In enzymology, a 3-hydroxybenzoate 4-monooxygenase (EC 1.14.13.23) is an enzyme that catalyzes the chemical reaction 3-hydroxybenzoate + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 3,4-dihydroxybenzoate + NADP+ + H2O The 4 substrates of this enzyme are 3-hydroxybenzoate, NADPH, H+, and O2, whereas its 3 products are 3,4-dihydroxybenzoate, NADP+, and H2O. (wikipedia.org)
The systematic name of this enzyme class is 3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). (wikipedia.org)
The styABCD cluster of strain 1CP harboring a styrene monooxygenase (StyA) and the associated oxidoreductase (StyB), as well as the styrene oxide isomerase (StyC) and the phenylacetaldehyde dehydrogenase (StyD) (Oelschlägel et al. (springeropen.com)
Pseudomonas1
Crystal structures of mutant Pseudomonas aeruginosa p-hydroxybenzoate hydroxylases: the Tyr201Phe, Tyr385Phe, and Asn300Asp variants. (cathdb.info)
Benzoate1
This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation. (wikipedia.org)
Acid2
A flavoprotein that catalyzes the synthesis of protocatechuic acid from 4-hydroxybenzoate in the presence of molecular oxygen. (nih.gov)
In fact treatment with two hydroxylated analogues of 4-hydroxybenzoic acid, namely, vanillic acid or 3-4-hydroxybenzoic acid, restored the respiratory growth of yeast Δcoq6 cells expressing the mutant huCOQ6-isoa proteins. (nih.gov)
Encodes1
Human COQ6 encodes a monooxygenase which is responsible for the C5-hydroxylation of the quinone ring of coenzyme Q (CoQ). (nih.gov)
Degradation3
Comment: An aerobic route for degradation of 4-hydroxybenzoate involves 4-hydroxybenzoate 3-monooxygenase pobA, which forms protocatechuate (3,4-dihydroxybenzoate). (lbl.gov)
Comment: In MetaCyc pathway glutaryl-CoA degradation ( link ), glutaryl-CoA is oxidized to (E)-glutaconyl-CoA and oxidatively decarboxylated to crotonyl-CoA (both by the same enzyme), hydrated to 3-hydroxybutanoyl-CoA, oxidized to acetoacetyl-CoA, and cleaved to two acetyl-CoA. (lbl.gov)
Meanwhile, in the oxidative degradation of hydroquinone under a supercritical condition (409.9°C and 24.5 MPa) and subcritical condition (359.9°C and 24.5 MPa), -benzoquinone was to be an important intermediate [ 3 ]. (hindawi.com)
Protocatechuate1
Comment: In the meta-cleavage pathway ( link ), the 4,5-dioxygenase ligAB splits protocatechuate to 4-carboxy-2-hydroxymuconate-6-semialdehyde. (lbl.gov)
Enzyme2
This enzyme is also called 3-hydroxybenzoate 4-hydroxylase. (wikipedia.org)
Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide. (uchicago.edu)
Gene1
The P. mendocina KR1 gene encoding p-hydroxybenzoate hydroxylase was linked to, but independently regulated from, the genes encoding toluene-4-monooxygenase, p-cresol methylhydroxylase, and p-hydroxybenzaldehyde dehydrogenase. (nih.gov)
The StyA1/StyA2B system of strain 1CP containing the styrene monooxygenase StyA1 and the self-sufficient StyA2B where the StyA part is fused to the StyB subunit. (springeropen.com)
Molecular1
Flavoproteína que cataliza la síntesis del ácido protocatechuico a partir de 4-hidroxibenzoato en presencia de oxígeno molecular. (bvsalud.org)