Specialized immune cells such as myeloid-derived suppressor cells and regulatory T cells also mediate their effects via adenosine generated by local ectonucleotidase. (wikipedia.org)
Tumor infiltration by cells which express NT5E such as myeloid derived suppressor cells (MDSC), Treg's, dendritic cells (DC) leads to accumulation of adenosine. (wikipedia.org)
The TME consists of various cells such as myeloid derived suppressor cells (MDSCs), Tumor Associated Macrophages (TAMs) and Regulatory T cells (Tregs) and Cancer associated fibroblasts (CAFs) that contribute to immune cell dysfunction in the TME. (screentx.com)
Tumor12
The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. (aacrjournals.org)
We previously established that an unidentified factor, or factors, present in ovarian tumor ascites fluids reversibly inhibited the activation of T cells by arresting the T-cell signaling cascade. (aacrjournals.org)
Over the past decade, numerous studies indicate that various mechanisms of tumor dormancy exist, including cellular dormancy (quiescence), angiogenic dormancy, and immunologic dormancy. (biomedcentral.com)
Three molecular mechanisms involved in tumor dormancy have been identified: cellular dormancy (quiescence or mitotic arrest), angiogenic dormancy (limited tumor size), and immunologic dormancy (immunosurveillance, balance between clearance and proliferation) (Figure 1 ). (biomedcentral.com)
Dormancy can be induced by more than one mechanism: cellular dormancy (quiescence), angiogenic dormancy (tumor mass size limit), and immunologic dormancy (immunosurveillance, balance between proliferation and apoptosis). (biomedcentral.com)
These findings suggest that the CMTM5 gene may act as a tumor suppressor gene, i.e. a normal gene whose product(s) inhibit the development and/or progression of various cancers. (wikipedia.org)
Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
Our study reveals that ALKBH5, characterized as a tumor suppressor, attenuates the expression of LYPD1 via an m 6 A-dependent manner in HCC cells. (biomedcentral.com)
Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
Cancer cells can produce factors that stimulate the formation of new blood vessels from the surrounding tissue, which can provide nutrients to the tumor. (screentx.com)
T cells carry out immunologic surveillance, then proliferate and destroy newly transformed tumor cells after recognizing TAAs. (msdmanuals.com)
Macrophages can kill specific tumor cells when activated by a combination of factors, including lymphokines (soluble factors produced by T cells) and interferon. (msdmanuals.com)
Journal of Clinical Immunology1
Journal of Clinical Immunology and Research is a full-length quality article describing the state of the art diagnostic and therapeutic care of patients with immune mediated disease and provides insights into high-level investigative research on the clinical description, pathogenesis, diagnosis approach, genetic and functional mechanisms, immunologic assessment and prognosis and treatment intervention. (scitechnol.com)
Genetic5
Genetic susceptibility and altered immunologic response to the normal bowel flora are the risk factors of CD. (studymode.com)
Objective: To explore the application of genetic abnormalities in the diagnosis of angioimmunoblastic T-cell lymphoma (AITL) and the reliable pathological prognostic factors. (bvsalud.org)
Arguably the two most prominent factors are genetic variability and immunologic status of the exposed individual. (hindawi.com)
Furthermore, accumulating data indicate that alterations of immune responsiveness are partly dependent on genetic factors [ 4 ]. (hindawi.com)
What initiates the autoimmune reaction in Crohn's disease is unclear, but genetic and environmental factors play roles. (hdkino.org)
Apoptosis1
Mesenchymal stem cells secrete factors that inhibit apoptosis in H9c2 cardiac myoblasts. (anl.gov)
Cells11
Through immune regulation, the oral liquid enhances the functions of immune organs such as thymus and spleen, increases the number of leucocyte, lowers the rate of sedimentation of erythrocyte and promotes the negative conversion of rheumatoid factor so as to reduce the generation of auto-antibody and its destroy of cells. (kordyceps.lt)
In addition, this product also plays a vital role in stimulating hemopoietic function to ameliorate patients' anemia condition and especially in the assistance of balance between T cells and suppressor T cells. (kordyceps.lt)
Their growth arrest is reversible and under certain conditions, such as induction by growth factors, cytokines, nutrients, or chemical agents, the cells can re-enter the cell cycle to proliferate again. (biomedcentral.com)
The interaction of all these factors could lead to cancer cells escaping the immune system ( 6 ). (amegroups.org)
In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity. (wakehealth.edu)
Hardy RR, Hayakawa K, Shimizu M, Yamasaki K, Kishimoto T. Rheumatoid factor secretion from human Leu-1+ B cells. (bdbiosciences.com)
Sakaguchi, S. Regulatory T cells: key controllers of immunologic self-tolerance. (nature.com)
Shevach, E. M. S. M. R., Piccirillo, C. A. & Thornton, A. M. Control of T-cell activation by CD4 + CD25 + suppressor T cells. (nature.com)
Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)
In contrast, suppressor T cells inhibit the immune response against tumors. (msdmanuals.com)
MACROPHAGES1
We hypothesize that aberrant CIITA, class II MHC and CD40 expression in microglia/macrophages results in detrimental immunologic activities in the CNS. (grantome.com)
Infectious3
A number of infectious and immunologic causes have been proposed, but the cause or causes of CFS remains unknown. (cdc.gov)
The latter conclusion infers that susceptibility to infectious disease can be modified by host-related factors. (hindawi.com)
Inherent in this technically accurate paradox is that while the former supports the well-established link between microbial pathogens and infectious diseases, the latter infers that disease susceptibility can be modified by extramicrobial factors [ 1 - 3 ]. (hindawi.com)
PROTEIN3
The expression of class II MHC genes is regulated by a non-DNA binding protein, class II transactivator (CIITA) the """"""""master control factor"""""""" for class II MHC transcription. (grantome.com)
Endometrial ( EN ) and placental ( PL ) morphology and protein synthesis during pregnancy ( PG ) and pseudopregnancy ( PS ) in the cat. (anl.gov)
Synthesis of insulin-like growth factor binding protein-1 ( IGFBP-1 ) in pregnant cat uteri. (anl.gov)
Transcription factors4
NT5E contains binding sites for transcription factors AP-2, SMAD proteins, SP-1 and elements responsive to c-AMP , which can be found in c-AMP promoter parts. (wikipedia.org)
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression . (lookformedical.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
Inflammatory1
A number of factors trigger the disease process by causing a juxtaepithelial inflammatory reaction in the oral mucosa. (medscape.com)
Warnke R, Miller R, Grogan T, Pederson M, Dilley J, Levy R. Immunologic phenotype in 30 patients with diffuse large-cell lymphoma. (bdbiosciences.com)
Disease1
Further studies are required to prove that these methylations contribute to the immunologic dysregulations occurring in these (and perhaps other) autoimmune diseases and can serve as clinical markers of disease severity and/or as therapeutic targets for controlling the diseases. (wikipedia.org)
Helper2
The immunologic aberrancy in all patients described appears limited to T-lymphocyte hyporesponsiveness and imbalance of T-helper and suppressor cubicles. (upb.ro)
Ledbetter JA, Evans RL, Lipinski M, Cunningham-Rundles C, Good RA, Herzenberg LA. Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. (bdbiosciences.com)
Susceptibility1
Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation. (uchicago.edu)
Prognostic1
We demonstrated that ALKBH5 was down-regulated in HCC, and decreased ALKBH5 expression was an independent prognostic factor of worse survival in HCC patients. (biomedcentral.com)
Patients3
Several subtle immunologic abnormalities have been described in some patients with CFS, although various studies have generated conflicting results. (cdc.gov)
Results Sixty-six patients were screened and 19 enrolled of whom 14 received at least 3 doses of the vaccine and thus evaluated for the primary immunologic endpoint. (bmj.com)
approximately 30-40% of patients and nonspecific immunologic activation can lead to immune-related adverse events. (screentx.com)
Cellular1
Viruses, exemplified by EBV, have evolved myriad strategies to evoke both host cellular and viral factors to evade IFN-I-mediated innate immune responses, to facilitate their infection, replication, and establishment of latency. (etsu.edu)
Human2
Furthermore, xenogeneic human suppressor factors were effective in mice and suppressed the responses as efficiently as syngeneic factors. (ox.ac.uk)
The mechanism of action of this unrestricted suppressor factor, and the use of mouse model for in vivo testing of human suppressor factors is discussed. (ox.ac.uk)
Gene1
Macrophage migration inhibitory factor gene polymorphisms and plasma levels in children with obstructive sleep apnea. (uchicago.edu)
Responses2
KLH-specific suppressor factors produced in vitro efficiently diminished primary and secondary responses to trinitrophenyl keyhole limpet haemocyanin (TNP-KLH) in vivo. (ox.ac.uk)
Both IgM and IgG responses were approximately equally affected, These suppressor factors were not genetically restricted, as allogeneic suppressor factors worked as efficiently as syngeneic factors. (ox.ac.uk)
Macrophage3
Macrophage Migration-Inhibitory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Macrophage Migration-Inhibitory Factors" by people in this website by year, and whether "Macrophage Migration-Inhibitory Factors" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Macrophage Migration-Inhibitory Factors" by people in Profiles. (uchicago.edu)
Effects2
I. Effects of in vitro produced suppressor factor. (ox.ac.uk)
5-9 Data also indicate that Carprofen inhibits the production of osteoclast-activating factor (OAF), PGE 1 , and PGE 2 by its inhibitory effects on prostaglandin biosynthesis. (drugs.com)
Arguably, the most important "other" factor is adaptive and innate immunity of the exposed individual. (hindawi.com)
Family1
Restricting expression of class II MHC and CD40 molecules in the CNS can be achieved by a new family of proteins termed Suppressors of Cytokine Signaling (SOCS). (grantome.com)
Risk2
Understanding BCC causes, risk factors and warning signs can help you detect them early, when they are easiest to treat and cure. (healthyskinworld.com)
The strongest risk factor for developing skin cancer is ultraviolet ray exposure, typically from the sun. (healthyskinworld.com)
Methods1
Clinical immunology and research cover the fragment of diagnostic techniques used for research surveys such as novel immunological methods, clinical laboratory immunology, clinical illustration, immunologic evaluation and diagnostic approach. (scitechnol.com)
Function1
It can adjust the immunologic function of the body without the side effect of immune suppressor. (kordyceps.lt)