Pharmacological activation of branched-chain α-ketoacid dehydrogenase (BCKDH), the rate-limiting enzyme of BCAA oxidation, lowers plasma BCAAs and improves insulin sensitivity. (princeton.edu)
The branched-chain α-keto acid dehydrogenase (BCKDH) complex is the most important regulatory enzyme in branched-chain amino acid (BCAA) catabolism. (fujita-hu.ac.jp)
We examined the regulation of hepatic BCKDH complex activity in spontaneous type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats and Zucker diabetic fatty rats. (fujita-hu.ac.jp)
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphatase (EC 3.1.3.52, branched-chain oxo-acid dehydrogenase phosphatase, branched-chain 2-keto acid dehydrogenase phosphatase, branched-chain α-keto acid dehydrogenase phosphatase, BCKDH', [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase, [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase) is an enzyme with systematic name (3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphate phosphohydrolase. (wikipedia.org)
A component of the multienzyme 2-oxo-acid dehydrogenase complexes. (expasy.org)
It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes. (expasy.org)
Enzyme4
An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. (lookformedical.com)
A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transamination of branched-chain AMINO ACIDS to 2-oxoglutarate. (lookformedical.com)
This enzyme catalyses the following chemical reaction [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate This mitochondrial enzyme is associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. (wikipedia.org)
A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. (qmul.ac.uk)
Phosphatase1
1. Fatania, H.R., Patston, P.A. and Randle, P.J. Dephosphorylation and reactivation of phosphorylated purified ox-kidney branched-chain dehydrogenase complex by co-purified phosphatase. (qmul.ac.uk)
Binds1
It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168 , dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4 , dihydrolipoyl dehydrogenase. (enzyme-database.org)
Branched-chain2
Elevated levels of plasma branched-chain amino acids (BCAAs) have been associated with insulin resistance and type 2 diabetes since the 1960s. (princeton.edu)
Pettit, F.H., Yeaman, S.J. and Reed, L.J. Purification and characterization of branched chain α-keto acid dehydrogenase complex of bovine kidney. (enzyme-database.org)
BCAA1
These results suggest that BCAA catabolism in type 2 diabetes is downregulated and enhanced by BCAA supplementation. (fujita-hu.ac.jp)
1.1681
It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168 . (enzyme-database.org)
Query1
Please see Release 3 Notes and query Release 3.1 [HERE] for the most up-to-date data. (fruitfly.org)
Mitochondrial1
This enzyme catalyses the following chemical reaction [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate This mitochondrial enzyme is associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. (wikipedia.org)
Complexes1
The family of giant multienzyme complexes metabolizing pyruvate, 2-oxoglutarate, branched-chain 2-oxo acids or acetoin contains several of the largest and most sophisticated protein assemblies known, with molecular masses between 4 and 10 million Da. (nih.gov)
Multienzyme1
It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168 , dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4 , dihydrolipoyl dehydrogenase. (enzyme-database.org)
Acid3
Evidence for the common identity of α-ketoisocaproic acid and α-keto-β-methyl-valeric acid dehydrogenases. (enzyme-database.org)
I. Isolation, purification, and partial characterization of bovine liver α-ketoisocaproic:α-keto-β-methylvaleric acid dehydrogenase. (enzyme-database.org)
Pettit, F.H., Yeaman, S.J. and Reed, L.J. Purification and characterization of branched chain α-keto acid dehydrogenase complex of bovine kidney. (enzyme-database.org)
Acids1
It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-oxopentanoate and ( S )-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. (enzyme-database.org)