• 2003. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. . (oregonstate.edu)
  • OBJECTIVE: We investigated the effects of sambar as a preventive measure for 1,2-dimethyl hydrazine (DMH)-induced CC in Wistar albino rats. (manipal.edu)
  • 6 groups of 14 (groups 1, 2 and 6) or 5 rats each (groups 3, 4 and 5) were used. (europa.eu)
  • Weekly subcutaneous injections of 1,2-dimethethyhydrazine into 6-week-old rats markedly increased thymidylate synthetase (TS) in the poorly differentiated, and thymidine kinase in the well-differentiated adenocarcinomas of the colon. (cancerprev.org)
  • Eighty 2-month-old male LIO rats were exposed weekly to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight. (spandidos-publications.com)
  • Control rats (group 1) received saline at a dose of 0.1 ml during the entire experiment. (spandidos-publications.com)
  • Rats in group 2 were treated with Epitalon at a dose of 1 µg, five times a week, for 6 months, from the first injection of DMH till the end of the experiment. (spandidos-publications.com)
  • 15. Sharma SH, Chellappan DR, Chinnaswamy P, Nagarajana S. Protective effect of p-coumaric acid against 1,2 dimethylhydrazine induced colonic preneoplastic lesions in experimental rats. (jptcp.com)
  • 2001. beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. . (oregonstate.edu)
  • 2002. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. . (oregonstate.edu)
  • Lipomas are common benign soft tissue tumors, with 15 to 20% of the cases affecting the head and neck region and 1 to 4% involving the oral cavity. (academicjournals.org)
  • DMH induced proliferation of the secretory epithelium, and this phenomenon was accompanied by a decrease in the size of the stromal area and the area of lymph infiltration in colon tumors and in the colon mucosa adjacent to the tumors (group 1). (spandidos-publications.com)
  • 2. Russell-jone G, Mctavish K, Mcewan J, Rice J, Nowotnik D. Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumors. (jptcp.com)
  • paniala seeds attenuated the early stage of diethylnitrosamine and 1,2-dimethylhydrazine-induced colorectal carcinogenesis. (bvsalud.org)
  • Colorectal carcinogenesis is considered to develop through multistep genetic or epigenetic alteration along with the pathological change called the adenoma-carcinoma sequence ( 1 - 5 ). (iiarjournals.org)
  • Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine. (geneticsmr.com)
  • After 3.5 weeks on the experimental diets, the animals were given 2 injections of dimethylhydrazine, 25 mg/kg i.p. (usda.gov)
  • The effect of diet on the lethality of 1, 2-dimethylhydrazine (DMH) injections was investigated using Swiss mice. (athabascau.ca)
  • Abbreviations used: ACF: aberrant crypt foci, CC: colon cancer, DMH: 1,2-dimethyl hydrazine, GSH: glutathione, IL-6: Interleukin-6, TNF-α: Tumor necrosis factor-alpha. (manipal.edu)
  • Mitotic activity of tumor cells was significantly inhibited by Epitalon when the treatment was given throughout the experiment (group 2). (spandidos-publications.com)
  • Twelve C57BL/6 J wild-type mice (WT) and 12 TLR2 knockout mice (TLR2-/-) were used to rapidly establish a colitis-associated cancer (CAC) model via the 1,2-dimethylhydrazine-dextran sodium sulfate (DMH-DSS) method and were divided into the normal WT control group (NC), TLR2 knockout control group (KC), normal wild-type tumor modeling group (NT), and TLR2 knockout tumor modeling group (KT), with 6 mice in each group. (biomedcentral.com)
  • 2. Viallard C, Larrivée B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. (ac.ir)
  • Role of metformin in suppressing 1, 2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation. (ac.ir)
  • 7. Eftekhari S, Montazeri H, Tarighi P. Synergistic anti-tumor effects of Liraglutide, a glucagon-like peptide-1 receptor agonist, along with Docetaxel on LNCaP prostate cancer cell line. (ac.ir)
  • Exenatide suppresses 1, 2-dimethylhydrazine-induced colon cancer in diabetic mice: Effect on tumor angiogenesis and cell proliferation. (ac.ir)
  • Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis. (ewha.ac.kr)
  • To investigate the expression pattern of G1 cyclins in 1,2- dimethyl-hydrazine dihydrochloride (DMH)-induced rat colon carcinogenesis, we studied the expression of cyclin D1 and cyclin E by quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry (IHC). (ewha.ac.kr)
  • Unsymmetrical dimethylhydrazine 74-79-3 1,2-Dimethylhydrazine 1,2-Dimethylhydrazine from PubChem Record of 1,2-Dimethylhydrazin in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 21 March 2008. (wikipedia.org)
  • The Department of Health and Human Services (DHHS) has determined that hydrazine and 1,1-dimethylhydrazine are known carcinogens. (cdc.gov)
  • The International Agency for Research on Cancer (IARC) has determined that hydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine are possible human carcinogens. (cdc.gov)
  • The American Conference of Governmental Industrial Hygienists (ACGIH) currently lists hydrazine and 1,1-dimethylhydrazine as suspected carcinogens, but has recently recommended that the listing of hydrazine be changed to that of animal carcinogen, not likely to cause cancer to people under normal exposure conditions. (cdc.gov)
  • 1,2-dimethylhydrazine are possible human carcinogens. (cdc.gov)
  • The EPA requires that spills or accidental releases into the dimethylhydrazine, and 1,2-dimethylhydrazine are probable environment of 1 pound or more of hydrazine or 1,2- human carcinogens. (cdc.gov)
  • This study aimed to investigate the effect of Sorafenib against 1,2-dimethylhydrazine (DMH)-induced CRC in mice. (oncologyradiotherapy.com)
  • 2002. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
  • The effect of cichorium extract and fluorouracil (5-FU) against colorectal cancer (CRC) induced by 1, 2- Dimethyl hydrazine (DMH) was examined in male albino mice. (arjournals.org)
  • Groups of Kunming mice were immunized at weeks 0 and 2, and challenged intraperitoneally with the Ee strain at week 4. (geneticsmr.com)
  • Breathing cigarette smoke indirectly or using tobacco products may expose you to small amounts of hydrazine or 1,1-dimethylhydrazine. (cdc.gov)
  • There are many kinds of hydrazine compounds, products may expose you to small amounts of hydrazine including hydrazine, 1,1-dimethylhydrazine, and 1,2- or 1,1-dimethylhydrazine. (cdc.gov)
  • A member of the class of hydrazines that is hydrazine substituted by two methyl groups at position 1. (contaminantdb.ca)
  • With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. (iiarjournals.org)
  • Groups 1-6 were administered methylurea plus sodium nitrite (group 1), Morpholine plus sodium nitrite (group 2), methylurea (group 3), Morpholine (group 4), sodium nitrite (group 5) or basal diet alone (group 6). (europa.eu)
  • Animals were starved overnight, then given 0.4 % methylurea or 2.0 % Morpholine in the diet for 1 hour. (europa.eu)
  • After overnight fasting, but with access to water, animals were given powdered basal diet containing 0.4 % methylurea (groups 1 and 3) or 2.0 % Morpholine (groups 2 and 4). (europa.eu)
  • Symmetrical dimethylhydrazine is a potent carcinogen that acts as a DNA methylating agent. (wikipedia.org)
  • Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. (ijpbp.com)
  • Working in greenhouses where the chemical Alar is used may result in your being exposed to small amounts of 1,2-dimethylhydrazine. (cdc.gov)
  • 1,2-Dimethylhydrazine has caused colon cancer in laboratory animals following a single exposure. (cdc.gov)
  • Colorectal cancer (CRC) is the third most common cancer 1 and the second leading cause of cancer deaths in the United States. (naturalmedicinejournal.com)
  • 2 Overall risk of colon cancer is approximately 5% in the general population without family history, with 92% of colorectal cancers diagnosed after age 50. (naturalmedicinejournal.com)
  • Those at greatest risk for colon cancer are carriers of 1 of 2 familial genetic disorders, familial adenomatous polyposis (FAP) or hereditary non-polyposis colon cancer (HNPCC), also known as Lynch syndrome. (naturalmedicinejournal.com)
  • Results: We observed a lower mutation rate in adenomatous polyposis coli (APC) (16.7%(2/12) vs. 75.9%(161/212), respectively, p=0.0001) and KRAS (16.7%(2/12) vs. 42% (89/212), respectively, p=0.04) in colitic cancer than in sporadic CRC. (iiarjournals.org)
  • Phycocyanin lowers the amount of cyclooxygenase-2 which is up regulated in cancer cells. (nutraculture.com)
  • It is established that Phycocyanin induces apoptosis in cancer cells by changing the Bcl-2/Bax ratio (Bcl-2 is an anti apoptotic protein, Bax is a pro-apoptotic protein, the ratio of Bcl-2/Bax represents the degree of apoptosis) and the release of Cyt-c in the cytosol (Lu et. (nutraculture.com)
  • This study provides evidence to support using Met in combination with Lira as a treatment option for patients with type-2 diabetes and cancer. (ac.ir)
  • Moreover, ellagic acid reduced the COX-2-induced exacerbation of inflammation. (hindawi.com)
  • However, while the anti-inflammatory effects of dexamethasone treatment were due to the reduced activation of NF- κ B and AP-1, the ellagic acid treatment led to reduced BALF levels of IL-6 and increased levels of IL-10. (hindawi.com)
  • This study investigated whether the DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine (aza-dC) would alter the effect of dietary selenium (Se) on the formation of aberrant crypts. (usda.gov)
  • Epitalon attenuated this effect, especially when the treatment was continued throughout the experiment (group 2). (spandidos-publications.com)
  • Occupational exposure limits (OELs) chemicals (asbestos, benzene, and 2-bromopropane) were updated during the last twenty years. (cdc.gov)
  • Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening syndromes that cause high morbidity and mortality [ 1 ]. (hindawi.com)
  • Journal of Clinical Oncology, 21(1), 123-128. (ijpbp.com)
  • The first set of OELs in 1986 was identical to 2. (cdc.gov)
  • During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
  • Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase‐9 activation through a calcium and protein kinase Cα‐dependent pathway: Phorbol‐12‐myristate‐13‐acetate‐induced/extracellular signal‐regulated kinase/activator protein‐1. (ac.ir)
  • 13. Wu X, Li S, Xue P, Li Y. Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involving β-catenin. (ac.ir)
  • Half of the animals were injected weekly with aza-dC (1 ug/g, sc) and half were injected with the vehicle control. (usda.gov)
  • The incidence ranges from 64.2 to 78.9 cases/100.000 person-years in the USA, and in Northern Europe, it is of 17 cases/100.000 person-years [ 2 ]. (hindawi.com)
  • They are represented by superoxide anion, hydrogen peroxide, and hydroxyl radicals [ 2 ]. (hindawi.com)
  • MSM has most often been used by adults in doses of 1-6 grams by mouth daily for up to 16 weeks. (medlineplus.gov)
  • Despite the availability of multiple therapeutic options such as radiation, chemotherapy, curative resection, and immunotherapy, the early signs of GI cancers are generally undetectable and identified at an advanced stage, leaving patients with limited treatment options, and a poor prognosis ( 2 ). (frontiersin.org)
  • While IBD-related colorectal cancers account for only 1-2% of all CRC cases, CRC accounts for 10-15% of deaths in patients with IBD. (naturalmedicinejournal.com)
  • Results The participants were divided into 5 egg intake groups (o1/w, 1-2/w, 1/2d, 1/d, and ≥2/d). (deepdyve.com)