In 1968, Migeon et al described 6 patients with a syndrome of adrenal unresponsiveness to ACTH characterized by hypoglycemia, hyperpigmentation, feeding problems in infancy, low urinary 17-hydroxycorticosteroids, an ability to conserve sodium and increase aldosterone secretion in response to salt deprivation, and a lack of elevation of 17-hydroxycorticosteroid secretion or plasma cortisol concentration with ACTH administration. (medscape.com)
ACTH5
This test, usually given on an outpatient basis, determines plasma 11-desoxycortisol and/or ACTH levels after a single dose of Metopirone. (nih.gov)
Approximately 8 hours after administration of Metopirone, evaluate the values of ACTH and 11-desoxycortisol. (nih.gov)
Normal values will depend on the method used to determine ACTH and 11‑desoxycortisol levels. (nih.gov)
An intact HPA axis function is generally indicated by an increase in 11‑desoxycortisol to over 70 mcg/L. Because of an overlap between a normal ACTH response and an abnormal ACTH response, the ACTH response alone cannot be used to distinguish between healthy individuals and those with adrenal insufficiency. (nih.gov)
The second sister had low levels of plasma 11-hydroxycorticosterone that did not respond to adrenocorticotropic hormone (ACTH). (medscape.com)
Hydroxy3
Hydroxycorticosteroids (OHCSs) are corticosteroids that have an additional hydroxy (-OH) group. (wikipedia.org)
There are two main positions where the hydroxy group may be added: at carbon atom 11, and at carbon atom 17. (wikipedia.org)
Kuingizwa kwa chalasana katika ugumu wa kila siku huruhusu tu kupunguza kiwango cha katekamini katika damu, lakini pia kuongeza yaliyomo kwenye cortisol katika plasma yake, na 17-ketosteroids na 17-hydroxycorticosteroids kwenye mkojo. (sportexistence.com)
Years1
Fewer than 20 cases of thyrotropinoma in children have been reported, all with onset after age 11 years. (medscape.com)
Urinary2
These metabolites are readily determined by measuring urinary 17-hydroxycorticosteroids (17-OHCS) or 17-ketogenic steroids (17-KGS). (nih.gov)
Urinary testosterone, 17-ketosteroids, 17-hydroxycorticosteroids, and serum androgen, follicle-stimulating hormones, and corticosteroid levels ramained within normal values with candicidin therapy. (bvsalud.org)
Adrenal1
An intact HPA axis function is generally indicated by an increase in 11‑desoxycortisol to over 70 mcg/L. Because of an overlap between a normal ACTH response and an abnormal ACTH response, the ACTH response alone cannot be used to distinguish between healthy individuals and those with adrenal insufficiency. (nih.gov)
Corticosteroids2
Hydroxycorticosteroids (OHCSs) are corticosteroids that have an additional hydroxy (-OH) group. (wikipedia.org)
A group of corticosteroids bearing a hydroxy group at the 11-position. (nih.gov)
PMID- 5428635 TI - Circadian rhythms in plasma concentration of 11-hydroxycorticosteroids in men working on night shift and in permanent night workers. (nih.gov)
English1
There were 9% more English strings and 11% more concepts than in the 2002 edition. (nih.gov)