• The influx of bone marrow-derived cells during tissue repair was monitored in wild-type inbred Fischer 344 rats reconstituted with bone marrow from transgenic F344 rats expressing hPLAP under the control of the ubiquitous R26 promoter. (uni-muenchen.de)
  • Genetic contributions were assessed using three strains of male rats with different genetic backgrounds [Fischer-344 (F344), Sprague-Dawley (SD), Brown-Norway (BN)] maintained on a standard or high fat (HF) diet for 24 wk. (cdc.gov)
  • This study was conducted to investigate the chemopreventive potential of camel ( Camelus dromedarius ) and bovine milk as well as the impact of fermenting these milks with Lactobacillus acidophilus and Streptococcus thermophilus against early colon carcinogenesis as measured by the reduction of aberrant crypt foci (ACF) in azoxymethane (AOM)-treated Fischer 344 rats. (scialert.net)
  • Walker 256 (W256) cells or vehicle were injected into the left upper thigh muscle of male Fischer rats, which were killed 7, 10 or 14 days later. (mcmaster.ca)
  • Objective The present study assessed the effect of prolonged betamethasone use in ligature-induced periodontitis in adult Fischer-344 rats. (bvsalud.org)
  • Pharmacokinetic studies showed that at 30,000 U/kg, streptokinase caused systemic fibrinolysis in the Fischer rat, as demonstrated by the thrombin time and fibrin plate lysis assay. (ox.ac.uk)
  • To investigate whether exercise training can reverse age-related impairment of myogenic vasoconstriction in skeletal muscle arterioles, young (4 mo) and old (22 mo) male Fischer 344 rats were randomly assigned to either sedentary or. (fsu.edu)
  • Because these compounds are toxic to aquatic animals, we studied the effects of OP on splenocytes removed from male Fischer 344 rats or male Balb/c mice and cultured in vitro. (unboundmedicine.com)
  • Background: Subchronic administration of the potent pharmaceutical estrogen diethylstilbestrol (DES) to female Fischer 344 (F344) rats induces growth of large, hemorrhagic pituitaries that progress to tumors. (utmb.edu)
  • In the present study we investigated the effect of a brief exposure (15 s) to a conditioned aversive stimulus (CS) on the proliferative response of spleen and peripheral blood lymphocytes (PBL) in Lewis, Fischer 344 and Sprague-Dawley rats. (researchwithrutgers.com)
  • Enhancement of PBL responsiveness to mitogens was observed in Fischer and Sprague-Dawley rats immediately after exposure to the CS. (researchwithrutgers.com)
  • The PBL response of Sprague-Dawley and Fischer rats returned to baseline at 30 min, but not in Lewis rats. (researchwithrutgers.com)
  • Fischer rats had the largest percentage of suppression. (researchwithrutgers.com)
  • The earliest suppression of spleen mitogenic function after exposure to the CS was in Fischer rats, while the Lewis rats had the latest onset of suppression, with the Sprague-Dawley rats being intermediate. (researchwithrutgers.com)
  • We sought to achieve this 'fine mapping' by increasing the marker density within the interval and undertaking a linkage analysis in a previously defined population of F2 hybrids generated from inbred spontaneously hypertensive rats (SHR) of the Okamoto strain and Fischer rat (F344) progenitors. (mcw.edu)
  • A total of 337 F344 rats,20 Sprague Dawley rats, and 40 OF1 mice were all given initiating dose(s) of colon carcinogen, and were randomly allocated to experimental groups 7 d later. (aacrjournals.org)
  • PEG was active in F344 rats, in Sprague Dawley rats ( P =0.0005), and in OF1 mice ( P = 0.001). (aacrjournals.org)
  • A significant decrease in the response of PBL to mitogens was found in Lewis and Sprague-Dawley rats 10 min after exposure to the CS. (researchwithrutgers.com)
  • Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
  • The LEXF: a new set of rat recombinant inbred strains between LE/Stm and F344. (mcw.edu)
  • Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits. (mcw.edu)
  • One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and FlyBase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. (wikipedia.org)
  • The F344/Stm rat is a parental strain of the LEXF/FXLE recombinant inbred (RI) strains. (nig.ac.jp)
  • The BAC browser for the parental strains (F344 & LE) of the LEXF/FXLE recombinant inbred panel has been released. (kyoto-u.ac.jp)
  • In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
  • The production of female mice with pseudopregnancy induced using sonic vibration was as efficient as rats. (nature.com)
  • A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (lookformedical.com)
  • Based on our recent silibinin efficacy studies in human colorectal cancer cells, we investigated the effects of its dietary feeding on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associated biomarkers in male Fisher 344 rats. (nih.gov)
  • A three-day PEG treatment was sufficient to halve the number of azoxymethane-induced aberrant crypt foci in F344 rats ( P = 0.0006). (aacrjournals.org)
  • BAC clones are available from RIKEN BioResource Center by NBRP Rat Genome Information Upgrading Program ( Kyoto University , RIKEN Genomic Sciences Center, and Comparative Genomics Laboratory, National Institute of Genetics ) in Japan. (nig.ac.jp)
  • Stable superovulation, in vitro fertilization and high effective genome editing in rat have been accomplished by Dr. Honda and others! (kyoto-u.ac.jp)
  • The recent release of the rat genome sequence allowed us to retest and refine this relatively broad QTL with a view to identifying within it candidate genes worthy of structural investigation. (mcw.edu)
  • By reference to the ENSEBL rat genome data bank, we identified within Lvm1 27 known genes, 109 predicted genes and 7 pseudogenes. (mcw.edu)
  • Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. (kyoto-u.ac.jp)
  • A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
  • Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. (wikipedia.org)
  • Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis. (mcw.edu)
  • Significant differences were found in both the kinetics and the magnitude of altered mitogenic responsiveness of PBL between the different strains of rats. (researchwithrutgers.com)
  • Plasma levels of ACTH and corticosterone peaked at 10 min in all strains of rats. (researchwithrutgers.com)
  • We have previously shown that dietary polyethylene-glycol (PEG)suppresses the occurrence of azoxymethane-induced cancers in an accelerated rat model of colon carcinogenesis. (aacrjournals.org)
  • Toxicity of MPA (dose range of 0.2-5.0 mg/kg X 7 over 3 weeks) was first established in non-tumor bearing rats as assessed by their relative failure to gain weight. (duke.edu)
  • Five-week-old male Fisher 344 rats were fed control or silibinin-supplemented (0.033%, 0.1%, 0.33%, or 1%, w/w) diet. (nih.gov)
  • Each of 60 weanling male rats was assigned to one of 6 experimental diet groups: Fermented and unfermented camel milk with AOM, fermented and unfermented bovine milk with AOM and positive (PC, AOM only) and negative (NC, saline vehicle only) control groups. (scialert.net)
  • Four-week-old inbred male F-344 rats were used in the study. (thestemcellfoundation.com)
  • 2012. MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. . (oregonstate.edu)
  • 2011. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
  • 2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)
  • 2006. Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. . (oregonstate.edu)
  • Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • In vivo experiments were conducted using doses of BrO 3 - ranging from 0.077 to 15.3mg/kg, administered intravenously (IV) or orally (gavage) to female F344 rats. (arizona.edu)
  • Moreover, PEG is one of the most potent inhibitors of colon tumor in the standard rat model. (aacrjournals.org)
  • In rats bearing ASV-induced gliomas, treatment with 3,000 cGY (nine fractions over a 3-week period) alone or with 0.2 or 1.0 mg MPA/kg (X 6 during the 3-week radiotherapy course) produced a significantly prolonged survival compared with that of untreated, tumor bearing rats. (duke.edu)
  • These animals had a median survival time that was significantly less than that of tumor-bearers receiving radiotherapy alone, but not significantly different from untreated rats with gliomas. (duke.edu)
  • Nude rats bearing the LC-6 JCK tumor xenograft (LC-6 rats) exhibited high bone turnover and HHM. (unboundmedicine.com)
  • SNP and haplotype mapping for genetic analysis in the rat. (mcw.edu)
  • Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). (wikipedia.org)
  • Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain. (wikipedia.org)
  • Inbreeding animals will sometimes lead to genetic drift. (wikipedia.org)
  • Using human placental alkaline phosphatase (hPLAP) as a genetic marker for cell tracking, we examined the therapeutic efficacy and the homing of intravenously administered, hPLAP labeled cells in marker tolerant, immunocompetent rats after induction of MI. (uni-muenchen.de)
  • Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
  • Pictures of the XVIIIth International Workshop on Genetic Systems in the Rat can be seen. (kyoto-u.ac.jp)
  • The website of the XVIIIth International Workshop on Genetic Systems in the Rat was opened. (kyoto-u.ac.jp)
  • 2007. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. . (oregonstate.edu)
  • 1987. The influence of physical activity in 1 ,2dimethylhydrazine induced colon carcinogenesis in the rat. (cdc.gov)
  • Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (wikipedia.org)
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
  • Effect of diet and occupational exposure in different rat strains on serum biomarkers and peripheral blood mononuclear cell telomere length: development of an animal model to examine the exposome. (cdc.gov)
  • The magnitude of hormonal elevation differed in the different rat strains, suggesting that corticosterone may not have a variable immunomodulatory role in each strain. (researchwithrutgers.com)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method. (kyoto-u.ac.jp)
  • Scholars@Duke publication: Effect of methylprednisolone on radiotherapy of F344 rats with avian sarcoma virus induced gliomas. (duke.edu)
  • The 12S E1A virus induced proliferation and immortalization of epithelial cells in rat kidney, liver, heart, pancreas, and thyroid primary cultures. (cshl.edu)
  • The strain was developed by Shisa et al at the Saitama Cancer Center Research Institute from the F344/DuCrj strain (Charles River Japan, Inc.). The coat color is albino (c). (nig.ac.jp)
  • A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)
  • NBRP Rat & Mouse News vol.1 (Functional analysis tools for GAD isoforms) has been published. (kyoto-u.ac.jp)
  • The 11th training of rat reproduction technology in NBRP-Rat was held (Nov. 4-5, 2021). (kyoto-u.ac.jp)
  • The 10th training of rat reproduction technology in NBRP-Rat was held (Oct. 28-29, 2021). (kyoto-u.ac.jp)
  • The 9th training of rat reproduction technology in NBRP-Rat was held (Jul. (kyoto-u.ac.jp)
  • The 7th training of rat reproduction technology in NBRP-Rat was held (Jun. (kyoto-u.ac.jp)
  • The 6th training of rat reproduction technology in NBRP-Rat was held (Apr. (kyoto-u.ac.jp)
  • The 5th training of rat reproduction technology in NBRP-Rat was held (Mar. 4-5, 2020). (kyoto-u.ac.jp)
  • The 4th training of rat reproduction technology in NBRP-Rat was held (Feb.13, 2020). (kyoto-u.ac.jp)
  • The 2nd training of rat reproduction technology in NBRP-Rat was held (Jan.23-24, 2020). (kyoto-u.ac.jp)
  • The 1st training of rat reproduction technology in NBRP-Rat was held (Oct.1-2, 2019). (kyoto-u.ac.jp)
  • Table on reporter gene transgenic rat has been released. (kyoto-u.ac.jp)
  • In an HLA-B27 transgenic rat model repetitive dosing of HD5 reduced the expansion of pro-inflammatory CD4+ T-cells, and decreased the levels of soluble TNF and number of cell-surface B272 molecules. (ox.ac.uk)
  • 2008. beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet. . (oregonstate.edu)
  • Cirrhotic rats showed characteristic hepatic histology, as well as significant portosystemic shunting. (elsevierpure.com)
  • 1978. Effects of short-term administration of maleic hydrazide or hydrazine on rat hepatic microsomal enzymes. (cdc.gov)
  • Rats, Inbred F344" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • Spontaneous cholangiofibrosis adjacent to a dilated common bile duct with intestinal metaplasia in a Royal College of Surgeons rat. (kyoto-u.ac.jp)
  • Positional cloning of rat mutant genes reveals new functions of these genes. (kyoto-u.ac.jp)
  • Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)
  • Rat mutant map has been renewed. (kyoto-u.ac.jp)
  • Using this model of neonatally tolerized marker tolerant rats, we showed that only very few hPLAP labeled BMC injected intravenously one week post-MI homed to the infarction site. (uni-muenchen.de)
  • Background/Aim: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss. (elsevierpure.com)
  • Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
  • Skin grafts showed that neonatal exposure of wild-type F344 rats to hPLAP transgenic F344 cells results in lifelong tolerance to hPLAP expressing tissues and cells. (uni-muenchen.de)
  • A separate set of rats from each strain were allowed to recover from WF exposure until the end of the 24 wk period. (cdc.gov)
  • Generally, the exposome components of diet and WF exposure had the greater influence on the parameters measured compared to the changes associated with rat strain except for the body weight changes observed with the HF diet that were more pronounced in the inbred F344 and BN strains. (cdc.gov)
  • Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
  • In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
  • Results Jac-E and Jac-O of groups B and S were not significantly different, but they differed significantly from those of group C. Conclusion Prolonged use of betamethasone did not affect the progression of induced periodontitis in rats. (bvsalud.org)
  • Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
  • Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. (wikipedia.org)
  • Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all the test animals should be as similar as possible. (wikipedia.org)
  • At 1 year, transplanted hepatocytes formed large clusters containing several-fold more cells than normal control animals, which was in agreement with increased cell turnover in the cirrhotic rat liver. (elsevierpure.com)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
  • The current experiment examined coherence of theta and gamma in young and aged rats at sub-millimeter and millimeter distant locations both within and across layers in CA1 of the dorsal hippocampus. (nih.gov)
  • This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. (wikipedia.org)
  • At the end of the experiment all the rats were killed by exsanguination, the abdominal large vessels were cut under a light ether anesthesia and a complete autopsy was performed. (thestemcellfoundation.com)
  • The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3. (kyoto-u.ac.jp)
  • Since the adenoviral E1A gene has been shown to partially transform some epithelial cells from primary rat cell cultures, we constructed retrovirus vectors containing either the 12S or 13S E1A cDNA sequences to facilitate the transfer of these genes into a variety of primary cell types. (cshl.edu)
  • Dipeptidyl peptidase IV-deficient F344 rats were used to localize transplanted hepatocytes isolated from the liver of syngeneic normal F344 rats. (elsevierpure.com)
  • 2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
  • Proliferative activity of spleen lymphocytes in response to the CS was suppressed from baseline in all rat strains, but the timing and degree of suppression differed. (researchwithrutgers.com)
  • To determine the consistency of this preventive effect, we carried out a long-term study in rats fed the standard American Institute of Nutrition 1976 diet, and 7 short-term prevention studies in rodents. (aacrjournals.org)
  • Effect of oxidant challenge on contractile function of the aging rat diaphragm. (tamu.edu)
  • The results of these studies demonstrate that OP is toxic to cultured rat and mouse splenocytes and suggest that this toxic effect is exerted, at least partially, through Ca2+-dependent apoptosis. (unboundmedicine.com)
  • The immune modulating effect of HD5 was tested in HLA-B27 transgenic rats. (ox.ac.uk)
  • 3H-dialkylhydrazines in the neuroendocrine system and their antigonadotropic effect in rats. (cdc.gov)
  • All rats were sacrificed at 16 weeks of age, and colon samples were evaluated for ACF, followed by proliferation, apoptosis, and inducible nitric oxide synthase and cyclooxygenase-2, by immunohistochemistry and/or immunoblotting. (nih.gov)
  • We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. (nature.com)
  • Furthermore, fiber bundles from old rats suffered greater fatigue during the stimulation protocol. (tamu.edu)
  • The percentages of viable rat or mouse cells after 27 hr of culture were decreased significantly by 10(-12) M OP or greater concentrations. (unboundmedicine.com)
  • HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats. (ox.ac.uk)
  • CONCLUSION: HD5 predominantly inhibits early TNF production and expansion of pro-inflammatory CD4+ T-cells in HLA-B27 transgenic rats. (ox.ac.uk)
  • The urinary elimination of BrO 3 - and Br - was measured from female F344 rats for four days following administration of single doses of 8.1mgKBrO 3 /kg and for 15 days after a single dose of 5.0mgKBr/kg. (arizona.edu)