• Compared to normal lymphocyte count, the adjusted hazard ratio (HR) for mortality was 1.31 (95% confidence interval [CI] 1.21-1.41) and 1.97 (95% CI 1.75-2.22) for relative and severe lymphopenia, respectively. (viamedica.pl)
  • Lymphocyte Count Kinetics and the Effect of Different Radiotherapy Techniques on Radiation-Induced Lymphopenia in Patients with Breast Cancer Receiving Hypofractionated Postmastectomy Radiotherapy. (bvsalud.org)
  • Trophoblast IFN-tau differentially induces lymphopenia and neutropenia in lambs. (tamu.edu)
  • The most common laboratory abnormalities (≥ 10% Grade 3 or 4) were lymphopenia and neutropenia. (nih.gov)
  • Type I interferons (IFN), including IFN-alpha and IFN-beta, cause severe lymphopenia, resulting from altered lymphocyte recirculation and redistribution. (tamu.edu)
  • We also explore the potential aetiologies of the lymphopenia associated with severe COVID-19: the virus' expanded tropism, elevated serum cytokines (particularly interleukin-6 and tumour necrosis factor-α), and excessive lymphocyte recruitment to the lungs. (ersjournals.com)
  • NK) cells (T-B-NK-SCID) and severe lymphopenia. (researchgate.net)
  • a Severe combined immunodeficiencies defined by T cell lymphopenia. (springer.com)
  • ADA deficiency results in absence of T, B, and NK cells, resulting in a SCID with marked lymphopenia. (medscape.com)
  • Relation between lymphopenia and bacteraemia in UK adults with medical emergencies. (ox.ac.uk)
  • AIMS: To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia. (ox.ac.uk)
  • RESULTS: Neutrophilia and lymphopenia were both associated with bacteraemia. (ox.ac.uk)
  • Both neutrophilia and lymphopenia were more predictive of bacteraemia than the total white blood cell count. (ox.ac.uk)
  • High RDW may enhance the predictive ability of lymphopenia. (viamedica.pl)
  • Clinical laboratory findings can include lymphopenia, thrombocytopenia, and elevated creatinine. (cdc.gov)
  • PNP deficiency causes profound T lymphopenia and variable numbers of B and NK cells. (medscape.com)
  • Lymphopenia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sdsu.edu)
  • We aimed to determine the association between lymphopenia and mortality in patients presenting to coronary angiography and investigate whether elevated red blood cell distribution width (RDW), an established cardiovascular prognostic marker, further refines risk stratification. (viamedica.pl)
  • The association of lymphopenia with mortality remained significant after additional adjustment to RDW. (viamedica.pl)
  • lymphopenia is associated with increased risk of mortality during long-term follow-up in patients undergoing coronary angiography, regardless of the coronary presentation. (viamedica.pl)
  • Lymphopenia at ICU admission and its persistence at day 3 were associated with an increased risk of ICU-acquired infection, while only persisting lymphopenia predicted increased 28-day mortality. (springeropen.com)
  • Furthermore, a very recent study showed that persistent lymphopenia on the fourth day after bacteremia diagnosis predicts early and late mortality in those patients, including in the subgroup of patients with sepsis [ 15 ]. (springeropen.com)
  • Lymphopenia is associated with adverse prognosis in chronic disease states that are related to immune dysregulation. (viamedica.pl)
  • PTPN2-deficient CD8(+) T cells undergo rapid lymphopenia-induced proliferation (LIP) when transferred into lymphopenic hosts and acquire the characteristics of antigen-experienced effector T cells. (monash.edu)
  • We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. (ersjournals.com)
  • This graph shows the total number of publications written about "Lymphopenia" by people in this website by year, and whether "Lymphopenia" was a major or minor topic of these publications. (sdsu.edu)
  • Idiopathic T cell lymphopenia (ICL). (primaryimmune.org)
  • treated rats with the superagonistic anti-CD28 antibody JJ316 and found that it rapidly induced a marked T cell lymphopenia by trapping T cells in the spleen and lymph nodes (see the related article on page 1405). (jci.org)
  • This dramatic redistribution of T cells simulated the profound T cell lymphopenia observed in human recipients of TGN1412. (jci.org)
  • Sometimes the cause of lymphopenia is not known. (nih.gov)
  • Therefore, AIDS is a possible cause of lymphopenia. (proprofs.com)
  • Idiopathic CD4 lymphopenia : still more questions than answers / Irini Sereti. (nih.gov)
  • Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia. (unm.edu)
  • Lymphopenia (also called lymphocytopenia) is a disorder in which your blood doesn't have enough white blood cells called lymphocytes. (nih.gov)
  • If you have low numbers of lymphocytes (lymphopenia), you are at higher risk of infection. (nih.gov)
  • CHICAGO ― Patients with esophageal cancer who develop severe lymphopenia after receiving chemoradiotherapy have significantly worse outcomes than those whose lymphocytes are not compromised by treatment, underscoring how important the immune system is in cancer control, say researchers. (medscape.com)
  • Lymphopenia is a blood disorder that results in a decrease in certain white blood cells, called B and T lymphocytes, and affects the effectiveness of the immune system. (dailymedicalhealth.com)
  • Lymphopenia is a blood disorder in which there is a decrease in certain white blood cells, called B and T lymphocytes . (dailymedicalhealth.com)
  • Lymphopenia is first assessed by measuring the level of B and T lymphocytes in the blood via the blood count. (dailymedicalhealth.com)
  • Lymphopenia is a condition characterized by a low number of lymphocytes in the blood. (proprofs.com)
  • This destruction of lymphocytes leads to lymphopenia. (proprofs.com)
  • Although patients with HIV infection or Venezuelan equine encephalitis often present with relative lymphopenia, the relative lymphopenia of WNE is usually more profound and may be prolonged, which should be suggestive. (medscape.com)
  • PNP deficiency causes profound T lymphopenia and variable numbers of B and NK cells. (medscape.com)
  • Although many ongoing studies are investigating measurement of proinflammatory cytokines and other biomarkers as a way to prognosticate infection severity, we investigated use of 2 easily obtained predictors: lymphopenia and leukocytosis ( 3 ). (cdc.gov)
  • Lymphopenia leads to recurrent infections or infections with unusual organisms. (dailymedicalhealth.com)
  • Lymphopenia is a predictor of severe infections SIE in MPA on immunosuppressives. (rheumnow.com)
  • The most common infection that can lead to lymphopenia is HIV (human immunodeficiency virus), which causes AIDS. (nih.gov)
  • Sometimes inherited, lymphopenia is most often secondary to other causes, the most common of which are malnutrition and AIDS. (dailymedicalhealth.com)
  • Cancer patients with CD4 lymphopenia have an increased risk of severe toxicity after administration of cytotoxic chemotherapy. (nih.gov)
  • Among those whose lymphocyte counts were severely compromised, median recurrence-free survival was only 1.8 years, compared to 4.0 years for patients who did not develop lymphopenia ( P = .02). (medscape.com)
  • Median overall survival (OS) was also significantly attenuated in patients with grade 4 lymphopenia, at only 2.4 years, compared to 4.0 years for patients whose lymphocyte counts were not compromised by chemoradiotherapy. (medscape.com)
  • Lymphopenia: Obtain a CBC including lymphocyte count before initiating BAFIERTAM, after 6 months, and every 6 to 12 months thereafter. (nih.gov)
  • the second was intended to identify ways in which current treatment regimens might be modified so as to make the development of grade 4 lymphopenia less likely for patients who undergo chemoradiotherapy. (medscape.com)
  • T cells undergo lymphopenia-induced proliferation (LIP) upon transfer into lymphopenic hosts, and this process requires interactions with self-pMHC as well as signals from cytokines such as IL-7 and IL-15 ( 13 ). (frontiersin.org)
  • We found that [radiation] dose to the heart, spine, aorta, and body predict for grade 4 lymphopenia, which is associated with worse recurrence-free and overall survival, and that achieving planning constraints for these parameters may decrease grade 4 lymphopenia and improve outcomes," he reported. (medscape.com)
  • Lymphopenia is often associated with PLE secondary to lymphangiectasia. (vin.com)
  • Lymphopenia symptoms can range from mild to serious and are correlated to the severity of the lymphopenia as well as its duration. (nih.gov)
  • To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. (cdc.gov)
  • BACKGROUND: Excessive inflammation and lymphopenia are linked to poor Covid-19 clinical outcomes. (saisei-hawaii.com)
  • The impact of CD4 lymphopenia on long term overall survival (OS) of cancer patients was explored in this work. (nih.gov)
  • Alopecia (accelerated hair loss), eczema, pyoderma (purulent skin disease), telangiectasia (dilation of small blood vessels located near the surface of the skin, mucous membranes or the white of the eye) are all skin abnormalities that may suggest the presence of lymphopenia. (dailymedicalhealth.com)
  • For patients with grade 4 lymphopenia, OS was reduced by 55% compared to those who did not have lymphopenia. (medscape.com)
  • In the test series, all patients with metastatic cancers and CD4 lymphopenia ≤ 200/μL (12% of metastatic patients) died within 18 months with a median OS of 5.9 months. (nih.gov)
  • 68 (30.8%) patients had lymphopenia. (ssrn.com)
  • Routine laboratory studies in patients with scrub typhus reveal early lymphopenia with late lymphocytosis. (medscape.com)
  • The main risk factor for lymphopenia worldwide is poor nutrition. (nih.gov)
  • When the volume of the body receiving 10 Gy exceeded 18%, the risk for grade 4 lymphopenia was increased more than sevenfold. (medscape.com)
  • Who is at risk to lymphopenia? (dailymedicalhealth.com)
  • Almost half of the group (45%) developed grade 4 lymphopenia, the team reported. (medscape.com)
  • Similarly, there was a strong likelihood of grade 4 lymphopenia if more than 72% of the volume of the thoracic spine received 5 Gy, or if more than 50% of the total lung received 5 Gy of radiation, or if more than 50% of the volume of the aorta received 5 Gy. (medscape.com)
  • That dose appears to be the strongest predictor of grade 4 lymphopenia. (medscape.com)
  • On univariable analysis, the group found that if more than 73% of the volume of the heart received 15 Gy of radiation, that there was a strong likelihood of lymphopenia, "so to avoid lymphopenia, we want to keep the percentage of the heart receiving 15 Gy of radiation to below 73%," Zhang emphasized. (medscape.com)
  • His team presented a study on lymphopenia here at the American Society for Radiation Oncology (ASTRO) 2019 Annual Meeting. (medscape.com)
  • Lymphopenia is confirmed when this level is less than 1,500 per mm3 in adults and 4,500 mm3 in children under eight months of age. (dailymedicalhealth.com)
  • One of the early clues to an acquired immunodeficiency state is the development of absolute lymphopenia. (mhmedical.com)
  • If lymphopenia doesn't cause health problems, your healthcare provider may not recommend any treatment. (nih.gov)