Glycerol-3-phosphate acyltransferaLysophosphatidicLysophospholipidEnzymeProteinFattyDihydroxyacetone phosphateABHD5Lyso-phosphatidic acidBiosynthesisMetabolicBiolTriacylglycerolGeneMitochondrialCharacterizationActsActivitySequenceCloningLoss of subcutaneousLipodystrophyDehydrogenaseLeptin10.1016HumanDomainAdiposeFamilyInsulinDiabetes
Glycerol-3-phosphate acyltransfera9
- Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. (wikipedia.org)
- Here we show that SLC4 (Yor175c), a gene of hitherto unknown function, encodes a second 1-acyl-sn-glycerol-3-phosphate acyltransferase. (unifr.ch)
- SLC4 harbors a membrane bound O-acyl transferase (MBOAT) motif, and down regulation of SLC4 strongly reduces 1-acyl-sn-glycerol-3-phosphate acyltransferase activity in microsomes from slc1Δ cells. (unifr.ch)
- 2008). AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (geneticsmr.com)
- 2008). Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice. (geneticsmr.com)
- Functional characterization of the human 1-acylglycerol- 3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3. (geneticsmr.com)
- 2005). Cloning and characterization a novel human 1-acyl-sn-glycerol-3- phosphate acyltransferase gene AGPAT7. (geneticsmr.com)
- Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic acid or LPA). (smpdb.ca)
- The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone. (smpdb.ca)
Lysophosphatidic6
- Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. (geneticsmr.com)
- The 1-acylglycerol-3-phosphate acyltransferase (AGPAT) acts as a crucial enzyme in the process of triacylglycerol (TAG) synthesis, enabling the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA). (bvsalud.org)
- Lysophosphatidic acid acyltransferase (LPAT) is a key enzyme in biosynthesis pathway of vegetable oil in plant. (chinacrops.org)
- We constructed a full-length cDNA library of peanut ( Arachis hypogaea ) seed via a large number of sequences of expressed sequence tag (EST) and gene functional annotation, a lysophosphatidic acid acyltransferase gene, designated AhLPAT, and its genomic DNA sequence were isolated from peanut. (chinacrops.org)
- Cloning and Expression Analysis of Lysophosphatidic Acid Acyltransferase (LPAT) Encoding Gene in Peanut[J]. Acta Agron Sin, 2012, 38(02): 245-255. (chinacrops.org)
- 2]Maisonneuve S, Bessoule J J, Lessire R, Delseny M, Roscoe T J. Expression of rapeseed microsomal lysophosphatidic acid acyltransferase isozymes enhances seed oil content in Arabidopsis. (chinacrops.org)
Lysophospholipid3
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis. (umbc.edu)
- Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. (umbc.edu)
- Conserved domains prediction indicated that AhLPAT comprised a typical conserved acyltransferase domain and a conserved lysophospholipid acyltransferases domain. (chinacrops.org)
Enzyme8
- In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) is an enzyme that catalyzes the chemical reaction acyl-CoA + 1-acyl-sn-glycerol 3-phosphate ⇌ {\displaystyle \rightleftharpoons } CoA + 1,2-diacyl-sn-glycerol 3-phosphate Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate. (wikipedia.org)
- This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. (wikipedia.org)
- The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. (wikipedia.org)
- This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism. (wikipedia.org)
- Deletion of SLC1 is not lethal and does not eliminate all microsomal 1-acylglycerol-3-phosphate O-acyltransferase activity suggesting that an additional enzyme may exist. (unifr.ch)
- In non-adipose tissues lacking perilipin-1 the role of HSL is less well characterized and the enzyme expression is low. (imingo.net)
- First, dihydroxyacetone phosphate (or glycerone phosphate) from glycolysis is used by the cytosolic enzyme glycerol-3-phosphate dehydrogenase [NAD(+)] to synthesize sn-glycerol 3-phosphate. (smpdb.ca)
- Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA. (smpdb.ca)
Protein1
- Recombinant full length protein within Human Agpat2 aa 1 to the C-terminus. (abcam.co.jp)
Fatty3
- Thus, Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases, but also be involved in fatty acid exchange at the sn-2 position of mature glycerophospholipids. (unifr.ch)
- Polymorphisms in the casein alpha S1 (CSN1S1), beta-casein (CSN2), kappa-casein (CSN3), beta-lactoglobulin (LGB), acyl-CoA diacylglycerol transferase 1 (DGAT1), leptin (LEP), fatty acid synthase (FASN), stearoyl CoA desaturase 1 (SCD1), and 1-acylglycerol-3-phosphate O-acyltransferase 6 (AGPAT6) genes were genotyped, and association analysis to the SCS in the cow's milk was performed. (vuzv.cz)
- It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. (wakehealth.edu)
Dihydroxyacetone phosphate1
- These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. (umbc.edu)
ABHD51
- ABHD5 encodes an acyltransferase required for lipid metabolism. (tamu.edu)
Lyso-phosphatidic acid2
- In yeast it is generated from lyso-phosphatidic acid, which is acylated by Slc1p, a sn-2-specific, acyl-Coenzyme A-dependent 1-acylglycerol-3-phosphate O-acyltransferase. (unifr.ch)
- Indeed, affinity-purified Slc1p displays Mg²⁺-dependent acyltransferase activity not only towards lyso-phosphatidic acid but also lyso forms of phosphatidylserine and phosphatidylinositol. (unifr.ch)
Biosynthesis1
- 1]Ohlrogge J, Browse J. Lipid biosynthesis. (chinacrops.org)
Metabolic1
- Acts upstream of or within acylglycerol metabolic process and hematopoietic progenitor cell differentiation. (nih.gov)
Biol1
- Dev Biol, 2004 Apr 1. (nih.gov)
Triacylglycerol2
- lyrata (Lyre-leaved rock-cress) F15A23.3 triacylglycerol lipase 1 precursor (EC 3.1.1.3) , arath-LIP2 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. (inrae.fr)
- lyrata (Lyre-leaved rock-cress) Triacylglycerol lipase 2 gene At5g1418 MUA22.18 MUA22.19 MYZUS PERSICAE-INDUCED LIPASE 1 , arath-Q8LPF5 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. (inrae.fr)
Gene3
- The ε4 allele of the Apolipoprotein E (APOE) gene in individuals infected by Herpes simplex virus type 1 (HSV-1) has been demonstrated to be a risk factor in Alzheimer's disease (AD). (j-alz.com)
- Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. (geneticsmr.com)
- Agarwal AK, Sukumaran S, Cortes VA, Tunison K, Mizrachi D, Sankella S, Gerard RD, Horton JD, Garg A: Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. (smpdb.ca)
Mitochondrial1
- Further biochemical analysis revealed that PPARγ-mediated lipid synthesis depletes nicotinamide adenine dinucleotide phosphate (NADPH), consequently resulting in increased mitochondrial reactive oxygen species (ROS) level that subsequently disrupted REDOX balance in lung cancer. (oncotarget.com)
Characterization1
- Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. (nih.gov)
Acts1
- CGI-58, at least in vitro, also acts as an acyl-CoA-dependent acylglycerol-3-phosphate acyltransferase. (imingo.net)
Activity2
- Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. (nih.gov)
- It should be noted that interferons display antiviral activity in HSV-1-infected AD patients. (j-alz.com)
Sequence1
- The sequence of AhLPAT cDNA was 1 629 bp, and its genomic sequence was 5 331 bp. (chinacrops.org)
Cloning1
Loss of subcutaneous1
- Over the next 3 years, a complete generalized loss of subcutaneous fat developed that began focally in the lower extremities. (medscape.com)
Lipodystrophy3
- Related articles include Type 1 Diabetes Mellitus , Type 2 Diabetes Mellitus , Acanthosis Nigricans , Dermatologic Manifestations of Localized Lipodystrophy , Progressive Lipodystrophy , and Lipodystrophy in HIV . (medscape.com)
- 1 Based on these characteristics, four subgroups of generalized and partial forms are identified: congenital generalized lipodystrophy (CGL), acquired generalized lipodystrophy, familial partial lipodystrophy, and acquired partial lipodystrophy. (omjournal.org)
- 1 About 300 patients have been described in the literature as having generalized lipodystrophy. (omjournal.org)
Dehydrogenase1
- In the sixth step of the glycolytic pathway, the first step of the second phase, the payoff phase, glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) catalyses the oxidation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate (1,3-BPG), with the concomitant reduction of NAD + to NADH. (imingo.net)
Leptin1
- 3,5 Leptin has an essential role in regulating glucose and lipid metabolism, an appetite suppressive effect, and an insulin-sensitizing effect. (omjournal.org)
10.10161
- http://dx.doi.org/10.1016/S0163-7827(03)00051-1 Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, et al. (geneticsmr.com)
Human3
- Orthologous to human AGPAT5 (1-acylglycerol-3-phosphate O-acyltransferase 5). (nih.gov)
- RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)
- Finally, HSV-1 DNA has been confirmed as present in human brains and is associated with APOE ε4 in AD. (j-alz.com)
Domain1
- Exoribonuclease, phosphorolytic domain 1 [Interproscan]. (ntu.edu.sg)
Adipose1
- Whole cell extracts (30 µg lysate) of 3T3-L1 (Lane 1), 3T3-L1 differentiated to adipocytes (Lane 2), Mouse Adipose (Lane 3), Rat Adipose (Lane 4), Mouse Brown Fat (Lane 5) and Mouse Skeletal Muscle (Lane 5) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322B. (thermofisher.com)
Family1
- A common normal chromosome variant, heterochromatic 9qh+, has been found in some affected individuals, but as would be expected, in 1 family, it also was observed in an unaffected sibling. (medscape.com)
Insulin1
- 3 Localized lipodystrophies, affecting small areas can result at sites of insulin and steroids injection. (omjournal.org)
Diabetes4
- In 1959, Seip described a similar congenital syndrome, but without diabetes mellitus, in 3 young Norwegian children. (medscape.com)
- This disease ranges from 1% to 5% in all cases of diabetes and is less affected by behavior and environment. (pfmjournal.org)
- however, it remains challenging to distinguish MODY from type 1 and 2 diabetes due to the lack of a single diagnostic criteria and genetic testing. (pfmjournal.org)
- Neonatal diabetes mellitus (NDM) and maturity-onset diabetes of the young (MODY) account for a major proportion of monogenic diabetes, while syndromic diabetes constitutes a smaller proportion [ 3 , 4 ]. (pfmjournal.org)