• IL1R2 is a cytokine receptor which is a part of the interleukin-1 receptor family. (prospecbio.com)
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
  • The protein encoded by this gene belongs to the cytokine receptor family. (creativebiomart.net)
  • This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. (creativebiomart.net)
  • We selected most pathways IL10RB participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. (creativebiomart.net)
  • Dynamics of cytokine/receptor endocytic trafficking can significantly impact cell responses through effects of receptor down-regulation and ligand depletion, and in turn are governed by ligand/receptor binding properties. (physiomeproject.org)
  • Thus, this type of model may enable prediction of beneficial cytokine/receptor binding properties to aid development of molecular design criteria for improvements in applications such as in vivo cytokine therapies and in vitro hematopoietic cell bioreactors. (physiomeproject.org)
  • Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22 RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). (rndsystems.com)
  • Activated T-lymphocytes play an important role in asthma pathogenesis and release soluble interleukin-2 receptor (sIL-2R), which can be detected in the serum. (ersjournals.com)
  • Interleukin-1 alpha, soluble interleukin-2 receptor, and IgG concentrations in cystic fibrosis treated with prednisolone. (bmj.com)
  • In investigating T cell function, it was found that the administration of CMF led also to a similarly prolonged impairment of phytohemagglutinin (PHA-)stimulated soluble interleukin 2 receptor (sIL-2R) production and to a decrease in the proliferation of peripheral blood mononuclear cells following mitogenic stimulation with PHA. (curehunter.com)
  • Cytokines, such as interleukins, growth factors, interferons and tumour necrosis factors are soluble messengers that communicate locally between many different cells of the immune system. (avacta.com)
  • Plasma soluble interleukin-2 and transferrin receptor in schizophrenia and major depression. (bvsalud.org)
  • Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. (diabetesjournals.org)
  • Outcomes in Elderly Renal Transplant Recipients Using Thymoglobulin or Interleukin-2 Receptor Antagonist Induction. (atcmeetingabstracts.com)
  • To date, there are no studies comparing patient and graft outcomes based on rabbit anti-thymocyte globulin (rATG) or IL-2 receptor antagonist (IL-2 RA) induction in this population. (atcmeetingabstracts.com)
  • Jasiak N, Thielke J, Chen J, Hilal N, Salah S, Wu D, Benedetti E, West-Thielke P. Outcomes in Elderly Renal Transplant Recipients Using Thymoglobulin or Interleukin-2 Receptor Antagonist Induction. (atcmeetingabstracts.com)
  • The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. (wikipedia.org)
  • Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. (prospecbio.com)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • The receptor usage of the CXC chemokine granulocyte chemotactic protein-2 (GCP-2) was compared with that of interleukin-8 (IL-8) and epithelial-cell-derived neutrophil attractant-78 (ENA-78). (tau.ac.il)
  • IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. (novusbio.com)
  • The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). (thermofisher.com)
  • It is most often associated with heterozygous mutations in the gene that encodes the Fas protein tumor necrosis factor receptor superfamily 6 (TNFRSF6) and other related effector proteins that regulate lymphocyte survival. (medscape.com)
  • some mice were given dextran sodium sulfate to induce colitis, with or without a FFAR2 agonist or an antibody against interleukin 27 (IL27). (nih.gov)
  • Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC) is a Mouse Monoclonal Antibody conjugated to APC against Interleukin 2 Receptor Alpha (IL2Ra) for use in flow cytometry. (markelab.com)
  • Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC) is a Mouse Monoclonal Antibody conjugated to FITC against Interleuk. (markelab.com)
  • A novel human cell line, KMT-2, from umbilical cord blood cells was established based on the selection of cultures in the presence of recombinant human interleukin-3 (IL-3) and the sorting of cells with anti-My 10 antibody. (ashpublications.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 10 Receptor Alpha (IL10Ra) in Tissue homogenates, cell lysates and other biological fluids. (tuberculosisdrugresearch.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 10 Receptor Alpha (IL10Ra) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (tuberculosisdrugresearch.org)
  • Description: The BC96 monoclonal antibody reacts with human CD25, the 55 kDa interleukin-2 receptor alpha chain (IL-2Ralpha). (thermofisher.com)
  • Daclizumab is a humanized monoclonal antibody that selectively binds to the high-affinity interleukin-2 receptor subunit (CD25), which is expressed at abnormally high levels on T cells in patients with MS. (medscape.com)
  • In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
  • Previously, we showed that diesel exhaust particles (DEPs) suppressed pulmonary clearance of Listeria monocytogenes (Listeria) and inhibited the phagocytosis of alveolar macrophages and their response to Listeria in the secretion of interleukin (IL)-1β, tumor necrosis factor , and IL-12. (cdc.gov)
  • This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. (nih.gov)
  • Structure, function, and regulation of the interleukin-2 receptor and identification of a novel immune activation gene. (agri.gov.il)
  • Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. (thermofisher.com)
  • IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. (thermofisher.com)
  • Here we investigated transcriptional and epigenetic changes after acute, periodic and persistent IL-2 receptor (IL-2R) signaling in mouse peripheral Treg cells in vivo using IL-2 or the long-acting IL-2 -based biologic mouse IL-2 -CD25. (bvsalud.org)
  • Mouse IL-2 -CD25 supported greater expansion and a more extensive transcriptional state than IL-2 in Treg cells , consistent with greater efficacy to control autoimmunity . (bvsalud.org)
  • By itself, CD25 binds IL-2 only with low affinity. (thermofisher.com)
  • However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. (thermofisher.com)
  • CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
  • Present data suggest that the newly established human cell line will be a valuable tool for the biologic assay of hIL-3, and a model for biochemical studies of IL-3 receptors. (ashpublications.org)
  • It is proposed that p55 and p70 be referred to as the α and β subunits, respectively, of the high-affinity IL-2 receptor. (agri.gov.il)
  • IL2-Ra is one of the three constituent subunits of the IL2 receptor. (prottech.com.cn)
  • The half-maximal effective concentrations for migration of CXCR2-transfectants in response to GCP-2 and ENA-78 were similar (0.1 nM), whereas GCP-2 was tenfold more potent than ENA-78 on CXCR1-transfectants, Half-maximal migration of CXCR1-transfected and CXCR2-transfected cells was obtained with IL-8 at concentrations of no more than 0.01 nM. (tau.ac.il)
  • IL1R2 binds IL1A, IL1B and IL1RN preventing them from binding to their regular receptors and thus inhibiting the transduction of their signaling. (prospecbio.com)
  • Interleukin-2 (IL-2) binds to both high- and low-affinity classes of IL-2 receptors on activated T lymphocytes. (agri.gov.il)
  • From these data, it can be concluded that, in addition to IL-8, GCP-2, but not ENA-78, efficiently binds to both CXCR1 and CXCR2. (tau.ac.il)
  • 1994). "Expression cloning of a human IL-12 receptor component. (wikipedia.org)
  • At 7 days postinfection, lymphocytes from Listeria-infected rats showed significant increases in CD4+ and CD8+ cell counts and the CD8+/CD4+ ratio and exhibited increased production of IFN-gamma and IL-2 receptor expression compared with the noninfected control. (cdc.gov)
  • Mice homozygous for Fas mutations develop hypergammaglobulinemia, glomerulonephritis, massive lymphadenopathy, and expansion of an otherwise rare population of T-cell receptor (TCR) α/β cells that lack expression of both CD4 and CD8 (double-negative T [DNT] cells). (medscape.com)
  • 27 kg/m 2 and were randomly assigned to receive 13 weeks of anakinra, a recombinant human IL-1Ra, or placebo, 67 completed treatment and were included in this double-blind 39-week follow-up study. (diabetesjournals.org)
  • Binding studies with 125I-labeled recombinant human (rh) IL-3 indicated that IL- 3 bound to a single class of high affinity receptors (approximately 4,000 receptors/cell) on KMT-2 cells with a kd of approximately 200 pmol/L. The chemical cross-linking assay demonstrated that radiolabeled hIL-3 bound three molecules with molecular masses of 170, 130, and 70 Kd. (ashpublications.org)
  • Recombinant Human IL‑2 (Catalog # 202-IL) stimulates proliferation in the MO7e human megakaryocytic leukemic cell line in a dose-dependent manner (orange line). (novusbio.com)
  • In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse IL-2 R gamma is observed, less than 10% cross-reactivity with recombinant human (rh) IL-2 R beta is observed, and less than 2% cross-reactivity with rhIL-2 R alpha is observed. (novusbio.com)
  • ABSTRACT: Multisubunit cytokine receptors such as the heterotrimeric receptor for interleukin-2 (IL-2) are ubiquitous in hematopoeitic cell types of importance in biotechnology and are crucial regulators of cell proliferation and differentiation behavior. (physiomeproject.org)
  • In this report we examined the effects of DEPs and/or Listeria on T-cell development and secretion of IL-2, IL-6, and interferon (IFN)-gamma. (cdc.gov)
  • Besides IL-3, granulocyte-macrophage colony-stimulating factor supported the growth of the KMT-2 cells, but IL-1 alpha, IL-2, IL-4, IL-5, and erythropoietin did not. (ashpublications.org)
  • Computational results from this model predict that IL-2 depletion can be reduced by decreasing its binding affinity for the IL-2R betagamma subunit relative to the alpha subunit at endosomal pH, as a result of enhanced ligand sorting to recycling vis-a-vis degradation, and that an IL-2 analogue with such altered binding properties should exhibit increased potency for stimulating the T cell proliferation response. (physiomeproject.org)
  • Description: A sandwich ELISA kit for detection of Interleukin 10 Receptor Alpha from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 Receptor Alpha (IL10Ra) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
  • THP-1 cells have Fc and C3b receptors and lack surface and cytoplasmic immunoglobulins. (sigmaaldrich.com)
  • Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. (diabetesjournals.org)
  • Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not I?B degradation or tumour necrosis factor- release from monocytic THP-1 cells. (aston.ac.uk)
  • DEP exposure alone enhanced lymphocyte production of both IL-2 and IL-6 but inhibited lymphocyte secretion of IFN-gamma. (cdc.gov)
  • The isolated lymphocytes showed a significant increase in the CD4+ and CD8+ cell counts and the CD8+/CD4+ ratio and exhibited increased IL-2 responsiveness and increased capacity in the secretion of IL-2, IL-6, and IFN-gamma. (cdc.gov)
  • Type 2 diabetes is caused by inability of the functional β-cell mass to compensate for increased insulin needs due to insulin resistance ( 1 ). (diabetesjournals.org)
  • Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta cell failure resulting in uncompensated hyperglycemia, a process replicated in the Zucker diabetic fatty (ZDF) rat. (nature.com)
  • Endocannabinoids contribute to insulin resistance through activation of peripheral CB 1 receptors (CB 1 Rs) and also promote beta cell failure. (nature.com)
  • Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. (thermofisher.com)
  • In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. (wikipedia.org)
  • In vitro, long-term exposure to high glucose and the peptide hormone leptin secreted by adipose tissue induce β-cell apoptosis and production of the proinflammatory cytokine interleukin (IL)-1 in β-cells and pancreatic islets, respectively ( 7 , 8 ). (diabetesjournals.org)
  • 1:50 dilution will block 70-80% of CTLL proliferative response to 50 units of r.human IL-2 and will stain 70% of PHA-activated human T cells (by FACS) 10µl will stain 106 IL-2R positive cells for FACS analysis or sorting. (prottech.com.cn)
  • This band was not present when IL-2 was cross-linked to transfected C127 cells, which exclusively express low-affinity receptors. (agri.gov.il)
  • Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling. (bvsalud.org)
  • Regulatory T (Treg) cells require ( interleukin-2 ) IL-2 for their homeostasis by affecting their proliferation, survival and activation. (bvsalud.org)
  • Restimulation of IL-2R signaling after contraction activated signature IL-2 -dependent genes and others associated with effector Treg cells , whereas genes associated with signal transduction were downregulated to somewhat temper expansion. (bvsalud.org)
  • GCP-2 was equally potent at inducing a rise in [Ca 2+ ](i) in both CXCR1-transfected and CXCR2-transfected cells (minimal effective concentration 3 nM). (tau.ac.il)
  • GCP-2 desensitized the calcium increase induced by IL-8 in both CXCR1-transfected and CXCR2-transfected cells, but ENA-78 only affected the IL-8-induced calcium response in CXCR2-transfectants. (tau.ac.il)
  • Transfection of TLR-deficient HEK-293 cells with TLRs 1, 2, 4 or 6 did not increase sensitivity to the tested oxysterols. (aston.ac.uk)
  • 1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
  • THP-1 cells can also restore the response of purified T lymphocytes to Concanavlin A, show increased CO 2 production on phagocytosis and can be differentiated into macrophage-like cells using for example DMSO. (sigmaaldrich.com)
  • Further work observed that the T helper cells that attack the eye have large numbers of interleukin-2 (IL-2) receptors on their surface. (nih.gov)
  • This receptor activates the cell and acts like an alarm bell to recruit other immune cells into the eye, resulting in sight-threatening inflammation. (nih.gov)
  • In laboratory studies, NEI investigators, collaborating with researchers from the National Cancer Institute, found that daclizumab, which blocks IL-2 receptors and thereby prevents the immune response triggered by T helper cells, showed promise in treating an experimental model of uveitis. (nih.gov)
  • The discovery of the central role of these T helper cells carrying large numbers of IL-2 receptors in uveitis and the potential value of daclizumab has also spurred intense research activity in other autoimmune diseases, such as multiple sclerosis and ulcerative colitis, in which similar immune mechanisms have been implicated. (nih.gov)
  • IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. (thermofisher.com)
  • The significance of these DNT cells is also not fully understood but has been associated with elevated interleukin (IL)-10 levels and serum immunoglobulin levels in patients with ALPS. (medscape.com)
  • Treatment with recombinant IL-1Ra improves glycemia and β-cell function and reduces inflammatory markers in patients with type 2 diabetes. (diabetesjournals.org)
  • The differential receptor usage of the structurally related ELR + CXC chemokines GCP-2 and ENA-78 is indicative of a different role in inflammatory reactions. (tau.ac.il)
  • Recent studies have shown that Toll-like receptor (TLR)- signalling contributes significantly to the inflammatory events of atherosclerosis. (aston.ac.uk)
  • As products of cholesterol oxidation (oxysterols) accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery, we investigated the potential of 7-ketocholesterol (7-KC), 7β-hydroxycholesterol (7β-HC) and 25-hydroxycholesterol (25-HC) to stimulate inflammatory signalling via the lipid-recognising TLRs 1, 2, 4 and 6. (aston.ac.uk)
  • [ 2 ] HLH is caused by a defect in inflammatory signals that results in uncontrolled hypercytokinemia, usually in a setting of congenital or acquired defective natural killer (NK)/T-cell function in the cytotoxic pathway. (medscape.com)
  • Chemokine activities were evaluated by measurement of intracellular calcium increase and by chemotasis and binding assays, using CXC chemokine receptor (CXCR)-transfected cell lines. (tau.ac.il)
  • When 125I-labeled IL-2 was chemically cross-linked to activated human T lymphocytes, two major bands were identified. (agri.gov.il)
  • The human interleukin 2 receptor β chain (p70). (agri.gov.il)
  • Lactobacillus rhamnosus is an anaerobic facultative heterofermentative rod-shaped bacterium that can live in different parts of the human body, including the gastrointestinal tract (GIT) 2 . (nature.com)
  • Detects human Common gamma Chain/IL‑2 R gamma in direct ELISAs and Western blots. (novusbio.com)
  • The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. (novusbio.com)
  • Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2. (wikipedia.org)
  • Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. (wikipedia.org)
  • Figure 2: The effect of chronic JD5037 treatment on beta cell survival and function in ZDF rats. (nature.com)
  • IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. (rndsystems.com)
  • IL-10 R beta is also a component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29 (1, 2). (rndsystems.com)
  • We describe here a computational model for trafficking dynamics of the IL-2 receptor (IL-2R) system, which is able to predict T cell proliferation responses to IL-2. (physiomeproject.org)
  • Results: Change of modified Preclinical Alzheimer's Cognitive Composite (mPACC) in cognitively unimpaired (CU) was best predicted by p-tau/Aβ42 alone (R 2 ≥ 0.31) or together with NfL (R 2 = 0.25), while p-tau/Aβ42 (R 2 ≥ 0.19) was sufficient to accurately predict change of the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) patients. (lu.se)
  • Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
  • β-Cell mass is reduced through apoptosis ( 5 ) and type 2 diabetes is associated with a low-grade systemic inflammation ( 6 ), but the mechanisms underlying β-cell failure and destruction in type 2 diabetes remain elusive. (diabetesjournals.org)
  • We investigated the mechanisms by which free fatty acid receptor 2 (FFAR2), a receptor for short-chain fatty acids that can affect the composition of the intestinal microbiome, contributes to the pathogenesis of CRC. (nih.gov)
  • Besides IL-2, the gamma chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15. (novusbio.com)
  • Dr. Thomas Waldmann, a co-author of the current study and chief of the Metabolism Branch of the NIH's National Cancer Institute, previously discovered much of the role IL-2 receptors play in the immune system and subsequently developed daclizumab. (nih.gov)
  • IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). (guidetomalariapharmacology.org)
  • From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. (nature.com)
  • Increased number of islet-associated macrophages in type 2 diabetes. (nature.com)
  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. (nature.com)
  • Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. (novusbio.com)
  • It has been proposed that IL-2 R gamma be designated the common gamma chain ( gamma c ). (novusbio.com)
  • However, little is known about the combinative association of liver dysfunction and abnormal interleukins (ILs) in severe patients with COVID-19. (frontiersin.org)
  • The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, and the WHO declared it a pandemic on March 11, 2020. (frontiersin.org)
  • Meanwhile, abnormal interleukins (ILs) were detected in patients with severe SARS-CoV-2 compared with those with milder infections ( 9 , 10 ). (frontiersin.org)
  • Furthermore, in a study analyzing 3,377 cases of hematologic diseases, the mortality rate was 34% in adults and 4% in children, which is a key aspect to bear in mind when considering the prevention of COVID-19 infection and avoidance of severe disease by vaccination ( 2 ). (spandidos-publications.com)
  • Clinical characteristics and epidemiology features of patients infected with SARS-CoV-2 have been explored in the previous study. (frontiersin.org)
  • Baseline characteristics and renal transplant outcomes were analyzed between the 2 groups using either a Chi-square test or Student's t-test where appropriate. (atcmeetingabstracts.com)
  • 1988. Species-specific response to the rodent carcinogens 1,2-dimethylhydrazine and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays. (cdc.gov)
  • It is an accessory chain essential for the active interleukin 10 receptor complex. (creativebiomart.net)
  • Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response, Eric M. Fallon and Douglas A. Lauffenburger, 2000, Biotechnology Progress , 16, 905-916. (physiomeproject.org)
  • The model follows the path of an extracellular ligand as it is bound to a cell surface receptor, internalised, degraded or recycled. (physiomeproject.org)