Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
To analyze the relationship between mtDNA variants and cardiometabolic traits, we derived a set of rat conplastic strains (SHR-mtBN, SHR-mtF344 and SHR-mtLEW), harboring all major mtDNA haplotypes present in common inbred strains on the nuclear background of the spontaneously hypertensive rat (SHR). (bvsalud.org)
Plasma concentrations of unconjugated telmisartan in the SHR were about 5 fold higher when compared to BN rats while plasma levels of telmisartan glucuronide were similar between the strains. (bvsalud.org)
Testing of other rat strains, diets, and the ARB valsartan showed that toxic effects of telmisartan in combination with high fructose diet are specific for the SHR. (bvsalud.org)
Hypertensive rats4
Recently, we tested metabolic effects of telmisartan (5 mg/kg body weight) in spontaneously hypertensive rats (SHR) fed a diet containing 60 % fructose, a widely used model of the metabolic syndrome. (bvsalud.org)
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (wakehealth.edu)
P, Cervenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (uams.edu)
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. (uams.edu)
Autoimmune3
This study was to observe the dynamic changes of Treg in experimental autoimmune uveitis (EAU) rats and explore the role of Treg cells in the pathological process of EAU rats. (cjeo-journal.org)
Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis. (ox.ac.uk)
Previously, we found that overexpression of rapsyn by cDNA transfection protects AChRs in rat muscles from antibody-mediated loss in passive transfer experimental autoimmune myasthenia gravis (EAMG). (ox.ac.uk)
Mice4
Timed mated rats and mice are determined by observation of a vaginal plug. (inotivco.com)
For models fulfilled from Envigo Affiliates in Europe, the last stage of gestation for mice is over 17 days and for rats is over 18 days, each at shipping. (inotivco.com)
To avoid charges, cancellations for timed mated rats, mice, guinea pigs, and hamsters must be received one week prior to mating date, however, cancelled orders for timed mated rabbits will be charged at full price regardless of the amount of notice supplied. (inotivco.com)
If customer's research project requires such litters, Envigo recommends ordering timed mated pregnant rats and mice which can litter at customer's facility. (inotivco.com)
Isogeneic1
No immunosuppressed isogeneic (ISO) and allogeneic (ALO) rats mixture offered as control. (pkc-inhibitor.com)
F3444
The BN, F344 and LEW mtDNA differ from the SHR in multiple amino acid substitutions in protein coding genes and also in variants of tRNA and rRNA genes. (bvsalud.org)
Rats, Inbred F344" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
This graph shows the total number of publications written about "Rats, Inbred F344" by people in this website by year, and whether "Rats, Inbred F344" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Rats, Inbred F344" by people in Profiles. (jefferson.edu)
Transplantation1
Modulation of the NO pathway during short or prolonged blood reperfusion following ischaemia in a heterotopic rat heart transplantation model. (ox.ac.uk)
Strain3
The Rat Strain Ontology (RS) is currently being developed at the Rat Genome Database. (mcw.edu)
An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. (jefferson.edu)
A cinnamon-colored strain of Long-Evans rats which carries a mutation causing fulminant hepatitis and jaundice, with an associated gross accumulation of copper in the liver. (nih.gov)
Implants2
Based on prior experimental results, we hypothesized that rat periodontal ligament (PDL)-derived DPCs can be used to bioengineer PDL tissues on titanium implants in a novel, in vivo rat maxillary molar implant model. (nih.gov)
Use of bone morphogenetic protein 2 on ectopic porous coated implants in the rat. (rush.edu)
Tacrolimus2
Effect of tacrolimus and splenectomy on engraftment and GVHD after bone marrow xenotransplantation in the reciprocal hamster to rat animal models. (uchicago.edu)
Inside our prior experimental function we considered an optimistic aftereffect of low-dose tacrolimus immunosuppression over the inhibition of severe cell- and antibody-mediated rejection of cold-stored arterial grafts in rats [13,14]. (pkc-inhibitor.com)
Lewis3
Inbreeding of the Lewis rat is begun by Dr. Margaret Lewis from a Wistar stock. (inotivco.com)
Strategies and Components Cryopreserved stomach aortic grafts were transplanted between Brown-Norway and Lewis Rabbit polyclonal to Albumin rats. (pkc-inhibitor.com)
Active immunization against purified AChR was performed in female Lewis rats. (ox.ac.uk)
Brown-Norway1
Concentrations of both unconjugated telmisartan and telmisartan glucuronide in the liver of SHR rats fed a high fructose diet were approximately 4 fold higher when compared to Brown Norway (BN) rats fed the same diet. (bvsalud.org)
Protein3
A monoclonal antibody to the mycobacterial 65 kDa heat shock protein (ML 30) binds to cells in normal and arthritic joints of rats. (ox.ac.uk)
A monoclonal antibody reactive with the mycobacterial 65 kDa heat shock protein (ML 30) was investigated for reactivity with biopsies from normal rat joints and with inflamed joints due to adjuvant arthritis (AA) or collagen induced arthritis (CIA). (ox.ac.uk)
Consequently, we quantified NO synthase (NOS) isoform protein levels in a rat heart transplant model during short and prolonged reperfusion following ischemia. (ox.ac.uk)
Liver1
Rats on HCD exhibited similar body weights and weights of fat depots, reduced levels of serum insulin, and reduced oxidative stress in the liver. (bvsalud.org)
Acute1
Acute adiponectin delivery is cardioprotective in the aged female rat heart. (jefferson.edu)
Model4
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS. (ox.ac.uk)
In this study, we aimed at evaluating the effects of high cysteine diet administered to SHR-CRP transgenic rats, a model of metabolic syndrome and inflammation. (bvsalud.org)
Intra-articular injection in an adjuvant-induced rat model of RA induces apoptosis of FLS, leading to significant decrease in joint inflammation, joint damage, and bone loss with improvement in joint function and mobility. (hal.science)
Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model. (hal.science)
Arthritis1
The demonstration of epitopes cross-reactive with hsp 65 of mycobacteria in normal and, in higher quantity, in arthritic rat joints, suggests, together with our preliminary biochemical findings, that a recently identified mammalian counterpart to bacterial hsp 65 is both preferentially expressed in normal joints and subject to increased expression in arthritis of different aetiologies. (ox.ac.uk)
Care1
The use and care of the rats complied with the ARVO Statement. (cjeo-journal.org)
Control1
In control rat brain, mRNA for all of the MMPs examined was detectable. (ox.ac.uk)
Cells3
Rat PDL DPCs also exhibited differentiative potential characteristic of stem cells. (nih.gov)
The pathogenesis and development is closely associated with the dynamic changes of CD4 + CD25 + Foxp3 + Treg cells in EAU rats. (cjeo-journal.org)
Immunohistochemical stainings with the anti-hsp 65 antibody on paraffin sections from normal rat joints revealed a weak but exclusive staining of cells within the synovial lining. (ox.ac.uk)
Strains2
These data show region-specific differences of IL-1β mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation. (elsevierpure.com)
Reliable surgical methods, together with the availability of inbred strains and a rapidly developing knowledge of its MHC and immune system in general, have made the rat a prime species in which to study the immunological events which follow liver grafting. (nih.gov)
Genetic3
Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. (mcw.edu)
A genetic map for rat chromosome 1 was constructed using 66 microsatellite markers typed on either or both of two populations derived from inbred Dahl salt-sensitive (S) rats: F2(LEW x S) n = 151, and F2(WKY x S) n = 159. (mcw.edu)
Nevertheless, there are some physiological and genetic differences between humans and rats, which should be carefully considered when rats are chosen as a model organism. (biomedcentral.com)
Liver transplantation3
Methyl palmitate prevents Kupffer cell activation and improves survival after orthotopic liver transplantation in the rat. (musc.edu)
Glycine in Carolina rinse solution reduces reperfusion injury, improves graft function, and increases graft survival after rat liver transplantation. (musc.edu)
PMID- 3894220 TI - The immunology of experimental liver transplantation in the rat. (nih.gov)
Therapeutic1
Celastrus was fed to LEW rats by gavage daily, beginning either before Mtb challenge (preventive regimen) or after the onset of AA (therapeutic regimen). (biomedcentral.com)
Inflammatory3
The obese phenotype is correlated with a characteristic distribution of inflammatory lesions and BDV-antigen in the rat brain. (nih.gov)
In parallel, the draining lymph node cells of Celastrus-treated rats were tested for proliferative and cytokine responses, whereas their sera were tested for the inflammatory mediator nitric oxide. (biomedcentral.com)
The expression of interleukin-1 beta (IL-1β) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. (elsevierpure.com)
Experimental1
The aim of the present study was to evaluate the immunosuppressive activity of mycophenolate mofetil (MMF), sirolimus, and their combination in an experimental model of hepatocyte allotransplantation in rats with acute liver failure. (nih.gov)
Grafts2
Noda K, Shigemura N, Tanaka Y, Bhama J, D'Cunha J, Kobayashi H, Luketich JD, Bermudez CA. Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats. (uams.edu)
This is especially so in the rat where, without immunosuppressive treatment, liver grafts between certain strain combinations are accepted permanently, whereas skin, heart and renal allografts undergo acute rejection. (nih.gov)
Protein1
METHODS: To characterize the role of the P450 system in the synthesis of NO, NO production, NOS enzyme activity, and steady state NOS mRNA and protein expression were characterized in the setting of P450 isoform activity inhibition by using a model of isolated rat hepatocytes in primary culture. (duke.edu)
Rejection3
Improvement of rejection-induced diastolic abnormalities in rat cardia" by P F Soto, C X Jia et al. (lvhn.org)
Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition. (lvhn.org)
OBJECTIVE: Inhibition of inducible nitric oxide synthase (nitric oxide II) activity has been proposed as a method to attenuate capillary leak and edema during rejection of heterotopically transplanted rat hearts. (lvhn.org)
Animals1
To date, there exist numerous well-established procedures to mimic different forms of injury patterns in rats, animals that are uncomplicated in handling and housing. (biomedcentral.com)
Data1
Combining the present data with our previously published data on the F2(LEW x S) population showed that four separate quantitative trait loci with additive effects accounted for 106 mmHg and 38% of the total variance of blood pressure and for 506 mg and 34% of the total variance of heart wt. (mcw.edu)
Year1
This graph shows the total number of publications written about "Rats, Inbred Lew" by people in UAMS Profiles by year, and whether "Rats, Inbred Lew" was a major or minor topic of these publications. (uams.edu)
People1
Below are the most recent publications written about "Rats, Inbred Lew" by people in Profiles over the past ten years. (uams.edu)
Group1
An additional group of rats was given methotrexate for comparison. (biomedcentral.com)
Combination1
For this purpose, heartlung grafting was performed in a strong hystoincompatible combination of rats (BN/LEW). (wustl.edu)
Expression2
At 12 h after LPS administration, increased IL-1β mRNA expression was detected in the hypothalamus of LEW/N rats. (elsevierpure.com)
In contrast, increased IL-1β mRNA expression was detected in the cerebral cortex of F344/N rats. (elsevierpure.com)
Time1
Chucky wastes no time adding rat poison to one of the dinner bowls. (thescreamqueen.reviews)