts with LFA-1 (CD18/CD11a) and provides a costimulatory signal for T cells which is thought to be essential for initiation of immune responses. (biosave.com)
Multiple inherited mutations in the integrin β2 protein (CD18) that reduce expression or function have been identified as the causative factor in patients with LAD1. (guidetopharmacology.org)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
1% expression of CD18). (medscape.com)
With this, we analyzed the phenotypes of CD34 + HSCs and showed that primitive HSCs or CD34 + CD33 - cells expressed adhesion molecules such as CD43, CD44, CD11a, CD11c, CD18, and leukocyte adhesion molecule (LAM-1). (elsevierpure.com)
Leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) was expressed on some populations of hematopoietic cells and contributed to the proliferation by interacting with stromal cells. (elsevierpure.com)

Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. (wikipedia.org)
LFA-1 belongs to the integrin superfamily of adhesion molecules. (wikipedia.org)
LFA-1, a leukocyte integrin, was first discovered by Timothy Springer in mice in the 1980s. (wikipedia.org)
The β2-integrin lymphocyte function-associated antigen 1 (LFA-1) plays an important role in the migration, adhesion and intercellular communication of dendritic cells (DCs). (northumbria.ac.uk)
Among the potential binding partners we identified not only established components of integrin signalling pathways and cytoskeletal proteins, but also several novel LFA-1 binding partners including CD13, galectin-3, thrombospondin-1 and CD44. (northumbria.ac.uk)
It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). (guidetopharmacology.org)
Lifitegrast works by binding to the integrin lymphocyte function-associated antigen-1, blocking the cell surface protein's interaction with its ligand, intercellular adhesion molecule-1, which is excessive in the corneal and conjunctival tissues of dry eye patients. (pharmacytimes.com)
LFA-1, an alpha-beta complex, is a member of the leukocyte integrin family which mediate lymphocyte adhesion. (biovendor.com)
Here, we evaluated the effect of integrin a4b7 blocker as a strategy to overcome immune resistance in the setting of combination immunotherapy (anti-CTLA-4, anti-PD-1 and/or anti-Lag-3). (bmj.com)
Methods To evaluate synergy between ICB (anti-CTLA-4 and anti-PD-1 or anti-PD-1 and anti-Lag-3) and VLA-4 integrin blocker, once mice with B16 melanoma, Lewis lung carcinoma (LLC) or pancreatic adenocarcinoma (PAN-02) had developed tumors of approximately 20mm 2 , they were treated with either IgG control, VLA-4 blocker, ICB, or combination of both therapies together. (bmj.com)
Interestingly, we observed that a4b7 integrin blocker demonstrated therapeutic synergy with anti-CTLA-4 and anti-PD-1 but not anti-PD-1 and anti-Lag-3. (bmj.com)
Lifitegrast binds to the integrin lymphocyte function-associated antigen-1 (LFA-1), a cell surface protein found on leukocytes and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1). (drugbank.com)
Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. (ox.ac.uk)

Cellular interactions regulated by the CD58/CD2 antigens are involved in the antigen-independent adhesion pathway and cytotoxic T lymphocyte (CTL) activity. (bdbiosciences.com)
Background: Human leukocyte antigen (HLA) class I genes mediate cytotoxic T-lymphocyte responses and natural killer cell function. (cdc.gov)

Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants. (bmj.com)
Intercellular Adhesion Molecule-3 (ICAM-3) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). (biovendor.com)
The integral membrane protein with five immunoglobulin-like domains shares high homology to ICAM-1 and ICAM-2 in the extracellular region. (biovendor.com)
The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)

The process of activating LFA-1 is known as inside out signaling, which causes LFA-1 to shift from low affinity to high affinity by opening the ligand-binding site. (wikipedia.org)
During the differentiation of human DCs from monocyte precursors, LFA-1 ligand binding capacity is completely lost, even though its expression levels were remained constant. (northumbria.ac.uk)
The CD58 antigen, known as the lymphocyte function-associated antigen-3 (LFA-3), mediates cellular adhesion and participates in signal transduction when it binds to its ligand, the CD2 antigen. (bdbiosciences.com)
ICAM-3 is expressed on resting lymphocytes, monocytes and neutrophils, representing the major LFA-1 ligand on these cells. (biovendor.com)

Functional Applications: Antibody blocks binding of CD11a (LFA-1) to CD50 (ICAM-3) Applications: Suitable for use in Flow Cytometry, Immunohistochemistry. (biosave.com)

Additionally, LFA-1 is involved in the process of cytotoxic T cell mediated killing as well as antibody mediated killing by granulocytes and monocytes. (wikipedia.org)
The LFA-1 activating antibody MEM-83, or its Fab fragment, decreased the rolling velocity of I-GPI cells on ICAM-1-containing membranes. (ox.ac.uk)
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Function Associated Antigen 3 (LFA3) in serum, plasma, cell lysatesand other biological fluids. (envite.org)
These data provide a rationale for the administration of anti-LFA-1 antibody after bone marrow transplantation for reducing the graft failure. (elsevierpure.com)
We have generated a high affinity and selective humanized monoclonal IgG4 antibody, TSR-033, which binds human LAG-3 and serves as a functional antagonist, enhancing in vitro T-cell activation both in mixed lymphocyte reactions and staphylococcal enterotoxin B-driven stimulation assays. (aacrjournals.org)
Although all 3 patients tested had abnormal cellular-immune function, no definitive conclusion regarding the role of CMV infection in these 5 cases can be reached because of the lack of published data on cellular-immune function in healthy homosexual males with and without CMV antibody. (cdc.gov)
Cohort 1 and Cohort 2: Prior therapy must have included: - Anthracycline or bendamustine-containing chemotherapy and - Anti-CD20 monoclonal antibody therapy and - Ibrutinib or acalabrutinib Cohort 3: Prior therapy must have included anthracycline, bendamustine-, or high dose cytarabine-containing chemotherapy and anti-CD20 monoclonal antibody therapy. (who.int)

Our predictions generate hypotheses on protein conformations controlling biological processes - such as protein recognition, signal transduction, and enzyme active site gating - and are laying the foundation for our work reengineering and "reshaping" protein interfaces and active sites for new functions. (ucsf.edu)

The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. (wikipedia.org)
In 1949, Billingham and Medawar came across Owen's work in a monograph by Frank Macfarlane Burnet and Frank Fenner entitled "The Function of Antibodies. (medscape.com)
Analogous studies in a murine syngeneic tumor model using surrogate antibodies demonstrated significant synergy between LAG-3 and PD-1 blockade-combination treatment led to a marked improvement in therapeutic efficacy, increased T-cell proliferation, IFNγ production, and elicited durable immunologic memory upon tumor rechallenge. (aacrjournals.org)
Molecular mimicry between antibodies directed against infectious agents (eg, bacteria, Epstein-Barr virus [EBV]) and self-antigens has been implicated in SLE. (medscape.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

However, SARS-CoV-2 constantly changes its antigens, resulting in escape from vaccine-induced protection, and the longevity of immunity induced by vaccines remains an issue. (bvsalud.org)
Our study demonstrates Ad5-S.Mod has the potential to confer protective immunity against SARS-CoV-2 and that lung macrophages support the maintenance of vaccine-induced tissue-resident memory lymphocytes. (bvsalud.org)
Progressive upregulation of checkpoints on tumor-infiltrating lymphocytes promotes an immunosuppressive tumor microenvironment, severely compromising tumor immunity. (aacrjournals.org)

To study the adhesive properties of the LFA-1 I domain, we stably expressed a GPI-anchored form of this I domain (I-GPI) on the surface of baby hamster kidney cells. (ox.ac.uk)
I-GPI cells bound soluble ICAM-1 (sICAM-1) with a low avidity and affinity. (ox.ac.uk)
Flow cell experiments demonstrated a specific rolling interaction of I-GPI cells on bilayers containing purified full length ICAM-1 or ICAM-3. (ox.ac.uk)
To address the many current challenges in the field - from developing more predictive computational design methods to determining the requirements for function in cells - we combine concepts from computer science, physics, chemistry, mathematics, engineering and biology. (ucsf.edu)
Over the past several years, we have engineered a range of proteins with new functions, including protein-protein interactions that are specific enough to control complex biological processes in mammalian cells (Kapp*, Liu* et al. (ucsf.edu)
LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
Traditionally, microcirculatory physiologists studied the essential transport functions of lymphatic vessels in removing fluid, molecules, and cells after leaking from blood vessels in the periphery and before returning them to the blood circulation. (jci.org)
Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
Lymphatic endothelial cells (LECs) themselves have been shown to play active roles in controlling their transport functions and in directly communicating with immune cells to modulate their immediate and downstream functions. (jci.org)
While we particularly focus on LEC interactions with DCs and T cells, we also highlight features that support immune regulation, including the structure and function of lymphatic vessels and the compartmentalization of the LN stroma, which help control the manner in which LECs can interface with immune cells. (jci.org)
The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
Mechanistic studies revealed that this progression was mediated by suppressed TNFα levels, both locally and systemically, resulting in reduced expression of tumor endothelial adhesion molecules, particularly intercellular adhesion molecule-1 (ICAM-1) and a subsequent decrease in the number of activated and effector CD8 + T cells in the tumor. (aacrjournals.org)
In the case of melanoma, circulating cells may find a suitable microenvironment in the first draining lymph node, known as the sentinel lymph node, in other lymphnodes or in distant organs, leading to secondary tumor growth (Figure 1 ). (hindawi.com)
Piperlongumine inhibited inflammatory mediators and adherence of lymphocyte function-associated antigen 1 to MH-S cells following TDM activation. (chemnews-japan.com)
Biopsies have demonstrated a measurable repopulation of goblet cells and a decrease in both conjunctival epithelial cell turnover and the number of lymphocytes. (aao.org)
LFA-1 also plays a role of cytotoxic killing by T cells. (medscape.com)
LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade. (bmj.com)
Neuroscience currently identifies four main functions of glial cells: to surround neurons and hold them in place, to supply nutrients and oxygen to neurons, to insulate one neuron from another, and to destroy pathogens and remove dead neurons. (anti-agingfirewalls.com)
cDC1 cells were required for the generation of antigen-specific CD8+ T-cell responses and CD8+ tissue-resident memory T-cell development in intranasal Ad5-S.Mod vaccinated mice. (bvsalud.org)
Using human monocyte THP-1 cells, we confirmed that ZIKV infection promotes inflammatory cell death and increases IL-1ß secretion. (bvsalud.org)
However, more primitive cells capable of reconstituting hematopoiesis did not express LFA-1. (elsevierpure.com)
Tumor persistence leads to sustained exposure of T cells to neoantigens-this results in repeated cycles of activation which culminate in a state of severe T-cell dysfunction or exhaustion, characterized by distinct epigenetic and transcriptional profiles ( 1-3 ). (aacrjournals.org)
In vitro studies demonstrated that lifitegrast may inhibit T-cell adhesion to ICAM-1 in a human T-cell line and may inhibit secretion of inflammatory cytokines, inflammatory mediators, chemokines, TNF-α, and IL-1 in human peripheral blood mononuclear cells. (drugbank.com)
Some EBOV infections generate a cytokine storm, which hinders peripheral natural killer cells (NK) and T and B lymphocytes. (cdc.gov)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
immune destruction of insulin-pro- vestigate the relationship of VDR gene ducing beta cells by T-cell infiltration polymorphism to the risk of type 1 DM DNA isolation and PCR experiments of the pancreatic islets [1]. (who.int)

Further comparison to the LFA-1 interaction partners in monocytes indicated that DC differentiation was accompanied by an overall increase in LFA-1 associated proteins, in particular cytoskeletal, signalling and plasma membrane (PM) proteins. (northumbria.ac.uk)
The finding that adhesion of resting T lymphocytes to LFA-1 occurs primarily via ICAM-3 combined with the fact that ICAM-3 is much better expressed than other LFA-1 ligands on monocytes and resting lymphocytes implies an important role for ICAM-3 in the initiation of immune responses. (biovendor.com)

This Review summarizes the emergent evidence that LECs are important in maintaining peripheral tolerance, limiting and resolving effector T cell responses, and modulating leukocyte function. (jci.org)
In this Review, we highlight these connections to reveal new roles of LECs, along with their transport functions, in modulating adaptive immune responses. (jci.org)
Three patients had profoundly depressed in vitro proliferative responses to mitogens and antigens. (cdc.gov)

As of 2007, LFA-1 has 6 known ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A. LFA-1/ICAM-1 interactions have recently been shown to stimulate signaling pathways that influence T cell differentiation. (wikipedia.org)
Yet LFA-1-mediated adhesive capacity on DCs can be regained by exposing DCs to the chemokine CCL21, suggesting a high degree of regulation of LFA-1 activity during the course of DC differentiation. (northumbria.ac.uk)
Leucocyte typing IV : white cell differentiation antigens. (bdbiosciences.com)

Leukocyte adhesion deficiency Lifitegrast, a drug that blocks LFA-1 from binding to ICAM-1 Lackie JM (2010). (wikipedia.org)
Lifitegrast is in a class of medications called lymphocyte function-associated antigen-1 (LFA-1) antagonist. (medlineplus.gov)
Lifitegrast, 5%, preservative-free topical solution, a lymphocyte function-associated antigen 1 (LFA-1) antagonist administered twice daily, was approved by the FDA in 2016 for treatment of dry eye. (aao.org)

It inhibits binding of intercellular adhesion molecule-1 (ICAM-1) to LFA-1 and has been effective in reducing ocular surface inflammation. (aao.org)
Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease. (dadamo.com)
METHODS: To investigate effects of the IL-1 gene cluster polymorphisms on wasting and inflammation, we studied 189 ESRD patients (52+/- 12 years, 62% males) close to the start of renal replacement therapy. (dadamo.com)
CONCLUSION: The investigated IL-1 gene cluster polymorphisms were associated with nutritional status and inflammation in ESRD patients, but marked differences were found between the genders. (dadamo.com)

Immunologic tolerance is a state of immune unresponsiveness specific to a particular antigen or set of antigens induced by previous exposure to that antigen or set. (medscape.com)
These new ideas, in turn, reveal a paradigm whereby the transport and immune functions of lymphatic vessels, which were previously considered separately, are in fact intimately coupled. (jci.org)
Chimeric antigen receptor (CAR) T-cell therapy is effective in relapsed/refractory large B-cell lymphoma and results in a unique toxicity profile, namely cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome. (chemnews-japan.com)
Thus potential function of ICAM-3 at the initiation phase of LC-leukocyte interactions taking place during skin localized immune reactions can be postulated. (biovendor.com)
IL-1 is one of the most important immune modifying interleukins. (dadamo.com)
In a humanized mouse non-small cell lung carcinoma model, TSR-033 boosted the antitumor efficacy of PD-1 monotherapy, with a concomitant increase in immune activation. (aacrjournals.org)
These theories hold that in SLE, the immune system generates autoantibodies to foreign antigens, and these autoantibodies, in turn, attack the patient's own tissues. (medscape.com)
CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)
as applicable for subjects in cohort 1 and cohort 2) at the time the subject is planned for leukapheresis, except for systemic inhibitory/stimulatory immune checkpoint therapy. (who.int)

The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow. (ox.ac.uk)
The I domain of lymphocyte function-associated antigen (LFA)-1 contains an intercellular adhesion molecule (ICAM)-1 and ICAM-3 binding site, but the relationship of this site to regulated adhesion is unknown. (ox.ac.uk)
The crystal structures of the glycosylated N-terminal two domains of ICAM-1 and ICAM-2 provided a framework for understanding the role of glycosylation in the structure and function of intercellular adhesion molecules (ICAMs). (nih.gov)
ICAM-3 was found to be involved in the regulation of LFA-1/ ICAM-1 dependent leukocyte intercellular interactions. (biovendor.com)

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. (bdbiosciences.com)

Chemokines stimulate the activation process of LFA-1. (wikipedia.org)
We previously showed that lymphocyte function associated antigen-1 (LFA-1) activation is critical for converting CD8 T cell exclusionary tumor microenvironment (TME) and allowing enhanced ICB-induced tumor control. (bmj.com)
1,2 Whereas very late antigen-4 (VLA-4) activation did not contribute to anti-CTLA-4 therapy antitumor response. (bmj.com)
Lymphocyte activation gene-3 (LAG-3) is a coinhibitory receptor associated with impaired T-cell function and is frequently coexpressed with programmed cell death protein-1 (PD-1) in the context of human cancers. (aacrjournals.org)
LFA-1/ICAM-1 interaction can contribute to the formation of an immunological synapse resulting in T-cell proliferation/activation and migration to target tissues. (drugbank.com)

Patients are mostly young and late diagnosis, which means thicker tumors (thicker than 1 mm, or Breslow index ≥1 mm: the Breslow index is the measurement in mm of the vertical thickness of the primary tumor) and/or involvement of regional lymph nodes, causes a greater risk of developing a disseminated disease. (hindawi.com)

Two sets of primers were used for DNA amplification targeting the specific sequence of a 529 bp repeat element and another set of primers was utilised for the surface antigen protein-1 gene. (chemnews-japan.com)

1984. Depression in B- and T-lymphocyte mitogen- induced blastogenesis in mice exposed to low concentrations of benzene. (cdc.gov)

205. Prior chimeric antigen receptor therapy or other genetically modified T cell therapy 206. (who.int)

Leukocyte adhesion deficiency is an immunodeficiency caused by the absence of key adhesion surface proteins, including LFA-1. (wikipedia.org)
We used highly sensitive label free quantitative mass-spectrometry to identify proteins co-immunoprecipitated (co-IP) with LFA-1 from ex vivo generated DCs. (northumbria.ac.uk)
The here presented LFA-1 interactome composed of 78 proteins thus represents a valuable resource of potential regulators of LFA-1 function during the DC lifecycle. (northumbria.ac.uk)
Create new proteins and devices with more advanced functions by experimental engineering. (ucsf.edu)
We have also engineered proteins whose functions can be switched by phosphorylation or light. (ucsf.edu)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

CD8+ human peripheral blood lymphocytes were stimulated lyophilized negative control (left) or SARS-CoV-2 peptide pool (right) for 20 minutes, then stained with anti-human LFA-1 PE followed by surface cocktail. (biolegend.com)
CD44 percentage values in peripheral T-lymphocytes were significantly higher in patients than controls, as detected by flow cytometry. (who.int)

Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs. (cdc.gov)

The molecular mechanisms underlying this regulation of LFA-1 function in DCs, however, remain elusive. (northumbria.ac.uk)
By building new functions through a combination of computational design and experimental engineering, I also hope to learn how molecular design principles shape systems-level properties of biological functions. (ucsf.edu)
Our research aims to invent approaches to engineer new molecules that operate as predicted in biological contexts, and to utilize prediction and engineering to address fundamental questions on the relationship of molecular mechanisms and systems-level function. (ucsf.edu)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

4 ]. A relationship between activated or lymphocytes and enzyme-linked immuno- memory-effector lymphocyte populations sorbent assay (ELISA) for CD117. (who.int)

LFA-1 has two subunits designated as the alpha subunit and beta subunit. (wikipedia.org)
1987) Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. (guidetopharmacology.org)

Patients with LAD also have poorly functioning neutrophils. (wikipedia.org)

The SARS-CoV-2 reactive T cell kit contains SARS-CoV-2 peptide pool (tube S), negative control (tube N) and positive control (tube P) in a convenient packaging for stimulating human blood/ PBMCs along with anti-human LFA-1 PE and a surface stain cocktail consisting of anti-human CD45 PerCP, CD8 Pacific Blue™, CD4 FITC and CD14, CD41, CD15, CD16, CD19 APC/Cyanine7. (biolegend.com)
The IL-1 receptor antagonist, IL-1Ra, is an agent which binds to the same receptor on the cell surface as IL-1, and thus prevents IL-1 from sending a signal to that cell. (dadamo.com)
Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation", JOURNAL OF EXPERIMENTAL MEDICINE , vol. 196, 2002, pp. 493-503. (uni-bielefeld.de)

Description: A sandwich ELISA kit for detection of Lymphocyte Function Associated Antigen 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)

LFA-1 is a heterodimeric glycoprotein with non-covalently linked subunits. (wikipedia.org)

It has been determined previously that polymorphonuclear leukocytes, or PMNs, can facilitate melanoma cell extravasation through the endothelium under shear conditions [1,2]. (psu.edu)

LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. (wikipedia.org)
Visual impairment is common, affecting between 2.8% and 10% of patients, 1 - 3 and may result directly from damage to uveal tract structures, or may occur due to secondary effects on neighboring tissues: for example, accelerated cataract formation, glaucoma, and macular edema. (dovepress.com)
ICAM-1 may be overexpressed in corneal and conjunctival tissues in dry eye disease. (drugbank.com)

Rap1 assists in breaking the constraint between the alpha and beta subunits of LFA-1. (wikipedia.org)
In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. (ox.ac.uk)

2019) Inflammatory consequences of inherited disorders affecting neutrophil function. (guidetopharmacology.org)

My research seeks to invent approaches to engineer new biological functions at multiple scales, ranging from atomic details to macromolecular machines to cellular processes. (ucsf.edu)
For the most part, these two forms of IL-1 bind to the same cellular receptor. (dadamo.com)

Diagnosis is by antigen or PCR (polymerase chain reaction) testing of upper or lower respiratory secretions. (msdmanuals.com)

In an inactive state, LFA-1 rests in a bent conformation and has a low affinity for ICAM binding. (wikipedia.org)

En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)

Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)

The absence of this motif in human ICAM-1 exposes regions used in receptor dimerization and rhinovirus recognition. (nih.gov)
The authors postulated that the age of the animal at the time of its first encounter with a foreign body was the critical factor in determining its responsiveness and, hence, its recognition of nonself antigens. (medscape.com)
A subtle role for CD2 in T cell antigen recognition. (ox.ac.uk)

Using an adenoviral (Ad) vector platform, we generated Ad5-S.Mod, a recombinant COVID-19 vaccine that encodes modified-spike (S) antigen and the genetic adjuvant human CXCL9. (bvsalud.org)
We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). (cdc.gov)

1,2 This is a huge population-estimated to be more than 10 times that of other common conditions such as glaucoma-in need of awareness, diagnosis and treatment. (reviewofoptometry.com)

Precipitating factors include: poor eyelid function, environmental factors, inflammatory processes such as Sjogren syndrome and some ocular or systemic drugs such as antihistamines, retinoids, and selective serotonin reuptake inhibitors. (standardofcare.com)

In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)
It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent accumulation of damage, and preserve visual function for patients with the minimum possible side effects. (dovepress.com)
Patients with prior VTE did not have progression https://joplink.net/antigens/ or evidence of new VTE. (chemnews-japan.com)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
Most patients with DILE have 1 or more clinical symptoms of SLE, such as arthralgias, lymphadenopathy, rash, and fever, and have had no prior history of autoimmune disease. (medscape.com)
Lymphocyte studies were not performed on the other 2 patients. (cdc.gov)
Pneumocystis pneumonia in the United States is almost exclusively limited to severely immunosuppressed patients (1). (cdc.gov)
We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
We identified putative risk factors for ESCrE and CRE colonization among patients in 1 urban and 3 rural hospitals in Kenya. (cdc.gov)
A group of 69 patients with type 1 diabetes mellitus and 45 unrelated healthy subjects were recruited. (who.int)
Un groupe de 69 patients atteints de diabète de type 1 et 45 témoins en bonne santé sans lien entre eux ont été recrutés pour cette étude. (who.int)

Anatomy40

Organisms13

Diseases8

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Health Care3

Receptors5

Integrins4

CD186

Integrin13

Cytotoxic T lymphocy2

Immunoglobulin4

Ligand4

CD11a1

Antibody8

Signal Transduction1

Antibodies5

Immunity3

Cells26

Monocytes2

Responses3

Differentiation3

Lifitegrast3

Inflammation4

Immune9

Intercellular4

Interactions1

Activation5

Tumor1

Gene1

Mice1

Chimeric1

Proteins6

Peripheral2

Alleles1

Molecular4

Populations1

Subunit2

Neutrophils1

Surface3

ELISA1

Glycoprotein1

Endothelium1

Tissues3

Rap12

20191

Cellular2

Polymerase1

Affinity1

Soluble1

Leukocyte adhesion defici1

Recognition3

Human2

Diagnosis1

Processes1

Patients12