Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)
Histological changes in the trachea were accompanied by increased mRNA expression of interleukin (IL)-4, tumour necrosis factor alpha, lymphotoxin beta, lymphotactin and Rantes, as well as TDI-specific IgG antibodies and elevated levels of total IgE. (cdc.gov)
Chegini N. An inverse relation between the expression of tumor necrosis factor alpha (TNF-alpha) and TNF-alpha receptor in human endometrium. (aaem.pl)
It does not react with receptor-bound TNF-alpha. (abcam.com)
Does not cross-react with TNF-beta, lymphotoxin and receptor bound TNF-alpha. (lsbio.com)
Lymphotoxin β-receptor (LTβR) and TNF receptor-1 (TNFR1) are important for the development of secondary lymphoid organs during embryonic life. (uni-luebeck.de)
Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. (abcam.cn)
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. (lu.se)
A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers, Science , Vol.271 , No.5253 , 1289-1291, 1996. (tokushima-u.ac.jp)
Distinct roles of lymphotoxin-alpha and the type I TNF receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells, The Journal of Experimental Medicine , Vol.186 , No.12 , 1997-2004, 1997. (tokushima-u.ac.jp)
Lymphotoxin-alpha deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers, Immunological Reviews , Vol.156 , (号) , 137-144, (month) 1997. (tokushima-u.ac.jp)
Soluble3
It reacts with free soluble (17 kDa) and membrane (26 kDa) human TNF-alpha. (abcam.com)
Reacts with soluble (17kD) and membrane (26kD) human TNF-alpha. (lsbio.com)
The released forms of TNF alpha from the membrane occur as the soluble form. (pediaa.com)
Polymorphism2
A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study. (wakehealth.edu)
A tumor necrosis factor-alpha promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1652 pregnant women. (cdc.gov)
Molecule3
One of the significant players in this event is the molecule cytokine lymphotoxin-alpha (LTA), which helps to regulate inflammation, a result of the emergency call upon the body's immune system. (news-medical.net)
Intact class I molecules consist of an alpha heavy chain bound to a beta-2 microglobulin molecule. (msdmanuals.com)
Tumor necrosis factor has been reported to generate nitric oxide in vitro, so we have measured levels of this molecule and its products in the plasma of mice after they have received an injection of tumor necrosis factor, lymphotoxin, interleukin-1, gamma interferon, or interleukin-6, all of which have been reported to be increased in malaria. (ox.ac.uk)
Genes2
For the PE data, this analysis revealed three genes, lymphotoxin alpha (LTA), von Willebrand factor (VWF), and alpha 2 chain of type IV collagen (COL4A2) with possible incompatibility effects. (wayne.edu)
TNF-alpha and lymphotoxin (LT, TNF-beta) genes are tandemly arranged and map within the MHC centromeric to HLA-B and telomeric to the class III genes. (ox.ac.uk)
Inflammation4
There is growing evidence that TNF-alpha and its two receptors play an important role in hormonal regulation, metabolism, inflammation and cancer. (aaem.pl)
Absence of lymph nodes in lymphotoxin-alpha (LTalpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration, Journal of Inflammation , Vol.45 , (号) , 72-78, 1995. (tokushima-u.ac.jp)
The two main biological functions mediated by TNF alpha through these receptors are inflammation and cell death. (pediaa.com)
TNF alpha refers to an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. (pediaa.com)
Cytokine2
Lymphotoxin alpha, a member of the tumor necrosis factor superfamily, is a cytokine produced by lymphocytes. (wikipedia.org)
TNF alpha is a cytokine with a pleiotropic effect on various cell types. (pediaa.com)
Antibody5
Western Blot: TNF-alpha Antibody [NBP1-19532] - Recombinant human TNF alpha (10 ng) was separated on a 12% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. (novusbio.com)
Western Blot: TNF-alpha Antibody [NBP1-19532] - Scutellarin attenuates hypertension-induced brain expression of NF-kappaB, TNF-alpha, IL-1beta, and IL-18. (novusbio.com)
Immunohistochemistry-Paraffin: TNF-alpha Antibody [NBP1-19532] - Analysis of a FFPE tissue section of mouse intestine using TNF-alpha antibody (NBP1-19532) at 1:300 dilution. (novusbio.com)
TNF Alpha antibody LS-B2123 is an unconjugated mouse monoclonal antibody to TNF Alpha from human. (lsbio.com)
Anti-TNF Alpha antibody IHC of human lung. (lsbio.com)
Tumor necro6
Tumor necrosis factor alpha (TNF α ) stimulates the expression of monocyte chemoattractant protein 1 (MCP-1) [ 11 ]. (hindawi.com)
Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor. (aaem.pl)
Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. (childrensmercy.org)
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. (pediaa.com)
Humans1
Lymphotoxin-alpha (LT-α) formerly known as tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. (wikipedia.org)
Gene3
Polymorphisms in the tumor necrosis factor and lymphotoxin-alpha gene region and preeclampsia. (cdc.gov)
The most distinct hypermethylation was observed at a CpG site annotated to the lymphotoxin alpha gene. (scilifelab.se)
Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene. (ox.ac.uk)
Macrophages3
The main difference between TNF alpha and beta is that TNF alpha is cachectin, produced by activated macrophages , whereas TNF-beta is lymphotoxin, produced by activated lymphocytes . (pediaa.com)
Activated macrophages produce TNF alpha, while activated lymphocytes produce TNF beta. (pediaa.com)
TNF alpha is also known as cachectin, and the activated macrophages produce it. (pediaa.com)
Proteins1
TNF alpha and beta are two proteins in the TNF family. (pediaa.com)
Protein3
Full length native protein (purified) corresponding to Human TNF alpha. (abcam.com)
Structure-wise, TNF alpha is a protein with 157 amino acids. (pediaa.com)
Importantly, TNF alpha, the other type of TNF protein, shows 35% identity and 50% homology to TNF beta. (pediaa.com)
Mice1
Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice, Nature , Vol.382 , No.6590 , 462-466, 1996. (tokushima-u.ac.jp)
Functional1
Functional analysis using specific inhibitors was used to test their suppressive properties and we identified Lymphotoxin alpha (LTA) as a new and potent Breg ligand implicated in Breg suppressive properties. (bvsalud.org)
Cachectin1
TNF alpha is also known as cachectin, while TNF beta is also known as lymphotoxin. (pediaa.com)
Receptors4
The biological effects of TNF-alpha are mediated by two receptors, p55 and p75. (aaem.pl)
Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. (aaem.pl)
Furthermore, the biological activities of the TNF alpha are mediated by the type 1 and 2 receptors. (pediaa.com)
Therefore, both TNF alpha and TNF beta use the same receptors. (pediaa.com)
Recombinant1
Recognizes human native and recombinant TNF-alpha. (lsbio.com)
Roles1
In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria. (ox.ac.uk)
Tumor necrosis factor, lymphotoxin, and interleukin-1 all induced reactive nitrogen intermediates in vivo, with interleukin-1 showing the most activity. (ox.ac.uk)
These results are consistent with the possibility that tumor necrosis factor, lymphotoxin, and interleukin-1 may contribute to host pathology and parasite suppression through generation of nitric oxide. (ox.ac.uk)
Inflammatory cytokines increase in RA, such as TNF alpha, interleukin 1, and interleukin 6. (pediaa.com)
Molecules1
Cachexia is thought to be caused by bioactive molecules produced by the tumor, such as alpha-lymphotoxin (tumor necrosis factor [TNF] alpha), peptides, and nucleotides, which are able to affect metabolism. (medscape.com)
Form1
Initially synthesized precursor form is the transmembrane TNF alpha. (pediaa.com)
Beta7
It does not cross-react with TNF beta or lymphotoxin. (abcam.com)
9-alpha, 11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. (mcgill.ca)
Another name for the TNF beta is lymphotoxin α (LT-α). (pediaa.com)
At the same time, TNF beta refers to lymphotoxin-alpha produced predominantly by mitogen-stimulated T-lymphocytes and leukocytes. (pediaa.com)
TNF alpha is a major regulator of the inflammatory response, while TNF beta participates in tumor immunity. (pediaa.com)
In comparison, TNF beta is also known as lymphotoxin, and activated lymphocytes produce it. (pediaa.com)
Therefore, their production is the main difference between TNF alpha and TNF beta. (pediaa.com)
Medicine1
Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses, The Journal of Experimental Medicine , Vol.185 , No.12 , 2111-2120, 1997. (tokushima-u.ac.jp)
Expression1
Lymphotoxin alpha (LT α ) and TNF α were shown to induce the expression of homing chemokines in B and T cell areas of the spleen [ 13 ]. (hindawi.com)
Results1
The inhibition of the target-specific cytokines, such as TNF alpha, gives promising results for RA. (pediaa.com)