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Methylenetetrahydrofolate Reductase (NADPH2)5,10-Methylenetetrahydrofolate Reductase (FADH2)Oxidoreductases Acting on CH-NH Group DonorsMethylenetetrahydrofolate Dehydrogenase (NADP)HomocysteineMethylenetetrahydrofolate Dehydrogenase (NAD+)Folic AcidTetrahydrofolatesPolymorphism, GeneticGenotype5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseHyperhomocysteinemiaVitamin B 12Ferredoxin-NADP ReductaseHomozygoteFactor VGenetic Predisposition to DiseaseCystathionine beta-SynthaseThymidylate SynthaseThrombophiliaCase-Control StudiesFolic Acid DeficiencyGene FrequencyGlycine HydroxymethyltransferaseRiboflavinFlavin-Adenine DinucleotideHomocystinuriaHomocystineProthrombinOxidoreductasesAllelesPolymorphism, Single NucleotideRisk FactorsMethionineAminohydrolasesVitamin B ComplexFormate-Tetrahydrofolate LigaseMacedonia (Republic)Point MutationS-AdenosylmethionineMutationVitamin B 6ThymineMethenyltetrahydrofolate CyclohydrolaseOdds RatioNeural Tube DefectsBetaineFertility Agents, MaleFMN ReductaseReduced Folate Carrier ProteinNitrate ReductasesCytosineNADPPolymerase Chain ReactionAsian Continental Ancestry GroupSpinal DysraphismMethotrexateAbortion, HabitualHydroxymethylglutaryl CoA ReductasesPolymorphism, Restriction Fragment LengthAmino Acid Metabolism, Inborn ErrorsTranscobalaminsRibonucleotide ReductasesPyridoxineDietary SupplementsAlcohol OxidoreductasesDietColorectal NeoplasmsFluorodeoxyuridylateCytochrome-B(5) ReductaseNitrite ReductasesHeterozygoteDeoxyribodipyrimidine Photo-LyaseChinaDNA Mutational AnalysisDNA MethylationGenetic Association StudiesGlutathione ReductaseKineticsThioredoxin-Disulfide ReductaseTetrahydrofolate DehydrogenaseConfidence IntervalsNADPH-Ferrihemoprotein ReductaseGenetic VariationOxidation-ReductionPharmacogeneticsPteroylpolyglutamic AcidsRiskBase SequencePregnancyMolecular Sequence DataCytochrome ReductasesOxidoreductases Acting on CH-CH Group DonorsVascular DiseasesDihydropteridine ReductaseEnzyme StabilityHaplotypesJapanFlavinsReference Values
HomocysteineMethylProteinsFull flat fileHumanGeneMethionineSpecific
Homocysteine3
  • Methionine synthase reductase (MTRR) is primarily involved in the reductive methylation of homocysteine to methionine, utilizing methylcob(I)alamin as an intermediate methyl carrier. (wikipedia.org)
  • The enzyme bound cob(I)alamin cofactor of the MTR enzyme functions as a methyl carrier between 5-MTHF and homocysteine. (wikipedia.org)
  • 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase MSR [Methionine Synthase]- Cobalamin Methyltransferase (Cob(II)Alamin Reducing) Methionine Synthase Reductase, Mitochondrial EC 1.16.1.8 CblE The gene was mapped to human chromosome 5. (wikipedia.org)
Methyl1
  • Circulating blood folate (5-methyl tetrahydrofolate, 5-MTHF) donates methyl groups to MTR to be utilized in cellular methylation. (wikipedia.org)
Proteins1
  • MTR reactivation can also be NADPH dependent involving two redox proteins, soluble cytochrome b5 and reductase 1. (wikipedia.org)
Full flat file1
  • For detailed information about 5,10-methylenetetrahydrofolate reductase (FADH2), go to the full flat file . (brenda-enzymes.org)
Human2
  • Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma. (harvard.edu)
  • Gene specific primer pairs resulted in PCR amplification of a product matched by size to a hybrid-mapping panel containing only chromosome 5 as its human genetic material. (wikipedia.org)
Gene5
  • The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) has been linked to unipolar major depressive disorder (MDD) and magnetic resonance imaging (MRI) hyperintensities. (nih.gov)
  • Methionine synthase reductase, also known as MSR, is an enzyme that in humans is encoded by the MTRR gene. (wikipedia.org)
  • The Methionine Synthase Reductase (MTRR) gene primarily acts in the reductive regeneration of cob(I)alamin (vitamin B12). (wikipedia.org)
  • Gene specific primer pairs resulted in PCR amplification of a product matched by size to a hybrid-mapping panel containing only chromosome 5 as its human genetic material. (wikipedia.org)
  • The MTRR gene is associated with a family of electron transferases known as the Ferredoxin-NADP(+) reductase (FNR) family. (wikipedia.org)
Methionine2
  • Homocystinuria caused by 5,10-methylenetetrahydrofolate reductase deficiency: a case in an infant responding to methionine, folinic acid, pyridoxine, and vitamin B12 therapy. (nih.gov)
  • Methionine synthase reductase regenerates a functional methionine synthase via reductive methylation. (wikipedia.org)
Specific1
  • It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. (nih.gov)