• Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. (umassmed.edu)
  • Nitrate, thiocyanate, and perchlorate can reversibly bind to the sodium-iodide symporter (NIS) protein resulting in reduced iodine absorption by the thyroid. (cdc.gov)
  • Inhibition of the sodium-iodide symporter by perchlorate : an evaluation of life stage sensitivity using physiologically based pharmacokinetic (PBPK) modeling. (epa.gov)
  • These studies provide initial insights into substrate selectivity in AgcS symporters. (rcsb.org)
  • Placental MSCs and their derivatives as vehicles for the Na/I symporter (hNIS): A new antitumoral therapy. (araid.es)
  • The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid gland. (elsevierpure.com)
  • In the roots of plants, the H+/K+ symporters are only one member of a group of several symporters/antiporters that specifically allow only one charged hydrogen ion (more commonly known as a proton) and one charged K+ ion. (wikipedia.org)
  • Since carriers are much more closely related, at least mechanistically, to symporters and antiporters than to channels, they are the type of uniporter emphasized in this volume. (biologists.com)
  • Nelson and Lill, 1994 ) the decision as to whether they are symporters or antiporters depends upon the direction of translocation, relative to that of the primary driving ion, of the substrate of greatest physiological importance. (biologists.com)
  • The aim of this study was to investigate the in vivo properties and function of the high-affinity monosaccharide/proton symporter AtSTP1 of Arabidopsis . (edu.au)
  • carbohydrate transmembrane transporter/ hexose:hydrogen symporter/ high-affinity hydrogen:glucose symporter/ su. (cornell.edu)
  • A symporter is an integral membrane protein that is involved in the transport of two (or more) different molecules across the cell membrane in the same direction. (wikipedia.org)
  • Iodine 131 is taken up by the thyroid through the sodium/iodide symporter (NIS), a protein that is also expressed in other tissues such as the salivary glands, stomach and breast. (bvsalud.org)
  • If this symporter did not exist, individual sodium channels and glucose uniporters would not be able to transfer glucose against the concentration gradient and into the bloodstream. (wikipedia.org)
  • Sodium Potassium Chloride Symporter Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in this website by year, and whether "Sodium Potassium Chloride Symporter Inhibitors" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in Profiles. (umassmed.edu)
  • Methods: Quantitative measurements of iodine avidity in surgical specimens (primary tumour and lymph node metastases) of 28 patients were compared to immunohistochemical expression of the thyroid-stimulating hormone receptor, thyroid peroxidase (TPO), pendrin, sodium-iodide symporter (NIS) and mutational status of BRAF and the TERT promoter. (lu.se)
  • The iodine is transported from plasma into the thyroid cell via a sodium-iodide symporter. (medscape.com)
  • The transporter is called a symporter, because the molecules will travel in the same direction in relation to each other. (wikipedia.org)
  • Marine invertebrates use symporters to transport against strong chemical gradients. (wikipedia.org)
  • A subclass of symporters that specifically transport SODIUM CHLORIDE and POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process. (wakehealth.edu)
  • The dopamine and noradrenaline transporters, together with SERT, are members of the neurotransmitter sodium symporter (NSS) family. (rcsb.org)
  • The symporter works in the plasma membrane and molecules are transported across the cell membrane at the same time, and is, therefore, a type of cotransporter. (wikipedia.org)
  • Here, we report two crystal structures of an APC member from Methanococcus maripaludis , the alanine or glycine:cation symporter (AgcS), with l- or d-alanine bound. (rcsb.org)
  • An oncolytic measles virus with an additional transcriptional unit encoding the sodium iodide symporter (NIS), as a reporter for viral infection, was mixed with a 1:10 dilution of Omnipaque 300 (GE Healthcare, Milwaukee, WI, USA) contrast agent and injected directly into tumors. (elsevierpure.com)
  • Abstract: DESCRIPTION (provided by applicant): The broad objective of this project is the detailed molecular characterization of the Na+/l- symporter (NIS), a key intrinsic plasma membrane transport protein that mediates active translocation of I- into the thyroid. (nih.gov)
  • We develop a mathematical model that examines the role of various membrane-based ion transporters in tumour pH regulation, in particular, with a focus on the interplay between lactate and H ions and whether the lactate/H symporter activity is sufficient to give rise to the observed reversed pH gradient that is seen is some tumours. (ebi.ac.uk)
  • Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. (nih.gov)
  • The symporter works in the plasma membrane and molecules are transported across the cell membrane at the same time, and is, therefore, a type of cotransporter. (wikipedia.org)
  • The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. (nih.gov)
  • The sodium-iodide symporter. (nih.gov)
  • Sodium-iodide symporter, also called sodium iodide pump or iodide pump is present in thyroid gland and helps in the active transport of iodide to follicular cells of thyroid. (allmedicalstuff.com)
  • NIS (sodium iodide symporter) is also called sodium iodide pump, iodide pump and sodium iodide cotransporter. (allmedicalstuff.com)
  • Therefore, sodium iodide symporter is only present in the baso lateral membrane of follicular cells of thyroid. (allmedicalstuff.com)
  • Background: This study was designed to explore the therapeutic potential of suppressing MAP kinase and PI3K/Akt pathways and histone deacetylase (HDAC) to induce the expression of sodium/iodide symporter (NIS) and radioiodine uptake in non-thyroid cancer cells. (johnshopkins.edu)
  • Liu, Z & Xing, M 2012, ' Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells ', PloS one , vol. 7, no. 2, e31729. (johnshopkins.edu)
  • The Na+/I- symporter (NIS) is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells. (cancer-pictures.org)
  • The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. (medscape.com)
  • 1. The importance of sodium/iodide symporter (NIS) for thyroid cancer management. (nih.gov)
  • 2. Sodium/iodide symporter in thyroid cancer. (nih.gov)
  • 3. Sodium/iodide symporter: a key transport system in thyroid cancer cell metabolism. (nih.gov)
  • 5. Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma. (nih.gov)
  • 7. [The practical relevance of the sodium iodide symporter]. (nih.gov)
  • 8. Relationship between expression of the sodium/iodide symporter and 131I uptake in recurrent lesions of differentiated thyroid carcinoma. (nih.gov)
  • 9. Reintroducing the Sodium-Iodide Symporter to Anaplastic Thyroid Carcinoma. (nih.gov)
  • 10. Sodium iodide symporter: its role in nuclear medicine. (nih.gov)
  • 11. Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers. (nih.gov)
  • 12. A perspective view of sodium iodide symporter research and its clinical implications. (nih.gov)
  • 13. Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy. (nih.gov)
  • 14. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. (nih.gov)
  • 15. Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas. (nih.gov)
  • 16. [The sodium-iodide symporter. (nih.gov)
  • 17. Sodium-iodide symporter (NIS) gene expression in lymph-node metastases of papillary thyroid carcinomas. (nih.gov)
  • 18. Expression pattern of the pendrin and sodium/iodide symporter genes in human thyroid carcinoma cell lines and human thyroid tumors. (nih.gov)
  • 19. Expression of the human sodium/iodide symporter (hNIS) in xenotransplanted human thyroid carcinoma. (nih.gov)
  • 20. Iodide symporter gene expression in human thyroid tumors. (nih.gov)
  • Inhibition of the sodium-iodide symporter by perchlorate : an evaluation of life stage sensitivity using physiologically based pharmacokinetic (PBPK) modeling. (epa.gov)
  • SiaT is one of those transporters, belonging to the sodium solute symporter (SSS) family (3) (with for some weird reason is associated with the Pfam family "SSF", an eternal source of confusion in discussions within this project). (microbiology.se)
  • SYMPORTERS may use secondary active transporters to transport ions in the same direction (symport). (bvsalud.org)
  • In the roots of plants, the H+/K+ symporters are only one member of a group of several symporters/antiporters that specifically allow only one charged hydrogen ion (more commonly known as a proton) and one charged K+ ion. (wikipedia.org)
  • and GXS1 , which encodes a glucose/xylose proton symporter. (microbiologyresearch.org)
  • TSH is the hormone responsible for facilitating sodium-iodine symporter. (napiers.net)
  • Predicted to enable bile acid:sodium symporter activity. (nih.gov)
  • If this symporter did not exist, individual sodium channels and glucose uniporters would not be able to transfer glucose against the concentration gradient and into the bloodstream. (wikipedia.org)
  • Het eerste deel kost energie, in de vorm van ATP, om het glucose-molecuul vast te zetten en stapsgewijs te veranderen. (jove.com)
  • De glycolytische route zet één hexose (koolhydraat met zes koolstofatomen zoals glucose) om in twee triosemoleculen (koolhydraat met drie koolstofatomen) zoals pyruvaat, en een netto van twee ATP moleculen (vier zijn er geproduceerd, en twee zijn verbruikt) en twee nicotinamide adenine dinucleotide (NADH) moleculen. (jove.com)
  • Therfore if you read these names somewhere instead of symporter, don't confuse yourself with it. (allmedicalstuff.com)