Receptors lymphocyte homing. Medical search. Frequent questions

High endothelial venules (HEVs) are cells found in secondary lymphoid organs that express large quantities of cell adhesion molecules, enabling undifferentiated lymphocytes to bind. (wikipedia.org)
CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte "rolling" on activated endothelium. (biolegend.com)
90% of binding of human lymphocytes to high endothelial venules (HEV) in frozen sections of peripheral, but not mucosal lymphoid tissue. (bdbiosciences.com)
The α 4 β 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM-1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (southernbiotech.com)

Mediated by lymphocyte receptors and vascular ligand interactions, "tethering" is a reversible linkage that leads to either rolling along the vessel wall or transient immediate arrest. (wikipedia.org)
Additionally, α4β1 with the ligand vascular adhesion molecule-1(VCAM-1) function in lymphocyte trafficking and inflammation. (wikipedia.org)
The cellular ligand for CXCL13 is CXCR5 also known as BLR-1 (Burkitt's Lymphoma Receptor 1). (thermofisher.com)
Bidirectional induction of the cognate receptor-ligand α4-VCAM-1 pair defines a novel mechanism of tumor intravasation. (southernbiotech.com)
The ligand CXCL12 (SDF-1) is a homeostatic chemokine with a central role in hematopoietic cells homing to and release from bone marrow. (lu.se)
The multi-functional class A macrophage scavenger receptor (SRA)/CD204 has emerged as an important class of pattern recognition receptors with broad ligand binding ability. (cdc.gov)

B lymphocytes migrate better to mucosa-associated lymphoid tissue (Peyer's patches), and T lymphocytes preferentially to the peripheral lymph nodes. (wikipedia.org)
Naive lymphocytes are able to circulate into secondary lymphoid tissues, Peyer's patches, lymph nodes, and the spleen. (wikipedia.org)
It preferentially promotes the migration of B lymphocytes (both B-1 and B-2) to the follicles of the spleen, lymph nodes, and Peyer's patches. (thermofisher.com)
This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. (southernbiotech.com)
The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling. (southernbiotech.com)
CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes. (southernbiotech.com)
Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
It is expressed at high levels in the lymph nodes, thymus and appendix, and elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. (quanterix.com)
Because antigen-presenting cells pass through lymph nodes, they present antigen to lymphocytes residing there. (mhmedical.com)
They can skin and can extend to the bone marrow, simulate benign skin disorders, making them blood lymphocytes, lymph nodes, and a diagnostic challenge for dermatologists1,2. (bvsalud.org)

In the cecal tonsils, Thr deficienct birds had a lower percentage of lymphocytes expressing CD4, CD8, CD3 and Bu-1 regardless of challenge (P = 0.01), along with the lower mRNA expression of the chemokine receptor CCR9 for gut homing T cells and B cells (P (usda.gov)
It is expressed as the percentage of lymphocytes to the total number of white blood cells. (biologyonline.com)
The aim of this study was finding dependence between otitis media with effusion and coexistent hypertrophy adenoids, and percentage of lymphocytes CD19+ with expression of antigen CD23+ in hypertrophy adenoids. (unboundmedicine.com)
In the study showed higher significant percentage of lymphocytes CD19+ CD23+ at children in otitis media with effusion (20.08+/-2.93) with reference to comparative group, which was only hypertrophy adenoid (18.16+/-2.25). (unboundmedicine.com)

Lymphocyte homing receptors are cell adhesion molecules expressed on lymphocyte cell membranes that recognize addressins on target tissues. (wikipedia.org)
Lymphocyte homing refers to adhesion of the circulating lymphocytes in blood to specialized endothelial cells within lymphoid organs. (wikipedia.org)
These diverse tissue-specific adhesion molecules on lymphocytes (homing receptors) and on endothelial cells (vascular addressins) contribute to the development of specialized immune responses. (wikipedia.org)
Furthermore, lymphocytes can alter cell adhesion molecule "activatability" to increase binding ability. (wikipedia.org)
L-selectin is able to mediate vessel adhesion whereas α4 integrins, α4β1 or α4β7, can perform primary or secondary adhesion through a stronger tethering and even contribute to transendothelial migration of lymphocytes. (wikipedia.org)
While initial adhesion indicates the start of lymphocyte homing, there is regulation of each step of extravasation. (wikipedia.org)
α4β7 is an α4 integrin class homing receptor that targets lymphocytes in the gut expressing mucosal adhesion molecule-1(MAdCAM-1), mostly expressed in Peyer's patches. (wikipedia.org)
Human CD49d molecules are integrin a4 chains that are expressed as heterodimers with CD29 (b1 integrin) or (b7 integrin) and function as adhesion receptors. (biosave.com)
CD44 is an integral cell membrane glycoprotein with a postulated role in matrix adhesion lymphocyte activation and lymph node homing. (wdv.com)
Adhesion receptors in the interactions between lymphocytes and stromal cells from murine spleen. (anid.cl)
The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as integrin α 4 β 7 , is a member of the integrin family of cell surface receptors. (southernbiotech.com)
Distinct but overlapping epitopes are involved in α 4 β 7 -mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. (southernbiotech.com)

The syndrome is cause by mutations in CXCR4, a chemokine receptor expressed by hematopoietic and non-hematopoietic cells. (lu.se)

T-cell-receptor-independent activation of cytolytic activity of cytotoxic T lymphocytes mediated through CD44 and gp90 MEL-14 . (southernbiotech.com)
The large lymphocytes include the natural killer cells, i.e. cytotoxic cells involved in the innate immune response of vertebrates. (biologyonline.com)
Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients. (cdc.gov)

It thus defines L-selectin as a human lymphocyte homing receptor for peripheral lymph node HEV. (bdbiosciences.com)

CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. (biolegend.com)
In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. (southernbiotech.com)
Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. (southernbiotech.com)
Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. (southernbiotech.com)
CD62L is expressed on neutrophils, monocytes, T- and B-lymphocyte subsets and NK cells. (bdbiosciences.com)
Neutrophils and lymphocytes from affected patients present a chemotaxis towards CXCL12 that could explain the innapropriate retention of mature neutrophils in the bone marrow causing the peripheral neutropenia. (lu.se)

Upon exposure to antigens, lymphocytes lack homing ability during a period of sessile differentiation and cell division, and antigen specific lymphocytes are stored in the spleen for 1-3 days. (wikipedia.org)
1989) demonstrated that the lymphocyte homing receptor is identical to the human leukocyte surface glycoprotein called CDw44, on the basis of studies at the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)
Lymphocytes are a type of white blood cell capable of producing a specific immune response to unique antigens. (biologyonline.com)
In this tutorial, learn about these lymphocytes and the mechanisms they employ to defend the body against the same antigens. (biologyonline.com)

In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T cells in vivo. (nih.gov)

15 Integrin 47 has an important function in the homing of turned on lymphocytes to PPs also to the intestinal lamina propria. (kinasechem.com)
α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. (southernbiotech.com)

MIP-3β and plays a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation, migration and homing. (quanterix.com)
mice, which Capn1 have normal lymphocyte counts but lack the two cytokines TNF- and LT, 26 to B cell-deficient MT mice, 27 and to RAG-1? (kinasechem.com)

The migration of lymphocytes shares many similarities in mode and mechanism with the metastasis of lung cancer tumor cells. (biomedcentral.com)

The human CD44 cell-surface glycoprotein participates in a wide variety of cell-cell interactions including lymphocyte homing and tumor metastasis. (ox.ac.uk)
This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. (antibodies-online.com)
8 That is perhaps because B lymphocytes stimulate maturation of follicular dendritic cells (FDCs) by giving tumor necrosis aspect- (TNF-) and lymphotoxin / (LT/) trimers to lymphoid organs. (kinasechem.com)

1989) refined the assignment of the lymphocyte homing receptor gene to 11pter-p13 by study of Chinese hamster-human cell hybrids in which the human parent cells had various deletions of human chromosome 11. (wdv.com)
Shires, J., Theodoridis, E. & Hayday, A.C. Biological insights into TCRγδ + and TCRαβ + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). (nature.com)
18 Studies on B cell receptor gene usage of these infiltrating IgG positive lymphocytes demonstrate that they are of peripheral and not mucosal origin in UC versus controls. (bmj.com)

Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain. (ox.ac.uk)
1990) demonstrated that CD44 is the main cell surface receptor for hyaluronate. (wdv.com)

The microarchitecture of secondary lymphoid organs plays an important role in facilitating the activation and maturation of antigen-specific lymphocytes and ultimately the mounting of an adaptive immune response ( 1 ). (rupress.org)

Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. (bvsalud.org)

Mature lymphocytes are constantly recirculating in the blood and can traffic to secondary lymphoid tissue as well as target tissue including mucosal tissues of the lamina propria, inflammation, and other extralymphoid immune effector sites. (wikipedia.org)
In these diseases, levels of IP-10 correlate with the tissue infiltration of T lymphocytes, suggesting that IP-10 plays an important role in the recruitment of T cells to sites of tissue inflammation. (quanterix.com)
Three weeks after moving into an older single-family home rotizing granulomas, a nonspecific indicator of inflammation, in Connecticut with her family, a girl aged 5 years (patient A) were present. (cdc.gov)

The process of lymphocyte homing is deliberate, mediated by lymphocyte-endothelial recognition mechanisms that enable antigen-specific immune responses. (wikipedia.org)
Lymphocyte homing receptor control of organ-specific lymphocyte trafficking is thought to prevent autoreactivity in immune responses during B and T cell differentiation. (wikipedia.org)
Studies sug- terized by flow cytometry using anti between the immune response and the gest that HCV inhibits receptor genes in CD3, CD56 and CD16 monoclonal virus replication rate [5] and play a cru- the activation of NK cells [20], and the antibodies. (who.int)
Vitamin D receptors are expressed on the principal cell populations involved in the innate and adaptive immune responses. (springer.com)
The B lymphocytes are involved in the production of antibodies in the humoral immune response. (biologyonline.com)
The T lymphocytes participate in the cell-mediated immune response. (biologyonline.com)
It has been shown that the effective response of the immune system depends on the regulation of lymphocyte migration and homing in many ways. (biomedcentral.com)
Thus, lymphocyte plays an important role in the human immune system. (biomedcentral.com)
The first aim of this investigation focuses on intestinal CD103+ dendritic cells (CD103+DC), which are known as important agents of atRA-driven immune processes, including homing of lymphocytes to the intestinal tract. (harvard.edu)
The power of B and T lymphocytes to become recruited to the website of infection is crucial for a highly effective immune system response. (kinasechem.com)

The first area of research, representing a long-term project in the lab, involves characterization of the role of T cell antigen receptor (TCR) signals, and in particular, individual TCR signal transducing subunits and signal transducing motifs in T cell development. (nih.gov)

Interactions of HLA-C with killer immunoglobulin-like receptors (KIR) on natural killer cells or natural killer T cells can be deregulated by streptococcal infection. (medscape.com)

Figure 2: Pathways involved in nutrient signaling in some lymphocytes. (nature.com)
Like other Ly6/uPAR-related proteins, SLURP-1 folds into a particular shape and is thought to attach (bind) to other proteins called receptors to carry out signaling within cells. (medlineplus.gov)
Nicotinic acetylcholine receptors are best known for their role in chemical signaling between nerve cells, but they are also found in other tissues. (medlineplus.gov)

Subsequently, antigen-stimulated B and T cells express homing receptors particularly for the HEV in initial site of immunization tissue. (wikipedia.org)
L-selectin, for example, is also able to be cleaved by an enzyme, ensuring proper binding of lymphocytes and allowing release of non-target cells. (wikipedia.org)
However, insulin-induced downregulation of insulin receptors was: (1) demonstrable in receptor-positive cells, (2) dependent on insulin concentration, (3) temporally unrelated to insulin internalization, and (4) prevented by culture at 4°C but not by cycloheximide at 37°C. Recovery of insulin receptors required further culture of cells in media depleted of insulin for 24 h. (diabetesjournals.org)
Insulin-induced increases in glucose transport and oxidation were demonstrable in receptor-positive cells but not in receptor-negative cells. (diabetesjournals.org)
Using mouse-human T-lymphocyte hybrids and hybrids of Chinese hamster ovary cells with human amniotic fibroblasts, Ala-Kapee et al. (wdv.com)
7. Diamant E, Keren Z, Melamed D. CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. (southernbiotech.com)
Aryl hydrocarbon receptor is critical for homeostasis of invariant γδ T cells in the murine epidermis. (nature.com)
This combination of effector cells requires a crosslinking antigen to evoke an antibody driven PMN inflammatory response via their Fc receptors. (bmj.com)
Lymphocytes are derived from the stem cells of the lymphoid series, thus the name. (biologyonline.com)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
The role of dendritic cells in the establishment of the homing potential of lymphocytes. (anid.cl)
This observation coincides with depletion and functional alteration of intestinal CD103+DC, along with reduced expression of gut-homing receptors on intestinal T-cells. (harvard.edu)
It is expressed primarily on mucosal lymphocytes but is also present on NK cells and eosinophils. (southernbiotech.com)
Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells. (bvsalud.org)
HIV progressively destroys certain types of white blood cells called CD4 + lymphocytes. (msdmanuals.com)
Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)

Organ-specific lymphocyte homing is important for antigen-specificity and in avoiding autoimmune cross-reactions. (wikipedia.org)

Research in the Section on Hematopoiesis and Lymphocyte Biology is focused on elucidating the cellular and molecular processes that regulate mammalian hematopoiesis. (nih.gov)

Naive lymphocyte extravasation into Peyer's patches is often mediated by L-selectin and limited expression of α4 integrins and other homing receptors prevents these lymphocytes from accessing mucosal effector tissue. (wikipedia.org)

But changes in the expression of lymphocyte migration regulation related proteins in urine exosomes remain unclear. (biomedcentral.com)
This study is to investigate the expression changes of lymphocyte migration regulation related proteins in urine exosomes of lung cancer patients, and further verify their correlation with the development and progression of lung cancer. (biomedcentral.com)
Mass spectrometry was used to screen and explore the expression changes of lymphocyte migration regulation related proteins in healthy people of different ages. (biomedcentral.com)
Enzyme-linked immunosorbent assay and western blotting were used to detect the expression changes of lymphocyte migration regulation related proteins in lung cancer patients. (biomedcentral.com)
Analyzing the data of urine exosome proteomics, a total of 12 lymphocyte related proteins were identified, 5 of which were lymphocyte migration regulation related proteins. (biomedcentral.com)
Lymphocyte migration regulation related proteins were differentially expressed in the urine exosome of lung cancer patients, and WASL, STK10 and WNK1 may serve as potential biomarkers for lung cancer diagnosis. (biomedcentral.com)

Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. (medlineplus.gov)

Despite the heterogeneity of expression patterns in the 2 subsets, GrB + Tregs demonstrate higher expression of coinhibitory, antiapoptotic, and homing markers. (jci.org)

It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). (antibodies-online.com)

Stange, J. & Veldhoen, M. The aryl hydrocarbon receptor in innate T cell immunity. (nature.com)

A cell-surface molecule involved in organ-specific homing of lymphocytes. (southernbiotech.com)

T lymphocytes and cytokines are believed to cause the characteristic inflammatory changes appreciated on histopathologic examination of lesions. (medscape.com)
As regards on different functions of antigen CD23+ the assessment of percentage lymphocytes B with expression of CD23+ can be additional marker in course immunological and inflammatory processes to occur in hypertrophy adenoids at children are sick otitis media with effusion. (unboundmedicine.com)
Pattern recognition scavenger receptor A/CD204 regulates airway inflammatory homeostasis following organic dust extract exposures. (cdc.gov)
Overall, the data demonstrate that SRA/CD204 plays an important role in the normative inflammatory lung response to ODE, as evidenced by the enhanced dust-mediated injury viewed in the absence of this receptor. (cdc.gov)

These studies demonstrate the activated human T-lymphocyte is an insulinsensitive tissue that is capable of limiting its physiologic response to insulin by receptor- and postreceptor-mediated mechanisms. (diabetesjournals.org)
Mechanisms regulating T cell homing. (anid.cl)

A homing receptor-bearing cortical thymocyte subset: implications for thymus cell migration and the nature of cortisone-resistant thymocytes. (southernbiotech.com)
Lymphocytes are a type of white blood cell s. (biologyonline.com)
Lymphocyte count is typically part of the complete blood cell count. (biologyonline.com)
Mature T lymphocytes that have not yet been exposed to the antigen rely on homing receptors on their cell surface to colonize the thymus-dependent zones of the peripheral lymphoid organ. (biomedcentral.com)
Furthermore, B lymphocytes exert a significant organogenic function in the GALT 21,22 and so are apt to be mixed up in B cell-dependent advancement of the follicle-associated epithelium (FAE). (kinasechem.com)
This study aimed to investigate which cell types express Cox-2 and prostaglandin E2 receptors and what functions are mediated through this pathway during renal development. (bvsalud.org)
subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. (bvsalud.org)

The mouse monoclonal antibody Hermes-3 recognizes the 85-95 kD human lymphocyte homing receptor. (wdv.com)

Insulin receptorswere not regulated by insulin before mitogen activation and culture of T-lymphocytes. (diabetesjournals.org)
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (nature.com)
Subpopulation dominates in tonsil pharyngeal are lymphocytes B, and their markers activation are expression of antigen CD23+. (unboundmedicine.com)

Lymphocyte homing receptor expression is altered by antigen exposure. (wikipedia.org)
Ontogeny of lymphocyte homing receptor expression in the mouse thymus. (southernbiotech.com)
Overall, Thr deficiency worsened the detrimental effects on growth performance of coccidiosis by compromising oocyst shedding, intestinal morphology, barrier function, lymphocyte profiles and IFN-' expression. (usda.gov)

Human T-lymphocytes activated by phytohemagglutin acquire insulin receptors in culture. (diabetesjournals.org)

Free lymphocytes constantly recirculate in blood after their re-entry from lymphoid tissue, via lymphatic and thoracic ducts. (wikipedia.org)
Homing happens in tissue-specific manner-e.g. (wikipedia.org)
While attached to the vessel, lymphocytes test target tissue for chemokines and pro-adhesive factors that then prompt "arrest. (wikipedia.org)

Although the challenge increased all the above lymphocyte proportions (P = 0.05), the limited increase of CD3 lymphocyte (49% of Bu-1 lymphocytes) for the 0.49% Thr group induced the lowest CD3 to Bu-1 ratio (Thr × challenge, P = 0.09). (usda.gov)

Histologically, a mature lymphocyte is characterized by the large nucleus, scanty cytoplasm, and the absence of distinct nucleolus and organelles. (biologyonline.com)

In addition to α4 integrins, LFA-1 and Mac-1 mediate the prevention of lymphocyte transendothelial migration into target tissues. (wikipedia.org)

6,7 B lymphocytes play an essential function in peripheral prion pathogenesis: mice without B lymphocytes usually do not develop disease after intraperitoneal publicity. (kinasechem.com)
mice 28 which lack all T and B lymphocytes. (kinasechem.com)

Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. (harvard.edu)

the lymphocyte homing receptor' 'also appears to be identical'' to the Pgp-1 glycoprotein of Omary et al. (wdv.com)

Anatomy53

Organisms17

Diseases11

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology1

Phenomena and Processes44

Disciplines and Occupations1

Information Science4

Health Care1

High endothe4

Ligand6

Lymph nodes10

Percentage of lymphocytes4

Adhesion12

Chemokine1

Cytotoxic3

Peripheral lymph node1

Neutrophils6

Antigens4

Effector T cel1

Integrin2

Normal lymphocyte2

Migration of lymphocytes1

Tumor3

Gene3

CD442

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Endothelial cells1

Inflammation3

Immune10

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Signaling3

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Hyaluronic acid1

Innate1

Organ-specific1

Inflammatory4

Mechanisms2

Cell9

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Activation3

Expression3

Human1

Tissue3

0.051

Mature1

Mediate1

Mice2

Regulation1

Glycoprotein1