• 5-Aminolaevulinic acid synthase-1 (ALAS-1) catalyses the first and rate-controlling step of haem biosynthesis. (umassmed.edu)
  • 5'-aminolevulinate synthase 1 [Source:H. (gsea-msigdb.org)
  • A review of the disease progression among the eight reported cases found an elevation in circulating levels of the rate-limiting hepatic enzyme 5-aminolevulinic acid synthase-1 (ALAS1) and response to treatment with hemin. (medscape.com)
  • 5-Aminolevulinic acid dehydratase deficiency porphyria: a twenty-year clinical and biochemical follow-up. (medscape.com)
  • delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations. (medscape.com)
  • It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid and inhibiting thymidylate synthetase and, subsequently, cell proliferation. (medscape.com)
  • Decreased heme production de-represses ALA synthetase and further increases ALA levels. (medscape.com)
  • The most common chemotherapeutic agent used in superficial basal cell carcinoma is topical 5-fluorouracil. (medscape.com)
  • In addition, exogenous haem (20 microM) repressed the basal and Glut- and DHA-induced activity of luciferase reporter constructs containing 9.1 and 6.3 kb of ALAS-1 5'-flanking region but not the construct containing the first 3.5 kb of promoter sequence. (umassmed.edu)
  • ALA synthetase activity is also closely associated with cytochrome P-450 activity. (medscape.com)
  • Transworld Research Network 37/661 (2), Fort P.O. Plants in Traditional and Modern Medicine: Chemistry and Activity, 2010: 69-175 ISBN: 978-81-7895-432-5 Editor: Eugene Kokkalou 2. (gotomydoctor.com)
  • These results demonstrate that there are regulatory regions in the 5'-flanking region of the cALAS-1 gene that respond to haem and provide a basis for further investigations of the molecular mechanisms by which haem down-regulates expression of the ALAS-1 gene. (umassmed.edu)
  • X-linked sideroblastic anemia (XLSA) in four unrelated male probands was caused by missense mutations in the erythroid-specific 5-aminolevulinate synthase gene (ALAS2). (nih.gov)
  • A review of the disease progression among the eight reported cases found an elevation in circulating levels of the rate-limiting hepatic enzyme 5-aminolevulinic acid synthase-1 (ALAS1) and response to treatment with hemin. (medscape.com)
  • 14. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxygenase-1, biliverdin IXalpha reductase and delta-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor. (nih.gov)
  • An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. (wakehealth.edu)
  • The enzyme is an aminomutase that transfers the amino group from the C-2 of the substrate to the neighboring carbon atom (C-5). (pougetlaw.com)
  • The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. (nih.gov)
  • Topical fluorouracil (5-FU) cream and imiquimod cream are the usual first-line drug treatments. (msdmanuals.com)
  • 5-Aminolevulinate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • The most common chemotherapeutic agent used in superficial basal cell carcinoma is topical 5-fluorouracil. (medscape.com)
  • 5-Fluorouracil topical 5% cream or solution is used topically for the management of superficial BCC. (medscape.com)
  • 2. Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer. (nih.gov)
  • 11. Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer. (nih.gov)
  • Methyl aminolevulinate cream is a porphyrin precursor used in combination with narrow-band, red-light illumination for nonhyperkeratotic, nonpigmented actinic keratoses. (medscape.com)
  • 3. Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4. (nih.gov)
  • A promoter is experimentally determined if a corresponding transcription initiation site is mapped with a precision of +/- 5 bp or higher. (expasy.org)
  • Regarding the docking analysis, the model suggested that four hydrogen bonds contribute to the binding energy of curcumin's interaction with the ligand binding site of S. aureus tyrosyl-tRNA synthetase. (bvsalud.org)