Proto oncogene proteins c bcl 2. Medical search. Frequent questions

Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. (uchicago.edu)
Apoptosis is a strictly regulated process and many genes and proteins participate in its control. (medscape.com)
Proteínas de la membrana codificadas por los GENES BCL-2 y que sirven como potentes inhibidores de la muerte celular por APOPTOSIS. (bvsalud.org)
however, a direct extrapolation to mechanisms of disease demands proof that manipulation of candidate genes, proteins, or pathways result in relevant behavioral changes. (unboundmedicine.com)
Here, transgenic tomato plants expressing animal antiapoptotic genes bcl-xL and ced-9 were generated through agrobacterium-mediated transformation. (uea.ac.uk)
activation of protooncogenes and inactivation of tumor-suppressor genes. (kritischderblog.de)
This study examined the involvement of three genes- bcl-2, bcl-6 , and bcl-10 -in PIOL cells. (arvojournals.org)
Cellular proteins encoded by the c-mos genes (GENES, MOS). (uams.edu)
PURPOSE: We aimed to assess the etiological role of apoptotic genes Bcl-2 and Bax in the background of major obstetric and gynaecological diseases. (ox.ac.uk)
In addition, gene expression assessment of the genes Bax and Bcl-2 was performed in 101 uterine leiomyoma tissue samples at our disposal with 110 control cases. (ox.ac.uk)
Our objective was to investigate the quantitative expression of BCL-2 (anti-apoptotic), BAX and Caspase3 (pro-apoptotic genes) mRNAs in salivary gland neoplasms and examine the association of these data with tumour size, proliferative activity and p53 staining (parameters associated with a poor prognosis of salivary tumours patients). (biomedcentral.com)
As the transcription of apoptosis related genes could help to elucidate the pathogenesis of tumours, we propose to investigate the quantitative expression of BCL-2 (anti-apoptotic), BAX and Caspase3 (pro-apoptotic genes) using qPCR. (biomedcentral.com)

Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (uchicago.edu)
B-cell lymphoma-2 downregulation is a useful feature supporting a neoplastic phenotype in mature T-cell lymphomas. (uchicago.edu)
Activation of AMPK inhibits cell proliferation and induces apoptosis through the inhibition of phosphorylated (p)‑Akt and control of B‑cell lymphoma 2 (Bcl‑2) family members. (nih.gov)
1 2 PIOL is usually a diffuse large B cell lymphoma (DLBCL) but occasionally presents as a T cell lymphoma. (arvojournals.org)
The B-cell lymphoma (BCL-2) family comprises different regulators involved in apoptosis. (biomedcentral.com)
Leha ho le joalo, ho na le maikutlo a feteletseng (kapa a mangata haholo) a Liprotheine tsa MYC le BCL liseleng tsa lymphoma. (lymphoma.org.au)
Ob chav expressor hais txog cov protein ntau ntawm koj cov qog nqaij hlav lymphoma. (lymphoma.org.au)
Txawm li cas los xij, muaj ib qho overexpression (los yog ntau dhau) ntawm cov MYC thiab BCL proteins ntawm cov qog lymphoma. (lymphoma.org.au)

Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. (nih.gov)
Bcl-x(L) overexpression completely blocked all apoptotic events, except Ca(2+) overload, and maintained normal rod mitochondrial function throughout adulthood. (nih.gov)
This study presents images of mitochondrial contact sites in an in vivo apoptosis model and shows that Bcl-x(L) overexpression blocks increased contact sites and apoptosis. (nih.gov)
Because overexpression of Bcl-2 family members are implicated in chemotherapeutic resistance in prostate cancer, we investigated the cooperative effects of Pim kinase inhibition with ABT-737, a small molecule antagonist of Bcl-2 family members. (arizona.edu)
Notably, these specific protein changes were essential to the apoptotic process because ABT-737 did not inhibit Mcl-1 protein activity and Mcl-1 overexpression blocked the apoptotic activity of ABT-737. (arizona.edu)
Our results therefore suggest that this combination treatment could be developed as a potential therapy for human prostate cancer where overexpression of Pim kinases and antiapoptotic Bcl-2 family members drives tumor cell resistance to current anticancer therapies. (arizona.edu)
The p53 protein is activated by various cellular events such as DNA damage, hypoxia, heat shock, and overexpression of oncogenes. (kritischderblog.de)
4. Epstein-Barr virus and bcl-2 protein overexpression are not detected in the neoplastic cells of nodular lymphocyte predominance Hodgkin's disease. (nih.gov)

Bcl-2 is a proto-oncogene that encodes the largest known antiapoptotic protein. (medscape.com)
Bcl-2 is an antiapoptotic molecule whose gene is located on chromosome 18. (arvojournals.org)
Antiapoptotic Bcl-2 gene expression was found to be significantly increased in fibroid tissues. (ox.ac.uk)
Decrease in the placental expression of the antiapoptotic gene Bcl-2 may upset the balance of programmed cell death. (ox.ac.uk)

This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES . (lookformedical.com)

Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer. (uchicago.edu)
The concomitant elevation in Bcl-2 expression may represent a survival mechanism for the remaining germ cells. (manchester.ac.uk)
We studied bcl-2 expression in patients with non-small-cell lung carcinoma and correlated this phenomenon with survival. (ox.ac.uk)
The possibility that bcl-2 expression correlated with survival was investigated with use of the log-rank test, hazard ratios, and their confidence intervals. (ox.ac.uk)
Survival rates were compared among inoculated transgenic lines expressing bcl-xL, ced-9, and bcl-xL (G138A), a loss-of-function mutant of bcl-xL. (uea.ac.uk)
More than 80% of the bcl-xL and ced-9 T(1) transgenic lines showed higher survival rates than the average for bcl-xL (G138A) transgenic lines. (uea.ac.uk)
Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. (musc.edu)
An analysis of clinical outcome in 23 PIOL patients revealed no significant association between bcl-2 t(14;18) translocations and survival or relapse. (arvojournals.org)
[ 2 ] Literature since the rituximab era has shown a further increase in overall survival. (medscape.com)
It mediates survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X (L)/BCL2L1. (asdreports.com)
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. (nih.gov)
May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. (nih.gov)
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. (icr.ac.uk)
Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. (icr.ac.uk)

Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. (umassmed.edu)
Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease. (musc.edu)

BACKGROUND: The proto-oncogene bcl-2 encodes a protein that inhibits programmed cell death (apoptosis). (ox.ac.uk)

The pro‑apoptotic proteins Bcl‑2‑associated X protein (Bax) and Bcl‑2‑homologous antagonist killer (Bak), are activated by their translocation to mitochondria from the cytosol. (nih.gov)
Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. (prinsesmaximacentrum.nl)
This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 mRNA in PIOL cells. (arvojournals.org)
A medical record review was also conducted to determine whether the bcl-2 t(14;18) translocation correlated with prognosis. (arvojournals.org)
Forty of 72 (55%) PIOL patients expressed the bcl-2 t(14;18) translocation at the major breakpoint region. (arvojournals.org)
The bcl-2 t(14;18) translocation brings the bcl-2 gene under the control of the IgH enhancer, resulting in deregulated bcl-2 expression. (arvojournals.org)
The translocation of Bax protein from the cytosol to the mitochondria triggers the activation of the caspases cascade, leading to death [ 8 ]. (biomedcentral.com)

In addition, Pim inhibition transcriptionally increased levels of the BH3 protein Noxa by activating the unfolded protein response (UPR), lead to eIF-2α phosphorylation and increased expression of CHOP. (arizona.edu)
The TP53 gene is mutated in around 50% of cancer cells, but in addition to its role in tumor suppression, cancer cells themselves can find ways to …Figure 2: Phosphorylation sites of human p53. (kritischderblog.de)
Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. (icr.ac.uk)

c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. (nih.gov)

Bcl-2 regulates apoptosis through the formation of homodimer and heterodimer proteins with the other proteins belonging to the Bcl-2 group, especially the proapoptotic protein Bax. (medscape.com)
Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. (icr.ac.uk)

A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. (lookformedical.com)

To determine whether imiquimod modifies the expression of proteins such as Bcl-2, Ki67, p53 and the BCC apoptotic index. (medscape.com)
The BCC expression of Bcl-2, Ki67 and p53 was determined in paraffin samples and the apoptotic index of the BCC was studied using the TUNEL technique (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick end labelling) in frozen samples. (medscape.com)
The BCCs treated with imiquimod showed a decrease in the expression of Bcl-2 (88·7% before treatment, 61·4% day 15, P = 0·01) and an increase in the apoptotic index (0·53% before treatment, 1·66% day 15, P = 0·002), which were not observed in the BCCs treated with the excipient. (medscape.com)
Imiquimod reduces the expression of Bcl-2 in the BCC cells and increases the BCC apoptotic index. (medscape.com)
To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. (nih.gov)
Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. (geneticsmr.com)
However, the expression of Bcl-2 and Bax was up-regulated at 8 days after EDS administration. (manchester.ac.uk)
The protein is expressed in basal cells in normal human epithelium, but no data are available on the frequency or clinical importance of its expression in carcinoma. (ox.ac.uk)
CONCLUSIONS: The proto-oncogene bcl-2 is abnormally expressed in some lung carcinomas, and its expression may have prognostic importance. (ox.ac.uk)
We tested whether DLBCLs with high expression of MYC protein and BCL2 protein share the clinical features and poor prognosis of DHLs. (duke.edu)
The DHS-2 group, defined by high expression of both MYC and BCL2 protein, comprised 29% of the patients. (duke.edu)
High expression of bcl-xL or ced-9 affected plant growth and seed development. (uea.ac.uk)
Thus, expression of bcl-xL and ced-9 improved tolerance to, rather than resistance to, CMV/D satRNA infection. (uea.ac.uk)
In addition, expression of bcl-xL and ced-9 specifically abrogated the formation of necrotic lesions, but not other symptoms, in tomato leaves during chilling at 4 degrees C. At 7 degrees C, temperature-induced leaf senescence was dramatically delayed in bcl-xL and ced-9 transgenic plants, and high levels of anthocyanins accumulated, possibly limiting oxidative stress. (uea.ac.uk)
Viral oncogene expression in the stem/progenitor cell compartment of the mouse intestine induces adenomatous polyps. (musc.edu)
Epstein-Barr virus infection and bcl-2 proto-oncogene expression separate events in the pathogenesis of Hodgkin's disease? (uaeu.ac.ae)
The present study was undertaken to investigate whether Epstein-Barrvirus-(EBV) encoded latent membrane protein (LMP) induces the expression of BCL-2 in Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin's disease (HD) and thereby provide a possible mechanism for the role of EBV in the pathogenesis of this disease. (uaeu.ac.ae)
BCL-2 expression in HRS cells was detected in 16 cases (30%), but only two of these were also EBV-positive. (uaeu.ac.ae)
These results demonstrate that BCL-2 expression can be detected in HRS cells in routinely processed HD tissue and that whereas EBV does not induce the expression of BCL-2 in HD, BCL-2 may have a role in the patho-genesis of EBV-negative cases of HD. (uaeu.ac.ae)
Microdissection and PCR analysis were used to examine vitreous specimens in patients with PIOL for the presence of bcl-2 t(14;18) translocations, the bcl-10 gene, and expression of bcl-6 mRNA. (arvojournals.org)
Although cancer prognosis has historically been based on clinical and laboratory findings, analysis of the expression of various gene translocations and proteins has burgeoned as a method for determining prognosis. (arvojournals.org)
The co-expression of Buffy, the sole anti-apoptotic Bcl-2 gene family member in Drosophila, and CG3814/LFG by stable inducible RNA interference, suppresses the shortened lifespan and the premature age-dependent loss in climbing ability. (geneticsmr.com)
RESULTS: The expression of the Bcl-2 gene was decreased in placental samples with intrauterine growth restriction. (ox.ac.uk)
BCL-2 is thought to be involved in resistance to conventional cancer treatment and its increased expression has been implicated in a number of cancers [ 4 ]. (biomedcentral.com)
Age-related expression patterns of Bag-1 and Bcl-2 in growth plate and articular chondrocytes. (omeka.net)
1. Epstein-Barr virus infection and bcl-2 proto-oncogene expression. (nih.gov)
2. Expression of bcl-2 protein and Epstein-Barr virus latent membrane protein in Hodgkin's disease. (nih.gov)
3. Correlation of the expression of Epstein-Barr virus latent membrane protein and in situ hybridization with biotinylated BamHI-W probes in Hodgkin's disease. (nih.gov)
5. Expression of the Epstein-Barr virus encoded latent membrane protein in tumor cells of Hodgkin's disease occurring in childhood. (nih.gov)
8. Frequent expression of Epstein-Barr virus latent membrane protein-1 in tumour cells of Hodgkin's disease in HIV-positive patients. (nih.gov)
9. Expression of EBV encoded latent membrane protein 1 (LMP-1) and bcl-2 protein in childhood and adult Hodgkin's disease: application of microwave irradiation for antigen retrieval. (nih.gov)
10. Expression of c-myc and bcl-2 oncogene products in Reed-Sternberg cells independent of presence of Epstein-Barr virus. (nih.gov)
19. Epstein-Barr virus latent membrane protein expression by Hodgkin and Reed-Sternberg-like cells in acute infectious mononucleosis. (nih.gov)

A decrease in the anti-apoptotic protein, Mcl-1, was detected in QUE-treated HL-60 cells, whereas other Bcl-2 family proteins including Bax, Bcl-2, Bcl-XL, and Bag remained unchanged. (duke.edu)

They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. (uams.edu)
Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 or EC 2.7.11.1) - Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme encoded by the PIM1 gene. (asdreports.com)
Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 or EC 2.7.11.1) pipeline Target constitutes close to 14 molecules. (asdreports.com)
The latest report SerineThreonine Protein Kinase Pim 1 - Pipeline Review, H1 2020, outlays comprehensive information on the Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (asdreports.com)
It also reviews key players involved in Serine/Threonine Protein Kinase Pim 1 (Oncogene PIM1 or PIM1 or EC 2.7.11.1) targeted therapeutics development with respective active and dormant or discontinued projects. (asdreports.com)

Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA. (lookformedical.com)

The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (uchicago.edu)
It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN. (nih.gov)
HN - 2017 (1997) MH - ADAM17 Protein UI - D000072198 MN - D8.811.277.656.675.374.102.375 MN - D9.400.430.500.375 MN - D12.776.395.33.375 MN - D23.50.301.264.35.57 MN - D23.101.100.110.57 MS - A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. (nih.gov)
The levels of Bcl-2 and Bax, the changes of mitochondria membrane potential (MMP), cytochrome c release and activation of caspase-3 were also investigated in both cell lines. (unboundmedicine.com)
Berberine-induced apoptosis was accompanied by increased levels of Ca+2 and a decrease in the mitochondrial membrane potential, leading to the release of cytochrome c and the cleavage of pro-caspase-3. (unboundmedicine.com)
BCL-2 staining was predominantly cytoplasmic with some membrane pattern. (uaeu.ac.ae)
The release of these proteins is the result of the outer mitochondrial membrane becoming permeable. (unige.ch)
The NEXT3 synthesis of NOTCH3 is further well-insulated at the S3 matrix by the provirus protein membrane, leading the different integrin migration into the Werge( Groot et al. (evakoch.com)
6. Immunohistochemical detection of Epstein-Barr virus-encoded latent membrane protein in Reed-Sternberg cells and variants of Hodgkin's disease. (nih.gov)
14. Detection of Epstein-Barr virus in Hodgkin-Reed-Sternberg cells : no evidence for the persistence of integrated viral fragments inLatent membrane protein-1 (LMP-1)-negative classical Hodgkin's disease. (nih.gov)

QUE, but not RUT or QUI, caused rapid and transient induction of caspase 3/CPP32 activity, but not caspase 1 activity, according to cleavage of caspase 3 substrates poly(ADP-ribose) polymerase (PARP) and D4-GDI proteins, and the appearance of cleaved caspase 3 fragments being detected in QUE- but not RUT- or QUI-treated HL-60 cells. (duke.edu)
Flow cytometry assay also showed that berberine induced ROS and Ca+2 production, decreased the levels of MMP and increased the activity of caspase-3 in both cell lines examined. (unboundmedicine.com)
To investigate the apoptotic signaling pathways relevant to the restoration of DA-induced apoptosis by resveratrol , we carried out quantitative analysis of Bcl-2, caspase-3 , and cleaved poly ADP-ribose polymerase (PARP) by immunoblot analysis . (bvsalud.org)
Resveratrol pretreatment led to a decrease in cleavage of PARP, an increase in the Bcl-2 protein , and activation of caspase-3 . (bvsalud.org)
Lifeguard is an integral transmembrane protein that modulates FasL-mediated apoptosis by interfering with the activation of caspase 8. (geneticsmr.com)
They integrate death signals through Bcl-2 family members and co-ordinate caspase activation through the release of apoptogenic factors that are normally sequestered in the mitochondrial intermembrane space. (unige.ch)
An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. (lookformedical.com)
Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain. (lookformedical.com)

The bcl-10 gene was detected in 6 of 26 (23%) patients, whereas 4 of 4 (100%) PIOL patients expressed higher levels of bcl-6 mRNA compared with inflammatory lymphocytes. (arvojournals.org)
We demonstrated that BCL-2 mRNA is overexpressed in salivary neoplasms, leading to an overall anti-apoptotic profile. (biomedcentral.com)
Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein. (lookformedical.com)

And Bcl-2, amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors, and inositol homeostasis represent important pharmacological targets for mood stabilizers, but additional behavioral research is needed to more fully delineate their behavioral effects. (unboundmedicine.com)
Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES . (lookformedical.com)

Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization. (uchicago.edu)
In the present study, the apoptotic effects and influence on mitochondria‑mediated apoptotic proteins of CME in HCT116 cells were assessed. (nih.gov)
Results of DCHF-DA assay indicate that no significant increase in intracellular peroxide level was found in QUE-treated cells, and QUE inhibited the H(2)O(2)-induced intracellular peroxide level. (duke.edu)
Song, JH & Kraft, AS 2012, ' Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737 ', Cancer Research , vol. 72, no. 1, pp. 294-303. (arizona.edu)
In adjacent normal respiratory epithelium, bcl-2 was expressed only in basal cells. (ox.ac.uk)
The aim of this study was to clarify the mechanisms of apoptosis, cytotoxicity, DNA damage and fragmentation, as well as the production of reactive oxygen species (ROS) and Ca+2, induced by berberine in human promyelocytic leukemia HL-60 and murine myelomonocytic leukemia WEHI-3 cells. (unboundmedicine.com)
Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. (ox.ac.uk)
These cells also show an upregulation of the oncoprotein Bcl-2, which is protective against hypoxic cell death when transiently transfected into Ishikawa cells. (ox.ac.uk)
Since Ishikawa cells express the putative ADM-receptor CRLR-RAMP2 the production and secretion of ADM with the consecutive upregulation of Bcl-2 could establish an autocrine/paracrine mechanism rescuing malignant cells from hypoxic cell death. (ox.ac.uk)
This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer. (kritischderblog.de)
Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel-/- B cells. (musc.edu)
In both of these cases, only occasional HRS cells expressed BCL-2, in contrast to LMP, which was detected in nearly all such cells. (uaeu.ac.ae)
In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. (lookformedical.com)
Third, WWTR1( TAZ) and YAP1 enzyme ZO-1 and 2 cells( Remue et al. (evakoch.com)

This contains subunits of IRSs with sufficient proteinases mitochondrial as PI-3K via its Src tyrosine 2( SH2) rRNAs depending to lead function opportunities essential as Glut4( Slc2a4) Impact. (evakoch.com)

MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280.249.600 - pulmonary surfactant-associated protein a MeSH D12.776.503.280.249.625 - pulmonary surfactant-associated protein d MeSH D12.776.503.499.968.900 - wheat germ agglutinin-horseradish peroxidase conjugate See List of MeSH codes (D12.776.543). (wikipedia.org)
HN - 2017 MH - ADAM10 Protein UI - D000072197 MN - D8.811.277.656.675.374.102.250 MN - D9.400.430.500.250 MN - D12.776.395.33.250 MN - D23.50.301.264.35.48 MN - D23.101.100.110.48 MS - A disintegrin and metalloproteinase domain-containing protein. (nih.gov)
HN - 2017 MH - ADAM12 Protein UI - D000072199 MN - D8.811.277.656.675.374.102.125 MN - D9.400.430.500.125 MN - D12.776.395.33.125 MS - A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS. (nih.gov)
HN - 2017 (1996) MH - ADAMTS Proteins UI - D000071096 MN - D8.811.277.656.675.374.102.500 MN - D9.400.430.500.500 MN - D12.776.395.33.500 MN - D12.776.860.300.85 MS - A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). (nih.gov)
HN - 2017 MH - ADAMTS1 Protein UI - D000071097 MN - D8.811.277.656.675.374.102.500.500 MN - D9.400.430.500.500.500 MN - D12.776.395.33.500.500 MN - D12.776.860.300.85.500 MS - An ADAMTS protease that contains two disintegrin loops and three C-terminal thrombospondin (TS) motifs. (nih.gov)
HN - 2017 MH - ADAMTS13 Protein UI - D000071120 MN - D8.811.277.656.675.374.102.500.813 MN - D9.400.430.500.500.813 MN - D12.776.395.33.500.813 MN - D12.776.860.300.85.813 MS - An ADAMTS protease that contains eight thrombospondin (TS) motifs. (nih.gov)

Pim inhibitors decreased levels of the Bcl-2 family member Mcl-1, both by blocking 5′-cap dependent translation and decreasing protein half life. (arizona.edu)
High cyclin-dependent kinase inhibitors in Bcl-2 and Bcl-xL-expressing CD34+-proliferating haematopoietic progenitors. (musc.edu)

Lifeguard interacts with anti-apoptotic Bcl-2 proteins and possibly pro-apoptotic proteins to exert its neuroprotective function. (geneticsmr.com)

Immunostaining for BCL-2 on paraffin material was performed using microwave treatment of tissue sections before the application of the primary monoclonal antibody. (uaeu.ac.ae)

A member of the myeloid leukemia factor (MLF) protein family with multiple alternatively spliced transcript variants encoding different protein isoforms. (nih.gov)
As the download Windows 7 Annoyances of times is to public end, defects can bind involved an phosphorylated citron of the IL1R and IL18R leading structures, capping dermatan medicine influencing to endothelial end proteins known by reverse isoforms( TLRs). (evakoch.com)

ADM is thought to act through the G protein-coupled receptor calcitonin receptor-like receptor (CRLR), with specificity being conferred by the receptor associated modifying protein 2 (RAMP2). (ox.ac.uk)

Ligand 2-arachidonoylglycerol phosphorylates a abasic bind in NOTCH3, which stops the lysosomal thrombosis in the GM1 order of NOTCH3. (evakoch.com)

A clinically relevant mouse model of progressive rod photoreceptor-selective apoptosis was produced by low-level developmental lead exposure and studied in combination with transgenic mice overexpressing Bcl-x(L) only in the photoreceptors. (nih.gov)

Adrenocortical carcinomas (ACs) are rare malignancies, with an annual incidence rate of only 0.7-2 cases per million population in Western countries. (medscape.com)
RESULTS: We detected bcl-2 protein in 25 percent of squamous-cell carcinomas (20 of 80) and 12 percent of adenocarcinomas (5 of 42). (ox.ac.uk)

Haeba u na le DHL kapa THL, liphatsa tsa lefutso (liphatsa tsa lefutso tsa MYC le BCL) li-chromosome tsa hau li hlophisitsoe bocha. (lymphoma.org.au)

Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. (nih.gov)
The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. (icr.ac.uk)

The present study demonstrated that CME induced the release of LDH and apoptosis through its inhibition of p‑Akt to control Bcl‑2 and activate Bax and Bak. (nih.gov)

We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. (prinsesmaximacentrum.nl)

BAX (Bcl-2-associated protein X) is the most characteristic death-promoting member of the BCL-2 family. (biomedcentral.com)
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. (nih.gov)

Adenosine monophosphate‑activated protein kinase (AMPK), the major regulator of energy metabolism, is activated by metabolic stress, including hypoxia and glucose deprivation. (nih.gov)
Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. (nih.gov)

The p53 tumour suppressor protein acts as a major barrier against cancer initiation and progression. (kritischderblog.de)
The evolutionarily conserved p53 protein and its cellular pathways mediate tumour suppression through an informed, regulated and integrated set of responses to environmental perturbations resulting in either cellular death or the maintenance of cellular homeostasis. (kritischderblog.de)

Anatomy10

Organisms3

Diseases20

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

GENES12

Lymphoma8

Overexpression8

Antiapoptotic4

Peptides1

Survival14

Hepatocyte Growth2

Encodes1

Translocation7

Phosphorylation3

Immunohistochemistry1

Regulates2

Homologous1

Expression33

Anti-apoptotic protein1

Serine5

Messenger RNA1

Membrane10

Caspase8

MRNA3

Receptors2

Cells14

Mitochondrial1

D12.7766

Inhibitors2

Interacts1

Paraffin1

Isoforms2

Receptor1

Ligand1

Transgenic1

Carcinomas2

Chromosome1

Tumorigenesis2

Inhibition1

Differentiation1

Family2

Metabolism2

Tumour2