• HHV-6 increases risk of an "idiopathic" pneumonia syndrome after HCT as does murine roseolovirus in a BMT mouse model. (hhv-6foundation.org)
  • A research team formed by members of Bethany Moore's Lung Immunology Lab and Gregory Yanik's BMT clinical team at the University of Michigan demonstrated that murine roseolovirus (MRV) is a useful homolog for the study of HHV-6 reactivation in lung disease post-hematopoietic cell transplantation (HCT). (hhv-6foundation.org)
  • Following up on the work done by investigators at Washington University who characterized murine roseolovirus as a mouse homolog of HHV-6 and HHV-7 ( Patel 2017 ), Xiaofeng Zhou, PhD, infected newborn mice with MRV and later performed a bone marrow transplant (BMT) protocol after 8-10 weeks to reactivate the virus. (hhv-6foundation.org)
  • Heterologous Immunity and Persistent Murine Cytomegalovirus Infection. (umassmed.edu)
  • Roseolovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. (wikipedia.org)
  • The genus consists of the following six species: Human betaherpesvirus 7 Human betaherpesvirus 6A Human betaherpesvirus 6B Macacine betaherpesvirus 9 Murid betaherpesvirus 3 Suid betaherpesvirus 2 Viruses in Roseolovirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. (wikipedia.org)
  • A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. (umassmed.edu)
  • HHV-6 was the sixth herpesvirus discovered, and infection in humans is nearly ubiquitous in the first two years of life, with seroprevalence rates surpassing 95% in most studies. (medscape.com)
  • There is growing evidence that host cells try to control Herpesvirus infections by activating the autophagic machinery. (mdpi.com)
  • Inflammation of brain tissue caused by infection with the varicella-zoster virus (HERPESVIRUS 3, HUMAN). (wakehealth.edu)
  • Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection. (biopticka.cz)
  • Herpes labialis, commonly known as cold sores, is a viral infection caused by the herpes simplex virus (HSV). (labialisherpes.com)
  • 242 or 32% of the HCT patients studied had a viral infection and overall survival was significantly lower in patients with an infection, compared to those without. (hhv-6foundation.org)
  • 40% mortality following viral infection. (what-when-how.com)
  • Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. (umassmed.edu)
  • Such infections usually cause fever, with exanthem subitum ( Roseola /rash) [1] only being observed in 10% of cases. (wikidoc.org)
  • The primary infection of HHV-6 frequently occurs as a vague illness with a fairly high fever, sometimes accompanied by convulsions. (biopticka.cz)
  • After primary infection, latency is established in myeloid and bone marrow progenitors and exists for the life time of the host. (wikidoc.org)
  • First you get a primary infection, with red blisters and an itching or burning as I play with your nerves. (blogspot.com)
  • [ 8 ] Acute HHV-6 infection is rare in immunocompetent adults but may manifest as a mononucleosislike illness characterized by fever, lymphadenopathy, and hepatitis . (medscape.com)
  • COVID-19 survivors often suffer from post-acute sequelae of SARS-CoV-2 infection (PASC). (bvsalud.org)
  • NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections. (umassmed.edu)
  • Infection increases ROS, induces ER stress and activates STAT3, NF-κB and mTOR pathways. (hhv-6foundation.org)
  • HHV-6 also contributes to immune suppression caused by HIV co-infection and induces the production of cytokines. (biopticka.cz)
  • Although rare, this initial infection can also cause febrile seizures, encephalitis or intractable seizures. (wikipedia.org)
  • Infection is typically self-limited in children, but HHV-6 encephalitis can occur in immunocompromised patients and is the most feared complication of HHV-6 disease. (medscape.com)
  • It presents again as a febrile illness, but also encephalitis, pneumonia, hepatitis and symptoms of bone marrow suppression and deterioration of a CMV infection. (biopticka.cz)
  • HHV-6 primary infections account for up to 20% of infant hospitalizations in the United States and are associated with several more severe complications, such as encephalitis , lymphadenopathy , myocarditis and myelosuppression . (wikidoc.org)
  • [ 2 ] Management of HHV-6 infection in immunocompetent hosts is supportive. (medscape.com)
  • Primary HHV-6 infection usually occurs in infants or children and is a common cause of fever-induced seizures in children aged 6-24 months. (medscape.com)
  • In older infants and toddlers up to one-fifth of the fever is of a roseolovirus origin. (biopticka.cz)
  • Similar to other herpesviruses, HHV-6 infects a wide variety of cells and remains latent after initial infection. (medscape.com)
  • [ 6 ] Unlike other herpesviruses, HHV-6 has the ability to be chromosomally integrated, which, while occurring in less than 1% of the total population who newly acquire infection, is the suggested route of vertical transmission. (medscape.com)
  • Although up to 100% of the population are exposed (seropositive) to HHV-6, most by 3 years of age, there are rare cases of primary infections in adults. (wikidoc.org)
  • Early "first" HHV-6 infection was associated with a highly significant increase in non-relapse mortality in a retrospective study of 738 HCT patients. (hhv-6foundation.org)
  • Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge. (hhv-6foundation.org)
  • Most of the pre-infected BMT mice developed active MRV infections in their lungs by 2 weeks after mismatched transplant, and histological examination 6 weeks after transplant found the MRV infected mice to show features consistent with IPS. (hhv-6foundation.org)
  • Of interest, the mice had little or no viral DNA in their BAL fluid by 8 weeks post BMT, which, the authors point out, is consistent with an "occult" infection being missed in patients with IPS. (hhv-6foundation.org)
  • A subset of ADI cells shows nuclear accumulation of TP53 at 6- and 14-days post infection (dpi), indicating a prolonged arrest in the ADI state. (bvsalud.org)
  • [32] Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. (alquds.edu)
  • Multivariable analysis showed that first onset infection with HHV-6, EBV and HSV resulted in a 5.5, 9.2 and 11 fold increased risk of IPS, respectively. (hhv-6foundation.org)
  • First infection with CMV increased the risk of bronchiolitis obliterans syndrome, by almost three-fold. (hhv-6foundation.org)
  • Less known is Pasteur\'s vision on infection prevention and control (IPC) that drove current infection control, public health, and much of modern medicine and surgery. (journalfilter.com)
  • lt;h4>Innovation for infection prevention and control-revisiting Pasteur\'s vision. (journalfilter.com)
  • Could some complications of CAR-T cell therapy be secondary to HHV-6 infection? (hhv-6foundation.org)
  • HHV-6 infection has been associated with complications of varying severity in hematopoietic stem cell transplant (HSCT) recipients, to a lesser degree in solid organ transplant (SOT) recipients, and in those who are otherwise immunosuppressed. (medscape.com)
  • [ 11 ] Methods to differentiate true infection from ciHHV-6 exist but are often not readily available clinically. (medscape.com)
  • [ 1 ] Infection is nearly ubiquitous by age 2 years. (medscape.com)