• Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. (bvsalud.org)
  • Sertaconazole 2% cream vs. miconazole 2% cream for cutaneous mycoses: a double-blind clinical trial. (harvard.edu)
  • The amplification of the beta-adrenergic cAMP response by these agents also occurred in the presence of isobutylmethylxanthine (10(-3) M) and Ro 20-1724 (10(-4) M), an observation suggesting that inhibition of cAMP phosphodiesterase activity is not the mechanism of action. (nih.gov)
  • Withdrawal of the inhibitory ligand unmasks the elevated enzyme activity and results in a prolonged 4- to 10-fold increase in cellular cyclic AMP levels. (nih.gov)
  • Activation of adenylate cyclase of NG108-15 neuroblastoma-glioma hybrid cells by prostaglandin E, resulted in the gradual loss of basal adenylate cyclase activity as well as enzyme activity stimulated by prostaglandin E), 2-chloroadenosine, NaF, or both pros- taglandin E, and guanyl-5'-yl imidodiphosphate. (nih.gov)
  • Exposure of NG108-15 cells to 8-Br cyclic AMP also resulted in the loss of basal, prostaglandin Ej-stimulated, and 2-chlo- roadenosine-stimulated adenylate cyclase activities. (nih.gov)
  • In contrast, exposure of NG108-15 cells to 2-chloroadenosine resulted in the rapid loss of response to 2-chloroadenosine with a half- life of 1.8 hr, but prostaglandin E,-stimulated and basal enzyme activities decreased only slightly. (nih.gov)
  • The cells were centrifuged for 4 min at 1000 x g, and the cell pellets were frozen in Dry Ice and stored over liquid nitrogen. (nih.gov)