• Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. (fishersci.com)
  • The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES. (rush.edu)
  • The group of common γ-chain receptor cytokines encompassing interleukin (IL)-2, IL-4, IL-9, IL-15, and IL-21 has been studied intensively over the recent years. (frontiersin.org)
  • CusabioProtein Description: Extracellular DomainAlternative Name (s) : CD137;ILA;TNFRSF9;4-1BB ligand receptor;CDw137;T-cell antigen. (joplink.net)
  • The 4-1BB receptor (CDw137), a member of the tumor necrosis factor receptor superfamily, has been shown to costimulate the activation of T cells. (rupress.org)
  • Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. (bmj.com)
  • El ligando es específico para el RECEPTOR 4-1BB y puede desempeñar un papel en la indución de la proliferación de los LINFOCITOS T activados de la sangre periférica. (bvsalud.org)
  • FLT 3-ligand binds to cells expressing tyrosine kinase receptor FLT3. (biofargo.com)
  • 4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. (kactusbio.cn)
  • 1)Vinay D S , Kwon B S. 4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy[J]. BMB Reports, 2014, 47(3):122-129. (kactusbio.cn)
  • The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. (bioxcell.com)
  • 4-1BB is a TNF receptor family member that signals via a complex that includes TRAF family members and the c-IAPs to upregulate NF-kappaB and ERK, and has been implicated in memory T-cell survival. (bioxcell.com)
  • CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. (fishersci.com)
  • 4-1BB ligand, also known as CD137L, is a 97 kD member of the TNF superfamily present on antigen-presenting cells (dendritic cells and macrophages) and activated B and T lymphocytes. (biolegend.com)
  • Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. (2bscientific.com)
  • The extracellular domain of CD137, comprised of four cysteine-rich domains (CRD-I, CRD-II, CRD-III, CRD-IV), trimerizes upon binding to CD137 ligand (CD137L) to induce cell stimulatory transcriptional and epigenetic changes. (bmj.com)
  • In this study, we evaluated the role of OX40L in costimulation of human antiviral CD8 T cell responses and compared it with two other important costimulators, B7.1 (CD80) and 4-1BBL (CD137L). (aai.org)
  • Synergistic or additive effects were observed when OX40L costimulation was combined with 4-1BBL (CD137L) or B7.1 (CD80) costimulation. (aai.org)
  • 4-1BBL interacts with 4-1BB (CD137) to induce T and B cell costimulation. (biolegend.com)
  • Autologous Ewing's tumors expressed 4-1BBL, and tumor-induced T cell proliferation and activation required costimulation by 4-1BBL. (johnshopkins.edu)
  • They further demonstrate a potential new therapeutic role for 4-1BBL mediated costimulation in expanding tumor reactive CTLs for use in the adoptive immunotherapy of cancer. (johnshopkins.edu)
  • 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. (bmj.com)
  • Costimulation of T cell responses with monoclonal antibody agonists (mAb-AG) targeting 4-1BB showed robust anti-tumor activity in preclinical models, but their clinical development was hampered by low efficacy (Utomilumab) or severe liver toxicity (Urelumab). (bioxcell.com)
  • Stimulation of PBL with anti-CD3/4-1BBL, but not anti-CD3/anti-CD28 induced tumor lytic effectors. (johnshopkins.edu)
  • Similarly, in a xenograft model, anti-CD3/4-1BBL expanded T cells controlled primary growth and prevented metastasis of autologous tumors while nonactivated and anti-CD3/anti-CD28 activated CD8+ cells did not. (johnshopkins.edu)
  • Absence of TIGIT, TIM-3 and CTLA-4, alone or combined, was beneficial to CD28- T cells. (bvsalud.org)
  • The second involves a network of co-inhibitory and co-stimulatory molecules pathways such as CD80/CD86-CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4), inducible co-stimulator (ICOS)-ICOS ligand (ICOSL), programmed death-1 (PD-1), programme death ligand-1/2 (PD-L1/PD-L2), 4-1BB-4-1BB ligand (4-1BBL), CD40-CD154 ligand, OX40-OX40 ligand and CD27-CD70. (biomedcentral.com)
  • CAR comprises an extracellular, cancer-specific antibody fused with the intracellular signaling activation domains of CD3 and co-activation ligands, such as CD28 or 4-1BB [ 17 , 18 ], which provide engineered T cells with an MHC‐independent mechanism through which to kill cancer cells directly. (biomedcentral.com)
  • Background CD137 (4-1BB) represents a costimulatory pathway that promotes T, NK, and dendritic cell effector functions favorable for antitumor immunity. (bmj.com)
  • Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. (bioxcell.com)
  • 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. (bioxcell.com)
  • B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
  • BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikidoc.org)
  • [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
  • All FcgammaRs can crosslink anti-41BB antibodies to strengthen co-stimulation, but activating FcgammaR-induced antibody-dependent cell-mediated cytotoxicity compromises anti-tumor immunity by deleting 4-1BB(+) cells. (bioxcell.com)
  • As a proof of this concept, we have developed LVGN6051, a humanized 4-1BB mAb-AG that shows high anti-tumor efficacy in the absence of liver toxicity in a mouse model of cancer immunotherapy. (bioxcell.com)
  • Recombinant Human 4-1BB/TNFRSF9 Protein is expressed from HEK293 with His tag at the C-Terminus. (kactusbio.cn)
  • Product Information Protein sequence A DNA sequence encoding the human 4-1BB Ligand (NP_003802.1) was expressed with a Fc-tag at the C-terminus. (biofargo.com)
  • Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
  • Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. (wikidoc.org)
  • [5] TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). (wikidoc.org)
  • All these ligands act as homotrimers (i.e. three of the same molecule) interacting with homotrimeric receptors, [6] although BAFF has been known to be active as either a hetero- or homotrimer (can aggregate into 60-mer depending on the primary structure of the protein). (wikidoc.org)
  • 2015). "c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival" Eur J Immunol 45(9): 2672-2682. (bioxcell.com)
  • FLT3 ligand is a growth factor that regulates the proliferation of early hematopoietic cells. (biofargo.com)
  • The FLT3 ligand itself does not stimulate the proliferation of early hematopoietic cells, but rather synergistically induces growth and differentiation with other CSFs and interleukins. (biofargo.com)
  • Unlike SCF, FLT3 ligand has no effect on mast cells. (biofargo.com)
  • Here we show that isotype and intrinsic agonistic strength co-determine the efficacy and toxicity of anti-4-1BB mAb-AG. (bioxcell.com)
  • Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. (2bscientific.com)
  • The purity of Human 4-1BB is greater than 95% as determined by SEC-HPLC. (kactusbio.cn)
  • Exons 1, 2 and most of exon 3 encode the N-terminal extracellular domain while the remainder of exon 3 and exon 4 encode transmembrane and cytoplasmic domains. (wikidoc.org)
  • Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. (kactusbio.cn)
  • This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)
  • This effect was most pronounced in the progression towards metaphase, too as 4-1BB Ligand Inhibitors products inside metaphase itself (video recordings of cells undergoing regular and prolonged, aberrant mitosis, see Supplemental Figure 6). (calcium-channel.com)
  • The majority of cases involved programmed death1/programmed death ligand 1 (PD1/PD-L1) inhibitors, and most occurred in patients with hematologic malignancies. (medscape.com)
  • The TKS-1 antibody inhibits binding of soluble 4-1BB to 4-1BBL in vitro . (biolegend.com)
  • The 4B4-1 monoclonal antibody specifically binds to CD137 which is also known as 4-1BB, and ILA (induced by lymphocyte activation). (bdbiosciences.com)
  • Here we show that anti-mouse 4-1BB monoclonal antibodies (mAbs) inhibit thymus-dependent antibody production by B cells. (rupress.org)
  • Methods We investigated the molecular and cellular effects of AGEN2373 (CRD-IV-binding, IgG1), a conditionally active CD137-targeting agonist antibody designed to bind and induce CD137 signaling upon FcγR cross-linking while permitting ligand binding to CD137. (bmj.com)
  • The antibody can also be used to isolate cells that have an FITC-labeled ligand on their surface. (gen9bio.com)
  • The 3H3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling in vivo . (bioxcell.com)
  • The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. (bioxcell.com)
  • 2019). "Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcgammaR affinity" Nat Commun 10(1): 2141. (bioxcell.com)
  • 4-1BBL induces the proliferation of activated peripheral blood T-cells. (2bscientific.com)
  • 4-1BB Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. (bioxcell.com)
  • Human 4-1BB Ligand (71-254), premium grade on SDS-PAGE under non-reducing (NR) condition. (2bscientific.com)
  • Immobilized Human 4-1BB, Mouse IgG2a Fc Tag, low endotoxin (Cat. (2bscientific.com)
  • No. 41B-H5256) at 2 ug/mL (100 uL/well) can bind Human 4-1BB Ligand (71-254), premium grade (Cat. (2bscientific.com)
  • Immobilized Human 4-1BB, His Tag (Cat. (2bscientific.com)
  • The gene for human PF4 is located on human chromosome 4 . (wikidoc.org)
  • The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole. (wikidoc.org)
  • Human 4-1BB on Tris-Bis PAGE under reduced condition. (kactusbio.cn)
  • Immobilized Human 4-1BB, His Tag at 1μg/ml (100μl/Well) on the plate. (kactusbio.cn)
  • Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation , apoptosis , [3] metabolism , homeostasis , immune response , wound repair , [4] and endocrine function. (wikidoc.org)
  • 12. 4-1BB-mediated immunotherapy of rheumatoid arthritis. (kseh.kr)
  • They can be activated rapidly via germ-line encoded receptors that recognize the presence of stress ligands or absence of self-antigens on target cells ( 1 - 5 ). (frontiersin.org)
  • For isolated CD8 T cells, 4-1BBL was also the most consistent costimulator, followed by B7.1. (aai.org)
  • 7. Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and natural killer T-cells. (kseh.kr)
  • Here, we show that effector and memory T cells from mice expressing a dominant negative E3-inactive c-IAP2 (c-IAP2(H570A) ) have impaired signaling downstream of 4-1BB. (bioxcell.com)
  • While intrinsically strong agonistic anti-4-1BB can activate 4-1BB in the absence of FcgammaRs, weak agonistic antibodies rely on FcgammaRs to activate 4-1BB. (bioxcell.com)
  • 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. (forextrading-madeeasy.com)
  • 13. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. (kseh.kr)
  • This suggests balancing agonistic activity with the strength of FcgammaR interaction as a strategy to engineer 4-1BB mAb-AG with optimal therapeutic performance. (bioxcell.com)
  • 4. The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation. (kseh.kr)
  • The results presented herein demonstrate that BRCA14P, with all 4 key SQ-cluster serine residues mutated to alanines mimicking un-phosphoryl. (calcium-channel.com)
  • Exon 1 encodes residues 1-16, exon 2 residues 17-35, exon 3 residues 36-63 and exon 4 residues 64-128. (wikidoc.org)
  • In the erythrocyte glycophorin C makes up ~4% of the membrane sialoglycoproteins . (wikidoc.org)
  • As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases. (2bscientific.com)
  • The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. (bioxcell.com)
  • In total T cell cultures, at low Ag dose, 4-1BBL provided the most potent costimulus for influenza-specific CD8 T cell expansion, followed by B7.1 (CD80) and then OX40L. (aai.org)
  • Sixteen BALB/c mice (6 weeks of age) were inoculated intranasally with 10 2 -10 5 TCID 50 /animal (30 μL), and 4 mice were inoculated intraperitoneally with 10 5 TCID 50 /animal (30 μL). (cdc.gov)
  • Despite the similar names glycophorin C and D are unrelated to the other three glycophorins which encoded on chromosome 4 at location 4q28-q31. (wikidoc.org)