• 4-Hydroxyphenylpyruvate dioxygenase (HPPD), also known as α-ketoisocaproate dioxygenase (KIC dioxygenase), is an Fe(II)-containing non-heme oxygenase that catalyzes the second reaction in the catabolism of tyrosine - the conversion of 4-hydroxyphenylpyruvate into homogentisate. (wikipedia.org)
  • The herbicide functions by inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD). (bcpc.org)
  • Populations of Palmer amaranth have been documented with resistance to one or more of the following classes: Dinitroanilines, triazines, ALS (acetolactate synthase) inhibitors, glyphosate and HPPD (4-hydroxyphenylpyruvate dioxygenase) inhibitor herbicide. (mn.us)
  • The table contains 22 products whose active ingredient are classified under the same pharmacologic class 4-Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor [EPC]. (ndclist.com)
  • Orfadin (nitisinone) is a hydroxyphenyl- pyruvate dioxygenase inhibitor used to treat a rare genetic condition called hereditary tyrosinemia type 1 ( HT -1). (rxlist.com)
  • ORFADIN contains nitisinone, which is a hydroxyphenyl- pyruvate dioxygenase inhibitor indicated as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 ( HT -1). (rxlist.com)
  • Orfadin, a 4-hydroxyphenylpyruvate dioxygenase inhibitor, is indicated for the treatment of hereditary tyrosinemia type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine. (empr.com)
  • Nitisinone (NTBC), a potent inhibitor of the 4-hydroxyphenylpyruvate dioxygenase (HPD) enzyme, rescues HT1 patients from severe illness and death. (edgehill.ac.uk)
  • A significantly increased excretion of aberrant tyrosine metabolites was detected, with 4-oxo-6-hydroxyheptanoic acid as the dominant metabolite. (biomedcentral.com)
  • Multiple resistance has evolved to herbicides in the Groups 2 (Legacy B), Inhibition of Protoporphyrinogen Oxidase HRAC Group 14 (Legacy E), and Inhibition of Hydroxyphenyl Pyruvate Dioxygenase HRAC Group 27 (Legacy F2). (weedscience.com)
  • These particular biotypes are known to have resistance to fomesafen, imazamethabenz-methyl, lactofen, mesotrione, and thifensulfuron-methyl and they may be cross-resistant to other herbicides in the Groups 2 (Legacy B), Inhibition of Protoporphyrinogen Oxidase HRAC Group 14 (Legacy E), and Inhibition of Hydroxyphenyl Pyruvate Dioxygenase HRAC Group 27 (Legacy F2). (weedscience.com)
  • Mesotrione, a 4-hydroxyphenylpyruvate dioxygenase-inhibiting herbicide, is labeled for PRE and POST crabgrass control. (cambridge.org)
  • The shift, accounts for the observation that C3 is bonded to C4 in 4-hydroxyphenylpyruvate but to C5 in homogentisate. (wikipedia.org)
  • In nearly all aerobic beings, 4-hydroxyphenylpyruvate dioxygenase is responsible for converting 4-hydroxyphenylpyruvate into homogentisate. (wikipedia.org)
  • Identification of 11 Novel Homogentisate 1,2 Dioxygenase Variants in Alkaptonuria Patients and Establishment of a Novel LOVD-Based HGD Mutation Database. (medscape.com)
  • Single gene expression heat map analysis revealed that exogenous Spd upregulated the expression of genes encoding zinc-iron transporter protein and 2'-deoxymugineic-acid 2'-dioxygenase, which improved the uptake and utilization of iron by the root system. (bvsalud.org)
  • Glyphosate-resistant (GR) giant ragweed can be controlled in soybean with glyphosate plus 2,4-D ester or amitrole applied preplant. (scirp.org)
  • Four field experiments were conducted in 2021 and 2022 to ascertain the effect of glufosinate rate and the addition of ammonium sulfate on annual weed control in glyphosate/glufosinate/2,4-D-resistant soybean. (cambridge.org)
  • TIM barrel domain, Glyoxalase/fosfomycin resistance/dioxygenase domain, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily [InterProScan]. (ntu.edu.sg)
  • Potential anti-infective targets in pathogenic yeasts: Structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans. (mpg.de)
  • Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate. (mpg.de)
  • Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate - Implications for the catalytic mechanism. (mpg.de)
  • Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC) - Implications for the catalytic mechanism and anti-malaria drug development. (mpg.de)
  • Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii. (mpg.de)
  • Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. (mpg.de)
  • In patients 5 years of age and older who have undetectable serum and urine succinylacetone concentrations after a minimum of 4 weeks on astable dosage of nitisinone, the total daily dose may be given once daily. (guidelinecentral.com)
  • If succinylacetone is still detectable in blood or urine 4 weeks after the start of nitisinone treatment, increase the NITYR dosage to 0.75 mg/kg twice daily. (guidelinecentral.com)
  • In China this weed first evolved resistance to Group 4 (Legacy O) herbicides in 2000 and infests Rice. (weedscience.com)
  • Comparison of Setaria species in Canada Character S.italica S.faberi S.pumila S.viridis S.verticillata Culms(cm) 100 250 50 200 30 130 20 250 30 100 Ligules(mm) 1 229 11 2to1 Blades(mmwide) 10 30 10 20 4 10 4 25 5 15 USDA Natural Resources Conservation Service. (luleaccordion.se)
  • The addition of ammonium sulfate to glufosinate increased control of common lambsquarters, 2 and 8 wk after application (WAA), and of foxtail species, 2, 4, and 8 WAA, but did not improve control of common ragweed and redroot pigweed. (cambridge.org)
  • The most significant part of the GO enrichment analysis shifted from responding to organic cyclic compounds and aldehyde/ketone group transferase activity to responding to trivalent iron ions and 2'-deoxymugineic-acid 2'-dioxygenase activity. (bvsalud.org)
  • 10). These values are in accordance with a normal 4-hydroxyphenylpyruvate dioxygenase activity (Table 1). (biomedcentral.com)
  • Field experiments evaluated the control of GR giant ragweed with IFT plus MTZ in tank-mix in a 1:4 ratio. (scirp.org)
  • 4-hydroxyphenylpyruvate dioxygenase (HPD) (EC 1.13.11.27) is a key enzyme involved in tyrosine catabolism. (nih.gov)
  • We have treated one acute and four subacute-chronic cases with 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), a potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27), to prevent the formation of maleylacetoacetate and fumarylacetoacetate and their saturated derivatives. (nih.gov)
  • It has a role as a herbicide, an agrochemical, an EC 1.13.11.27 ( 4-hydroxyphenylpyruvate dioxygenase) inhibitor and a carotenoid biosynthesis inhibitor. (baynoe.com)
  • In addition to dietary treatment, some advise the use of NTBC, which is a highly potent inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. (medscape.com)
  • Highly potent reversible inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. (medscape.com)
  • In addition to dietary treatment, appropriate medical therapy involves the use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), a highly potent inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. (medscape.com)
  • Nitisinone capsules are a hydroxy-phenylpyruvate dioxygenase inhibitor indicated for the treatment of adult and pediatric patients with hereditary tyrosinemia type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine. (nih.gov)
  • In this study, we kept 14CoS/14CoS mice alive for 60 d with oral 2-(2-nitro-4-trifluoromethyl-benzyol)-1,3-cyclohexanedione (NTBC), an inhibitor of p-hydroxyphenylpyruvate dioxygenase, second enzyme in the tyrosine catabolic pathway. (nih.gov)
  • Nitisinone (NTBC), a potent inhibitor of the 4-hydroxyphenylpyruvate dioxygenase (HPD) enzyme, rescues HT1 patients from severe illness and death. (edgehill.ac.uk)
  • A potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD) that is rapily metabolised by corn to non-active substances, it is used as a herbicide for the treatment of broadleaf weeds. (baynoe.com)
  • The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. (nih.gov)
  • An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. (nih.gov)
  • Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-containing non-heme oxygenase of unknown specificity and biological significance. (univaq.it)
  • Ruetschi U, Cerone R, Perez-Cerda C, Schiaffino MC, Standing S, Ugarte M, Holme E. Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III. (medlineplus.gov)
  • An open-label study of 207 patients (aged from birth to 21.7 y, median age 9 mo) revealed an improved overall survival rate compared with historical control subjects (29% vs 88% survival probabilities at 4 y) when patients who were younger than 2 months presented with hereditary tyrosinemia type I and were treated with nitisinone and dietary restriction. (medscape.com)
  • In tyrosinemia, type III (TYR III), the enzyme 4-hydrocyphenylpyruvate dioxygenase (HPD) is not working correctly. (babysfirsttest.org)
  • Brownlee JM, Heinz B, Bates J, Moran GR. Product analysis and inhibition studies of a causative Asn to Ser variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple route to the treatment of Hawkinsinuria. (medlineplus.gov)
  • Multiple resistance has evolved to herbicides in the Groups 5 (Legacy C1 C2), and Inhibition of Hydroxyphenyl Pyruvate Dioxygenase HRAC Group 27 (Legacy F2). (weedscience.com)
  • These particular biotypes are known to have resistance to atrazine, mesotrione, tembotrione, and topramezone and they may be cross-resistant to other herbicides in the Groups 5 (Legacy C1 C2), and Inhibition of Hydroxyphenyl Pyruvate Dioxygenase HRAC Group 27 (Legacy F2). (weedscience.com)
  • protein_coding" "CCP43931","fadH","Mycobacterium tuberculosis","Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) [Ensembl]. (ntu.edu.sg)
  • Therefore, five field trials were conducted over 3 yr (2019 to 2021) to determine the ED of atrazine to complement 30 g ai ha -1 of tolpyralate to achieve 80%, 90%, and 95% control of seven weed species 2, 4, and 8 wk after application (WAA). (bioone.org)
  • Topramezone is an aromatic ketone that is phenyl 1H-pyrazol-4-yl ketone in which the pyrazolyl group is substituted at positions 1 and 5 by methyl and hydroxy groups, respectively, and in which the phenyl group is substituted at positions 2, 3, and 4 by methyl , 4,5-dihydro-1,2-oxazol-3-yl, and methylsulfonyl groups, respectively. (baynoe.com)
  • Pterin 4 alpha carbinolamine dehydratase [Interproscan]. (ntu.edu.sg)
  • Instead, some 4-hydroxyphenylpyruvate forms an unusual sulfur-containing amino acid called hawkinsin. (medlineplus.gov)