Stem cellsPotentialBloodSquamous cell carcBone marrowTreatmentAdipose tissueNovelRoleSurvivalReplacementMacrophageStudyClinicalMicrovascularWorkTherapeuticDevelopmentHelpInvasiveCellules souchesShownSous-jacentesIrradiated miceMolecularMarrowParticularPotentielModificationsSkinPatientsDeepAvonsMaladieEnhanceTypeEffectsRechercheCentral
Stem cells3
- Since the microenvironment is mainly composed of mesenchymal stem cells (MSCs)-derived cells, we evaluated the potential of MSCs to improve hematopoietic tissue regeneration by bone marrow niche reconstitution. (umontreal.ca)
- This finding, published in Cell Stem Cell on September 18, 2008, reveals important insights into how researchers can manipulate and engineer different stem cells for the treatment of human degenerative disorders. (asso.fr)
- More specifically, we study how retinal stem cells proliferate and differentiate into the different cell types that compose the mature retina. (umontreal.ca)
Potential3
- Overall, the findings presented in this thesis indicate that bone marrow microenvironment and G-CSF levels are important in hematopoietic homing process, and that the decline in hematopoietic tissue regeneration potential following irradiation can be reversed by cellular therapy using MSC genetically modified or not. (umontreal.ca)
- Preclinical studies in rodent models have shown the potential benefit of cell therapy for ED after radical prostatectomy or caused by metabolic diseases, and PD. (urofrance.org)
- Similarly, when we overexpressed the ZFAND3 gene in non-invasive GBM cells in mice, we noticed that the tumour lost the circumscribed growth pattern typical of control NI cells and that the number of cells escaping the primary tumour increased considerably, further confirming that ZFAND3 expression confers invasion potential to GBM cells even if they were initially non-invasive", adds Eliane Klein, second author of the study. (lih.lu)
Blood4
- The tissues used to obtain the therapeutic product were bone marrow, adipose tissue and blood (PRP, platelet-rich plasma). (urofrance.org)
- Silicone facial cups are also very easy to use: first, you need to squeeze out air from cups and apply them to on your face or other body areas, then slide them along the skin to stimulate tissue and blood circulation. (lierre.ca)
- GBM cells insinuate themselves in the interstitial space of the neural tissue and migrate along blood vessels to more distant locations where they then metastasise. (lih.lu)
- This is achieved by means of a therapeutic protocol including fluid administration, red blood cells transfusion, and infusion of vasoactive and/or inotropic agents. (revuesonline.com)
Squamous cell carc3
- Le projet de Lori Bridal (ITD) et de François LEMOINE (Centre d'Immunologie et des Maladies infectieuses CIMI-Paris) "Multi-parametric UltraSonic monitoring of novel, non-thermal Plasma therapy for improved treatment of Oral Cavity Squamous Cell Carcinoma" est soutenu par Sorbonne Universités. (upmc.fr)
- This project applies a prototype NTP system in an orthotopic murine model for oral cavity squamous cell carcinoma (OCSCC). (upmc.fr)
- Upfront surgery is associated with improved survival in patients with p16-negative oropharyngeal squamous cell carcinoma. (orltoulon.com)
Bone marrow1
- Gaucher disease (GD) is an inherited deficiency of glucocerebrosidase leading to accumulation of glucosylceramide in tissues such as the spleen, liver, and bone marrow. (cri1149.fr)
Treatment5
- Cancer treatment using ionizing radiation may lead to significant side effects, including delayed hematopoietic tissue repair and regeneration. (umontreal.ca)
- Regardless of the type of treatment, many back pain patients can benefit from alternative therapies. (lifeonamission143.com)
- Its characteristicPrecocità of access to the service Impact of the Pro12Ala of pparÎ32 onmere always piÃ1 characteristics type of stimulant, playful andattention to our case mix.treatment that includes nutritional therapy, an interventionRecommendation 4. (rosengrenska.org)
- A resorbable shape-memory starch-based stent for the treatment of salivary ducts under sialendoscopic surgery. (orltoulon.com)
- Stray' cancer cells can therefore escape surgical resection, radio- and chemotherapy, thereby accounting for the limited success of current treatment approaches and for the poor patient prognosis observed. (lih.lu)
Adipose tissue1
- it also burns fat fast, due to its high androgenicity causing atrophy of adipose tissue, top steroide avis. (lifeonamission143.com)
Novel3
- We hope that this work will lead to the development of novel stem cell based cell replacement therapies to reconstruct various regions of the central nervous system. (umontreal.ca)
- They brought forward the novel role of protein ZFAND3 in promoting the transcription of several genes that stimulate the invasion of GBM cells in the surrounding parenchyma, the functional tissue in the brain. (lih.lu)
- Focusing on the cells that displayed reduced invasiveness following RNA interference, the scientists carried out sequencing and bioinformatics analysis to characterise novel genes associated with infiltration. (lih.lu)
Role2
- The role of IMMuneOSteoclasts in CANcer - Implications for therapy (IMMOSCAN: ERAnet TRANSCAN-3). (univ-cotedazur.fr)
- When we deactivated the ZFAND3 gene in highly invasive GBM cells, we observed that colonisation of healthy tissue was significantly impaired, indicating that ZFAND3 plays a key role in promoting GBM invasiveness", explains Dr Anne Schuster, first author of the publication. (lih.lu)
Survival1
- They revealed that the same transcription factor, which is crucial for the survival of different stem cell types, can behave differently. (asso.fr)
Replacement1
- To investigate this issue, we explored the iron status of a large cohort of 90 type I GD patients, including 66 patients treated with enzyme replacement therapy. (cri1149.fr)
Macrophage1
- To further explore eventual iron sequestration in macrophages, we produce a Gaucher cells model by treating the J774 macrophage cell line with a glucocerebrosidase inhibitor and showed induced local hepcidin and membrane retrieval of the iron exporter, ferroportin. (cri1149.fr)
Study1
- The aims of this study are to give an update on biotherapy for ED and PD and to describe the regulatory framework for these therapies. (urofrance.org)
Clinical2
- Singapore scientists have recently made a significant discovery in understanding the behavior of a class of gene regulators, known as transcriptional factors, paving the way for important advancements in stem cell technology and clinical research. (asso.fr)
- Clinical trials of cell therapy for erectile dysfunction (ED) and Peyronie's disease (PD) were recently conducted after preclinical studies. (urofrance.org)
Microvascular2
- Therapeutic effect will be investigated and monitored noninvasively using multiparametric ultrasonic cartography (microvascular function, tissue stiffness and parameters of tissue microstructure). (upmc.fr)
- 15 years experience with microvascular free tissue transfert for repair of head and neck cancer defects]. (orltoulon.com)
Work1
- They can be used on wet or dry skin, and when used with either water, lotion or toners, they can work to deeply clean the skin and remove dead skin cells. (lierre.ca)
Therapeutic3
- Image-based assessment of tumor modifications will be confronted with invasive reference measurements (immunological and histological markers, interstitial fluid pressure) to better understand NTP's therapeutic effect and to validate noninvasive monitoring techniques. (upmc.fr)
- Most of these therapeutic strategies using autologous cells were considered as "Advanced Therapy Medicinal Products" with strict regulatory frameworks imposing heavy constraints, in particular in case of "substantial" modification of the cells. (urofrance.org)
- Since the development of a HIV- 1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary. (medecinesciences.org)
Development2
- We are interested in uncovering the cellular and molecular mechanisms involved in the generation of cell diversity during nervous system development. (umontreal.ca)
- To help resolve these questions, we use mouse genetics and live imaging technologies to visualize retinal stem cell development in real time. (umontreal.ca)
Help1
- Anabolic steroids help build muscle tissue and increase body mass by acting like the body's natural male hormone, testosterone. (libertypac4u.com)
Invasive5
- One of the hallmarks of Glioblastoma (GBM), the most aggressive type of brain cancer, is its high invasive capacity, which leads to its expansion into the normal brain tissue. (lih.lu)
- The research team leveraged RNA interference - a technique commonly used to uncover the function of a gene and its contribution to observed cellular characteristics - to progressively silence and deactivate the entire set of genes of highly invasive patient-derived GBM cells and observe the consequences on the cell's ability to invade healthy tissues. (lih.lu)
- This selection was further narrowed down by analysing their expression in non-invasive (NI), low-invasive (LI) and highly invasive (HI) GBM cells, both in vitro and when implanted into mouse brains in vivo. (lih.lu)
- They noted that ZFAND3 was predominantly localised in the nucleus of invasive cells and that this feature was necessary to maintain their invasiveness, suggesting that ZFAND3 may act directly in the nucleus to regulate the activation of specific genes. (lih.lu)
- The authors propose that ZFAND3 forms a protein complex that activates gene transcription, giving rise to the penetrative behaviour that characterises highly invasive GBM cells. (lih.lu)
Cellules souches2
- Les cellules souches sont importantes pour la thérapie à base de cellule pour beaucoup de désordres tissulaires dégénératifs. (asso.fr)
- Étant donné l'énorme complexité de chaque type cellule souchet et leurs bases génétiques sous-jacentes pour leur but unique, cela a été un défi majeur pour des scientifiques pour dénouer les ressemblances et les différences entre les cellules souches différentes. (asso.fr)
Shown1
- Compared to standard therapy, this aggressive management has been shown to significantly decrease in-hospital mortality. (revuesonline.com)
Sous-jacentes1
- Quels sont les mécanismes de base des perturbations sous-jacentes du rythme cardiaque observées de façon courante? (ottawaheart.ca)
Irradiated mice1
- This therapy led to remarkable enhancement of hematopoietic homing in irradiated mice. (umontreal.ca)
Molecular1
- Researchers from the NORLUX Neuro-Oncology Laboratory at the LIH Department of Oncology (DONC) explored the molecular mechanisms responsible for the ability of Glioblastoma (GBM) to infiltrate and spread to healthy brain tissue. (lih.lu)
Marrow1
- Inflammation-independent hyperferritinemia was found in 65% of the patients, and Perl's staining of the spleen and marrow smear revealed iron accumulation in Gaucher cells. (cri1149.fr)
Particular1
- Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin wound therapy, incisional/excisional wound, deep burns, diabetic ulcers, and alkali burns, which may be generalized to the other tissues healing. (savearosefoundation.org)
Potentiel2
- Nous avons évalué le potentiel d'une thérapie à base de CSM sécrétant le récepteur soluble du G-CSF afin de séquestrer le G-CSF transitoirement et les résultats obtenus démontrent que le blocage du G-CSF favorise le nichage hématopoïétique. (umontreal.ca)
- HD-SCT (HD-Stem Cell Therapy) traite de l'analyse approfondie du potentiel thérapeutique de hPSC comme une source de greffon pour le traitement de la maladie de Huntington. (anr.fr)
Modifications1
- The regulatory framework remains unclear and more permissive for PRP and cell therapy processes with extemporaneous preparation/injection and no "substantial" modifications. (urofrance.org)
Skin1
- Compare to surgical facelift or laser and chemical treatments, cupping massage is a natural and completely painless therapy with minimum irritant to skin. (lierre.ca)
Patients1
- These data reveal the involvement of Gaucher cells in abnormal iron sequestration, which may explain the mechanism of hyperferritinemia in GD patients. (cri1149.fr)
Deep1
- These qualities are what make silicone facial cups safe and hygienic tools for deep tissue massages. (lierre.ca)
Avons1
- Notre objectif était de mettre au point et valider une technique de détection ultra-sensible basée sur le NGS ciblé pour détecter des mutations dans l'ADN circulant, Nous avons développé la méthode BPER (Base Position Error-Rate) qui permet d'analyser les données issues du séquençage avec une plus grande sensibilité que les méthodes actuelles pour un coût identique. (theses.fr)
Maladie1
- Le caractère instable de cette expansion de séquences CTG répétées se manifeste dans différents tissus tout au long de la vie du patient mais également entre générations successives, et représente la base moléculaire du phénomène d'anticipation observé dans cette maladie. (recherche-myologie.fr)
Enhance1
- It has demonstrated promising anti-tumor effects associated with creation of reactive oxygen species (ROS) that can modify endothelial cell proliferation and enhance apoptosis. (upmc.fr)
Type2
- Le second type de régime protéiné est celui à base de poudre, que l'on pourrait également appeler régime protéiné de synthèse ou artificiel. (saraleephotography.com)
- The gene coding for the AN1-Type Zinc Finger protein 3 (ZFAND3) showed a significantly higher expression in HI cells compared to NI and LI, both in vitro and in vivo, with the amounts of ZFAND3 protein produced being consequently greater in HI cells located in the periphery of the tumours. (lih.lu)
Effects1
- Relevance of cell subcompartmentalization techniques to predict adverse effects of metals in bivalves and fish. (uco.fr)
Recherche1
- Un service de recherche et développement solide et dynamique constitue la base de n'importe quel secteur. (vwr.com)
Central1
- The hemodynamic management, first described by Rivers in 2001 and called "early goal-directed therapy" (EGDT), aims to target a central venous oxygen saturation (ScvO 2 ) ≥ 70% within the first six hours of management. (revuesonline.com)