One of the first molecules described to inhibit RAD51 was the 4,4 -diisothiocyanato-stilbene-2,2 -disulfonic acid (DIDS) molecule. (univ-nantes.fr)
Stilbene1
The response was inhibited by the apical Cl- channel blocker, diphenylamine-dicarboxylic acid, and the Ca2+-activated Cl- channel blocker, disulfonic acid stilbene, indicating that Cl- may pass through two types of Cl- channels on the apical side. (nih.gov)
Fatty2
This group of compounds includes amino acids and fatty acids. (lookformedical.com)
Fatty acid oxidation (FAO) fuels many cancers. (bvsalud.org)
Compounds1
Organic compounds that contain 1,2-diphenylethylene as a functional group. (nih.gov)
Organic1
After a brief exposure to 20 mM NH4Cl, pHi fell by approximately 0.7 and recovered at a rate of 0.89 +/- 0.15 pH/min in the nominal absence of Na+, HCO3-, organic anions, and SO4(2-) (lumen, bath). (jci.org)
Form1
Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
Inositol 1,4,5-trisphosphate1
The sulfated form of TLC (TLCS) causes Ca 2+ signalling in pancreatic acinar cells via an inositol 1,4,5-trisphosphate (IP 3 )-dependent mobilization of sequestered intracellular Ca 2+ (49). (pancreapedia.org)
Metabolism2
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. (nih.gov)
Bile acids (BAs) are natural end products of cholesterol metabolism (12). (pancreapedia.org)
Intracellular2
Intracellular pH (pH(i)), a major modulator of cell function, is regulated by acid/base transport across membranes. (ox.ac.uk)
changes of intracellular Na + concentrations ([Na + ] i ) induced by readmission of different external K + concentrations ([K + ] o ) to tissues depleted of K + by 4‐h exposure to K + ‐free solution. (comprehensivephysiology.com)
Unfortunately, we do not know the concentration of bile acids that can reach the pancreatic ductal cells under pathological conditions. (pancreapedia.org)
Hydrogen1
PMID- 9298188 OWN - NLM STAT- MEDLINE DA - 19971117 DCOM- 19971117 LR - 20061115 PUBM- Print IS - 0003-6072 (Print) VI - 72 IP - 2 DP - 1997 Aug TI - Formation of formate and hydrogen, and flux of reducing equivalents and carbon in Ruminococcus flavefaciens FD-1. (nih.gov)
Cells4
It has been shown that one of the most toxic BAs to acinar cells is the secondary BA, taurolithocholic acid (TLC) that forms from LCA after re-absorption from the intestine. (pancreapedia.org)
When HCO(3)(-) flux was pharmacologically inhibited, acid extrusion in multicellular HT29 and HCT116 spheroids (∼10,000 cells) was highly non-uniform and produced low pH(i) at the core. (ox.ac.uk)
This is because H(+) transporters require extracellular mobile pH buffers, such as CO(2)/HCO(3)(-), to overcome low H(+) ion mobility and chaperone H(+) ions away from cells. (ox.ac.uk)
CO(2)/HCO(3)(-) exerts a dual effect: as substrate for membrane-bound HCO(3)(-) transporters and as a mobile buffer for facilitating extracellular diffusion of H(+) ions extruded from cells. (ox.ac.uk)
Activity2
Difference in slope between curves 1 and 2 represents Na + ‐K + ‐ATPase activity. (comprehensivephysiology.com)
Difference in slope between curve 2 and 3 represents Ca 2+ ‐Mg 2+ ‐ATPase activity. (comprehensivephysiology.com)
Higher2
p = 0.363), with higher grade 3-4 hematologic toxicity. (bvsalud.org)
PMID- 9339686 OWN - NLM STAT- MEDLINE DA - 19971114 DCOM- 19971114 LR - 20061115 PUBM- Print IS - 0028-3878 (Print) VI - 49 IP - 4 DP - 1997 Oct TI - Higher neonatal cerebral blood flow correlates with worse childhood neurologic outcome. (nih.gov)
Years1
Follow-up information at ages 4 to 12 years was obtained on all 26 subjects. (nih.gov)