• This LC-MS/MS method provides a rapid, accurate, sensitive, and cost-effective alternative to other methods for detection of 25(OH)D(2) and 25(OH)D(3) at nanomolar concentrations. (nih.gov)
  • However, despite multiple observational studies and several meta-analyses that have shown a positive association between circulating 25-hydroxyvitamin D concentrations and the risk of T2D, no randomized clinical trials supplementing with different doses of vitamin D have confirmed this hypothesis definitively. (nih.gov)
  • We investigated the data according to quartiles of 25(OH)D concentrations. (e-apem.org)
  • Systolic blood pressure and diastolic blood pressure with adjustment for sex and age differed significantly between the serum 25(OH)D groups and exhibited negative trend as 25(OH)D concentrations increased. (e-apem.org)
  • Design Umbrella review of the evidence across systematic reviews and meta-analyses of observational studies of plasma 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D concentrations and randomised controlled trials of vitamin D supplementation. (bmj.com)
  • Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. (prohealth.com)
  • Since early human evolution occurred under UV-rich conditions, typical 25(OH)D concentrations were surely higher than 100 nmol/L [40 ng/mL]. (westonaprice.org)
  • Likewise, the circulating 25-hydroxyvitamin D concentrations of early humans were surely far higher than what is now regarded as normal. (westonaprice.org)
  • We evaluated the associations between serum 25(OH)D and multiple measurements of adiposity, serum lipid concentrations, fasting glucose and insulin resistance in children aged 6-18 years with adjustments for multiple covariates. (vitamindwiki.com)
  • 0 Children deficient in 25(OH)D compared with those with normal 25(OH)D concentrations. (vitamindwiki.com)
  • Objective -To determine the effects of UVB radiation produced by artificial lights on serum 25-hydroxyvitamin D concentrations in domestic rabbits ( Oryctolagus cuniculi ). (avma.org)
  • Serum concentrations of total calcium, ionic calcium, parathyroid hormone (PTH), 25-hydroxyvitamin-D3, and 1,25-dihydroxyvitamin-D3 were measured to monitor calcium homeostasis. (cdc.gov)
  • Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: results from the EPIC-Oxford study. (bvsalud.org)
  • The reliable evidence that excess vitamin D can cause hypercalcemia in generally healthy adults comes from daily intakes of vitamin D greater than 100,000 IU or serum 25(OH)D exceeding 240 nmol/L, which are far higher than those necessary to achieve the benefits. (naturalhealthperspective.com)
  • Overall, 5 % of the general population has serum 25-hydroxyvitamin D (25(OH)D) concentration below the traditional cut-off of 27-5 nmol/l (11 ng/ml)(2). (vitamindwiki.com)
  • Normal plasma levels of 25OHD are 25 to 250 nanomoles (nmol)/L (10 to 100 mcg/L) (SACN 2016). (e-lactancia.org)
  • Vitamin D deficiency is defined by most experts as a serum 25(OH)D level of less than 20 ng/mL (50 nmol/L). (medscape.com)
  • Vitamin D insufficiency has been defined as a serum 25(OH)D level of 21-29 ng/mL (52-72 nmol/L). This is based on the observed physiological changes in calcium absorption and parathyroid hormone levels that occur with changes in vitamin D levels. (medscape.com)
  • In healthy postmenopausal women with serum 25(OH)D levels averaging 34.4 ng/mL (86.5 nmol/L), intestinal calcium absorption increased from 45% to 65% compared to those with mean 25(OH)D levels of 20 ng/mL (50.1 nmol/L). (medscape.com)
  • Chapuy et al reported an inverse correlation between serum intact parathyroid hormone (iPTH) and serum 25(OH)D. Serum iPTH held a stable plateau level when serum 25(OH)D values exceeded 31 ng/mL (78 nmol/L) but started to rise when the serum 25(OH)D values fell below this level. (medscape.com)
  • Vitamin D sufficiency has been defined as serum 25(OH)D levels of 30 ng/mL (75 nmol/L) and above based on analysis of observational studies of vitamin D and various health outcomes. (medscape.com)
  • Their conclusion based on all endpoints was that 25(OH)D levels of 30 ng/mL (75 nmol/L) or greater are more effective in achieving positive outcomes than lower levels. (medscape.com)
  • The best outcomes were seen with 25(OH)D levels from 36-40 ng/mL (90-100 nmol/L). (medscape.com)
  • Vitamin D toxicity is observed when serum 25(OH)D levels are greater than 150 ng/mL (374 nmol/L). (medscape.com)
  • Deficiency of 25(OH)D has been confirmed to affect the synthesis and secretion of insulin in both animal models and human studies 4− [4]. (researchsquare.com)
  • In vivo, subjects recently diagnosed T2D who were supplemented with 25(OH)D had a tendency toward a better insulin secretory response [ 8 ] , and people with 25(OH)D deficiency might predispose to glucose intolerance [ 9 ] . (researchsquare.com)
  • Vitamin D deficiency was defined as a 25(OH)D below 20 ng/ml and insufficiency as a 25(OH) D of 20 29 ng/ml. (endocrine-abstracts.org)
  • Vitamin D deficiency was higher in TRAb-positive GD patients than TRAb-negative patients (respectively 75.5% (77/102) vs 24.5% (25/102) beside according to vitamin D insuffiency there was no difference between TRAb-positive and negative GD patients. (endocrine-abstracts.org)
  • Research has shown that vitamin D deficiency is related to musculoskeletal disease, cardiovascular disease, type 2 diabetes mellitus, certain types of cancers, and autoimmune diseases 3 , 4 , 5) . (e-apem.org)
  • The associations between vitamin D status and COVID-19 risk continue to strengthen, with new data from Quest Diagnostics and Boston University indicating that people with deficiency in the sunshine vitamin may have a significantly higher positivity rate for SARS-CoV-2, the coronavirus that causes COVID-19. (nutraingredients-usa.com)
  • Data published in PLoS ONE ​ ​ indicated that, compared to people with sufficient levels of vitamin D (blood level 25-hydroxyvitamin D of at least 30 ng/mL), people with a vitamin D deficiency (blood level 25-hydroxyvitamin D less than 20 ng/mL) have a 54% higher SARS-CoV-2 positivity rate. (nutraingredients-usa.com)
  • When the researchers separated the individual according to 25(OH)D levels they found that the SARS-CoV-2 positivity rate was higher for those with vitamin D deficiency, compared to those with adequate or higher vitamin D levels. (nutraingredients-usa.com)
  • While even this basic practice is problematic, the extraordinary influence of what I like to call the "naked ape hypothesis of optimal serum 25(OH)D" has created a paradigm wherein "deficiency" and "insufficiency" are together seen as the norm, and 25(OH)D levels that may actually be quite dangerous - especially when not adequately balanced by other nutrients in the diet - are specifically sought out as a panacea. (westonaprice.org)
  • Despite the significant effort in the last century to eradicate or minimize vitamin D deficiency among the population, especially children, there is still a high prevalence for vitamin D insufficiency/deficiency worldwide [ 1, 2 ]. (karger.com)
  • Vitamin D deficiency and insufficiency are also more common across type 2 diabetes mellitus (T2DM) patients. (karger.com)
  • Vitamin D deficiency also contributes to many extraskeletal outcomes, including higher risk of type 1 or type 2 diabetes mellitus, allergy, autoimmunity, pregnancy complications, and many other pathologies. (karger.com)
  • 8.1% (with deficiency defined as serum 25-hydroxyvitamin D level less than 12 ng/mL). (consumerlab.com)
  • Among children fed milk from a bottle, milk consumption did not increase median 25-hydroxyvitamin D but dramatically decreased median serum ferritin, supporting previous findings that children using a bottle are at increased risk for iron deficiency. (contemporarypediatrics.com)
  • The high prevalence of vitamin D deficiency in obese subjects [ 3 ] suggests that adipose tissue (AT) has a major role in the body distribution of vitamin D, but the causal relationship between obesity and low levels of circulating 25(OH)D has not been completely elucidated yet. (medscape.com)
  • Furthermore, describing how vitamin D levels fluctuate month-to-month may provide a basis for implementing public health strategies to increase 25(OH)D levels when deficiency is most acute. (cdc.gov)
  • The enzyme catalyzes the hydroxylation of calcifediol to calcitriol (the bioactive form of Vitamin D): calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 ⇌ calcitriol + 2 oxidized adrenodoxin + H2O The enzyme is also able to oxidize ercalcidiol (25-OH D2) to ercalcitriol, secalciferol to calcitetrol, and 25-hydroxy-24-oxocalciol to (1S)-1,25-dihydroxy-24-oxocalciol. (wikipedia.org)
  • Collectively, the two forms together are referred to simply as 25-hydroxyvitamin D, also known as calcifediol or calcidiol. (creighton.edu)
  • The role of vitamin D in immunity is regulated by the availability of 25(OH)D - also known as calcifediol or calcidiol - in the bloodstream (i.e. the active form of vitamin D in the body), which is further converted to 1,25-dihydroxyvitamin D and utilized by immune cells. (dsm.com)
  • 2. in the liver it is hydroxylated to calcifediol, also called calcidiol or 25-hydroxyvitamin D (25OHD). (e-lactancia.org)
  • Objective To explore the correlation between serum 25-hydroxy vitamin D [25(OH)VitD] concentration and blood viscosity in type 2 diabetic (T2DM) patients. (shsmu.edu.cn)
  • Methods Two hundred and thirteen T2DM patients were enrolled and the serum 25(OH)VitD concentration and whole blood viscosity at different shear rates (1/s, 5/s, 30/s, and 200/s) were measured with enzyme-linked immunosorbent assay and electronic blood rheology analyzer. (shsmu.edu.cn)
  • The correlation between serum 25(OH)VitD concentration and blood viscosity at different shear rates was analyzed and a gender-stratified analysis was performed. (shsmu.edu.cn)
  • Conclusion In T2DM patients, especially in female patients, serum 25(OH)VitD concentration is positively correlated to the blood viscosity. (shsmu.edu.cn)
  • The purpose of our study was to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) concentration and factors that characterize metabolic syndrome in Korean children and adolescents. (e-apem.org)
  • 12) reported a negative correlation between BMI and serum 25-hydroxy-vitamin D [25(OH) D] concentration, whereas Baradaran et al. (e-apem.org)
  • Thus, we investigated the association between serum 25(OH)D concentration and the components of metabolic syndrome and IR in Korean children and adolescents using data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) conducted from 2008 to 2010. (e-apem.org)
  • We carried out a dose-response meta-analysis to quantitatively examine the association of circulating 25-hydroxyvitamin D (25[OH]D) concentration with prostate cancer. (dovepress.com)
  • Only prospective studies examining the associations of circulating 25[OH]D concentration with prostate cancer were eligible for the meta-analysis. (dovepress.com)
  • A random-effect meta-analysis was done first, to calculate the summary relative risk (RR) and 95% confidence intervals (CIs) comparing the higher concentration with the lower concentration of 25[OH]D. A dose-response meta-analysis using random-effects model was then carried out to evaluate the nonlinearity and calculate the summary RR caused per 10 ng/mL increment. (dovepress.com)
  • Higher 25[OH]D concentration was significantly correlated with elevated risk of prostate cancer (RR =1.15, 95% CI 1.06-1.24). (dovepress.com)
  • No nonlinear relationship was found between 25[OH]D concentration and risk of prostate cancer ( P =0.654). (dovepress.com)
  • Dose-response meta-analysis showed that the summary RR caused per 10 ng/mL increment in circulating 25[OH]D concentration was 1.04 (95% CI 1.02-1.06). (dovepress.com)
  • 17 Meta-analyses of epidemiological studies have suggested that higher circulating 25-hydroxyvitamin D (25[OH]D) concentration is correlated with decreased risks of several common cancers, such as colorectal cancer and bladder cancer. (dovepress.com)
  • 18 , 19 Considering the preventive effect of vitamin D against cancer, many researchers also studied the association of circulating 25[OH]D concentration with prostate cancer. (dovepress.com)
  • When the children and adolescents were stratified by gender, we found stronger associations between serum 25(OH)D concentration and both HDL-cholesterol and insulin resistance in girls. (vitamindwiki.com)
  • Conclusions: Our results suggest a potential harmful association between low serum 25(OH)D concentration and the risk of obesity among children. (vitamindwiki.com)
  • Procedures -After an acclimation period, rabbits were anesthetized with isoflurane, and an initial blood sample was collected for determination of serum 25-hydroxyvitamin D concentration. (avma.org)
  • On day 14, another blood sample was collected from anesthetized rabbits for determination of serum 25-hydroxyvitamin D concentration. (avma.org)
  • Chez les femmes préménopausées et postménopausées, la concentration sérique en 25-OHD, en phosphore et en calcium était stable dans la fourchette d'âge. (who.int)
  • The concentration of the preactivated vitamin D, 25-hydroxyvitamin-D [25(OH)D], is considered the most reliable marker of vitamin D status. (medscape.com)
  • The relationship between vitamin D status, calcium intake and the risk of developing type 2 diabetes (T2D) is a topic of growing interest. (nih.gov)
  • This condition could be a problem especially in growing children because vitamin D plays an important role in bone metabolism and calcium homeostasis 1 , 2) . (e-apem.org)
  • After Vitamin D Supplementation there Is an Increase in Serum 25 Hydroxyvitamin D but no evidence of a Threshold Response in Calcium Absorption. (creighton.edu)
  • Historically, vitamin D had been linked to skeletal disease including calcium, phosphorus, and bone metabolism, 1 2 osteoporosis, 3 fractures, 4 5 muscle strength, 6 and falls. (bmj.com)
  • By day 21, there appeared to be a dose dependent effect of EGME treatment on most of these variables including a significant increase in total calcium and ionic calcium while 1,25- dihydroxyvitamin-D3 was significantly decreased in groups treated at the 100mg/kg level. (cdc.gov)
  • In premenopausal and postmenopausal women, serum levels of 25-OHD, phosphorus and calcium were stable across the age span. (who.int)
  • Vitamin D is a lipophilic hormone playing a key role in bone metabolism and calcium homeostasis, [ 1 ] and it is also involved in many other pathological processes [ 2 ] commonly linked with obesity. (medscape.com)
  • Ultimately, 25-hydroxyvitamin D is further hydroxylated in the kidney to 1α,25-dihydroxyvitamin D, or calcitriol, the active form of vitamin D [3]. (creighton.edu)
  • One exception is that 25(OH)D levels do not indicate clinical vitamin D status in patients with chronic renal failure or type 1 vitamin D-dependent rickets or when calcitriol (1,25-dihydroxyvitamin D) is used as a supplement. (medscape.com)
  • 25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene. (wikipedia.org)
  • 25-hydroxyvitamin D is a metabolite of vitamin D that is present in food, is the predominant form of circulating vitamin D, and is the form that healthcare professionals measure to determine an individual's vitamin D status. (creighton.edu)
  • 25-OHD (25-hydroxyvitamin D), the major circulating metabolite of vitamin D, was measured in serum by competitive protein-binding (CPB) assay and radioimmunoassay kit (Nichols, San Juan Capistrano, California). (who.int)
  • Effects of meat consumption and vegetarian diet on risk of wrist fracture over 25 years in a cohort of peri- and postmenopausal women. (llu.edu)
  • Deming regression of radioimmunoassay and LC-MS/MS methods for total 25(OH)D levels yielded a slope of 0.97 (95% confidence interval, 0.88-1.05) and y-intercept of -1.74 ng/mL. (nih.gov)
  • The reference range of the total 25(OH)D level is 20-100 ng/mL. (medscape.com)
  • Serum levels of 25-hydroxyvitamin D are important in establishing true vitamin D levels in humans. (nih.gov)
  • The OLS regression and quantile regression further showed that 25(OH)D was associated with glucagon and fasting C-p levels in T2D patients with abdominal obesity. (researchsquare.com)
  • The aim of this study was to investigate the association of 25-hydroxy-vitamin D (25[OH]D) levels and TSH receptor antibody (TRab) levels in GD. (endocrine-abstracts.org)
  • The levels of 25(OH)D and TRAb were examined. (endocrine-abstracts.org)
  • Patients were assigned to Q1 group (53 cases), Q2 group (54 cases), Q3 group (53 cases), and Q4 group (53 cases) according to the quartiles of serum 25(OH)VitD levels. (shsmu.edu.cn)
  • An important question is the identification of what 25-hydroxyvitamin D levels are necessary to influence glycemic homeostasis and the risk of developing T2D. (nih.gov)
  • To achieve a 25(OH)D blood levels of at least 30 ng/mL, the Endocrine Society Guidelines recommends infants, children and adults receive 400-1000 IUs, 600-1000 IUs and 1000-1500 IUs of vitamin D daily respectively. (nutraingredients-usa.com)
  • This finding is not surprising, given the established inverse relationship between risk of respiratory viral pathogens, including influenza, and 25(OH)D levels. (nutraingredients-usa.com)
  • When 25(OH)D levels in the blood are insufficient or deficient, immune responses can be limited, leading to increased risk of infection incidence and severity. (dsm.com)
  • Individuals who supplement their diet with vitamin D have a significantly reduced incidence of respiratory tract infections, with some indication that the greatest positive effects of supplementation may be seen in individuals with the lowest 25(OH)D levels. (dsm.com)
  • 11 Individuals with deficient 25(OH)D levels had a 54% higher rate of a positive test than those who had adequate levels. (dsm.com)
  • A 2021 meta-analysis of 54 observational clinical studies representing 1.4 million people provided further strong evidence that low 25(OH)D levels are associated with greater COVID-19 incidence, severity and mortality. (dsm.com)
  • Thirty-five per cent (35 %) of the children and 21 % of the mothers had low serum ferritin levels, while 30 % of the mothers had low serum 25-hydroxyvitamin D with 28 % of mothers having a low serum folate status. (who.int)
  • Indeed, this paradigm heavily influenced some of my early articles on the fat-soluble vitamins, such as my 2006 article " From Seafood to Sunshine: A New Understanding of Vitamin D Safety ," where I contributed original ideas about the interactions between the fat-soluble vitamins, but essentially took the popular ideas advocating high levels of serum 25(OH)D for granted. (westonaprice.org)
  • Dr. Vieth articulated the same hypothesis in an incredibly popular and influential 1999 article ( 2 ) wherein he provided specific data supporting the high serum 25(OH)D levels referred to in the quote above. (westonaprice.org)
  • For most people, supplementation with vitamin D-3 supplements is the most practical and cost effective method of boosting their serum 25(OH)D levels so that they can experience the simply amazing health benefits of vitamin D . (naturalhealthperspective.com)
  • Patients with HS had lower serum 25-hydroxyvitamin D levels and a higher percentage of degraded and partially degraded bone microarchitecture than controls. (medpagetoday.com)
  • maternal supplementation with 1,200 IU per day did assure maternal levels of 25 OHD, but not those of infants (Czech 2014). (e-lactancia.org)
  • Bischoff-Ferrari et al reviewed evidence from studies that evaluated the thresholds of serum 25(OH)D levels and their relation to bone mineral density (BMD), lower-extremity function, dental health, and the risk of falls, fractures, and colorectal cancer. (medscape.com)
  • In IR adipocytes, uptake of D3 and 25-hydroxyvitamin-D3 was higher, but, after adrenaline stimulation, the decrement in D3 and 25-hydroxyvitamin-D3 was stronger in control cells, which also showed increased expression of Cyp27a1 and Cyp27b1 and higher levels of 25-hydroxyvitamin-D3. (medscape.com)
  • [ 10 ] On these bases, we can understand why orally administrated vitamin D3 has a lower impact on 25(OH)D levels in obese subjects, [ 5 , 11 ] as it is markedly stored in AT. (medscape.com)
  • "Our findings provide further rationale to explore the role of vitamin D supplementation in reducing the risk for SARS-CoV-2 infection and COVID-19 disease," ​wrote the researchers, led by Harvey Kaufman, MD, from Quest Diagnostics and Michael Holick, PhD, MD, professor of Medicine, Physiology and Biophysics and Molecular Medicine at Boston University Medical Campus. (nutraingredients-usa.com)
  • Rabbits were randomly assigned to receive 12-hour exposure to UVB radiation produced by 2 compact fluorescent lights daily (n = 5) or no UVB supplementation (4) commencing on day 1. (avma.org)
  • Supplementation with 25-hydroxyvitamin-D3 was more effective in achieving vitamin D sufficiency in obese, but not in normal weight subjects. (medscape.com)
  • for these reasons supplementation with 25-hydroxyvitamin-D3 is more effective in obese individuals. (medscape.com)
  • p=3.6e-9) in plasma 25OHD (nadir days 1-2). (bmj.com)
  • Plasma 25-hydroxyvitamin d and the longitudinal risk of sepsis in the REGARDS cohort. (ahrq.gov)
  • In this paper, researchers studied low baseline plasma 25-hydroxyvitamin D (25(OH)D) and its association with long-term risk of sepsis. (ahrq.gov)
  • Findings reveals that, among community-dwelling US adults, low plasma 25(OH)D measured at a time of relative health was independently associated with increased risk of sepsis. (ahrq.gov)
  • Longitudinal associations of plasma metabolites with persistent fatigue among colorectal cancer survivors up to 2 years after treatment. (who.int)
  • the evidence supporting a protective effect of vitamin D against severe COVID‐19 disease is very suggestive, a substantial proportion of the population in the Northern Hemisphere will currently be vitamin D deficient, and supplements, for example, 1000 international units (25 micrograms) per day are very safe. (nutraingredients-usa.com)
  • Among children and adolescents, approximately 9 % of the population is 25(OH)D deficient(4). (vitamindwiki.com)
  • 25-hydroxyvitamin D is the predominant circulating form of vitamin D found in the bloodstream, and is the form measured by medical professionals to determine a person's vitamin D status. (creighton.edu)
  • Vitamin D has to be metabolically activated in the kidney, and patients with CKD including diabetic kidney disease (DKD) are not able to produce enough of the active form of vitamin D (1,25(OH) 2 D). Vice versa, the kidneys are assumed to be a classical 1,25(OH) 2 D target. (karger.com)
  • Both D3 and D2 precursors are transformed in the liver and kidneys into 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form, and the active form 1,25-dihydroxyvitamin D (1,25(OH)2D). (nutraingredients-usa.com)
  • Previous studies indicate that low circulating 25-hydroxyvitamin D (25OHD) is associated with poor colorectal cancer (CRC) survival yet sample timing and inflammatory response to cancer or surgery may confound these findings. (bmj.com)
  • We aimed to investigate the association between 25(OH)D and islet function homeostasis in type 2 diabetes (T2D) patients. (researchsquare.com)
  • With increase in 25(OH)D level, FPG, HbA1c, glucagon and C-p were significantly decreased in trend in T2D patients. (researchsquare.com)
  • 25(OH)D was negatively associated with glucagon and C-p in T2D patients with abdominal obesity. (researchsquare.com)
  • Duration of diabetes influence the effect of 25(OH)D on the ratio of glucagon/C-p, on behalf of islet function homeostasis, in T2D patients with abdominal obesity. (researchsquare.com)
  • Epidemiological survey of periodontal health in patients with type 2 diabetes mellitus of different ages [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 217-222. (shsmu.edu.cn)
  • Indeed, nowadays psoriasis is considered a systemic pathology, including also other conditions, from psoriatic arthritis to obesity and metabolic disease (MetS), which increased cardiovascular risk in psoriatic patients [ 2 - 4 ]. (springer.com)
  • 2 There has been a lot of progress in the therapeutic options including novel molecularly targeted therapeutics for prostate cancer patients in the past decade. (dovepress.com)
  • For the new study, the researchers analyzed data from 191,779 patients from all 50 states with SARS-CoV-2 results and matching 25(OH)D results from the preceding 12 months. (nutraingredients-usa.com)
  • It has become increasingly common for health enthusiasts and now even typical patients in the doctor's office to have a lab estimate their vitamin D status by measuring serum 25-hydroxyvitamin D, abbreviated 25(OH)D, and use vitamin D supplements to bring this value into the "sufficient" range. (westonaprice.org)
  • 2 The results of their findings, which were recently published in the Swedish journal Acta Dermato-Venereologica , suggest that patients with HS have lower trabecular bone score (TBS) and total hip bone mineral density (BMD) values than population-based controls. (medpagetoday.com)
  • 2 In fact, TBS has been evaluated in several rheumatic diseases, and values consistent with degraded microarchitecture have been linked to disease activity in patients with ankylosing spondylitis, systemic sclerosis, and RA. (medpagetoday.com)
  • 25(OH)D level was associated with HbA1c, glucagon and HOMA-β in non-abdominal obesity group after adjustment. (researchsquare.com)
  • As for abdominal obesity group, there was the significant association between 25(OH)D and HbA1c, glucagon, HOMA-IR, baseline insulin and C-p. (researchsquare.com)
  • The moderate analyses revealed significantly interaction effect of 25(OH)D and glucagon on C-p ( P =0.0124), as well as the effect of 25(OH)D and duration of diabetes on glucagon/C-p in abdominal obesity group. (researchsquare.com)
  • Objective: To explore the relationships of serum 25-hydroxyvitamin D (25(OH)D) with obesity and metabolic parameters in US children. (vitamindwiki.com)
  • HbA1c greater than or equal to 6.5%]) or 2 out of 4 components of metabolic syndrome (obesity, dyslipidemia, elevated blood pressure, elevated fasting glucose). (who.int)
  • The role of circulating 25 hydroxyvitamin D in asthma: a systematic review. (edu.au)
  • Nowadays the relationship between 25-hydroxyvitamin D (25(OH)D) level and the risk of T2D has become a hotspot of research. (researchsquare.com)
  • So in response to high glucose level or in type 2 diabetes, how 25(OH)D impact glucagon secretion from islet α-cells as well as the islet function homeostasis between islet α-cells and β-cells should be elucidated, which can provide new strategies for treating glucose metabolism disorders. (researchsquare.com)
  • Low serum 25(OH)D level is associated with an increase of insulin resistance and metabolic syndrome in children and adolescents. (e-apem.org)
  • Data from a 1981 United Arab Emirates study suggested that 45% of United Arab Emirates schoolchildren have a haemoglobin level of below 11 g/dl [2]. (who.int)
  • thus, the total serum 25(OH)D level is currently considered the best indicator of vitamin D supply to the body from cutaneous synthesis and nutritional intake. (medscape.com)
  • 7.1 Measurement of 25-hydroxyvitamin D level. (who.int)
  • 2 (16.60%), where most of the individuals with normal level were grouped. (bvsalud.org)
  • Anthropometric indices, biochemical parameters, serum 25(OH)D, and islet function including C-peptide (C-p) and glucagon were measured. (researchsquare.com)
  • Recent studies showed that glucagon served as an insulinotropic hormone rather than counter-regulatory hormone to insulin [ 3 ] , which suggested that both a-and β-cells dysfunction contribute to the development of type 2 diabetes (T2D). (researchsquare.com)
  • Metabolic syndrome is a cluster of medical disorders that, when manifested altogether, increases the risk of developing cardiovascular disease and type 2 diabetes 6) . (e-apem.org)
  • In particular, insulin resistance (IR) plays a central role in the pathogenesis of type 2 diabetes mellitus and other cardiovascular complication 8) . (e-apem.org)
  • D is a natural component of breast milk where it is found primarily as cholecalciferol, but also as ergocalciferol and its respective 25-hydroxylated metabolites. (e-lactancia.org)
  • [ 10 ] In general, these assays depend on an antibody that recognizes 25(OH)D2 and 25(OH)D3 in equimolar proportions and the competitive displacement of tracer 25(OH)D (25(OH)D that has been tagged with a radioactive isotope such as 125-I or a chemiluminescent ligand) by acetonitrile extracted samples. (medscape.com)
  • 25-hydroxyvitamin D3 is also found in certain foods, particularly animal products such as meat, liver, and eggs. (creighton.edu)
  • At present, 25-hydroxyvitamin D3 is not available as a dietary supplement in the United States.If it were available, 25-hydroxyvitamin D3 could more rapidly and effectively optimize vitamin D status and support immune function. (creighton.edu)
  • 2 Vitamin D is scientifically proven to benefit the immune system, with many consumers already associating the 'sunshine vitamin' with immunity. (dsm.com)
  • In a study of more than 190,000 Americans, researchers found that reduced 25(OH)D status was strongly associated with increased risk of a positive COVID-19 PCR test. (dsm.com)
  • The effect of vigorous physical activity and risk of wrist fracture over 25 years in a low-risk survivor cohort. (llu.edu)
  • Basically all research about relationship between 25(OH)D and islet function in T2D has focused on the insulin-secreting β-cells. (researchsquare.com)
  • We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. (cdc.gov)
  • However, the relationship between 25(OH)D and individual biomarkers of cardiometabolic disease has not been explored in the Canadian population, and whether it differs by sex is unknown. (cdc.gov)
  • According to the range of the duration of diabetes, the conditional indirect effect of 25(OH)D on glucagon/C-p was significantly at 1 SD below the mean ( P =0.0002) and the mean of the duration of diabetes ( P =0.0007). (researchsquare.com)
  • 25(OH)D as an indicator of vitamin D status has likewise been implicated in islet β-cells function. (researchsquare.com)
  • A recent study of over 190,000 people in the United States confirms that low vitamin D status strongly correlates with increased rates of infection with SARS-CoV-2, the virus that causes COVID-19.This finding was consistent regardless of age, gender, race/ethnicity, or latitude. (creighton.edu)
  • 25-hydroxyvitamin D3 is approximately three times as effective vitamin D3 in optimizing vitamin D status, and can do so much more rapidly. (creighton.edu)
  • Serum 25-hydroxyvitamin D Status of vegetarians, partial vegetarians, and nonvegetarians: the Adventist Health Study-2. (llu.edu)
  • Requirements for obese adults are 2-3 times higher. (nutraingredients-usa.com)
  • in both IR cells and obese SAT, protein expression of β 2 -adrenergic receptor was reduced. (medscape.com)
  • [ 5 , 6 ] An alternative hypothesis considers low serum 25(OH)D in obese as a result of volumetric dilution of vitamin D in the large adipose stores. (medscape.com)
  • J Clin Oncol 2007;25(Suppl 18S):Abstract 4007. (medscape.org)
  • In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. (karger.com)
  • 0.001 μW/cm 2 for the control rabbits. (avma.org)
  • No association of 25(OH)D with any other metabolic parameter was found. (vitamindwiki.com)
  • A Canadian study examined the association between vitamin D and iron stores with daily milk consumption in 1,366 healthy urban children aged 2 to 5 years. (contemporarypediatrics.com)
  • Our objectives were to examine the association between 25(OH)D and traditional and novel biomarkers of cardiometabolic disease and to describe the extent of the month-to-month fluctuations of 25(OH)D in a representative sample of the general Canadian population. (cdc.gov)
  • Reference interval study results were compared with current 25(OH)D recommendations. (nih.gov)
  • Feasibility of running clinics to collect biological specimens in a nationwide cohort study - Adventist Health Study-2. (llu.edu)
  • Clinical indexes such as blood viscosity and 25(OH)VitD should be comprehensively evaluated during the diagnosis and treatment of diabetes mellitus. (shsmu.edu.cn)
  • The researchers found that 2 cups (500 mL) of cow's milk a day appeared sufficient to maintain healthy vitamin D stores without affecting serum ferritin, consistent with recommendations from the American Academy of Pediatrics. (contemporarypediatrics.com)