• the term carcinosarcoma was formerly used to describe lesions with homologous tumors, and "malignant mixed Müllerian tumor" or "mixed mesodermal tumor" was used to describe heterologous tumors. (wikipedia.org)
  • While "carcinosarcoma" now considered standard, "malignant mixed Müllerian tumor" has a lengthy history within gynecological literature and is expected to continue to be used. (wikipedia.org)
  • Determine the impact on survival and the antitumor effects of thalidomide in patients with sarcomas or carcinosarcoma (mixed mesodermal tumors) of gynecologic origin. (knowcancer.com)
  • Uterine carcinosarcoma, also known as malignant mixed Mullerian tumor (MMMT), is a rare and aggressive form of corpus uteri tumor. (cytojournal.com)
  • Ovarian carcinosarcoma (OSC), also known as mixed mesodermal tumor or mixed müllerian tumor, is a rare ovarian tumor, known to be highly aggressive representing less than 2% of ovarian cancers, it is characterized by the association of a carcinomatous component and a sarcomatous component. (scholarena.co)
  • Ovarian carcinosarcoma (OSC) also known as mixed mesodermal tumor or mixed mullerian tumor, is a rare, aggressive, ovarian tumor that accounts for less than 2% of ovarian cancers. (scholarena.co)
  • Uterine carcinosarcoma (UCS) is a highly aggressive tumor that accounts for less than 5% of uterine malignancies [ 1 , 2 ]. (por-journal.com)
  • If an ovary is not distinctly seen on an imaging study but there is a mixed cystic and solid mass in the adnexal region, it is most likely to be a benign lesion. (wdxcyber.com)
  • Blumenfeld Z, Kerner H, Thaler I, Deutsch M, Beck D: Increased alpha fetoprotein levels in mixed mesodermal tumors of ovary. (sapub.org)
  • A malignant mixed Müllerian tumor most often develops in the uterus (uterus), ovaries, or fallopian tubes (the conduit through which eggs are delivered from the ovary to the uterus) [2]. (scholarena.co)
  • BACKGROUND: Malignant mixed mesodermal tumors (MMMTs) are uncommon, highly aggressive tumors of the uterus composed of both carcinomatous and sarcomatous elements, both likely to be derived from the same original stem cell. (elsevierpure.com)
  • The remaining sarcomas are made up of heterologous tumors-tumors that contain histologic components foreign to the uterus, such as rhabdomyosarcomas , osteosarcomas , and chondrosarcomas . (medscape.com)
  • A malignant mixed Müllerian tumor, also known as malignant mixed mesodermal tumor (MMMT) is a cancer found in the uterus, the ovaries, the fallopian tubes and other parts of the body that contains both carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. (wikipedia.org)
  • MMMT account for between two and five percent of all tumors derived from the body of the uterus, and are found predominantly in postmenopausal women with an average age of 66 years. (wikipedia.org)
  • the "combination" theory is most widely held, and is due to evidence that the tumors develop from a single line of cells, developing in a fashion similar to the fundus of the uterus from the Müllerian duct - first from a stem cell into a population of cells, that then differentiates into epithelial and stromal components. (wikipedia.org)
  • GP Sutton, JA Blessing, N Rosenshein, G Photopulos, PJ DiSaia (1989) Phase II trial for ifosfamide and mesna in mixed mesodermal tumors in the uterus. (scholarena.co)
  • Other examples include Chondrosarcoma (of the cartilage), Leiomyosarcoma (smooth muscles), Rhabdomyosarcoma (skeletal muscles), Mesothelial sarcoma or mesothelioma (membranous lining of body cavities), Fibrosarcoma (fibrous tissue), Angiosarcoma or hemangioendothelioma (blood vessels), Liposarcoma (adipose or fatty tissue), Glioma or astrocytoma (the neurogenic connective tissue found in the brain), Myxosarcoma (primitive embryonic connective tissue) and Mesenchymous or mixed mesodermal tumor (mixed connective tissue types). (solutionpharmacy.in)
  • A cancerous growth is called a malignant tumor or malignancy and noncancerous growth is called benign growth. (solutionpharmacy.in)
  • Approximately 75%-80% of ovarian tumors are benign, occurring in patients under 40 years of age. (biomedcentral.com)
  • Benign epithelial tumors (adenoma and cystadenoma) are characterized by the absence of cell proliferation and invasion. (biomedcentral.com)
  • Since then, symptoms are related to its location in the about 300 cases have been documented in posterior fossa and may include headache, the literature.1 It is a slow-growing benign nausea, and visual problems.1-3 tumor composed of atypical ganglion cells. (bvsalud.org)
  • The behavior of MMMT overall is more related to the type and grade of the epithelium than the sarcoma, which suggests the sarcomal portion is an atypical "bystander" than primary driver of the tumor. (wikipedia.org)
  • A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. (rush.edu)
  • The distinction among the various subgroups of uterine sarcoma and between uterine sarcomas and other uterine tumors cannot be made on clinical grounds. (vrad.com)
  • Uterine carcinosarcomas, known as malignant mixed mullerian tumors (MMMT) show characteristics of both carcinomas and sarcomas. (e-roj.org)
  • Type I tumors include low-grade serous, low-grade endometrioid, clear cell and mucinous carcinomas and type II include high-grade serous, high-grade endometrioid and undifferentiated carcinomas. (biomedcentral.com)
  • Malignant mixed mesodermal tumors (carcinosarcomas) are included in the type II category because their epithelial components are identical to the pure type II carcinomas. (biomedcentral.com)
  • However, the vast majority of malignant ovarian tumors (80%-85%) are classified as epithelial tumors (carcinomas). (biomedcentral.com)
  • In contrast, 80%-90% of ovarian carcinomas are detected after the age of 40, and 40% of these tumors are detected after the age of 65. (biomedcentral.com)
  • As a type of malignant mixed Müllerian tumors and related to poorly differentiated endometrial carcinomas, UCS is characterized by biphasic morphology with carcinomatous and sarcomatous differentiation [ 3 , 4 ]. (por-journal.com)
  • Rare type of cancerous (malignant) tumor made up of both epithelial cells (cells that make up the inner lining of hollow organs and glands in the body) and stromal cells (cells that make up the connective tissues that surround and support various organs in the body) [1]. (scholarena.co)
  • The three most common histologic variants of uterine sarcomas are malignant mixed müllerian tumors, leiomyosarcomas, and endometrial stromal sarcomas. (vrad.com)
  • These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. (biomedcentral.com)
  • According to the 2014 World Health Organization (WHO) classification and tumor morphology, primary ovarian tumors are subdivided into three categories: epithelial (60%), germ cell (30%), and sex-cord stromal tumors (8%)[ 1 ]. (biomedcentral.com)
  • Malignant germ cell and sex-cord stromal tumors comprise approximately 10% of all malignant ovarian tumors. (biomedcentral.com)
  • Borderline tumors are characterized by cell proliferation and a minor degree of nuclear atypia without stromal invasion. (biomedcentral.com)
  • Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. (biomedcentral.com)
  • Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. (allenpress.com)
  • These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography-guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. (allenpress.com)
  • Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
  • To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. (allenpress.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • Immunohistochemistry was performed in primary and metastatic tumor lesions. (por-journal.com)
  • Vascular lesions in the hand may be secondary to local pathology (e.g. tumour, malformation, trauma, iatrogenic cause, or drug injection), a proximal source of emboli (e.g. dissections or aneurysms), or systemic diseases with vascular compromise (e.g. rheumatic and vaso-occlusive diseases). (springer.com)
  • This tumor, which occupies a small uterine cavity, grows primarily as a firm polypoid mass. (medscape.com)
  • Uterine sarcomas are rare tumors of mesodermal origin, constituting only 2-6% of uterine malignant tumors [1]. (vrad.com)
  • There is evidence that some tumors are better explained by the composition theory, due to the aggressive nature of the epithelial cells involved which tend to metastasize much more readily than the sarcomal component. (wikipedia.org)
  • a painless, slowly growing, mixed radiolucent-radiopaque lesion characterized histologically by cords of polyhedral epithelial cells, deposits of amyloid , and spherical calcifications. (en-academic.com)
  • Importantly, UCS is the prototype tumor for epithelial-mesenchymal transition (EMT), a reversible biological process that associates with tumor progression and metastasis and in which epithelial cells transform into more invasive mesenchymal cells by losing their epithelial properties [ 10 - 12 ]. (por-journal.com)
  • Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)
  • When cells in some area of the body duplicate without control, the excess of tissue develops called tumor or neoplasm. (solutionpharmacy.in)
  • Interestingly, expression patterns of EMT-related markers including E-cadherin and ZEB1 were shown to differ between UCS carcinomatous and sarcomatous tumor areas [ 14 ]. (por-journal.com)
  • alternatively, the tumor may contain two distinct and separate epithelial and mesenchymal components. (wikipedia.org)
  • The tumor is composed of two cellular components: Epithelial and mesenchymal. (cytojournal.com)
  • This morphology can be attributed to epithelial-mesenchymal transition (EMT) that often associates with tumor invasion and metastasis. (por-journal.com)
  • A Bicher, C Levenback, E G Silva, T W Burke, M Morris, et al (1995) Ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy. (scholarena.co)
  • Over the past three decades, surgical tumor debulking, followed by platinum-based chemotherapy is the standard treatment for advanced ovarian cancer. (biomedcentral.com)
  • Despite this, when purely endometrial tumors are compared to MMMTs, the MMMT tumor tends to have a worse prognosis. (wikipedia.org)
  • This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)
  • Studies have shown that epithelial ovarian cancer is not a single disease but is composed of a diverse group of tumors that can be classified based on distinctive morphologic and molecular genetic features [ 1 ]. (biomedcentral.com)
  • In terms of origin of ovarian cancer, many of researchers and gynecologic oncologists have traditionally understood that the various different ovarian tumors are all derived from the ovarian surface epithelium (mesothelium) and that subsequent metaplastic changes lead to the development of the different cell types (Table 2 ). (biomedcentral.com)
  • Ovarian tumors account for a considerable proportion of clinically relevant neoplasms in females, exhibiting a wide range of age at presentation (from infant to elderly patients). (biomedcentral.com)
  • Approximately two-thirds of ovarian tumors occur in women during reproductive age, whereas less than 5% occur in children. (biomedcentral.com)
  • Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)
  • They represent 30% of all epithelial tumors and 80%-85% of all ovarian cancers. (biomedcentral.com)
  • Type I tumors are clinically indolent and usually present at a low stage, while type II tumors exhibit papillary, grandular, and solid patterns and are highly aggressive and almost always present in advanced stage (Table 1 ). (biomedcentral.com)
  • The naming issue to a certain extent reflects histological characteristics and development of the tumors, in which the different types of tissues are believed to either develop separately and join into a single mass (the "collision" theory), that an adenocarcinoma stimulates the stroma to create a tumor (the "composition" theory), or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). (wikipedia.org)
  • Dense compact collagen, elastic tissue and cartilage are some of the Other instances, because of obstruction of the lymphatics by tissues that are sufficiently proof against invasion by tumour cells, the lymph flow is disturbed and tumour cells tumours. (ehd.org)
  • Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
  • They may instead be fusing with existing cells, creating genetically mixed-up tissues with unknown health effects" [1]. (i-sis.org.uk)
  • During embryonic development mesodermal differentiate into endothelial cells, hemangioblast and hematopoietic progenitors give rise to blood vessel, the vasculogenesis. (samploon.com)
  • mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)
  • Histopathological examination of the tumor mass revealed an admixture of spindle cells and epithelioid cells. (cytojournal.com)
  • Whereas immunohistochemistry of the metastatic tumor showed a predominantly sarcomatous vimentin positive tumor that has lost E-cadherin expression, PF338 cells demonstrated biphasic growth and carried mutations in KRAS , PIK3CA , PTEN and ARID1A . (por-journal.com)
  • PF338 tumor cells were resistant to MEK- and TGF-β signaling-inhibition but sensitive to PIK3CA- and PARP-inhibition and first-line chemotherapeutics. (por-journal.com)
  • Human induced pluripotent stem cells (hiPSCs) are cultured under serum-free conditions and induced into mesodermal progenitor cells via stimulation of Wnt signaling for 24 h. (biomedcentral.com)
  • Mesodermal progenitor cells are further differentiated into ECs by utilizing a combination of human vascular endothelial growth factor A165 (VEGF), basic fibroblast growth factor (bFGF), 8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt monohydrate (8Bro) and melatonin (Mel) for 48 h. (biomedcentral.com)
  • Neither the title of the paper, nor the abstract mentioned that in the experiment, five out of 25 rats receiving the transplant died with "teratoma-like tumors" in their brains, a well-known hazard of ES cells. (i-sis.org.uk)
  • 80% of cases) and CCNE1 (encoding cyclin E1) amplification but rarely has mutations that characterize most type 1 I tumors such as KRAS, BRAF, ERBB2, PTEN, CTNNB1, and PIK3CA [ 6 ]. (biomedcentral.com)
  • These tumors are primarily found in elderly patients with a median age of 60 years. (biomedcentral.com)
  • L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
  • Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
  • We report our experience on these rare tumors. (cytojournal.com)
  • Although the sample size is small, this study highlights the relevance of urine cytology in the preoperative diagnosis of these rare non-urothelial tumors of the bladder. (cytojournal.com)
  • It is a rare tumor, usually occurring between 15 and 35 years of age. (ouhsc.edu)
  • Although rare, thymoma is the most common tumor of the anterior superior mediastinum. (medscape.com)
  • Lhermitte-Duclos disease (LDD), also known system, it is a grade I mixed glioneuronal as dysplastic gangliocytoma of the cere- tumor.2 It usually occurs in patients between bellum, is a rare condition first described by 30 and 50 years of age, both sexes. (bvsalud.org)
  • Tumors may be cancerous and sometimes fatal or they may be quite harmless. (solutionpharmacy.in)
  • In general, type I tumors are genetically more stable than type II tumors and display a distinctive pattern of mutations that occur in specific cell types. (biomedcentral.com)
  • Type II tumors which show greater morphologic and molecular homogeneity are genetically unstable and have a very high frequency of TP53 mutations. (biomedcentral.com)
  • The role of urinary cytology in the preoperative diagnosis of the above-mentioned tumors has rarely been reported. (cytojournal.com)