• Secondary or metastatic neoplasms arise from hematologic spread of the originating tissue. (medscape.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Potentially, this nonspecificity could be a diagnostic pitfall when using immunoperoxidase on fine-needle aspiration (FNA) biopsy specimens to differentiate metastatic prostate cancer from primary salivary gland tumors. (johnshopkins.edu)
  • the reactivity of MGA in primary and metastatic CNS neoplasms has never been described. (wustl.edu)
  • Here, we describe the frequency and patterns of IHC reactivity for MGA in metastatic and primary CNS neoplasms from patients with well-documented histories of breast carcinoma. (wustl.edu)
  • They can also occur as metastatic foci from primary tumors. (health-care-clinic.org)
  • Extramedullary tumors may be intradural (meningiomas and schwannomas), which account for 60% of all primary spinal cord neoplasms, or extradural (metastatic tumors from breasts, lungs, prostate, leukemia, or lymphomas), which account for 25% of these neoplasms. (health-care-clinic.org)
  • They may either follow radiation therapy for squamous cell carcinoma, or the larynx may be the site of metastatic osteosarcoma (primary bone cancer). (wearethecure.org)
  • It is appropriate to query the physician for clarification if the cancer is not specified as primary or metastatic. (fortherecordmag.com)
  • However, data is limited regarding GATA1 expression in other myeloproliferative neoplasms (MPN) such as pre-fibrotic PMF (pre-PMF), polycythemia vera (PV) and essential thrombocythemia (ET) and in their respective fibrotic progression. (ox.ac.uk)
  • The classic myeloproliferative neoplasms, including chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are a phenotypically diverse category of malignancies that are derived from stem cells in the myeloid lineage. (mhmedical.com)
  • Recently, activating mutations in JAK2 and MPL have been found in the majority of BCR-ABL -negative myeloproliferative neoplasms. (mhmedical.com)
  • The 2008 World Health Organization (WHO) classification system considers five broad categories of myeloid malignancies: acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), MDS/MPN overlap, and molecularly characterized MPN with eosinophilia 1 ( Table 78-1 ). (mhmedical.com)
  • Myeloproliferative neoplasms (MPNs) are bone marrow diseases characterized by excess clonal hematopoiesis resulting in elevated peripheral blood counts. (researchgate.net)
  • Philadelphia-negative myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (researchgate.net)
  • Imago is a clinical stage biopharmaceutical company developing new medicines for the treatment of myeloproliferative neoplasms (MPNs) and other bone marrow diseases. (merck.com)
  • We look forward to working with the Imago team to further investigate the potential of bomedemstat for patients with myeloproliferative neoplasms. (merck.com)
  • Myeloproliferative neoplasms are a group of diseases of the bone marrow characterized by excessive production of red blood cells, platelets, or certain white blood cells. (merck.com)
  • Myeloproliferative neoplasms progress over time as the number of extra cells build up in the blood and/or bone marrow. (merck.com)
  • Certain myeloproliferative neoplasms may become acute myeloid leukemia (AML). (merck.com)
  • Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. (msdmanuals.com)
  • Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow hematopoietic stem cells, which can manifest as an increased number of functionally normal platelets, red blood cells (RBCs). (msdmanuals.com)
  • A benign or malignant neoplasm that arises from the brain or the spinal cord. (beds.ac.uk)
  • Our findings support a role of GATA1 in the pathogenesis of BCR-ABL1 negative MPN, particularly in their fibrotic progression and suggest that the immunohistochemical evaluation of GATA1 may be of use in the differential diagnosis of these neoplasms. (ox.ac.uk)
  • In all cases of intranasal or pharyngeal neoplasm the diagnosis of meningioma, craniopharyngeoma and glioma should be considered as differential diagnosis to optimize the surgical procedure. (biomedcentral.com)
  • Adeno-carcinoma is the predominant type and is included in the criteria established by Finn and Javert for diagnosis of primary carcinoma of fallopian tube [2]. (amrita.edu)
  • CT was quickly shown to be of value for the intracranial diagnosis and evaluation of primary tumors of the brain and surrounding structures. (ajnr.org)
  • Primary cardiac tumors (PCTs) occur along a pathologic spectrum that includes benign, malignant, and intermediate with uncertain biological behavior. (medscape.com)
  • Although the overall incidence of primary cardiac neoplasms is low (0.0001-0.5% in autopsy series), these tumors provide unique diagnostic and therapeutic challenges. (medscape.com)
  • Myxomas account for 40-50% of primary cardiac tumors in patients aged 30-60 years. (medscape.com)
  • Primary cardiac tumors appear to occur equally in all races, unless their presence is connected directly with underlying genetic disorders that demonstrate a race predilection. (medscape.com)
  • An analysis of outcomes of 747 patients with primary cardiac malignant tumors found a 90-day mortality rate of 29.4% following surgical treatment. (medscape.com)
  • There is evidence that bilateral tumors may increase the risk of death because of the association with primary intracranial PNET. (aao.org)
  • Primary kidney neuroendocrine tumors (NETs) are rare renal malignancies . (bvsalud.org)
  • A spinal neoplasm is anyone of many tumor types that are similar to intracranial tumors and involve the spinal cord or its roots. (health-care-clinic.org)
  • Primary spinal cord tumors may be extramedullary (occurring outside the spinal cord) or intramedullary (occurring within the cord itself). (health-care-clinic.org)
  • Gliomas, the most common primary brain neoplasms in adults, are very heterogeneous tumors. (ajnr.org)
  • In a similar fashion to sonography, CT proved very versatile for the evaluation of congenital malformations of the brain, CNS infections, trauma, and primary brain tumors. (ajnr.org)
  • Fewer than 40 cases of primary benign neoplasm of the ureter, substantiated by microscopic examination, have been reported in the literature. (coek.info)
  • Benign neoplasm of the liver is assigned to code 211.5. (fortherecordmag.com)
  • Metastases represent the most common type of intracranial neoplasm. (wustl.edu)
  • Some people with primary myelofibrosis do not have a mutation in any of the known genes associated with this condition. (medlineplus.gov)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • Background: Appendiceal neuroendocrine neoplasms (ANEN) are mostly indolent tumours treated effectively with simple appendectomy. (ox.ac.uk)
  • Primary neuroendocrine neoplasms of the kidney: a case report and literature review. (bvsalud.org)
  • However, detecting and monitoring neuroendocrine neoplasms remains challenging because of their nonspecific nature . (bvsalud.org)
  • Gould VE, Banner BF, Baerwaldt M: Neuroendocrine neoplasms in unusual primary sites. (karger.com)
  • Transarterially administered gene therapy for primary and secondary liver malignancies. (aetna.com)
  • Primary carcinoma of the fallopian tube is a rare neoplasm, accounting for only 0.3-1.1% of all gynecological malignancies [1]. (amrita.edu)
  • Second primary squamous cell malignancies are rampant. (wearethecure.org)
  • These findings suggest that MGA IHC staining intensity and distribution can distinguish metastases from primary CNS neoplasms (P=0.0086) in women with a history of breast carcinoma but also indicate that cytologic staining patterns must be interpreted for more accurate tumor classification. (wustl.edu)
  • Bolton DM, Chiu ST, Clarke S, Angus D: Primary small cell carcinoma of the prostate: unusual modes of presentation. (karger.com)
  • The ACC/AHA guidelines continue to emphasize the importance of primary prevention of ACS by decreasing coronary artery disease risk factors, including hypertension, hypercholesterolemia, diabetes mellitus, and smoking. (aafp.org)
  • 6 The atherosclerotic cardiovascular disease risk estimator is available online and in mobile app format at http://my.americanheart.org/cvrisk calculator and at http://www.cardiosource.org/en/Science-And-Quality/Practice-Guidelines-and-Quality-Standards/2013-Prevention-Guideline-Tools.aspx . (aafp.org)
  • the former constitutes the topic of this chapter and includes chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (mhmedical.com)
  • Subtypes include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (researchgate.net)
  • The mean latency for tumor development of a second tumor is approximately 9 years from management of the primary retinoblastoma. (aao.org)
  • In all patients, the tumor became manifest in symptoms resembling a primary extradural entity, like chronic sinusitis, chordoma or nasal polyposis. (biomedcentral.com)
  • Gliomatosis cerebri (GC) is a rare difuse, infiltrative and non destructive primary brain tumor from glial origin The term GC implies the affection of two or more brain lobes with possible extension to brain stem, cerebellum, spinal cord and subarachnoid space. (isciii.es)
  • Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. (ajnr.org)
  • these include an annual physical examination, with an assessment of the skin to identify second-primary skin cancers, as well as education regarding the signs and symptoms of bone and soft-tissue sarcomas. (aao.org)
  • The shortage of blood cells causes many of the signs and symptoms of primary myelofibrosis. (medlineplus.gov)
  • Other common signs and symptoms of primary myelofibrosis include fever, night sweats, and bone pain. (medlineplus.gov)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • In neurosurgical cases with ambiguous cellular morphology and/or limited biopsy material, immunohistochemistry (IHC) is often performed to distinguish metastases from primary central nervous system (CNS) neoplasms. (wustl.edu)
  • Importantly, the cytoarchitectural staining characteristics among all 4 MGA-positive primary CNS neoplasms (cytoplasmic and nuclear) differed from those of the metastases (cytoplasmic and membranous). (wustl.edu)
  • See here for a tabular overview of primary, secondary, in situ, and benign neoplasms. (wikipedia.org)
  • If liver cancer is documented with no further specification stating primary or secondary, assign code 155.2. (fortherecordmag.com)
  • 1 It is important for primary care physicians to be able to diagnose and manage acute coronary syndrome (ACS), which comprises two clinical presentations: ST elevation myocardial infarction (STEMI) and non-ST elevation acute coronary syndrome (NSTE-ACS). (aafp.org)
  • Reduced megakaryocytic expression of GATA1 has been linked to impaired hematopoiesis and bone marrow fibrosis in murine models and in vivo in patients affected by primary myelofibrosis (PMF). (ox.ac.uk)
  • Primary myelofibrosis is a condition characterized by the buildup of scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. (medlineplus.gov)
  • Initially, most people with primary myelofibrosis have no signs or symptoms. (medlineplus.gov)
  • Primary myelofibrosis is most commonly diagnosed in people aged 50 to 80 but can occur at any age. (medlineplus.gov)
  • Primary myelofibrosis is a rare condition that affects approximately 1 in 500,000 people worldwide. (medlineplus.gov)
  • Mutations in the JAK2 , MPL , CALR , and TET2 genes are associated with most cases of primary myelofibrosis. (medlineplus.gov)
  • Mutations in either the JAK2 gene or the MPL gene that are associated with primary myelofibrosis lead to overactivation of the JAK/STAT pathway. (medlineplus.gov)
  • However, in primary myelofibrosis, the excess collagen forms scar tissue in the bone marrow. (medlineplus.gov)
  • Although mutations in the CALR gene and the TET2 gene are relatively common in primary myelofibrosis, it is unclear how these mutations are involved in the development of the condition. (medlineplus.gov)
  • Children who survive bilateral retinoblastoma have an increased incidence of a second-primary nonocular malignancy later in life. (aao.org)
  • The most common type of second-primary cancer in these patients is osteosarcoma (also called osteogenic sarcoma ). (aao.org)
  • Effective screening strategies for second-primary nonocular cancers in this population is an area of active research. (aao.org)
  • Reperfusion therapy, preferably primary PCI, should be administered to eligible patients with STEMI and symptom onset within the previous 12 hours. (aafp.org)
  • Liver cancer, also documented as primary liver cancer or hepatoma, is usually caused by cirrhosis or scarring of the liver, which may be due to alcohol abuse, autoimmune diseases of the liver, hepatitis B or C, or hemochromatosis. (fortherecordmag.com)
  • The cancer cells detach from the primary site, such as the breast or the lungs, and travel through the circulatory or lymphatic system to the liver. (fortherecordmag.com)
  • Primary liver cancer is classified to ICD-9-CM code 155.0. (fortherecordmag.com)
  • The objective of this study was to investigate the association between persistent statin use and the risk of primary cancer in adults. (cdc.gov)
  • Although the skin is the most common primary site for MCTs in this species, they can arise from anywhere in the body. (wearethecure.org)
  • Consequently, this article focuses on the more common benign and malignant neoplasms of the GI tract in children, in addition to information gleaned from fairly sparse literature. (medscape.com)
  • Percutaneous ethanol injection (PEI) for liver neoplasms when criteria above are not met. (aetna.com)
  • Rapid reperfusion with primary percutaneous coronary intervention is the goal with either clinical presentation. (aafp.org)
  • This Clinical Policy Bulletin addresses treatment approaches for liver and other neoplasms. (aetna.com)
  • Primary neoplasms may arise from endocardium, valvular structures, primitive tissue rests, and the conduction system. (medscape.com)
  • A primary central nervous system neoplasm that is resistant to treatment. (nih.gov)