5α-Reductase inhibitors have medical applications in the treatment of benign prostatic hyperplasia, androgenic alopecia (pattern hair loss), and hirsutism (excessive hair growth). (wikipedia.org)
Proscar is used in the treatment of Benign Prostatic Hyperplasia and belongs to the drug class 5-alpha-reductase inhibitors . (drugs.com)
Saw palmetto extract (SPE), used widely for the treatment of benign prostatic hyperplasia (BPH) has been shown to bind alpha(1)-adrenergic, muscarinic and 1,4-dihydropyridine (1,4-DHP) calcium channel antagonist receptors. (nih.gov)
The PCPT (Prostate Cancer Prevention Trial) and REDUCE (Reduction by Dutasteride of Prostate Cancer Events) had found increases in Gleason 7 to 10 PCa among men treated with 5-ARIs for benign prostatic hyperplasia (BPH), investigators noted. (renalandurologynews.com)
An extended Fish ELS study was conducted to investigate the potential of dutasteride, as a 5-alpha-reductase inhibitor, to indirectly act as an endocrine disruptor. (janusinfo.se)
5-alpha reductase is the enzyme responsible for converting testosterone in to dihydrotestosterone (DHT) through the blood stream. (regrowhair.com)
Retrograde ejaculation1
Alpha blockers - can worsen men's quality of life, as these drugs cause impotence, retrograde ejaculation, depression, testicular pain and even dementia. (deccanchronicle.com)
However, PDE5 inhibitors can also relax muscles in the urinary tract to help relieve symptoms of BPH. (medicalnewstoday.com)
PDE5 inhibitors, such as CIALIS, have been shown to increase the hypotensive effects of this medicine. (medicines.org.uk)
Men who take nitrate drugs cannot use PDE5 inhibitors. (limamemorial.org)
Talk to your doctor about whether PDE5 inhibitor drugs are a safe choice for you. (limamemorial.org)
Erectile dysfunction1
The proportion of men taking 5ARIs and experiencing erectile dysfunction is likely around 5 percent, according to Dr. Landon Trost, who is head of andrology and male infertility at the Mayo Clinic in Rochester, Minnesota. (huffpost.com)
Pygeum africanum/Urtica dioica extract) PNU-157706 - inhibits types 1 and 2 Steroidal oximes Turosteride (FCE-26073) - inhibits type 2 and to a 15-fold lesser extent type 1 Z-350 - also an α1-adrenergic receptor antagonist Many plants, as well as their associated phytochemical constituents, have inhibitory effects on 5α-reductase. (wikipedia.org)
Dodder (Cuscuta reflexa) Eastern arborvitae, northern whitecedar (Thuja occidentalis) Euphorbia jolkinii Fatty acids: The relative inhibitory potencies of unsaturated fatty acids are, in decreasing order: Gamma-Linolenic acid, alpha-linolenic acid, linoleic acid, palmitoleic acid, oleic acid, and myristoleic acid. (wikipedia.org)
Nonsteroidal anti-inflammatory drugs (NSAIDs) and alpha blockers help with symptom relief. (medscape.com)
In patients with early Parkinson's disease, selegiline and other drugs in a class called monoamine oxidase type B inhibitors are cheap and effective treatments that reduce disability and the need for levodopa, researchers reported in the British Medical Journal. (digitalnaturopath.com)
No well-documented interactions have been identified apart from a potential to interact with hormone altering drugs such as a 5-alpha-reductase inhibitor. (drugs.com)
Medicines2
CIALIS contains the active substance tadalafil which belongs to a group of medicines called phosphodiesterase type 5 inhibitors. (medicines.org.uk)
If you are at an increased risk, your healthcare provider may talk with you about taking medicines called 5-alpha-reductase inhibitors (5-ARIs). (rochester.edu)
Androgen2
The goal of this clinical study is to determine the safety and efficacy of VT-464, a lyase-selective inhibitor of CYP17 and an androgen receptor antagonist, in patients with castration-resistant prostate cancer (CRPC) who have been previously treated with enzalutamide or abiraterone. (mayo.edu)
Prior use of other 2nd generation CYP17 inhibitors and androgen receptor antagonists are allowed in addition to abiraterone or enzalutamide. (mayo.edu)
Alpha blockers work by relaxing the smooth muscle of the bladder neck and prostate. (mayoclinic.org)
Alpha blockers include alfuzosin (Uroxatral), doxazosin (Cardura), tamsulosin (Flomax) silodosin (Rapaflo) and terazosin. (mayoclinic.org)
There are multiple types of alpha blockers, but Flomax (tamsulosin) specifically targets the prostate. (mayoclinichealthsystem.org)
Alpha blockers may also help to decrease recurrences, by diminishing urinary obstruction. (medscape.com)
Previous studies have raised concerns that 5-alpha reductase inhibitors (5-ARIs) might increase the risk of high-grade prostate cancer (PCa), but new research confirms that 5-ARIs are associated with no greater risks compared with alpha-adrenergic blockers (ABs). (renalandurologynews.com)
Medication1
Each patient treated with a 5-ARI (or a combination of a 5-ARI and AB) was matched to 6 AB users with similar ages, race, and BPH medication initiation. (renalandurologynews.com)
Therapy1
The scientific hypothesis is that this alternative schedule for follow-up will identify the aggressive cancers earlier with less health-care resources and better quality of life for the patients, without increasing the total proportion of patients receiving radical therapy within 5 years. (cancercentrum.se)
Controlled substance1
Proscar 5 mg is not a controlled substance under the Controlled Substances Act (CSA). (drugs.com)
Blocker1
Your health care provider might suggest that you take an alpha blocker and a 5-alpha reductase inhibitor at the same time if either medicine alone doesn't help enough. (mayoclinic.org)
Acid3
Saw palmetto (Serenoa repens, active substance possibly lauric acid) The berries of saw palmetto, a small palm native to the south east United States, possess a dual but weak 5a-reductase inhibition activity, due to their high content of phytosterols: β-sitosterol, stigmasterol, lupeol, lupenone, and cycloartenol. (wikipedia.org)
The results suggest that lauric acid and oleic acid bind noncompetitively to alpha(1)-adrenergic, muscarinic and 1,4-DHP calcium channel antagonist receptors. (nih.gov)
Similarly, all the fatty acids except palmitic acid inhibited 5alpha-reductase activity, with IC(50) values of 42.1 to 67.6 microg/ml. (nih.gov)
Symptoms2
Similar to prior studies, we found an increased prevalence of high-grade prostate cancers diagnosed among men who were exposed 5-ARIs for the treatment of lower urinary tract symptoms related to BPH," lead investigator Lauren P. Wallner, PhD, MPH, of the University of Michigan in Ann Arbor, told Renal & Urology News . (renalandurologynews.com)
In addition, SAMS will evaluate prognostic factors, criteria for intervention and the effects of 5-alpha-reductase inhibitors, the outcome after treatment with curative intent, time to symptoms and metastases from prostate cancer, prostate cancer specific survival, and overall survival. (cancercentrum.se)
Prostate cancer1
The FDA has not approved 5-ARIs to specifically prevent prostate cancer. (rochester.edu)
Type1
During this symposium, 16 international cataract experts were each given 7 minutes to highlight their 5 best pearls for a specific type of challenging case. (aao.org)
Activity2
We developed a novel and convenient method of determining 5alpha-reductase activity using LC/MS. With this method, SPE was shown to inhibit 5alpha-reductase activity in rat liver with an IC(50) of 101 microg/ml. (nih.gov)
Thujae occidentalis inhbits 5-alpha reductase activity suggesting it may be useful for treating male pattern baldness. (greenmedinfo.com)
Proscar1
Pill with imprint PROSCAR MSD 72 is Blue, U-shape and has been identified as Proscar 5 mg. (drugs.com)
Fatty2
Medium chain fatty acids such as those found in coconut and the kernel of many palm fruits have also been found to inhibit 5α-reductase. (wikipedia.org)
The aim of this study was to investigate binding affinities of these fatty acids for pharmacologically relevant (alpha(1)-adrenergic, muscarinic and 1,4-DHP) receptors. (nih.gov)
Medical1
5-star reviewed medical and legal information site. (drugwatch.com)
Patients1
After an episode of acute bacterial prostatitis, approximately 5% of patients may progress to CBP. (medscape.com)
Shown1
Nizoral shampoo has been shown to be a potent 5-alpha reductase inhibitor. (regrowhair.com)
Human1
Using this model for human acne, we examined the effects of inhibitors. (karger.com)